Abstracts tagged "Systemic lupus erythematosus (SLE)"

Abstract Number: 1678 • 2018 ACR/ARHP Annual Meeting
How Consistently Do Publications Define SLE? a Systematic Review
Linjia Jia¹, Ecem Sevim², Medha Barbhaiya² and Michael Lockshin³, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Barbara Volcker Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Systemic lupus erythematosus (SLE) is clinically heterogeneous. ACR and/or SLICC classification criteria provide homogeneous populations for research purposes, but studies differ in selection and…
Abstract Number: 687 • 2017 ACR/ARHP Annual Meeting
Homocysteine Levels Are Independently Associated with Damage Accrual in Systemic Lupus Erythematosus Patients (SLE)
Paola Zeña-Huancas¹, Manuel Ugarte-Gil^2,3, Rocío Gamboa-Cárdenas¹, Francisco Zevallos¹, Mariela Medina¹, Victor Pimentel-Quiroz², Claudia Elera-Fitzcarrald¹, Omar Sarmiento-Velasquez¹, Cristina Reategui-Sokolova¹, Mariano Cucho-Venegas¹, José Alfaro-Lozano¹, Zoila Rodriguez-Bellido^1,4, Cesar A. Pastor-Asurza^1,4, Graciela S. Alarcón⁵ and Risto Perich-Campos^4,6, ¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²Peru, GLADEL, Lima, Peru, ³Universidad Cientifica del Sur, Lima, Peru, ⁴Universidad Nacional Mayor de San Marcos, Lima, Peru, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Rheumatology, Hospital Guillermo Almenara Irigoyen, Lima, Peru
Background/Purpose: Homocysteine level is a predictor of the occurrence of cardiovascular diseases, however, its role as a predictor of damage in SLE has not been…
Abstract Number: 1646 • 2017 ACR/ARHP Annual Meeting
Cardiovascular disease in Systemic Lupus Erythematosus. The road to hell is paved with good intentions
Sophie Mavrogeni¹ and Loukia Koutsogeorgopoulou², ¹CMR Department, Onassis Cardiac Surgery Center, Athens, Greece, ²Department of Pathophysiology, Rheumatology Unit, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Accurate diagnosis of cardiovascular involvement in systemic lupus erythematosus (SLE) remains challenging, because echocardiography (echo), the cornerstone tool used, has serious limitations. We hypothesized…
Abstract Number: 1654 • 2017 ACR/ARHP Annual Meeting
Predictive Factors According to Type of Infection in Systemic Lupus Erythematosus Patients: Data from a Multi-Ethnic, Multi-National, Latin-American Cohort
Victor R. Pimentel-Quiroz¹, Manuel Ugarte-Gil¹, Guillermo J. Pons-Estel², Daniel Wojdyla³, Mario Cardiel⁴, Virginia Pascual-Ramos⁵, Ignacio Garcia-De La Torre⁶, Leonor Barile⁷, Mary Carmen Amigo⁸, Luis H. Silveira⁹, Maria Josefina Sauza del Pozo¹⁰, Marlene Guibert-Toledano¹¹, Gil A. Reyes¹², Antonio Iglesias-Gamarra¹³, Gloria Vasquez¹⁴, José Fernando Molina¹⁵, Jose A Gómez-Puerta¹⁶, Luis Alonso Gonzalez¹⁷, Rosa Chacón-Díaz¹⁸, Maria H Esteva Spinetti¹⁹, Isaac Abadi¹⁹, Eduardo M. Acevedo-Vásquez²⁰, Jose Alfaro-Lozano²¹, Ines Segami²², Loreto Massardo²³, Oscar Neira²³, Emilia Sato²⁴, Eloisa Bonfa²⁵, Eduardo Borba²⁶, Graciela S. Alarcón²⁷ and Bernardo Pons-Estel²⁸, ¹Peru, GLADEL, Lima, Peru, ²GLADEL, Rosario, Argentina, ³GLADEL consultant, Rosario, Argentina, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Instituto Nacional de Ciencias Médicas y Nutrició, Mexico City, Mexico, ⁶Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁷GLADEL, Mexico, Mexico, ⁸Centro Medico ABC, Mexico, Mexico, ⁹Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, ¹⁰Servicio de Reumatología, Instituto Mexicano de Seguro Social, Hospital de Especialidades Nº 25, Monterrey, Mexico, ¹¹Centro de Investigaciones Médico Quirúrgicas, Habana, Centro de Investigaciones Médico Quirúrgicas, Habana, La Habana, Cuba, ¹²GLADEL, Havana, Cuba, ¹³Clinical Development, Nordic Bioscience, Herlev, Denmark, ¹⁴GLADEL, Colombia, Antioquia, Colombia, ¹⁵GLADEL, Colombia, Antoquia, Colombia, ¹⁶Grupo de Reumatología, Universidad de Antioquia, Medellín, Colombia, ¹⁷Medicarte IPS, Medellín, Colombia, ¹⁸Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, ¹⁹GLADEL, Caracas, Venezuela (Bolivarian Republic of), ²⁰Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru, ²¹Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, ²²GLADEL, Peru, Lima, Peru, ²³GLADEL, Santiago, Chile, ²⁴Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, ²⁵Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²⁶Faculdade de Medicina, Hospital das Clínicas. Universidade de São Paulo, São Paulo, Brazil, ²⁷University of Alabama at Birmingham, Birmingham, AL, ²⁸GLADEL, Rosario, Santa Fe, Argentina
Background/Purpose: While infections are a one of the main causes of mortality in systemic lupus erythematosus (SLE), the type of infections and the factors predisposing…
Abstract Number: 2610 • 2017 ACR/ARHP Annual Meeting
Quantiferon Testing in a Clinical Trial of Systemic Lupus Erythematosus
Niti Goel¹, Stephen Wax², Amy Kao², Russell Reeve³ and Marsha Mackey⁴, ¹QuintilesIMS, Duke University School of Medicine, Durham, NC, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA), Billerica, MA, ³QuintilesIMS, Durham, NC, ⁴QuintilesIMS, Rockville, MD
Background/Purpose: Tuberculosis (TB) has been reported to occur at a higher rate in SLE patients than in the general population. As a result, most clinical…
Abstract Number: 2619 • 2017 ACR/ARHP Annual Meeting
Hemophagocytic Syndrome in Patients from SLE Registry from the Spanish Society of Rheumatology (RELESSER)
Ana Lois-Iglesias¹, Francisco J. de Toro², Antonio Zea³, María Galindo⁴, Esther Uriarte⁵, Iñigo Rúa-Figueroa⁶ and JM Pego-Reigosa⁷, ¹Rheumatology, University Hospital A Coruña, A Coruña, Spain, ²Rheumatology Division, INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC), A Coruna, Spain, ³Hospital Ramón y Cajal. Madrid, Madrid, Spain, ⁴Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁵Reumatología, Hospital de Donosti, Donosti, Spain, ⁶Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ⁷Rheumatology Section, Hospital de Meixoeiro, Pontevedra, Spain, Vigo, Spain
Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune systemic rheumatic disease that, in our area, presents hematologic manifestations in approximately 70% of cases1. Some of…
Abstract Number: 2627 • 2017 ACR/ARHP Annual Meeting
Characterization of Emergency Department Visits in an Urban Underserved Lupus Cohort
Justin Levinson¹, Maushmi Savjani¹, Diane Zisa² and Ellen M. Ginzler³, ¹Internal Medicine, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ²Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, ³Rheumatology, Division of Rheumatology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY
Background/Purpose: SLE patients frequently utilize the Emergency Department (ED), impacting the cost of care and quality of life. We performed a retrospective analysis of ED…
Abstract Number: 2629 • 2017 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Patients Not Complaining Raynaud’s Phenomenon Display Lower Skin Blood Perfusion Than Healthy Subjects
Barbara Ruaro¹, Alberto Sulli¹, Sabrina Paolino², Carmen Pizzorni³, Veronica Tomatis¹, Massimo Patanè¹ and Maurizio Cutolo¹, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genoa, Italy, ²University of Genova, IRCCS San Martino, Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ³Research Laboratory and Academic Unit of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, Genova, Italy
Background/Purpose: A clinical feature of patients with primary Raynaud's phenomenon (PRP) is the presence of low skin blood perfusion (BP) at the level of hands…
Abstract Number: 2631 • 2017 ACR/ARHP Annual Meeting
Validation of Clinically Relevant Improvement in Children and Adolescents with cSLE
Pinar Ozge Avar Aydin¹, Michael J. Holland², Simone Appenzeller³, Stacy P. Ardoin⁴, Tadej Avcin⁵, Michael W. Beresford⁶, Brian M. Feldman⁷, Francisco Flores⁸, Marisa S. Klein-Gitelman⁹, Beatrice Goilav¹⁰, Raju Khubchandani¹¹, Deborah M. Levy¹², Angelo Ravelli¹³, Nicolino Ruperto¹⁴, Clovis A Silva¹⁵, Scott E. Wenderfer¹⁶, Jun Ying¹⁷ and Hermine I. Brunner¹, ¹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Pediatric Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, ⁴Pediatric & Adult Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Istituto Giannina Gaslini - Pediatria II, Reumatologia - PRINTO, Genoa, Italy, ⁶On Behalf of the UK JSLE Study Group, Liverpool, United Kingdom, ⁷Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁸Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Division of Pediatric Rheumatology/PDD PTD, Lurie Children's Hospital of Chicago/Northwestern University, Chicago, IL, ¹⁰Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ¹¹Department of Paediatrics, Jaslok Hospital and Research Center, Mumbai, India, ¹²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ¹³University of Genova, IRCCS Istituto Giannina Gaslini, Genova, Italy, ¹⁴Istituto Giannina Gaslini, Genoa, Italy, ¹⁵Rheumatology Unit, Instituto da Criança, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, São Paulo, Brazil, ¹⁶Nephrology, Baylor College of Medicine, Texas Children's Hospital, houston, TX, ¹⁷Center for Biostatistical Services, University of Cincinnati College of Medicine, Cincinnati, OH
Background/Purpose: Childhood-onset systemic lupus erythematosus (cSLE) is a multisystem autoimmune disease that is characterized by episodes of flares followed by improvement in response to therapy.…
Abstract Number: 155 • 2017 Pediatric Rheumatology Symposium
A Single Center Review of Health Related Quality of Life in Children with Systemic Lupus Erythematosus Using the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scale
JaLeen Rogers¹, Anna Carmela P. Sagcal-Gironella², Patricia Rosillo³, Andrea A. Ramirez⁴, Rosa Banuelos⁵ and Marietta M. de Guzman⁶, ¹Outcomes and Impact Services, Texas Children's Hospital, Houston, TX, ²Rheumatology, Texas Children's Hospital, Houston, TX, ³Allergy, Immunology and Rheumatology, Baylor College of Medicine/Texas Children's Hospital, Houston, TX, ⁴Pediatric Rheumatology, Texas Children's Hospital, Houston, TX, ⁵Texas Children's Hospital, Houston, TX, ⁶Department of Pediatrics, Division of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Systemic lupus erythematosus (SLE) can cause adverse effects in various aspects of daily functioning for pediatric patients. Measuring Health-related Quality of Life (HRQOL) provides…
Abstract Number: 2791 • 2016 ACR/ARHP Annual Meeting
Targeting Micro-RNAs Derived from Extracellular Vesicles to Inhibit of TLR7 and TLR8 Signaling Suppresses Inflammation in a Novel Human-Mouse Chimeric Model of Systemic Lupus Erythematosus
Nicholas A. Young¹, Giancarlo R. Valiente², Holly Steigelman³, Jeffrey Hampton⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Rheumatology & Immunology, The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University, Columbus, OH, ⁴Immunology and Rheumatoloty, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Department of Rheumatology/Medicine, Ohio State University, Columbus, OH
Background/Purpose: Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease displaying a heavy female predominance during reproductive years. We have previously shown that toll-like receptor…
Abstract Number: 2812 • 2016 ACR/ARHP Annual Meeting
Clinical Trial Simulation Identifies Factors for Patient Engagement in Systemic Lupus Erythematosus and Lupus Nephritis Trials By African-Americans
S. Sam Lim¹, Doug McKinnell², M Edward Pierson³ and Faye O'Brien³, ¹Medicine, Emory University School of Medicine, Atlanta, GA, ²Deloitte UK Life Sciences Advisory, London, United Kingdom, ³AstraZeneca, Gaithersburg, MD
Background/Purpose: Clinical trials of patients with systemic lupus erythematosus (SLE) and lupus nephritis (LN) can be confounded by difficulties in engaging patients. Identifying factors of…
Abstract Number: 1383 • 2016 ACR/ARHP Annual Meeting
ANTI-RO/SSA and/or ANTI-La/SSB Antibodies: Association with Mild LUPUS Manifestations in 645 Childhood-Onset Systemic LUPUS Erythematosus
Glaucia V. Novak¹, Mariana Marques², Verena Balbi², Natali W. Gormezano², Katia T. Kozu², Ana Paula Sakamoto³, Rosa M R Pereira⁴, Maria Teresa Terreri³, Claudia S. Magalhães⁵, Silvana B. Sacchetti Sr.⁶, Adriana M E Sallum², Roberto Marini Sr.⁷, Virgínia Ferriani⁸, Cássia M. Barbosa⁹, Tânia C M Castro¹⁰, Valéria C. Ramos¹¹, Eloisa Bonfá¹² and Clovis A Silva¹³, ¹Pediatric Rheumatology Unit,, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, ³Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil, ⁴Rheumatology, University of São Paulo, São Paulo, Brazil, ⁵Pediatric Rheumatology Division, São Paulo State University (UNESP), Botucatu, Brazil, ⁶Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁸Department of Pediatrics School of Medicine of Ribeirão Preto, University of São Paulo (USP-RP), Ribeirão Preto, Brazil, ⁹Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, ¹⁰Pediatric Rheumatology Unit, Hospital Menino Jesus, São Paulo, Brazil, ¹¹Pediatric Rheumatology Unit, Pontifical Catholic University of Sorocaba, São Paulo, Brazil, ¹²Rheumatology, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ¹³Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Anti-Ro/SSA and anti-La/SSB antibodies were reported in 30-50% and 10-30% of adult SLE patients, associated mainly with cutaneous manifestations. However, to our knowledge there…
Abstract Number: 1386 • 2016 ACR/ARHP Annual Meeting
Outcome of 847 Childhood-Onset Systemic LUPUS Erythematousus Patients in Three Age Groups
Sandra R M Lopes¹, Natali W. Gormezano², Roberta C. Gomes Sr.³, Nadia E Aikawa⁴, Rosa M R Pereira⁵, Maria Teresa Terreri⁶, Claudia S. Magalhães⁷, Eunice M. Okuda⁸, Ana Paula Sakamoto⁶, Adriana M E Sallum², Simone Appenzeller⁹, Virgínia Ferriani¹⁰, Cássia M. Barbosa¹¹, Simone Lotufo¹², Adriana A. Jesus^13,14, Luis E C Andrade¹⁵, Lucia M A Campos⁴, Eloisa Bonfa¹⁶ and Clovis A Silva³, ¹Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Pediatric Rheumatology Unit, University of São Paulo, São Paulo, Brazil, ³Pediatric Rheumatology Unit, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁴Pediatric Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology Division, Rheumatology Division, Faculdade de Medicina da USP, São Paulo, Brazil, ⁶Pediatric Rheumatology Unit, Federal University of São Paulo, São Paulo, Brazil, ⁷Pediatric Rheumatology Division, São Paulo State University (UNESP), Botucatu, Brazil, ⁸Pediatric Rheumatology Unit, Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil, ⁹Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil, ¹⁰Department of Pediatrics School of Medicine of Ribeirão Preto, University of São Paulo (USP-RP), Ribeirão Preto, Brazil, ¹¹Pediatric Rheumatology Unit, Hospital Infantil Darcy Vargas, São Paulo, Brazil, ¹²Pediatric Rheumatology Unit, Hospital Municipal Infantil Menino Jesus, São Paulo, Brazil, ¹³Pediatrics Department, Universidade de São Paulo, São Paulo, Brazil, ¹⁴Pediatrics, Instituto da Criança da Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sao Paulo, Brazil, ¹⁵Pediatric Rheumatology Unit, Universidade Federal de São Paulo, São Paulo, Brazil, ¹⁶Rheumatology Divison, Hospital das Clinicas, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil
Background/Purpose: A recent large study comparing childhood systemic lupus erythematosus (cSLE) with adult-onset SLE revealed a more aggressive and worse outcome in the former group.…
Abstract Number: 1392 • 2016 ACR/ARHP Annual Meeting
Familial Aggregation of Autoimmune Diseases in Childhood and Adulthood Systemic Lupus Erythematosus
Nailu A. Sinicato¹, Luciana de Oliveira², Aline Tamires Lapa², Lilian Tereza Costallat³, Roberto Marini Sr.⁴, Timothy B. Niewold⁵ and Simone Appenzeller⁶, ¹Pediatrics, State University of Campinas, Campinas, Brazil, ²Medicine, State University of Campinas, Campinas, Brazil, ³RUA EZEQUIEL MAGALHAES,26, Unicamp, Campinas, Brazil, ⁴Pediatric Rheumatology Unit, State University of Campinas, São Paulo, Brazil, ⁵Rheumatology and Immunology, Mayo Clinic, Rochester, MN, ⁶Pediatric Rheumatology Unit, State University of Campinas, Campinas, Brazil
Background/Purpose: Genetic factors play a role in SLE, evidenced by the high sibling risk ratio (λs=8–29) and higher concordance rates between monozygotic twins (>35%) compared…

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