Abstracts tagged "Synovial Immune Biology"

Abstract Number: 1405 • 2017 ACR/ARHP Annual Meeting
Using Flow and Mass Cytometry to Demonstrate Robust Tissue Processing to Query Molecular Heterogeneity in Phase 1 of the Accelerating Medicines Partnership (AMP) – RA Network
Kevin Wei¹, Deepak Rao², Fan Zhang³, Chamith Fonseka³, Kamil Slowikowski³, Joshua Keegan⁴, Laura T. Donlin⁵, Jason Turner⁶, Mandy J. McGeachy⁷, Nida Meednu⁸, David Lieb⁹, Stephen Kelly¹⁰, Susan M. Goodman¹¹, David L. Boyle¹², William H. Robinson¹³, Paul J. Utz¹⁴, Gary S. Firestein¹⁵, Harris Perlman¹⁶, Edward F. DiCarlo¹⁷, Costantino Pitzalis¹⁰, Andrew Filer¹⁸, Brendan Boyce¹⁹, Ellen M. Gravallese²⁰, Chad Nusbaum²¹, James Lederer⁴, Nir Hacohen^22,23,24, Peter Gregersen²⁵, Larry W. Moreland²⁶, Michael Holers²⁷, Vivian P. Bykerk²⁸, Soumya Raychaudhuri³, Michael Brenner²⁹ and Jennifer H. Anolik⁸, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ⁶Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁷Medicine, University of Pittsburgh, Pittsburgh, PA, ⁸Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁹Broad Institute, Cambridge, MA, ¹⁰Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹¹Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ¹²University of California San Diego, La Jolla, CA, ¹³Stanford University School of Medicine, Stanford, CA, ¹⁴Medicine, Stanford University School of Medicine, Stanford, CA, ¹⁵Medicine, University of California San Diego, La Jolla, CA, ¹⁶Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Northwestern University Feinberg School of Medicine,, Chicago, IL, ¹⁷Laboratory Medicine, Hospital for Special Surgery, New York, NY, ¹⁸Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ¹⁹University of Rochester Medical Center, Rochester, NY, ²⁰Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, ²¹The Broad Institute and Harvard, Cambridge, MA, ²²Harvard Medical School, Boston, MA, ²³Massachusetts General Hospital, Charlestown, MA, ²⁴Broad Institute of MIT and Harvard, Cambridge, MA, ²⁵The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ²⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²⁷Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²⁸Divison of Rheumatology, Hospital for Special Surgery, New York, NY, ²⁹Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Discovery and application of new therapies for rheumatoid arthritis (RA) has been hampered by multiple factors, including disease heterogeneity and the lack of well…
Abstract Number: 1406 • 2017 ACR/ARHP Annual Meeting
Methods for Generating Multiple High-Dimensional Analyses of Cryopreserved Synovial Tissue Developed By the Accelerating Medicines Partnership RA/SLE Network
Deepak Rao¹, Laura T. Donlin², Kevin Wei³, Nida Meednu⁴, Jason Turner⁵, Mandy J. McGeachy⁶, Fumitaka Mizoguchi⁷, Joshua Keegan⁸, James Lederer⁹, Maria Gutierrez-Arcelus¹⁰, Kamil Slowikowski¹¹, Kaylin Muskat¹², Joshua Hillman¹², Cristina Rozo¹³, Edd Ricker¹⁴, Thomas Eisenhaure¹⁵, David Lieb¹⁵, Shuqiang Li¹⁵, Edward Browne¹⁵, Chad Nusbaum¹⁵, William H. Robinson¹⁶, Stephen Kelly¹⁷, Alessandra B. Pernis¹⁸, Lionel Ivashkiv¹⁹, Susan M. Goodman²⁰, Ellen M. Gravallese²¹, Michael Holers²², Nir Hacohen²³, Costantino Pitzalis¹⁷, Peter Gregersen²⁴, Vivian P. Bykerk²⁵, Larry W. Moreland²⁶, Gary Firestein²⁷, Soumya Raychaudhuri²⁸, Andrew Filer²⁹, David L. Boyle³⁰, Michael Brenner¹⁰ and Jennifer H. Anolik⁴, ¹Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, University of Pittsburgh, Pittsburgh, PA, ⁷Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ⁸Brigham and Women's Hospital, Boston, MA, ⁹Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹⁰Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical Schoo, Boston, MA, ¹²University of California, San Diego, San Diego, CA, ¹³Hospital for Special Surgery, New York, NY, ¹⁴Weill Cornell Graduate School of Medical Sciences, New York, NY, ¹⁵Broad Institute, Cambridge, MA, ¹⁶Stanford University School of Medicine, Stanford, CA, ¹⁷Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London, School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ¹⁸David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ¹⁹Medicine, Hospital for Special Surgery, New York, NY, ²⁰Medicine, Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ²¹Lazare Research Bldg, University of Massachusetts Medical School, Worcester, MA, ²²Medicine, Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²³Harvard Medical School, Boston, MA, ²⁴The Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, ²⁵2-005, Mt Sinai Hospital, Toronto, ON, Canada, ²⁶Rheumatology & Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ²⁷EGG, St Cloud, France, ²⁸Division of Medicine and Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²⁹Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ³⁰University of California San Diego, La Jolla, CA
Background/Purpose: Detailed analyses of cells from rheumatoid arthritis (RA) synovium may identify cell phenotypes and functions that drive tissue pathology and joint damage. The AMP…
Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting
Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis
Aurélie Najm^1,2, Benoît Le Goff MD PhD^2,3, Frédéric Blanchard¹, Jérome Amiaud⁴, Céline Charrier⁵ and Veit Krenn⁶, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁴UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁶Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany
Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
Abstract Number: 1030 • 2016 ACR/ARHP Annual Meeting
Synovial Tissue Resident Macrophages Play the Protective Role in the Development of Inflammatory Arthritis in CD11c-Flip-KO Mice
Qi Quan Huang¹, Renee E. Doyle², Robert Birkett³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL
Synovial Tissue Resident Macrophages Play the protective role in the Development of Inflammatory Arthritis in CD11c-Flip-KO MiceQi-Quan Huang1, Renee Doyle1, Robert Birkett1 and Richard M.…
Abstract Number: 1462 • 2016 ACR/ARHP Annual Meeting
Magnesium Is a New Mediator Arthritis Severity and Joint Damage
Teresina Laragione, Nasim Azizgolshani, Carolyn Harris, Erjing Gao and Percio Gulko, Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Given the effects of magnesium supplementation in suppressing components of the innate immunity in short-term studies, we examined the effect of dietary magnesium modifications…
Abstract Number: 534 • 2015 ACR/ARHP Annual Meeting
Antibodies to Malondialdehyde-Acetaldehyde Adducts Are Highly Expressed in Rheumatoid Arthritis Synovial Fluid
Rafid Rahman¹, Geoffrey M. Thiele², Andy Hollins³, Michael J. Duryee¹, Daniel Anderson³, Bartlett Hamilton⁴, Kaleb Michaud⁵, Lynell W. Klassen⁶ and Ted R. Mikuls³, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴University of Nebraska Medical Center and Omaha VA Medical Center, Omaha, NE, ⁵Rheumatology & Immunology, University of Nebraska Medical Center and National Data Base for Rheumatic Diseases, Omaha, NE, ⁶Dept of Internal Medicine, Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Malondialdehyde-acetaldehyde (MAA) adducts are expressed in synovial tissues in rheumatoid arthritis (RA). Post-translational MAA modifications are pro-inflammatory, promoting robust anti-MAA antibody responses that…
Abstract Number: 1141 • 2015 ACR/ARHP Annual Meeting
Synovial Ultrasound Power Doppler Enhancement Reflects Multiple Cytokine Expression in Synovial Tissue, Distinguishing Distinct High Macrophage-Associated and Low Inflammation Profiles
Lorraine Yeo¹, Dagmar Scheel-Toellner², Christian Ludwig³, Ilfita Sahbudin², Maria Juarez², Christopher Buckley⁴, Karim Raza⁵ and Andrew Filer⁶, ¹Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ²University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, Birmingham, United Kingdom, ³University of Birmingham, Institute of Cancer Studies, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom, ⁵University of Birmingham, Rheumatology Research Group, Institute of Inflammation and Ageing, United Kingdom, Birmingham, United Kingdom, ⁶University of Birmingham, Birmingham, United Kingdom
Background/Purpose: Power doppler ultrasound provides joint level data on the risk of erosive progression in patients with inflammatory arthritis. Understanding the synovial tissue correlates of…
Abstract Number: 1373 • 2015 ACR/ARHP Annual Meeting
Epigenetic Mechanisms Contribute to the Lack of LPS-Induced Tolerance in Rheumatoid Arthritis Synovial Fibroblasts
Kerstin Klein¹, Renate E. Gay¹, Christoph Kolling², Adrian Ciurea¹, Diego Kyburz¹, Beat A. Michel¹, Lih-Ling Lin³, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³Inflammation and Immunology Research Unit, Pfizer, Cambridge, MA
Background/Purpose: In macrophages, repeated stimulation of Toll-like receptor (TLR) 4 leads to a tolerant state of the cell which protects inflamed tissues from damage. We…
Abstract Number: 1940 • 2015 ACR/ARHP Annual Meeting
A Circulating Reservoir of Pathogenic-like CD4+ T Cells Shares a Genetic and Phenotypic Signature with the Inflamed Synovial Micro-Environment
Roberto Spreafico^1,2, Maura Rossetti^1,2, Jorg van Loosdregt¹, Carol A. Wallace³, Margherita Massa⁴, Silvia Magni-Manzoni⁵, Marco Gattorno⁶, Alberto Martini⁷, Daniel Lovell^8,9 and Salvatore Albani^2,10, ¹Sanford-Burnham Medical Research Institute, La Jolla, CA, ²SingHealth Translational Immunology and Inflammation Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³Seattle Children’s Hospital and Research Institute, Seattle, WA, ⁴Lab Biotecnologie, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Pediatric Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, ⁶Instituto Giannina Gaslini and University of Genova, Genova, Italy, ⁷Istituto G. Gaslini, Universita' di Genova, Genova, Italy, ⁸Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁹Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁰Duke-National University of Singapore Graduate Medical School, Singapore, Singapore
Background/Purpose: Systemic immunological processes are profoundly shaped by the micro-environments where antigen recognition occurs. Identifying molecular signatures distinctive of such processes is pivotal to understand…
Abstract Number: 2181 • 2014 ACR/ARHP Annual Meeting
Investigating Myeloid and Plasmacytoid Dendritic Cell Activation within the Synovium and Peripheral Blood of Rheumatoid Arthritis Patients
Mary Canavan, Michael Anthony O'Rourke, Douglas J. Veale and Ursula Fearon, Dublin Academic Medical Centre, Translational Rheumatology Research Group, Dublin, Ireland
Background/Purpose: Dendritic cells (DC) are a heterogeneous population of professional antigen presenting cells which link both the innate and adaptive arms of the immune system.…
Abstract Number: 1753 • 2014 ACR/ARHP Annual Meeting
Human T-Cells Express RANKL in Response to Combination of ZAP-70, Calcineurin and Voltage-Gated K+-Channel Signaling Following Co-Ligation of the Adhesion Molecule CD2 and the T-Cell Receptor Complex
Bohdan P. Harvey and Zehra Kaymakcalan, Biologics, AbbVie Bioresearch Center, Worcester, MA
Background/Purpose Human T lymphocytes promote osteolysis in rheumatic diseases through the production of the osteoclastogenic cytokine RANKL. We have previously demonstrated that RANKL secretion is…
Abstract Number: 1744 • 2014 ACR/ARHP Annual Meeting
CD4+ T Cell Subpopulations in Blood and Synovial Fluid Defined By Differential Expression of Integrins
Deepak A. Rao¹, Adam Chicoine², Peter A. Nigrovic³, Soumya Raychaudhuri⁴, Michael B. Brenner⁵ and ACR Authors 2014, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology, Allergy, Brigham and Women's Hospital, Boston, MA, ³Brigham and Women's Hospital/Harvard University, Cambridge, MA, ⁴Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁵Division of Rheumatology, Immunology, and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose CD4+ T cells are important mediators of inflammation in rheumatoid arthritis; however, the specific CD4+ T cell populations most important in driving disease pathology…
Abstract Number: 1038 • 2014 ACR/ARHP Annual Meeting
Macrophage-Fibroblast Crosstalk Pathways Amplify RA Joint Pathology
Laura T. Donlin¹, Jennifer Ding¹ and Lionel B. Ivashkiv^1,2, ¹Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY, ²Weill Cornell Graduate School of Medical Sciences, New York, NY
Background/Purpose Macrophages and synovial fibroblasts represent key cellular drivers of RA. The goal of this study was to define how the complex cellular programs of…
Abstract Number: 1022 • 2014 ACR/ARHP Annual Meeting
Fibroblast-like Synovial Cells and Monocytes Team up in the Organization and the Dynamic Modelling of the Synovial Tissue
Ruth Byrne¹, Karolina von Dalwigk², Thomas Karonitsch¹, Gunter Steiner³, Johannes Holinka⁴, Reinhard Windhager⁴, Josef Smolen⁵, Hans Peter Kiener¹ and Clemens Scheinecker⁶, ¹Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Department of Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ³Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Orthopaedics, Medical University of Vienna, Vienna, Austria, ⁵Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Divison of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose The synovial lining tissue consists of fibroblast-like synoviocytes (FLS) and monocyte-derived macrophage-like synoviocytes (MLS) within a self-built meshwork of dense extracellular matrix (ECM) components.…
Abstract Number: 1010 • 2014 ACR/ARHP Annual Meeting
Catecholaminergic-to-Cholinergic Transition of Sympathetic Nerve Fibers in Arthritis and in a Co-Culture System of Sympathetic Ganglia in Vitro
Hubert Stangl¹, Hans Robert Springorum², Dominique Muschter², Susanne Graessel² and Rainer Straub³, ¹Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany, ²Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital Regensburg, Regensburg, Germany
Background/Purpose: Sympathetic nerve fibers play an important role in bone and tissue homeostasis of joints. However sympathetic nerve fibers are able to switch their phenotype…

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