ACR Meeting Abstracts

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Abstracts tagged "synovium"

  • Abstract Number: 510 • 2015 ACR/ARHP Annual Meeting

    Histologic Scoring of Arthroplasty Synovial Samples May Predict RA Flare

    Susan M. Goodman1, Rivka Friedlander2, Caroline Figgie2, Alessandra B. Pernis3, Cristina T. Rozo4, Ellen M. Gravallese5, Edward F. DiCarlo6, Laura T. Donlin7, Mark P. Figgie8, Reena Khianey9, Anh Hoang1, Kathleen Andersen10, Luvana Chowdhury11 and VP Bykerk12, 1Rheumatology, Hospital for Special Surgery, New York, NY, 2Research, Hospital for Special Surgery, New York, NY, 3Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, 4535 East 70th Street, Hospital for Special Surgery, New York, NY, 5Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA, 6Laboratory Medicine, Hospital for Special Surgery, New York, NY, 7Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, 8Orthopaedics, Hospital for Special Surgery, New York, NY, 9Medicine, Hospital for Special Surgery, New York, NY, 10Hospital for Special Surgery, New York, NY, 11Autoimmunity and Inflammation Program/Research, Hospital for Special Surgery, New York, NY, 12Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Patients with established RA undergoing total joint arthroplasty (TJA) frequently experience a disease flare within 6 weeks of surgery. This study aims to determine…
  • Abstract Number: 2879 • 2014 ACR/ARHP Annual Meeting

    Epigallocatechin-3-Gallate (EGCG) Suppresses IL-1β-Induced IL-6 and IL-8 Synthesis By Selectively Inhibiting TAK1 Activation in Human Rheumatoid Arthritis Synovial Fibroblasts

    Anil Singh1, Sharayah Riegsecker2, Sadiq Umar1 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 2Department of Pharmacology, University of Toledo, Toledo, OH

    Background/Purpose: In rheumatoid arthritis (RA), the role of interleukin-1β (IL-1β) signaling proteins (IRAK-1/TAK-1/TRAF-6) proximal to IL-1 receptor in mediating proinflammatory response is not completely understood.…
  • Abstract Number: 2817 • 2014 ACR/ARHP Annual Meeting

    Histone Deacetylase One Contributes to the Auto-Aggressive Phenotype of Rheumatoid Arthritis

    Sarah Hawtree1, Munitta Muthana1, J. Mark Wilkinson2, Anthony G. Wilson1 and Mohammed Akil3, 1Infection and Immunity, University of Sheffield, Sheffield, United Kingdom, 2Academic Unit of Bone Metabolism, University of Sheffield, Sheffield, United Kingdom, 3Rheumatology Department, Sheffield South Yorkshire, United Kingdom

    Background/Purpose Rheumatoid arthritis (RA) is a chronic, autoimmune, inflammatory disease that affects synovial joints. A key characteristic of RA is hyperplasia of fibroblast-like synoviocytes (FLS)…
  • Abstract Number: 2785 • 2014 ACR/ARHP Annual Meeting

    Joint Specific Positional Differences in Coding and Noncoding Transcriptome of Synovial Fibroblasts As a Determinant of the Susceptibility of Synovial Joints to Rheumatoid Arthritis

    Caroline Ospelt1, Maria Armaka2, Giancarlo Russo3, Anna Bratus3, Michelle Trenkmann4, Emmanuel Karouzakis1, Christoph Kolling5, Renate E. Gay4, George Kollias6, Steffen Gay1 and Mojca Frank Bertoncelj1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Institute of Immunology,, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, 3Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Zurich, Switzerland, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 5Schulthess Clinic, Zurich, Switzerland, 6Institute of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece

    Background/Purpose The molecular mechanisms underlying the topographic differences in the susceptibility of synovial joints to develop rheumatoid arthritis (RA) are unknown. Positional embryonic expression of…
  • Abstract Number: 1979 • 2014 ACR/ARHP Annual Meeting

    Pseudostarvation By AMPK Activator Therapy Is Associated with Reduced Disease Activity and Downregulation of Pro-Inflammatory Responses in Rheumatoid Arthritis (RA)

    Lorna Gallagher1, Ursula Fearon2, Douglas J. Veale3, David Kane1, Luke A. O'Neill4 and Ronan Mullan1, 1Department of Rheumatology, Tallaght Hospital, TCD, Dublin 24, Ireland, 2Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland, 3Translational Rheumatology Research Group, St. Vincent's University Hospital, Dublin 4, Ireland, 4Inflammation Research, School of Biochemistry and Immunology, Dublin, Ireland

    Background/Purpose AMP-activated protein kinase (AMPK) is a highly conserved, regulator of cellular energy status. In inflammation, AMPK inactivation is associated with increased glucose consumption through…
  • Abstract Number: 1960 • 2014 ACR/ARHP Annual Meeting

    NF-κB-Inducing Kinase (NIK) Is Expressed in Synovial Endothelial Cells in Early Arthritis Patients and Correlates with Local Disease Activity and Systemic Markers of Inflammation

    Karen I. Maijer1, Ae-Ri Noort2, Maria J. H. de Hair1, Christiaan van der Leij3, Katinka P.M. van Zoest4, Danielle M. Gerlag5,6, Mario Maas3, Paul-Peter Tak1,7,8 and Sander W. Tas2, 1Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Clinical Immunology & Rheumatology and Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 3Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 4Department of Clinical Immunology & Rheumatology and Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 5Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 6GlaxoSmithKline, Cambridge, United Kingdom, 7University of Cambridge, Cambridge, United Kingdom, 8GlaxoSmithKline, Stevenage, United Kingdom

    Background/Purpose The NF-κB family of transcription factors is strongly involved in synovial inflammation. We have previously shown that NF-κB-inducing kinase (NIK) is a key regulator…
  • Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting

    Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a

    Salahuddin Ahmed1, Laura Walsh2, Anil Singh1, Maria Beamer3, Kuladeep Sudini4 and Douglas Leaman4, 1Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 2Department of Pharmacology, University of Toledo, Toledo, OH, 3Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, 4Department of Biological Sciences, University of Toledo, Toledo, OH

    Background/Purpose:  In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
  • Abstract Number: 850 • 2014 ACR/ARHP Annual Meeting

    Targeting Synovial Mast Cells in Spondyloarthritis: A Proof-of-Concept Study with the Tyrosine Kinase Inhibitor Nilotinib

    Jacqueline E. Paramarta1, Maureen C. Turina1, Tanja F. Heijda2, Iris C. Blijdorp3, Troy Noordenbos1, Nataliya Yeremenko2 and Dominique L. Baeten4, 1Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 2Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 3Department of Clinical Immunology & Rheumatology, Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands, 4Department of Clinical Immunology and Rheumatology and Department of Experimental Immunology, Academic Medical Centre/University of Amsterdam, Amsterdam, Netherlands

    Background/Purpose: Immunopathological studies on synovitis recently identified the mast cell as potential novel therapeutic target in spondyloarthritis (SpA).[1] Mast cells can be targeted by inhibiting…
  • Abstract Number: 456 • 2014 ACR/ARHP Annual Meeting

    AAA-Atpase p97 Regulates Autophagy-Associated Cell Death in Arthritis

    Masaru Kato1, Kerstin Klein2, Caroline Ospelt2, Christoph Kolling3, Michihito Kono1, Shinsuke Yasuda1, Renate E. Gay4, Steffen Gay2 and Tatsuya Atsumi1, 1Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan, 2Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Schulthess Clinic, Zurich, Switzerland, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland

    Background/Purpose: Recently we described a hypersensitivity of rheumatoid arthritis synovial fibroblasts (RASF) compared to osteoarthritis synovial fibroblasts to autophagy under conditions of severe endoplasmic reticulum…
  • Abstract Number: 26 • 2014 ACR/ARHP Annual Meeting

    Functional Osteoclasts Differentiate Spontaneously from the Rheumatoid Joint

    Stinne Greisen1, Halldór Bjarki Einarsson2, Malene Hvid3, Ellen Margrethe Hauge4,5, Bent Deleuran3,6 and Tue Kragstrup7, 1Dept of Biomedicine, Aarhus University, Aarhus, Denmark, 2Dept. of Biomedicine, Aarhus University, Aarhus, Denmark, 3Department of Biomedicine, Aarhus University, Aarhus, Denmark, 4Dept. of Anatomi, Aarhus University, Aarhus, Denmark, 5Rheumatology, Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 6Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, 7Aarhus University, Aarhus, Denmark

    Functional osteoclasts differentiate spontaneously from the rheumatoid joint Background/Purpose Osteoimmunology is a field of emerging interest in which bone formation and resorption are understood in…
  • Abstract Number: 1856 • 2013 ACR/ARHP Annual Meeting

    Potentiating Effects Of IL-17A, IL-17AF, IL-17F In Combination With TNF But Not With IL-1beta In Human Primary Fibroblast-Like Synoviocytes From Rheumatoid Arthritis Patients

    Christine Huppertz1, Marija Curcic Djuric1, Robert Hennze1, Friedrich Raulf1, Frank Kolbinger1, Anis Mir1 and David Lee2, 1Autoimmunity, Transplantation and Inflammatory Disease, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, SWITZERLAND, Basel, Switzerland, 2Novartis Pharma AG, Basel, Switzerland

    Background/Purpose: The pro-inflammatory cytokine interleukin-17A (IL-17A) activates fibroblast-like synoviocytes (FLS) and other mesenchymal cells via the IL-17RA/RC receptor. FLS are a major source of inflammatory…
  • Abstract Number: 1377 • 2013 ACR/ARHP Annual Meeting

    Decoy Receptor 3 Regulates the Expression of Tryptophan Hydroxylase TPH1 in Rheumatoid Synovial Fibroblasts

    Toshihisa Maeda1, Yasushi Miura2, Koji Fukuda3, Shinya Hayashi4 and Masahiro Kurosaka1, 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Rehabilitation Science, Graduate School of Health Sciences, Kobe University, Kobe, Japan, 3Dept. of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 4Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Tryptophan hydroxylase (TPH) which catalyzes the hydroxylation of L-tryptophan is the rate-limiting enzyme involved in the synthesis of serotonin. TPH has two isoforms; TPH1…
  • Abstract Number: 1383 • 2013 ACR/ARHP Annual Meeting

    Validation Of Popliteal Lymph Node Phenotype and Bin Expansion As Biomarkers Of Rheumatoid Arthritis Knee Flare

    Homaira Rahimi1, Ronald Wood2, Igor Kuzin3, Wakenda Tyler4, Gregory Dieudonne5, Stephen Kates6, Christopher T. Ritchlin3 and Edward M. Schwarz7, 1Pediatrics, University of Rochester, Rochester, NY, 2Department of Urology, University of Rochester Medical Center, Rochester, NY, 3Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 4Orthopedics, University of Rochester, Rochester, NY, 5Radiology, University of Rochester, Rochester, NY, 6Orthopedic Surgery, University of Rochester Medical Center, Rochester, NY, 7Center for Musculoskeletal Research, University of Rochester, Rochester, NY

    Background/Purpose: Factors precipitating joint flare in rheumatoid arthritis (RA) patients are poorly understood. Contrast enhanced (CE) MRI studies in murine models have identified popliteal lymph…
  • Abstract Number: 1314 • 2013 ACR/ARHP Annual Meeting

    Synovial Ectopic Lymphoneogenesis Predicts Clinical Response To Certolizumab Pegol In Patients With Rheumatoid Arthritis

    Maria Di Cicco1, Stephen Kelly1, Frances Humby2, Nora Ng1, Sabrina Dadoun3, Rebecca Hands2, Vidalba Rocher2, Alessandra Nerviani1, Michele Bombardieri2 and Costantino Pitzalis4, 1William Harvey Research Institute, Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 3APHP, Pitié-Salpêtrière University Hospital, Paris, France, 4Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom

    Background/Purpose: Predicting response to anti-TNF alpha inhibitors (TNFi) in rheumatoid arthritis (RA) patients is challenging. Therefore there is a high need for identification of biomarkers…
  • Abstract Number: 933 • 2013 ACR/ARHP Annual Meeting

    Characterizing The Expression and Function Of CCL28 and Its Corresponding Receptor CCR10 In The Pathogenesis Of RA

    Zhenlong Chen1, Seung-jae Kim1, Michael V. Volin2, Suncica Volkov1, William Swedler3, Nadera J. Sweiss4 and Shiva Shahrara1, 1Medicine/Rheumatology, University of Illinois at Chicago, Chicago, IL, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine Midwestern University, Downers Grove, IL, 3Section of Rheumatology, University of Illinois at Chicago, Chicago, IL, 4internal medicine section of rheumatology, University of Illinois at Chicago, Chicago, IL

    Background/Purpose: This study was conducted to determine the expression pattern and function of CCL28 and its corresponding receptor CCR10 in the pathogenesis of rheumatoid arthritis…
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