Abstract Number: 689 • 2014 ACR/ARHP Annual Meeting
Prednisone, Disease Activity and Hypertension Independently Predict Cataracts in Systemic Lupus Erythematosus (SLE)
Background/Purpose: Cataract is the most common ocular damage in SLE. It is the second most frequent item in the SLICC/ACR Damage Index. Apart from cumulative…Abstract Number: 2675 • 2014 ACR/ARHP Annual Meeting
The Selective Loss of SLAMF4+ CD8+ T Cells Contributes to the Decreased Cytotoxic Capacity Observed in Systemic Lupus Erythematosus
Background/Purpose Signaling lymphocytic activation molecule family member 4 (SLAMF4) engagement by its ligand SLAMF2 can mediate the cytotoxicity of CD8+ T cells and natural killer…Abstract Number: 677 • 2014 ACR/ARHP Annual Meeting
Pharmacokinetics, Safety, and Biological Activity of Intravenously or Subcutaneously Administered Tabalumab in Subjects with Rheumatoid Arthritis or Systemic Lupus Erythematosus
Background/Purpose : B-cell activating factor (BAFF) promotes B-cell survival and maturation, and increased serum levels are associated with autoimmune disease and disease activity in systemic…Abstract Number: 2674 • 2014 ACR/ARHP Annual Meeting
The Effect and Mechanisms of Icaritin on Regulating Foxp3/IL17a Expression in CD4+ T Cells from SLE
Background/Purpose : Systemic lupus erythematosus (SLE) is a female predominant autoimmune disease characterized by overproduction of autoantibodies. The pathogenesis of SLE is complex. Several studies…Abstract Number: 2689 • 2014 ACR/ARHP Annual Meeting
The CUL4CRBN E3 Ubiquitin Ligase Modulator CC-220 Induces Degradation of the Transcription Factors Ikaros and Aiolos: Immunomodulation in Healthy Volunteers and Relevance to Systemic Lupus Erythematosus
Background/Purpose: CC-220 is an immunomodulatory compound that binds to cereblon (CRBN), part of the CUL4CRBN E3 ubiquitin ligase complex, which has been shown to ubiquitinate…Abstract Number: 2667 • 2014 ACR/ARHP Annual Meeting
First-Trimester Disease Activity Does Not Predict Pre-Eclampsia in SLE Pregnancy
Background/Purpose: Preeclampsia complicates up to 35% of lupus pregnancies compared to 8% of general population pregnancies. SLE has up to a 3-fold increased rate of…Abstract Number: 2635 • 2014 ACR/ARHP Annual Meeting
Noncalcified Plaque Progression in Systemic Lupus Erythematosus
Background/Purpose: Coronary atherosclerosis is a major cause of morbidity and mortality in SLE. New technology, computed tomoangiography (CTA) can measure non-calcified coronary plaque (NCP),…Abstract Number: 2648 • 2014 ACR/ARHP Annual Meeting
Prednisone Is a Risk Factor for Incident Depression in Systemic Lupus Erythematosus
Background/Purpose: Depression affects as many as 30% of SLE patients. Most studies of risk factors for depression among SLE patients have been cross-sectional, and thus…Abstract Number: 2647 • 2014 ACR/ARHP Annual Meeting
Predictors of Incident Seizure in Systemic Lupus Erythematosus
Background/Purpose: We identified the rate and risk factors for first occurrences of seizure based on a large closely followed longitudinal cohort of patients with systemic…Abstract Number: 2622 • 2014 ACR/ARHP Annual Meeting
Systemic LUPUS Erythematosus in Spanish Males
Background/Purpose: To describe the demographic, clinical and immunological manifestations in male patients with Systemic Lupus Erythematosus(SLE) Methods: Patients diagnosed of SLE that were in the…Abstract Number: 1859 • 2014 ACR/ARHP Annual Meeting
Age-Specific Predictors of Mortality in SLE
Background/Purpose: Mortality is 3 to 5 times greater in SLE patients then it is in the general population – especially among younger patients where it…Abstract Number: 1652 • 2014 ACR/ARHP Annual Meeting
Biomarkers of Lupus Nephritis and Ethnic Disparities in Systemic Lupus Erythematosus
Background/Purpose: Lupus nephritis eventually occurs in 50% of Caucasian SLE patients and 75% of African-Americans. African Americans have a more severe presentation of SLE and…Abstract Number: 1595 • 2013 ACR/ARHP Annual Meeting
Electroclinical Correlates and Outcome Of Status Epilepticus In Systemic Lupus Erythematosus
Background/Purpose: Predictors of seizures and epilepsy in systemic lupus erythematosus (SLE) patients are well described but descriptions of status epilepticus (SE) have thus far been…Abstract Number: 1577 • 2013 ACR/ARHP Annual Meeting
Comparison Of Clinical and Serological Manifestations Among Juvenile-, Adult-, and Late-Onset Systemic Lupus Erythematosus Patients In Korea
Background/Purpose: Up to 30‑40% of patients with systemic lupus erythematosus (SLE) experience their onset prior to adulthood or at over 50 years of age. Patients…Abstract Number: 1060 • 2013 ACR/ARHP Annual Meeting
Perinatal Risk Factors For Systemic Lupus: A Register-Based Case-Control Study
Background/Purpose: One’s own fetal environment has been linked to future heart disease, breast cancer, and rheumatoid arthritis. Prior work showed that among older women in…
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