Session Information
Session Title: Systemic Lupus Erythematosus - Clinical Aspects and Treatment: Biomarker, Translational and Nephritis Studies
Session Type: Abstract Submissions (ACR)
Background/Purpose: Lupus nephritis eventually occurs in 50% of Caucasian SLE patients and 75% of African-Americans. African Americans have a more severe presentation of SLE and more often progress to end stage renal disease (ESRD). We have found a number of serum and urine biomarkers that have been associated with lupus nephritis. Therefore, we compared Caucasians and African-Americans with respect to levels of these biomarkers.
Methods: Urinary tumor necrosis factor-like weak inducer of apoptosis (TWEAK), vascular cell adhesion molecule 1 (VCAM-1), monocyte chemoattractant protein 1 (MCP-1) and osteoprotegrin (OPG) were measured in a longitudinal cohort of SLE patients by ELISA (R&D). We analyzed the relationship between these potential urine biomarkers and Caucasian or African-American ethnicity.
Results: Urinary TWEAK levels were higher among Caucasians than African-Americans (p=.033). Urinary VCAM-1, MCP-1 and OPG levels were higher among African-Americans than Caucasians, but the results were not statistically significant (Table 1).
Table 1: Mean (SD) of Each Biomarker by Ethnicity
|
|
TWEAK (p=.033) |
VCAM-1 (p=0.62) |
MCP-1 (p=0.16) |
OPG (p=0.21) |
||||
|
N |
Mean log-Tweak (SD) |
N |
Mean log OPG (SD) |
N |
Mean (SD) |
N |
Mean (SD) |
|
|
Caucasian |
175 |
0.12 (0.10) |
32 |
2.59 (0.96) |
37 |
3.40 (2.00) |
37 |
3.35 (2.44) |
|
African-American |
96 |
0.09 (0.09) |
40 |
2.80 (0.85) |
43 |
4.19 (1.77) |
43 |
4.17 (1.94) |
Conclusion: Systemic lupus erythematosus and lupus nephritis disproportionately affect racial/ethnic minorities. Renal outcome has not improved in African-Americans or in the South in United States. Our results show that not all urine biomarkers are worse in African-Americans. Surprisingly, urinary TWEAK was higher in Caucasians. The others, however, were higher in African-Americans. The identification of ethnicity-specific biomarkers of renal activity would allow ethnicity-specific regimens. Further larger studies are needed to corroborate our findings.
Disclosure:
A. Kiani,
None;
L. S. Magder,
None;
M. Petri,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/biomarkers-of-lupus-nephritis-and-ethnic-disparities-in-systemic-lupus-erythematosus/