Abstracts tagged "Synovitis"

Abstract Number: 0932 • ACR Convergence 2025
Compartment-specific NK-cell phenotypes reveal distinct maturation and activation states in inflammatory arthritis
Franca Sophie Deicher¹, Tarik Exner², Maren Claus³, Schayan Yousefian⁴, Lea Rodon⁵, sophie leonhardt⁶, Jörg Distler⁷, Carsten Watzl³, Hanns-Martin Lorenz⁸, Simon Haas⁴, Daniel Hübschmann⁹ and Wolfgang Merkt¹⁰, ¹Uniklinik Düsseldorf, Düsseldorf, Germany, ²University Hospital Heidelberg, Heidelberg, Germany, ³IfADo, Leibniz Institute Dortmund, Dortmund, Germany, ⁴Charite, Berlin, Berlin, Germany, ⁵University Hospital Heidelberg, Heidelberg, Hungary, ⁶Heidelberg University, Heidelberg, Germany, ⁷University Hospital Duesseldorf and HHU, Duesseldorf, Germany, ⁸Universitétsklinikum Heidelberg, Heidelberg, Germany, ⁹Heidelberg University, Berlin, Germany, ¹⁰University Hospital Düsseldorf, Düsseldorf, Germany
Background/Purpose: Synovial natural killer (NK) cells contribute to inflammation in arthritis by secreting cytokines and modulating synovial fibroblast activation. The aim of this study is…
Abstract Number: 0061 • ACR Convergence 2025
IL-22 Contributes to Autoantibody-induced Arthritis Via Modulation of Inflammatory Cytokine and Chemokine Expression in the Inflamed Synovium of a Murine Model
Shinjiro Kaieda¹, Suzuna Sugi¹, Takuma Koga², Takashi Kinoshita¹ and Tomoaki Hoshino¹, ¹Kurume university School of Medicine, Kurume, Japan, ²Kurume Universty School of Medicine, Kurume, Japan
Background/Purpose: IL-22 is a key cytokine involved in modulating tissue responses during inflammation and is markedly upregulated in inflammatory diseases, such as psoriasis, inflammatory bowel…
Abstract Number: 1961 • ACR Convergence 2025
Clinical Utility and Patient Experience of Ultrasound-Guided Synovial Biopsy in Refractory Arthritis: A Case Series from a Secondary Care Center
Maria Beatriz Paredes Romero¹, Elisabet Castañeda Estévez², Martina Steiner³, Marco Algarra- San José³, Ana Valeria Acosta³, Tatiana Cobo-Ibáñez⁴, Isabel De la Cámara³, Ana Victoria Esteban Vázquez⁵, Patricia Richi³, Maria Liz Romero-Bogado³, Laura Trives⁵, Cristina Vergara-Dangond⁴, Jorge palomar-Ramos³ and Santiago Muñoz⁵, ¹Infanta Sofía University Hospital, Madrid, Spain, ²Hospital Universitario Infanta Sofía, Madrid, Spain, ³Infanta Sofía University Hospital, Madrid, Spain, ⁴Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, San Sebastian de Los Reyes, Madrid, Spain, ⁵Hospital Universitario Infanta Sofía;Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Medicine; FIIB HUIS-HUHEN, Madrid, Spain
Background/Purpose: Diagnosing arthritis remains challenging in a subset of patients despite advances in imaging, serological markers, and clinical scoring systems. Ultrasound-guided synovial biopsy (USG-SB) stands…
Abstract Number: 0925 • ACR Convergence 2025
Pathogenic role of SPP1+ macrophages in Rheumatoid Arthritis
Megan M. Hanlon¹, Catherine Manning¹, Kevin Wei¹, Ursula Fearon² and Ellen M. Gravallese³, ¹Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ²Trinity College Dublin, Dublin, Dublin, Ireland, ³Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA
Background/Purpose: Synovial tissue macrophages (STMs) represent a mixed population of cells contributing to the pathogenesis of rheumatoid arthritis (RA). We identified an enrichment of Secreted…
Abstract Number: 1943 • ACR Convergence 2025
Searching for subclinical synovitis and erosions in seropositive palindromic rheumatism: the added value of the ultrasonographic study of feet
Andrés Ponce¹, Cynthia Vanesa del Valle Rojas², nuria Sapena³, Georgina Novell³, anastasia Motcritcaia³, Beatriz Frade Sosa⁴, Juan Camilo Sarmiento-Monroy⁵, Vicenç Torrente-Segarra⁶, Julio Ramirez⁷, Virginia Ruiz-Esquide⁸, ana Belen Azuaga³, Francisco Vilchez³, Sandra Farietta³, Patricia Corzo⁹, Juan Cañete¹⁰, José Gomez-Puerta¹¹ and Raimon Sanmartí⁸, ¹Hospital Clinic, Barcelona, Spain, ²Consorci Sanitari Alt Penedès-Garraf, Barcelona, Catalonia, Spain, ³Hospital Clinic, Barcelona, Catalonia, Spain, ⁴Hospital Clinic de Barcelona, Barcelona, Catalonia, Spain, ⁵Hospital Clínic Barcelona, Barcelona, Spain, ⁶Hospital Comarcal Alt Penedés Garraf, Vilafranca del Penedès, Spain, ⁷Clinic Barcelona Hospital Universitari, Barcelona, Catalonia, Spain, ⁸Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain, ⁹Rheumatology Department, Hospital Clínic, Barcelona, Barcelona, Spain, ¹⁰Rheumatology Department, Hospital Clínic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ¹¹Rheumatology Department, Hospital Clinic, Barcelona, Spain, Barcelona, Spain
Background/Purpose: Palindromic rheumatism (PR) is characterized by intermittent episodes of arthritis or periarthritis, and it can progress to rheumatoid arthritis (RA), particularly in patients with…
Abstract Number: 0919 • ACR Convergence 2025
Proteomic Profiling of Extracellular Vesicles from Synovial Fluid of RA and OA Patients Reveals Cell-type-specific subpopulations and Disease Related Patterns
Stefanie Kurth¹, Andre Tiaden¹, Edveena Hanser¹, Simone Häner¹, Stavros Giaglis¹, Florian Geier¹, Dominik Burri¹, Katarzyna Buczak¹, Ute Heider², Stefan Wild², Yves Acklin¹, Christian Egloff¹ and Diego Kyburz³, ¹University of Basel, Basel, Switzerland, ²Miltenyi Biotec, Bergisch-Gladbach, Germany, ³University Hospital Basel, Basel, Switzerland
Background/Purpose: Extracellular vesicles (EVs) are secreted by virtually all cells and are known to carry bioactive cargo including proteins, RNA, DNA and metabolites. Analysis of…
Abstract Number: L04 • ACR Convergence 2024
Performance of an Artificial Intelligence Model Compared to Multiple Human Experts in Scoring Synovitis Severity and Osteophyte Severity on Joint Ultrasound Images
Anders Weber¹, Mads Ammitzbøll Danielsen², Bill Aplin Frederiksen³, Hilde Berner Hammer⁴, Benjamin Schultz Overgaard³, Lene Terslev², Thiusius Rajeeth Savarimuthu⁵ and Soren Andreas Just³, ¹ROPCA, Odense, Denmark, ²Center for Rheumatology and Spine Disease, Rigshospitalet, Glostrup, Denmark, ³Section of Rheumatology, Department of Medicine, Svendborg Sygehus OUH, Svendborg, Denmark, ⁴Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, Faculty of Medicine, University of Oslo, Oslo, Norway, ⁵Mærsk Mc-Kinney Møller Institute, University of Southern Denmark, Odense, Denmark
Background/Purpose: To evaluate the agreement of an artificial intelligence (AI) model designed to assess greyscale and Doppler synovitis severity and osteophyte severity in hand joints…
Abstract Number: 0226 • ACR Convergence 2024
Global Ultrasound Scoring Systems for Assessing Synovitis in Rheumatoid Arthritis
Peter Mandl¹, Clara Watschinger¹, Enrico De Lorenzis², Brigitte Wildner³, Lene Terslev⁴, Irina Gessl¹, Helen Keen⁵, Carlos Pineda⁶ and Maria-Antonietta D'Agostino⁷, and OMERACT Ultrasound Working Group, ¹Department of Rheumatology, Medical University of Vienna, vienna, Austria, ²Catholic University of the Sacred Heart, Roma, Rome, Italy, ³Central Library, Medical University of Vienna, Vienna, Austria, ⁴Rigshospitalet-Glostrup & COPECARE, Glostrup, Denmark, ⁵University of Western Australia, Daglish, Western Australia, Australia, ⁶Instituto Nacional de Rehabilitacion, Mexico City, Mexico, ⁷Department of Rheumatology, Universita Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Rome, Italy, Rome, Italy
Background/Purpose: Musculoskeletal ultrasound (MSUS) is widely regarded as a valuable tool for assessing the full extent of synovitis in patients with rheumatoid arthritis (RA). In…
Abstract Number: 0552 • ACR Convergence 2024
Presence of MAIT Cells in Synovial Tissue of Patients with Axial Spondyloarthritis: A Comparative Study
Andre Ramon¹, Philippe Saas², Charline Vauchy³, Maxime Samson² and ERIC TOUSSIROT⁴, ¹Dijon University Hospital, Besançon, France, ²Franche-Comté University, EFS, INSERM, UMR RIGHT, Besançon, France, Besançon, France, ³INSERM CIC-1431, CHU de Besançon, Besancon, France, Besançon, France, ⁴university hospital of BESANCON, besancon, France
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate immune T cells that are located at the mucosal barriers. They play a role in mucosal defense,…
Abstract Number: 0926 • ACR Convergence 2024
Macrophages and Nociceptor Neurons Form a Sentinel Unit Around Fenestrated Capillaries to Defend the Synovium from Systemic Challenges
Tetsuo Hasegawa and Menna Clatworthy, University of Cambridge, Cambridge, United Kingdom
Background/Purpose: A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes…
Abstract Number: 1346 • ACR Convergence 2024
Early Diagnosis of Rheumatoid Arthritis: Role of Joint Ultrasound Assessment
Cristina Corrales Selaya¹, Carmen Secada Gómez², Sabela Fernandez-Aguado³, Isla Morante-bolado⁴, Montserrat Santos-gomez⁵, Sara Alonso-Castro⁶, Virginia Portilla-González⁷, Ricardo Blanco-Alonso⁸, Javier Rueda Gotor⁴ and alfonso Corrales-Martínez⁹, ¹Rheumatology, Marques de Valdecilla University Hospital. IDIVAL, Santander, Cantabria, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, ³Hospital Universitario Montecelo, Pontevedra, Galicia, Spain, ⁴Hospital Sierrallana, Torrelavega, Cantabria, Spain, ⁵Hospital universitario Central de Asturias, Oviedo, Asturias, Spain, ⁶Hospital Universitario Central de Asturias., Oviedo, Asturias, Spain, ⁷Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ⁸Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain, ⁹Hospital Universitario Marques de Valdecilla, Santander, Spain
Background/Purpose: Early diagnosis of Rheumatoid Arthritis (RA) is essential to establish treatment to improve long-term disease outcomes. Musculoskeletal ultrasound (US) is able to detect subclinical…
Abstract Number: 1351 • ACR Convergence 2024
Development of Noninvasive Assessment Technology for Rheumatoid Arthritis Based on Contact Property Measurements
Woo-Joong KIM¹, Chanseok PARK², Seungmo KOO², Jae-Young CHEONG² and Jiho KIM², ¹Chung-Ang University Hospital, Seoul, Korea, Seoul, Republic of Korea, ²Hongik University, Seoul, Korea, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease that requires regular monitoring to prevent joint damage and systemic complications. However, the shortage of trained…
Abstract Number: 1840 • ACR Convergence 2024
Synovial Resident Memory T Cell Formation During Inflammation Requires Cell Contact with Fibroblast-Like Synoviocytes
Yusuke Miyashita¹, Yang Yang¹, Madison Mangin¹, Maryrose Hahn², Kevin Wei³, Peter Nigrovic⁴ and Margaret Chang¹, ¹Boston Children's Hospital, Boston, MA, ²Boston Children's Hospital, Georgetown, MA, ³Brigham and Women's Hospital at Harvard Medical School, Boston, MA, ⁴Boston Children's Hospital, Brookline, MA
Background/Purpose: Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by recurrent inflammation in the same joints, a feature termed joint-specific memory. We previously demonstrated…
Abstract Number: 1959 • ACR Convergence 2024
A 3-arm, Randomized, Open-label, Parallel Active Controlled, Multicentre International Study to Compare the Response of Ultrasound-assessed Synovitis to Baricitinib, Alone and Combined with Methotrexate versus Etanercept in Rheumatoid Arthritis Patients
ESPERANZA NAREDO¹, Otto Olivas-Vergara², Pablo E. Borges², Sheila Recuero-Díaz², Fernando Saraiva³, Joana Martinho³, Filipa Costa³, Catarina Tenazinha³, Margarida Monteiro³, Ana Teresa Melo³, Ana Rodriguez-García⁴, Carlos A. Guillén-Astete⁵, Boris A. Blanco-Cáceres⁴, Alina L. Boteanu⁴, Antonio Mera-Varela⁶, Eva Pérez Pampín⁶, Yolanda López Golán⁶, Cristina Campos Fernández⁷, Jorge Juan Fragío Gíl⁷, roxana gonzalez mazarío⁷, Juan José De Agustín⁸, Gustavo Añez Sturchio⁹, Luis Coronel Tarancon⁸, Esther Vicente-rabaneda¹⁰, Santos Castañeda¹⁰, Irene Llorente-Cubas¹⁰, Maria S. Stoenoiu¹¹, NZEUSSEU TOUKAP Adrien¹², Ilaria Padovano¹³, Helene Gouze¹³, Ariane Leboime¹³, Maxime Breban¹⁴, Jaqueline Uson¹⁵, Virginia Villaverde¹⁶, Martina Steiner¹⁷, Cristina Vergara Dangond¹⁷, Maria Beatriz Paredes Romero¹⁷, Santiago Muñoz Fernández¹⁸, Carolina Pérez-García¹⁹, Juan Antonio Meraz-Ostiz¹⁹, Stephanie Finzel²⁰, Anna-Maria Kanne²¹, Aránzazu Mediero²², Carmen Herencia²³, Gabriel Herrero-Beaumont²⁴ and Raquel Largo²², ¹Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain, ²Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD, Madrid, Spain, ³Rheumatology Department, Unidade Local de Saúde de Santa Maria. Rheumatology Research Unit, Instituto de Medicina Molecular João Lobo Antunes, Lisbon, Portugal, ⁴Rheumatology Department. Ramón y Cajal University Hospital, Madrid, Spain, ⁵Rheumatology Department. Ramon y Cajal University Hospital, Madrid, Spain, ⁶Department of Rheumatology. Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain, ⁷Department of Rheumatology. Hospital General Universitario de Valencia, Valencia, Spain, ⁸Image and Technics Unit, Department of Rheumatology. Hospital Universitari Vall d’Hebron, Barcelona, Spain, ⁹Department of Rheumatology. Hospital Arnau de Vilanova, Lleida, Spain, ¹⁰Hospital Universitario de La Princesa, Madrid, Spain, ¹¹Cliniques Universitaires Saint-Luc, Brussels, Belgium, ¹²Institut de Recherche Expérimentale et Clinique, Cliniques universitaires Saint-Luc, Université catholique de Louvain, St.-Lambrechts-Woluwe, Belgium, ¹³Departement of Rheumatology, Hopital Ambroise Paré, Boulogne-Billancourt, Spain, ¹⁴Departement of Rheumatology, Hopital Ambroise Paré, Departement of Rheumatology, Hopital Ambroise Paré, Spain, ¹⁵Department of Rheumatology, Hospital Universitario de Móstoles. University Rey Juan Carlos, Madrid, Spain, ¹⁶Department of Rheumatology, Hospital Universitario de Móstoles, Madrid, Spain, ¹⁷Department of Rheumatology. Hospital Universitario Infanta Sofía., Madrid, Spain, ¹⁸Hospital Universitario Infanta Sofía. Universidad Europea de Madrid, Madrid, Spain, ¹⁹Department of Rheumatology, Hospital del Mar of Barcelona, Barcelona, Spain, ²⁰Department of Rheumatology and Clinical Immunology, University Medical Center Freiburg, Freiburg, DE, Freiburg im Breisgau, Germany, ²¹Department of Rheumatology and Clinical Immunology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany, ²²Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz, Madrid, Spain, ²³Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz, M, Spain, ²⁴Department of Rheumatology and Joint and Bone Research Unit. Hospital Universitario Fundación Jiménez Díaz and IIS-FJD. Autonomous University of Madrid, Madrid, Spain
Background/Purpose: To demonstrate non-inferiority of the response of musculoskeletal ultrasound (MSKUS)-assessed synovitis to baricitinib, alone and plus MTX vs. etanercept plus MTX in patients with…
Abstract Number: 2244 • ACR Convergence 2024
Unveiling Synovial Protein Contributions to Serum Inflammation, Disease Activity, and Treatment Outcomes in RA Patients
Chary Lopez-Pedrera¹, Sagrario Corrales², Julio Osuna³, Rafaela Ortega-Castro⁴, Jerusalén Calvo³, María Lourdes Ladehesa-Pineda¹, Ismael Sánchez Pareja², Laura Muñoz-Barrera², Desiree Ruiz-Vilchez³, Christian Merlo⁵, Mª Angeles Aguirre-Zamorano⁶, Nuria Barbarroja², Tomás Cerdó², Rosa ortega³, Marta Alarcon-Riquelme⁷, Carlos Perez-Sanchez², Alejandro Escudero-Contreras² and Concepción Aranda-Valera⁸, ¹IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Andalucia, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁴Hospital Reina Sofía, Cordoba, Andalucia, Spain, ⁵Rheumatology Service, Maimonides Institute of Biomedical Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain, ⁶IMIBIC/Reina Sofia Hospital/University of Cordoba, CÓRDOBA, Andalucia, Spain, ⁷Fundación Progreso y Salud, Andalusian Government, Granada, Spain, ⁸IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Andalucia, Spain
Background/Purpose: Characterize synovial tissue-secreted proteins in RA patients that contibute to serum inflammatory profiles based on immune cell infiltration.Identify RA patient subsets with distinctive serum…

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