Abstracts tagged "Synovial Immune Biology"

Abstract Number: 117 • 2019 ACR/ARP Annual Meeting
The Indole Derivative NecroX Blocks Th17 Cell Differentiation and Fibroblast-like Synoviocytes-mediated Th1/Th17 Responses in Rheumatoid Arthritis
Hyun Jung Yoo¹, Shin Eui Kang ², Ji Hye Lee ³, Ra Ham Kim ⁴ and Yeong-Wook Song ⁵, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, ²Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Seoul, Republic of Korea, ⁴Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life.…
Abstract Number: 781 • 2019 ACR/ARP Annual Meeting
Is down Syndrome Associated Arthritis (DA) a Distinct Disease from Juvenile Idiopathic Arthritis (JIA)?
Charlene Foley¹, Achilleas Floudas ², Sharon Ansboro ², Mary Canavan ², Monika Biniecka ², Emma Jane MacDermott ³, Ronan Mullan ⁴, Gerry Wilson ⁵, Ursula Fearon ⁶ and Orla Killeen ⁷, ¹Great Ormond Street Hospital, London, Ireland, ²TBSI, Dublin, Ireland, ³OLCHC, Dublin, Ireland, ⁴Tallaght Hospital, Dublin, Ireland, ⁵UCD, Dublin, Ireland, ⁶TBSI, Dublin, ⁷National Centre for Paediatric Rheumatology (NCPR), Our Lady’s Children’s Hospital Crumlin (OLCHC), Dublin, Ireland
Background/Purpose: Down syndrome associated Arthritis (DA) is 20 times more common than JIA. It is an erosive, polyarticular RF negative arthritis with predominance in the…
Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting
Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis
Ricardo Grieshaber-Bouyer¹, Till Kämmerer ², Nils Rosshirt ², Philipp Koniezke ², Sebastien Hagmann ², Elena Tripel ², Johannes Kirsch ², Tobias Gotterbarm ² and Babak Moradi ², ¹Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, ²Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany
Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
Abstract Number: 2060 • 2018 ACR/ARHP Annual Meeting
Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naïve Psoriatic and Rheumatoid Arthritis
Alessandra Nerviani¹, Frances Humby¹, Gloria Lliso Ribera¹, Wang Sin Tan¹, Marie Astrid Boutet¹, Katriona Goldmann¹, Fabiola Bene¹, Rebecca Hands¹, Stephen Kelly², Michele Bombardieri³, Myles J. Lewis³, Chris Buckley⁴, Peter C. Taylor⁵, Iain B. McInnes⁶ and Costantino Pitzalis¹, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ²Rheumatology Department, Barts Health NHS Trust, London, London, United Kingdom, ³Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ⁴Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, ⁵University of Oxford Botnar Research Centre, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, ⁶Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) are chronic joint conditions characterised by persistent inflammation of the synovial tissue (ST). Previous reports suggested less…
Abstract Number: 10 • 2018 ACR/ARHP Annual Meeting
Fibroblast like Synoviocytes (FLS) Are Capable of Inducing Phenotypical Changes Including Class Switch Recombination (CSR) in Naive B Cells, but Additional Factors Are Required to Trigger Immunoglobulin Secretion
Dennis Bleck¹, Torsten Lowin², Matthias Schneider³ and Georg Pongratz⁴, ¹Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, ²Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, ³Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, ⁴Dpt. of Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells.…
Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting
Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model
Michael J. Duryee¹, Jill Poole², Amy Nelson³, Katherine Janike², Lynell W. Klassen⁴, James R. O'Dell⁴, Bryant R. England⁵, Ted R. Mikuls⁶ and Geoffrey M. Thiele⁷, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²Medicine, University of Nebraska Medical Center, Omaha, NE, ³Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, ⁴Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, ⁶Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, ⁷University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
Abstract Number: 928 • 2018 ACR/ARHP Annual Meeting
Single Cell RNA-Sequencing of Rheumatoid Synovial Fibroblasts Reveals a Disease-Associated Spatial Gradient Modulated By Inductive Notch Signaling
Kevin Wei¹, Ilya Korsunsky², Jennifer Marshall³, Gerald Watts⁴, Anqi Gao⁵, Philip Blazar⁶, Jeffrey Lange⁶, Thomas Thornhill⁶, Chris Buckley⁷, Soumya Raychaudhuri⁸ and Michael Brenner⁹, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ³Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁶Orthopaedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁷University of Birmingham, Birmingham, United Kingdom, ⁸Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, ⁹Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: In rheumatoid arthritis (RA), tissue resident fibroblasts orchestrate chronic inflammation and regulate pathologic bone and cartilage remodeling that causes irreversible joint damage. Recently, we…
Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting
The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis
Cécile Lambert¹, Didier Borderie², Jean-Emile Dubuc³, François Rannou² and Yves Henrotin^4,5, ¹Bone and Cartilage Research Unit, University of Liege, Liege, Belgium, ²Inserm umr 1124, Laboratory of pharmacology, toxicology and cell signaling, University Paris Descartes, Paris, France, ³Orthopaedic Department, University Clinics St Luc, Brussels, Belgium, ⁴Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-Famenne, Belgium, ⁵Bone and Cartilage Research Unit, University of Liege, Liège, Belgium
Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…
Abstract Number: 1053 • 2018 ACR/ARHP Annual Meeting
Synovial Inflammation Identifies Patients Clusters in Osteoarthritis
Hannah Labinsky¹, Paul Panipinto¹, Kaytlyn Ly², Deric Khuat², Bhanupriya Madarampalli³, Vineet Mahajan¹, Jonathan Clabeaux⁴, Kevin MacDonald⁴, Peter Verdin⁴, Jane H. Buckner² and Erika H. Noss³, ¹Medicine, Division of Rheumatology, University of Washington, Seattle, WA, ²Benaroya Research Institute at Virginia Mason, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA, ⁴Orthopedics, Virginia Mason Hospital, Seattle, WA
Background/Purpose: Synovial membrane inflammation is common in osteoarthritis (OA). Inflammation may be present at all disease stages, increases the risk of cartilage injury, and is…
Abstract Number: 1078 • 2018 ACR/ARHP Annual Meeting
Standardization of Synovial Biopsies Procedures across Centers: A Consensus Initiative Using a Delphi Survey
Aurélie Najm^1,2, Benoît Le Goff MD PhD^3,4, Carl Orr⁵, Rogier Thurlings⁶, Juan D. Cañete⁷, Frances Humby⁸, Stefano Alivernini⁹, Søren Andreas Just¹⁰, Vasco C. Romão¹¹, Veit Krenn¹², Ulf Müller-Ladner¹³, Olga Addimanda¹⁴, Antonio Manzo¹⁵, Sander W. Tas¹⁶, Patrick Durez¹⁷, Laurent Meric de Bellefon¹⁷, Maria Stoenoiu¹⁸, Vibeke Strand¹⁹, Mihir D Wechalekar²⁰, João E. Fonseca²¹, Bernard R. Lauwerys²² and Douglas J. Veale²³, ¹INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, ²Department of Rheumatology, Nantes University Hospital, Nantes, France, ³Rheumatology, Nantes University Hospital, Nantes, France, ⁴UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, ⁵Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, ⁶Rheumatology, Radboud university medical center, Nijmegen, Netherlands, ⁷Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, ⁸Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, ⁹Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ¹⁰Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, ¹¹Rheumatology Department, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ¹²Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany, ¹³Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany, ¹⁴Medicine & Rheumatology Unit, Rizzoli Orthopaedic Institute, Bologna, ., Italy, ¹⁵Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, ¹⁶Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ¹⁷Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ¹⁸Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Bruxelles, Belgium, ¹⁹Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ²⁰Royal Adelaide Hospital, Adelaide, Australia, ²¹Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, ²²Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ²³Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Background/Purpose: Synovial biopsies are increasingly performed in both clinical setting and translational research. Synovial tissue analysis role in prediction of response to treatment is to…
Abstract Number: 1981 • 2018 ACR/ARHP Annual Meeting
A Molecular Bayesian Network for Rheumatoid Arthritis Reveals Multiple Candidate Key Regulators for Disease Severity
Wenhui Wang¹, Amit Lahiri², Teresina Laragione², Jun Zhu¹ and Percio S. Gulko^2,3, ¹Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, ²Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, ³Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune joint disease. RA is pathologically heterogeneous with multiple contributing factors. While there has been a…
Abstract Number: 2024 • 2018 ACR/ARHP Annual Meeting
Comparison of B and T Cell Subsets, Cytokine Expression and Synovial Pathology in Down’s Arthritis (DA) and Juvenile Idiopathic Arthritis (JIA)
Charlene Foley¹, Achilleas Floudas², Mary Canavan², Monika Biniecka², Emma-Jane MacDermott³, Orla G Killeen³, Ronan Mullan⁴ and Ursula Fearon⁵, ¹Our Lady's Children's Hospital Crumlin, National Centre for Paediatric Rheumatology, Dublin, Ireland, ²Trinity Biomedical Sciences Institute, Dublin, Ireland, ³National Centre for Paediatric Rheumatology, Dublin, Ireland, ⁴Rheumatology, Tallaght Hospital, Dublin, Ireland, ⁵Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland
Background/Purpose: Down syndrome (DS) is a common chromosomal disorder associated with a range of medical & immune abnormalities e.g. increased susceptibility to infections & a…
Abstract Number: 1020 • 2017 ACR/ARHP Annual Meeting
The Inflammatory and Proliferative Synovial Lesion in Post-Infectious Lyme Arthritis Results from Impaired Wound Healing
Robert Lochhead^1,2, David Ordonez-Del Valle^1,2, Klemen Strle^2,3, Sheila Arvikar^1,2, John Aversa⁴ and Allen Steere^1,2, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ²Department of Medicine, Harvard Medical School, BOSTON, MA, ³Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, ⁴School of Medicine, Yale University, New Haven, CT
Background/Purpose: Lyme arthritis (LA) is initially triggered by Borrelia burgdorferi infection, but in some patients, the synovitis persists despite 2-3 months of antibiotic therapy and…
Abstract Number: 1063 • 2017 ACR/ARHP Annual Meeting
Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6
Neha Sharma^1,2, Ashref Kayed^3,4, Cecilie F. Kjelgaard-Petersen^2,5, Thorbjørn G. Christiansen⁶, Morten Karsdal⁷, Christian S. Thudium² and Anne-C. Bay-Jensen⁸, ¹Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ²Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, ³Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, ⁵Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, ⁶Gentofte University Hospital, Orthopaedicsurgery unit, Gentofte, Denmark, ⁷Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, ⁸Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark
Background/Purpose: The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which…
Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting
Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis
Marta Fernandez Bustmanate¹, Jeffrey Smith², Adam Paul Croft³, Gary S. Firestein⁴, Chris Buckley⁵, Shigeki Miyamoto² and Monica Guma⁶, ¹Medicine, UCSD, San Diego, CA, ²Pharmacology, UCSD, La Jolla, CA, ³Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, ⁴Medicine, University of California San Diego, La Jolla, CA, ⁵University of Birmingham, Birmingham, United Kingdom, ⁶Medicine, UCSD, La Jolla, CA
Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…