Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 82 • 2019 ACR/ARP Annual Meeting
Rab4A Increases Mitochondrial Oxidative Stress and Glutathione Disulfide Accumulation That Underlie Neurobehavioral Changes in Lupus-Prone Mice
Thomas Winans¹, Tamas Faludi ², Brandon Wyman ¹, Nick Huang ², Joshua Lewis ¹, Manuel Duarte ¹, Laurence Morel ³, Frank Middleton ² and Andras Perl ⁴, ¹Upstate Medical University, Syracuse, ²Upstate Medical University, Syracuse, NY, ³University of Florida, Gainesville, FL, ⁴SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Background/Purpose The human GTPase HRES-1/Rab4 has been identified as a susceptibility locus for systemic lupus erythematosus (SLE) and is overexpressed in T cells of…
Abstract Number: 653 • 2019 ACR/ARP Annual Meeting
Newly Diagnosed Lupus Nephritis in Elderly Predicts Good Renal Outcome: A Distinct Disease Subset from Young-onset Lupus Nephritis
Kazuoto Hiramoto¹, Hironari Hanaoka ¹, Jun Kikuchi ¹, Shuntaro Saito ¹, Hiroshi Takei ², Tatsuhiro Oshige ¹, Noriyasu Seki ³, Hideto Tsujimoto ³, Yuko Kaneko ¹ and Tsutomu Takeuchi ¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ³Mitsubishi Tanabe Pharma Corporation Sohyaku. Innovative Research Division, Toda-shi, Saitama, Japan
Background/Purpose: Elderly-onset SLE is recognized to be benign disease entity with a favorable nature course. Although late-onset lupus nephritis (LN), long interval between onset of…
Abstract Number: 860 • 2019 ACR/ARP Annual Meeting
Efficacy of Belimumab in Patients of Black Race with Systemic Lupus Erythematosus and High Disease Activity or Renal Manifestations
Luiz Sergio Guedes Barbosa ¹, Amit Saxena ², Ellen M Ginzler ³, Richard Furie⁴, David D'Cruz ⁵, Susan Burriss ⁶, Jennifer Gilbride ⁷, Michelle Miller ⁶, James Groark ⁶, David Roth ⁶ and Beulah Ji ⁸, ¹NUTEC - Núcleo de Terapia Especializada em Cancerologia, Cuiaba, Brazil, ²New York University School of Medicine, New York, NY, ³State University of New York Downstate Medical Center, Brooklyn, NY, ⁴Northwell Health, Great Neck, NY, ⁵The Louise Coote Lupus Unit, Guy's Hospital, London, England, United Kingdom, ⁶GSK, Collegeville, PA, ⁷GSK, Stevenage, Hertfordshire, United Kingdom, ⁸GSK, Uxbridge, Middlesex, United Kingdom
Background/Purpose: Black patients have more severe SLE and more frequent lupus nephritis vs other racial groups. Efficacy and safety of intravenous (IV) belimumab was demonstrated…
Abstract Number: 1031 • 2019 ACR/ARP Annual Meeting
Expanded Circulating Peripheral Helper T Cells Are Associated with B Cell Differentiation in Systemic Lupus Erythematosus
Ayako Makiyama¹, Asako Chiba ², Daisuke Noto ¹, Goh Murayama ³, Tomohiro Mizuno ⁴, Taiga Kuga ⁵, Ken Yamaji ⁵, Naoto Tamura ⁵ and Sachiko Miyake ², ¹Juntendo University School of Medicine, Tokyo, Japan, ²Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rhumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Immunlogy, Juntendo University School of Medicine, Tokyo, Japan, ⁵Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Autoreactive T-B cell interactions in lymphoid tissue have been thought to play a crucial role in the autoantibody production in systemic lupus erythematosus (SLE).…
Abstract Number: 1207 • 2019 ACR/ARP Annual Meeting
A Quality Improvement Intervention to Reduce 30-Day Hospital Readmission Rates Among Patients with Systemic Lupus Erythematosus
Emily Bowers¹, Melissa Griffith ¹, Elena Weinstein ¹, Duane Pearson ¹ and Jason Kolfenbach ¹, ¹University of Colorado Department of Rheumatology, Denver, CO
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic immune-mediated disease with significant morbidity and mortality that often requires inpatient hospitalization. SLE has one of the…
Abstract Number: 1590 • 2019 ACR/ARP Annual Meeting
Clinical and Sociodemographic Associates of Depression and Anxiety in Systemic Lupus Erythematosus
David Eldeiry¹, Moe Zandy ², Oshrat Tayer-Shifman ², Andrew Kwan ³, Sherief Marzouk ², Jiandong Su ², Kathleen Bingham ² and Zahi Touma ², ¹Royal College of Surgeons in Ireland, Dublin, Ireland, ²University Health Network, University of Toronto, Toronto, ON, Canada, ³Queens University, Kingston, ON, Canada
Background/Purpose: In our recent systematic review, we have shown a high prevalence for depression (35%) and anxiety (25.8%) in Systemic Lupus Erythematosus (SLE)1. A better…
Abstract Number: 1625 • 2019 ACR/ARP Annual Meeting
Severe Infection Prior to Diagnosis of Systemic Lupus Erythematosus (SLE) Is Associated with Disease-Specific Attributes and Long-Term Comorbidities
Yu Deng ¹, Anh Chung ², Abel Kho ¹, Yuan Luo ¹, Rosalind Ramsey-Goldman ² and Theresa Walunas², ¹Northwestern University, Chicago, ²Northwestern University, Chicago, IL
Background/Purpose: Lupus is a systemic autoimmune disease whose mechanism of development is largely unknown. Prior infection is a suspected sentinel event that may trigger disease…
Abstract Number: 1919 • 2019 ACR/ARP Annual Meeting
Development of a Multi-Modality Imaging Approach to Evaluate Lupus Nephritis
Amit Saxena ¹, David Karp ², Brad Rovin ³, Mikael Boesen ⁴, Olga Kubassova ⁵, Claire Dykas ⁶, Anthony Yeo ⁷ and Peter Lipsky⁸, ¹New York University School of Medicine, New York, NY, ²UTSouthwestern Medical Center, Dallas, TX, ³The Ohio State University Medical Center, Columbus, OH, ⁴Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, ⁵Image Analysis Group, London, United Kingdom, ⁶AmpelBioSolutions, Charlottesville, VA, ⁷RILITE Research Institute, Charlottesville, VA, ⁸AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Lupus nephritis (LN) remains a significant cause of morbidity and mortality in subjects with Systemic Lupus Erythematosus (SLE). The gold standard for evaluation of…
Abstract Number: 2214 • 2019 ACR/ARP Annual Meeting
Assessment of Bone Quality by Trabecular Bone Score (TBS) in Systemic Lupus Erythematosus Patients
Andrea Casabella ¹, Sabrina Paolino ², Alberto Sulli³, Elisa Alessandri ⁴, Vanessa Smith ⁵, Barbara Ruaro ⁶, Carmen Pizzorni ² and Maurizio Cutolo ⁷, ¹1 Research Laboratory and Academic Division of the Clinical Rheumatology Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS San Martino Polyclinic Hospital, Genoa, Italy, Genova, ⁵Dept. of Rheumatology, Ghent University Hospital, Ghent, Belgium; Dept. of Internal Medicine, Ghent University, Ghent, Belgium; Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium, Gent, Belgium, ⁶1 Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 2 Cardinal Ferrari Centre, S. Stefano Rheabilitation, Fontanellato (Parma), Italy, Genoa, Italy, ⁷Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, IRCCS Ospedale Policlinico San Martino, Genoa, Italy, Genoa, Italy
Background/Purpose: Systemic lupus erythematosus (SLE) patients show an increased risk of low bone mass as a result of multifactorial events: physical inactivity, persistent inflammation, low…
Abstract Number: 2531 • 2019 ACR/ARP Annual Meeting
Low Vitamin D Is Associated with Miscarriage and Preterm Birth in SLE with a U-shaped Relationship
Michelle Petri¹ and Jessica Li ¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: In the general population, low vitamin D has been associated with adverse pregnancy outcomes including preterm birth, pre-eclampsia and small for gestational age. In…
Abstract Number: 2565 • 2019 ACR/ARP Annual Meeting
Pharmacokinetics and Exposure-response of Intravenous Belimumab in Children with Systemic Lupus Erythematosus
Richard Dimelow ¹, Beulah Ji² and Herbert Struemper ³, ¹GSK, Stevenage, United Kingdom, ²GSK, Uxbridge, Middlesex, United Kingdom, ³GSK, Research Triangle Park
Background/Purpose: Belimumab is approved in adults with active SLE and for childhood-onset SLE (cSLE). PLUTO, a Phase 2, placebo-controlled, double-blind trial (114055; NCT01649765), was the first…
Abstract Number: 2813 • 2019 ACR/ARP Annual Meeting
Pentameric, but Not Monomeric C-reactive Protein, Limits the SnRNP-immune Complex Triggered Type I Interferon Response: Implications for Lupus Pathogenesis
Cecilia Svanberg ¹, Helena Enocsson ¹, Klara Martinsson ¹, Lawrence Potempa ², Ibraheem Rajab ², Jonas Wetterö ¹, Marie Larsson ¹ and Christopher Sjöwall³, ¹Linköping University, Linköping, Sweden, ²Roosevelt University, Chicago, IL, ³Department of Clinical and Experimental Medicine, Rheumatology/Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune systemic disease affecting multiple organs and which is characterized by autoantibodies directed against nuclear constituents. Common autoantibody…
Abstract Number: 83 • 2019 ACR/ARP Annual Meeting
Dysfunction of TRIM21 Promotes Aberrant Plasmablast Differentiation in Systemic Lupus Erythematosus Due to the Reduction of TRIM21-mediated Ubiquitylation of IRF5
Yosuke Kunishita¹, Ryusuke Yoshimi ¹, Reikou Kamiyama ¹, Daiga Kishimoto ¹, Koji Yoshida ¹, Eijin Hashimoto ¹, Yumiko Sugiyama ², Takaaki Komiya ¹, Natsuki Sakurai ¹, Yohei Kirino ³ and Hideaki Nakajima ³, ¹Department of Stem Cell and Immune Regulation / Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatic Diseases / Yokohama City University Medical Center, Yokohama, Japan, ³Department of Stem Cell and Immune Regulation, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: TRIM21 is a member of the tripartite motif family proteins and is one of the autoantigens which react with anti-SS-A antibody (Ab) present in…
Abstract Number: 659 • 2019 ACR/ARP Annual Meeting
Diminished Memory B-cells in Systemic Lupus Erythematosus Patients with Low Disease Activity
Sabine Zenz¹, Barbara Dreo ¹, Angelika Lackner ¹, Barbara Prietl ², Selina Kofler ², Harald Sourij ², Florentine Moazedi-Fuerst ¹, Monica D'Orazio ¹, Martin Stradner ¹, Winfried Graninger ¹ and Hans-Peter Brezinschek ¹, ¹Department of Internal Medicine/Division of Rheumatology and Immunology, Graz, Austria, ²2CBmed GmbH – Center for Biomarker Research in Medicine, Graz, Austria
Background/Purpose: B-cells play a pivotal role in the initiation and perpetuation of systemic lupus erythematosus (SLE). Recently, it has been demonstrated that in active SLE…
Abstract Number: 862 • 2019 ACR/ARP Annual Meeting
First Use of Cenerimod, a Selective sphingosine-1-phosphate 1 (S1P1) Receptor Modulator, for the Treatment of Systemic Lupus Erythematosus: A Double-Blind, Randomised, Placebo-Controlled, Phase II, Proof-of-Concept Study
Viktoria Hermann¹, Anastas Batalov ², Svetlana Smakotina ³ and Peter Cornelisse ¹, ¹Idorsia, Allschwil, Switzerland, ²Medical University of Plovdiv, University Hospital Kaspela, Plovdiv, Bulgaria, ³Kemerovo Regional Clinical Hospital, Kemerovo, Russia
Background/Purpose: Aberrantly activated T- and B-lymphocytes play a major pathophysiological role in SLE. Cenerimod, a potent, selective sphingosine-1-phosphate 1 receptor modulator, blocks the egress of…

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