Abstract Number: 0418 • ACR Convergence 2023
Synovial Fluid Cell Counts Associated with Joint Histopathology in Rheumatoid Arthritis
Background/Purpose: While analysis of synovial fluid white blood cell counts (WBCs) is performed in clinical practice for diagnosing septic arthritis and differentiating noninflammatory from inflammatory…Abstract Number: 1757 • ACR Convergence 2023
Quantitative Assessment of Synovial Vascularity Using Power Doppler Index in Rheumatoid Arthritis and Psoriatic Arthritis Patients with High Disease Activity
Background/Purpose: Usefulness of quantitative assessment of synovial vascularity in ultrasound (US) imaging in patients with active RA and PsA (peripheral arthritis). Additionally the assessment of…Abstract Number: 0756 • ACR Convergence 2023
Validation of Quantitative Effusion-synovitis Volume Measured by Deep-learning: Data from the Osteoarthritis Initiative
Background/Purpose: Knee effusion-synovitis (ES) is an attractive target for therapeutic interventions in arthritis, since it is associated with stiffness, pain, and disease progression to arthroplasty.…Abstract Number: 1773 • ACR Convergence 2023
Integrated Analysis of Rheumatoid Arthritis (RA) Fibroblast-like Synoviocytes (FLS) Transcriptome and Chromatin Accessibility Identifies Mechanisms Associated with Location-specific Disease Severity
Background/Purpose: Mechanisms responsible for the distribution and severity of joint involvement in RA are not known. To explore whether site-specific FLS biology might contribute to…Abstract Number: 0865 • ACR Convergence 2023
Reactive Oxygen Species-scavenging Nanoparticles Target Macrophage Polarization for Osteoarthritis Therapy
Background/Purpose: Unbalanced M1/M2 polarization of synovial macrophages plays vital roles in the symptomatic and structural progression of osteoarthritis (OA). The accumulation of intracellular reactive oxygen…Abstract Number: 1779 • ACR Convergence 2023
A Novel Inhibitory Pathway of Synovial Inflammation Exerted by Glucocorticoids and TNF Inhibitors Through LAG-3 Up-Regulation
Background/Purpose: Psoriatic arthritis (PsA) is a chronic immune-mediated condition that results in systemic musculoskeletal (MSK) inflammation, including peripheral synovitis, enthesitis and axial involvement. Glucocorticoids (GCs)…Abstract Number: 0866 • ACR Convergence 2023
A Novel 3D-Synovium-Immune Microenvironment Mimics Macrophage-Synovial Fibroblast Interactions in Inflammatory Arthropathies
Background/Purpose: Autoimmunity, trauma, or infection lead to devastating arthropathies, within enormous socioeconomic impact due to its high frequency and chronicity. The development of novel treatments…Abstract Number: 1787 • ACR Convergence 2023
Regulatory Role of JAK-1/TYK2 Signaling on the Pannus Formation: Novel Mechanisms for JAK Inhibitors in Psoriatic Disease
Background/Purpose: In psoriatic arthritis (PsA) aberrant activation/migration of specific T cell subpopulations (Th17/Th9/MAIT cells) in the joint synovium induce synovial inflammation and pannus formation. Several…Abstract Number: 0872 • ACR Convergence 2023
Synovial 5-LOX-Derived Oxylipins Define a B Cell-Enriched Synovium
Background/Purpose: Oxylipins are bioactive lipids derived from polyunsaturated fatty acids (PUFAs) that modulate inflammation and may remain overexpressed in refractory synovitis. These mediators in plasma…Abstract Number: 2065 • ACR Convergence 2023
Exploring the Power of Ultrasound in Rheumatology: Insights from Young Rheumatologists in Mexico
Background/Purpose: Musculoskeletal ultrasound (MSUS) is a valuable tool in Rheumatology as it is non-invasive, cost-effective, and useful in regular clinical practice. However, its adoption has…Abstract Number: 0879 • ACR Convergence 2023
Recommendations for a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis
Background/Purpose: Synovial pathology is an active component of osteoarthritis (OA) that has been linked to disease progression and pain in patients. Macroscopic and microscopic grading…Abstract Number: 2436 • ACR Convergence 2023
Characterizing Spatial Organization of Immune Infiltrates in Rheumatoid Arthritis Synovia Using Spatial Transcriptomic Analysis
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by immune infiltration of the synovial tissue lining joints. RA is clinically heterogenous, with patients having…Abstract Number: 0880 • ACR Convergence 2023
CD14 Inhibition as a Potential Therapeutic in Post Traumatic OA
Background/Purpose: Osteoarthritis (OA) is the most common joint disorder, and growing evidence has identified inflammation to be a major driver of disease progression. During disease,…Abstract Number: 2472 • ACR Convergence 2023
Synovitis and the Risk of Incident Hand Osteoarthritis: Data from the Xiangya Osteoarthritis Study
Background/Purpose: Synovitis is a modifiable pathological lesion of hand osteoarthritis (HOA). Although synovitis has been related to the prevalence and symptoms of HOA, it remains…Abstract Number: 1045 • ACR Convergence 2023
Ultrasound Findings in Patients with Difficult to Treat Rheumatoid Arthritis
Background/Purpose: In recent years, the concept of D2T RA (difficult-to-treat rheumatoid arthritis) has become widespread, and D2T RA patients are defined as a state in…
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