Abstracts tagged "Synovitis"

Abstract Number: 2483 • ACR Convergence 2023
CD68 and Fibrinoid Necrosis Are Synovial Biomarkers of Severity in Early Rheumatoid Arthritis and Are Associated with a Better Response to Methotrexate: Analysis of the UCLouvain Brussels ERA Cohort
Francesco Natalucci¹, clement triaille², Emilie Sapart², Cécile VAN MULLEM², Tatiana Sokolova³, Laurent MERIC de BELLEFON², Adrien NZEUSSEU TOUKAP², Christine GALANT⁴, Bernard Lauwerys⁵ and Patrick Durez², ¹UCLouvain University, Sermoneta, Italy, ²Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Belgium, ³Université Catholique de Louvain, Brussels, Belgium, ⁴Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain), Anatomie pathologique, Brussels, Belgium, ⁵UCB Pharma, Brussels, Belgium
Background/Purpose: Rheumatoid Arthritis (RA) is a chronic autoimmune disease with persistent synovial inflammation. Despite early diagnosis and the treatment-to-target strategy in ERA, the treatment response…
Abstract Number: 1046 • ACR Convergence 2023
The Level of RF or Anti-CCP Antibody Affect Ultrasound Synovial Findings in Patients with Rheumatoid Arthritis?
Tadashi Okano¹, Kenji Mamoto¹, Yutaro Yamada¹, Shohei Anno², Yuka Domae¹, Shingo Washida¹, Asami Yagami¹, Yuko Yoshida¹, Tatsuya Koike³ and Hiroaki Nakamura¹, ¹Osaka Metropolitan University, Osaka, Japan, ²Yodogawa Christian Hospital, Osaka, Japan, ³Search Institute for Bone and Arthritis Disease (SINBAD), Shirahama Foundation for Health and Welfare, Shirahama, Japan
Background/Purpose: Positive for auto-antibodies such as rheumatoid factor (RF) and anti-citrullinated peptide antibodies (CCP) or having high autoantibody titers is associated with the progression of…
Abstract Number: 1051 • ACR Convergence 2023
Validation of Handheld Ultrasound Devices for Point of Care Use in Rheumatology: Interim Analysis
sibel aydin¹, seyyid acikgoz², Ummugulsum Oguz³, antonio Vieira⁴, patrick Leclerc⁴, Suharsh Shah⁴, Lihi Eder⁵ and Gurjit S Kaeley⁶, ¹University of Ottawa - Ottawa, Ottawa, ON, Canada, ²University of Ottawa, Rheumatology, Ottawa, ON, Canada, ³University of Ottawa, Ottawa, ON, Canada, ⁴Novartis Pharmaceuticals Canada Inc., Montreal, QC, Canada, ⁵Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada, ⁶University of Florida College of Medicine – Jacksonville, Ponte Vedra Beach, FL
Background/Purpose: Ultrasonography (US) has experienced a rapid evolution in rheumatology. Despite many advantages being shown repeatedly, several barriers persist and stand in the way of…
Abstract Number: 1342 • ACR Convergence 2023
The Delivery of the Super-repressor IκBα by Exosomes Has the Potential to Alleviate Inflammation Associated with Rheumatoid Arthritis
Ki-Jeong Park¹, Ji-Hyoun Kang¹, Hae-In Lee², Yu Jeong Lee¹, Moon-Ju Kim¹, So-Hee Ahn³, Jae-Kwang Yoo³, Chulhee Choi³ and Tae-jong Kim⁴, ¹Chonnam National University Hospital, Gwangju, South Korea, ²Chonnam National University, Gwangju, South Korea, ³ILIAS Biologics, Daejeon, South Korea, ⁴Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwang-Ju, South Korea
Background/Purpose: Rheumatoid arthritis (RA) is a persistent inflammatory disease primarily affecting the diarthrodial joints. Nuclear factor-κB (NF-κB) is a family of inducible transcription factors responsible…
Abstract Number: 1594 • ACR Convergence 2023
Oral Delivery of Δ9-Tetrahydrocannabinol Provides Symptom and Disease Modification in a Mouse Model of Knee Osteoarthritis
Jason rockel¹, Anca Maglaviceanu², Helena Fetter Filippini³, Ewa Wasilewski⁴, Melissa M. Lewis-Bakker⁴, Sarah Gabrial¹, Evgeny Rossomacha¹, Johana Garcia¹, Nizar Mahomed⁵, Timothy Leroux⁵, Hance Clarke⁶, Robert P. Bonin³, Lakshmi P. Kotra⁷ and Mohit Kapoor¹, ¹Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, and Krembil Research Institute, University Health Network; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada, ³Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, ⁴Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁵Division of Orthopaedics, Osteoarthritis Research Program, Schroeder Arthritis Institute, Krembil Research Institute, and Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁶Krembil Research Institute, and Department of Anesthesia and Pain Management, Toronto General Hospital, University Health Network, Toronto, ON, Canada, ⁷Krembil Research Institute, University Health Network; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
Background/Purpose: Osteoarthritis (OA) results in joint pain, cartilage degeneration, and synovitis. Recent studies suggest that some OA patients are self-medicating with cannabis. Δ9-tetrahydrocannabinol (THC) is…
Abstract Number: 0385 • ACR Convergence 2023
Heterogeneity of the Joint Location Supports the Importance of Local Factors in Early RA Synovitis : Analysis of the ERA UCLouvain Brussels Cohort
Laura BRICMAN¹, clement triaille², Francesco Natalucci³, Emilie Sapart², Tatiana Sokolova⁴, Aleksandra AVRAMOVSKA¹, Thomas KIRCHGESNER⁵ and Patrick Durez², ¹Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Belgium, ³UCLouvain University, Sermoneta, Italy, ⁴Université Catholique de Louvain, Brussels, Belgium, ⁵Rheumatology, Cliniques Universitaires Saint-Luc Département d'imagerie médicale – Université catholique de Louvain (UCLouvain), Brussels, Belgium
Background/Purpose: ERA is considered to be a systemic disorder, but the role of local factors in driving synovial inflammation is increasingly being recognized. These joint-specific…
Abstract Number: 1721 • ACR Convergence 2023
The Therapeutic Effects of Gingival Mesenchymal Stem Cells and Their Exosomes in a Chimeric Model of Rheumatoid Arthritis
shane Bruckner¹, Braden Zeno², Vittoria Capria¹, William Willis³, Latha Prabha Ganesan¹ and wael Jarjour¹, ¹Ohio State University, Columbus, OH, ²Ohio State University, Upper Arlington, OH, ³Ohio State University, Reynoldsburg, OH
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that leads to progressive joint destruction involving multiple joints. There is a large body of…
Abstract Number: 0399 • ACR Convergence 2023
Differential Synovial Tissue Enrichment of Oxylipins and Their Mediators Across Rheumatoid Arthritis Trajectory
Simone Perniola¹, Jessica Murillo-Saich², Barbara Tolusso³, Clara Di Mario³, Marco Gessi⁴, Dario Bruno⁵, Luca Petricca⁶, Maria Rita Gigante⁶, Elisa Gremese⁵, Monica Guma⁷ and Stefano Alivernini⁸, ¹Division of Clinical Immunology – Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ²Department of Medicine, University of California San Diego, La Jolla, CA, ³Immunology Research Core Facility – Gemelli Science and Technology Park (GSTeP) - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁴Division of Pathology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁵Division of Rheumatology, Institute of Rheumatology and Affine Sciences, School of Medicine, Catholic University of the Sacred Heart, Roma, Italy, ⁶Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy, ⁷University of California San Diego, La Jolla, CA, ⁸Immunology Research Core Facility, Gemelli Science and Technology Park, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Division of Rheumatology - Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy
Background/Purpose: Synovial membrane represents the target tissue of Rheumatoid Arthritis (RA) inflammation. Our study aimed to perform a comprehensive quantification of oxylipins and their precursors…
Abstract Number: 1727 • ACR Convergence 2023
Arthritogenicity of Homocitrullinated Peptides in HLA-DRB1 Transgenic Mice
Sheri Saunders, Garth Blackler, Patti Kiser, Ewa Cairns and Lillian Barra, Western University, London, ON, Canada
Background/Purpose: Most rheumatoid arthritis (RA) patients express autoantibodies to post-translationally modified antigens, including citrullinated and homocitrullinated (also known as carbamylated) peptides. Homocitrulline and citrulline are…
Abstract Number: 0401 • ACR Convergence 2023
Resolution of Swollen Joint Count Is an Important Clinical Objective in Early Rheumatoid Arthritis : Analysis of the UCLouvain Brussels ERA Cohort and Comparison with the Remission Composite Index
Francesco Natalucci¹, clement triaille², Emilie Sapart², Laura BRICMAN³, Cécile VAN MULLEM², Charlotte Desmet², Stéphanie DIERCKX⁴, Marie DOYEN², Tatiana Sokolova⁵, Aleksandra AVRAMOVSKA³ and Patrick Durez², ¹UCLouvain University, Sermoneta, Italy, ²Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Rheumatology, Brussels, Belgium, ³Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCLouvain) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁴CHU UCL Namur, Rheumatology, Mont-Godinne, Belgium, Mont Godinne, Belgium, ⁵Université Catholique de Louvain, Brussels, Belgium
Background/Purpose: Rheumatoid Arthritis is a chronic autoimmune disease characterized by persistent joint inflammation. According to international guidelines, the treatment target should aim to reach the…
Abstract Number: 1744 • ACR Convergence 2023
Histological and Molecular Comparison in the Synovial Tissue of Patients with Active Rheumatoid Arthritis to Remission
Selina Ohl¹, Klaus Frommer¹, Markus Rickert², Stefan Rehart³, Ulf Müller-Ladner¹ and Elena Neumann¹, ¹Justus Liebig University Gießen, Campus Kerckhoff, Bad Nauheim, Germany, ²Dept. of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ³Dept. of Orthopaedics and Trauma Surgery, Agaplesion Markus Hospital Frankfurt, Frankfurt, Germany
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease which leads to local and systemic manifestations. Subsequently, the inflamed synovium drives the destruction of…
Abstract Number: 0408 • ACR Convergence 2023
The Role of Synovial Biopsy in Evaluating Rheumatoid Arthritis Acitivity in Patients: Findings from a Study of 30 Patients Treated with Adalimumab
Rui Wu and YIlin Peng, the first affilated hospital of Nanchang University, Nanchang, China
Background/Purpose: Rheumatoid arthritis(RA）is a chronic autoimmune disease that is characterized by inflammation and destrction of synovial jionts which result in high disabilty. Treat-to-Target is critical…
Abstract Number: 1750 • ACR Convergence 2023
Dysregulated NUB1 and Neddylation Enhances Rheumatoid Arthritis Fibroblast-Like Synoviocyte Inflammatory Responses
Sho Sendo¹, Camilla R. L. Machado², Robert Benschop³, Narayanan B. Perumal⁴, Eunice Choi⁵, David Boyle⁵, Wei Wang⁵ and Gary Firestein², ¹Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²University of California San Diego, San Diego, CA, ³Eli Lilly and Company, Indianapolis, IN, ⁴Eli Lilly and Company, San Diego, CA, ⁵University of California San Diego, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) contribute to the pathogenesis of rheumatoid arthritis (RA), especially cartilage damage and cytokine production. These cells display an aggressive phenotype in…
Abstract Number: 0803 • ACR Convergence 2022
Performance of Adenosine Deaminase Activity in Sinovial Fluid for the Early Diagnosis of Tuberculous Arthritis: A Meta Analysis
Juan Carlos Cortés-Quiroz¹, Javier Ena², José Antonio Bernal³ and José Rosas⁴, ¹Marina Baixa Hospital, Mutxamel, Spain, ²Department of Internal Medicine. Marina Baixa Hospital, Villajoyosa, Spain, ³Rheumatology Department. Marina Baixa Hospital, Alicante, Spain, ⁴Rheumatology Department, Hospital Marina Baixa, Villajoyosa, Spain
Background/Purpose: Adenosine deaminase (ADA) activity has shown good performance in diagnosing pleural, peritoneal, and meningeal tuberculosis. This study aimed to evaluate the performance of measuring…
Abstract Number: 1232 • ACR Convergence 2022
Reliability and Validity of Single Axial Slice vs. Multiple Slice Quantitative Measurement of the Volume of Effusion-Synovitis on 3T Knee MRI in Knees with Osteoarthritis
Greg Gilles¹, Arjun Vohra¹, Chelsea Caruso¹, Dagoberto Robles¹, Mihra Taljanovic¹, Jeffrey Duryea², Erin Ashbeck¹, Edward Bedrick³ and Kent Kwoh⁴, ¹University of Arizona Arthritis Center, Tucson, AZ, ²Brigham and Women's Hospital, Boston, MA, ³Department of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, ⁴University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) on knee MRI has been identified as an important biomarker of OA. Semi-automated software methods offer objective measurements of ES volume on…

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