ACR Meeting Abstracts

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Abstracts tagged "Synovial Immune Biology"

  • Abstract Number: 117 • 2019 ACR/ARP Annual Meeting

    The Indole Derivative NecroX Blocks Th17 Cell Differentiation and Fibroblast-like Synoviocytes-mediated Th1/Th17 Responses in Rheumatoid Arthritis

    Hyun Jung Yoo1, Shin Eui Kang 2, Ji Hye Lee 3, Ra Ham Kim 4 and Yeong-Wook Song 5, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Repulbic of Korea, Seoul, Republic of Korea, 2Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 3Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Seoul, Republic of Korea, 4Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Republic of Korea, Seoul, Republic of Korea, 5Seoul National University Hospital, Seoul, Republic of Korea

    Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of synovium, which causes progressive joint destruction and reduction in quality of life.…
  • Abstract Number: 781 • 2019 ACR/ARP Annual Meeting

    Is down Syndrome Associated Arthritis (DA) a Distinct Disease from Juvenile Idiopathic Arthritis (JIA)?

    Charlene Foley1, Achilleas Floudas 2, Sharon Ansboro 2, Mary Canavan 2, Monika Biniecka 2, Emma Jane MacDermott 3, Ronan Mullan 4, Gerry Wilson 5, Ursula Fearon 6 and Orla Killeen 7, 1Great Ormond Street Hospital, London, Ireland, 2TBSI, Dublin, Ireland, 3OLCHC, Dublin, Ireland, 4Tallaght Hospital, Dublin, Ireland, 5UCD, Dublin, Ireland, 6TBSI, Dublin, 7National Centre for Paediatric Rheumatology (NCPR), Our Lady’s Children’s Hospital Crumlin (OLCHC), Dublin, Ireland

    Background/Purpose: Down syndrome associated Arthritis (DA) is 20 times more common than JIA. It is an erosive, polyarticular RF negative arthritis with predominance in the…
  • Abstract Number: 1985 • 2019 ACR/ARP Annual Meeting

    Divergent Mononuclear Cell Participation and Cytokine Release Profiles Define Hip and Knee Osteoarthritis

    Ricardo Grieshaber-Bouyer1, Till Kämmerer 2, Nils Rosshirt 2, Philipp Koniezke 2, Sebastien Hagmann 2, Elena Tripel 2, Johannes Kirsch 2, Tobias Gotterbarm 2 and Babak Moradi 2, 1Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Boston, MA, 2Department of Orthopedics, Heidelberg University Hospital, Heidelberg, Germany, Heidelberg, Germany

    Background/Purpose: Osteoarthritis (OA) is a progressive joint disease driven by a blend of inflammatory and biomechanical processes. Studies using human samples to understand inflammatory mechanisms…
  • Abstract Number: 1053 • 2018 ACR/ARHP Annual Meeting

    Synovial Inflammation Identifies Patients Clusters in Osteoarthritis

    Hannah Labinsky1, Paul Panipinto1, Kaytlyn Ly2, Deric Khuat2, Bhanupriya Madarampalli3, Vineet Mahajan1, Jonathan Clabeaux4, Kevin MacDonald4, Peter Verdin4, Jane H. Buckner2 and Erika H. Noss3, 1Medicine, Division of Rheumatology, University of Washington, Seattle, WA, 2Benaroya Research Institute at Virginia Mason, Seattle, WA, 3Rheumatology, University of Washington, Seattle, WA, 4Orthopedics, Virginia Mason Hospital, Seattle, WA

    Background/Purpose: Synovial membrane inflammation is common in osteoarthritis (OA). Inflammation may be present at all disease stages, increases the risk of cartilage injury, and is…
  • Abstract Number: 1078 • 2018 ACR/ARHP Annual Meeting

    Standardization of Synovial Biopsies Procedures across Centers: A Consensus Initiative Using a Delphi Survey

    Aurélie Najm1,2, Benoît Le Goff MD PhD3,4, Carl Orr5, Rogier Thurlings6, Juan D. Cañete7, Frances Humby8, Stefano Alivernini9, Søren Andreas Just10, Vasco C. Romão11, Veit Krenn12, Ulf Müller-Ladner13, Olga Addimanda14, Antonio Manzo15, Sander W. Tas16, Patrick Durez17, Laurent Meric de Bellefon17, Maria Stoenoiu18, Vibeke Strand19, Mihir D Wechalekar20, João E. Fonseca21, Bernard R. Lauwerys22 and Douglas J. Veale23, 1INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, 2Department of Rheumatology, Nantes University Hospital, Nantes, France, 3Rheumatology, Nantes University Hospital, Nantes, France, 4UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 5Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin 4, Ireland, 6Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 7Rheumatology Deparment, Hospital Clinic and IDIBAPS, Barcelona, Spain, Barcelona, Spain, 8Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 9Division of Rheumatology - Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, 10Department of Rheumatology, Department of Rheumatology, Odense University Hospital, Odense, Denmark, Odense, Denmark, 11Rheumatology Department, Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 12Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany, 13Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Bad Nauheim, Germany, 14Medicine & Rheumatology Unit, Rizzoli Orthopaedic Institute, Bologna, ., Italy, 15Rheumatology and Translational Immunology Research Laboratories (LaRIT), Division of Rheumatology, IRCCS Policlinico San Matteo Foundation/University of Pavia, Pavia, Italy, 16Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, 17Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 18Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Bruxelles, Belgium, 19Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, 20Royal Adelaide Hospital, Adelaide, Australia, 21Serviço de Reumatologia e Doenças Ósseas Metabólicas, Hospital de Santa Maria, CHLN, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 22Department of Rheumatology, Rheumatology - Cliniques universitaires Saint-Luc - Université Catholique de Louvain - Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, 23Centre for Arthritis and Rheumatic Diseases, Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland

    Background/Purpose: Synovial biopsies are increasingly performed in both clinical setting and translational research. Synovial tissue analysis role in prediction of response to treatment is to…
  • Abstract Number: 1981 • 2018 ACR/ARHP Annual Meeting

    A Molecular Bayesian Network for Rheumatoid Arthritis Reveals Multiple Candidate Key Regulators for Disease Severity

    Wenhui Wang1, Amit Lahiri2, Teresina Laragione2, Jun Zhu1 and Percio S. Gulko2,3, 1Genetics and Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, 2Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 3Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a common and chronic autoimmune joint disease. RA is pathologically heterogeneous with multiple contributing factors. While there has been a…
  • Abstract Number: 2024 • 2018 ACR/ARHP Annual Meeting

    Comparison of B and T Cell Subsets, Cytokine Expression and Synovial Pathology in Down’s Arthritis (DA) and Juvenile Idiopathic Arthritis (JIA)

    Charlene Foley1, Achilleas Floudas2, Mary Canavan2, Monika Biniecka2, Emma-Jane MacDermott3, Orla G Killeen3, Ronan Mullan4 and Ursula Fearon5, 1Our Lady's Children's Hospital Crumlin, National Centre for Paediatric Rheumatology, Dublin, Ireland, 2Trinity Biomedical Sciences Institute, Dublin, Ireland, 3National Centre for Paediatric Rheumatology, Dublin, Ireland, 4Rheumatology, Tallaght Hospital, Dublin, Ireland, 5Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland

    Background/Purpose: Down syndrome (DS) is a common chromosomal disorder associated with a range of medical & immune abnormalities e.g. increased susceptibility to infections & a…
  • Abstract Number: 2060 • 2018 ACR/ARHP Annual Meeting

    Comparative Histologic and Molecular Analysis of Synovial Tissue in Early Treatment-Naïve Psoriatic and Rheumatoid Arthritis

    Alessandra Nerviani1, Frances Humby1, Gloria Lliso Ribera1, Wang Sin Tan1, Marie Astrid Boutet1, Katriona Goldmann1, Fabiola Bene1, Rebecca Hands1, Stephen Kelly2, Michele Bombardieri3, Myles J. Lewis3, Chris Buckley4, Peter C. Taylor5, Iain B. McInnes6 and Costantino Pitzalis1, 1Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom, 2Rheumatology Department, Barts Health NHS Trust, London, London, United Kingdom, 3Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, 4Institute of Inflammation and Ageing (IIA), University of Birmingham, Birmingham, United Kingdom, 5University of Oxford Botnar Research Centre, Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Oxford, United Kingdom, 6Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) are chronic joint conditions characterised by persistent inflammation of the synovial tissue (ST). Previous reports suggested less…
  • Abstract Number: 10 • 2018 ACR/ARHP Annual Meeting

    Fibroblast like Synoviocytes (FLS) Are Capable of Inducing Phenotypical Changes Including Class Switch Recombination (CSR) in Naive B Cells, but Additional Factors Are Required to Trigger Immunoglobulin Secretion

    Dennis Bleck1, Torsten Lowin2, Matthias Schneider3 and Georg Pongratz4, 1Rheumatology Policlinic & Hiller Research Unit, Medical Faculty, University Hospital, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany, 2Department and Hiller Research Center for Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany, 3Department and Hiller Research Center for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, 4Dpt. of Rheumatology - Hiller Research Center Rheumatology, University Hospital Duesseldorf, Duesseldorf, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a disease characterized by chronic inflammation of the synovial tissue in joints. It is driven by highly activated B cells.…
  • Abstract Number: 46 • 2018 ACR/ARHP Annual Meeting

    Organic Dust Inhalants Shift Immune Responses and Extracellular Matrix Balance between Synovium and Lung in the Collagen-Induced Arthritis Mouse Model

    Michael J. Duryee1, Jill Poole2, Amy Nelson3, Katherine Janike2, Lynell W. Klassen4, James R. O'Dell4, Bryant R. England5, Ted R. Mikuls6 and Geoffrey M. Thiele7, 1Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 2Medicine, University of Nebraska Medical Center, Omaha, NE, 3Department of Medicine, University of Nebrasa Medical Center, Omaha, NE, 4Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, 5Rheumatology, VA Nebraska-Western Iowa Health Care System & University of Nebraska Medical Center, Omaha, NE, 6Internal Medicine, Division of Rheumatology, VA Nebraska-Western Iowa Health Care System and University of Nebraska Medical Center, Omaha, NE, 7University of Nebraska Medical Center, Omaha, NE

    Background/Purpose:   Emerging evidence suggests that the lungs may be an initiating site of autoimmunity leading to RA with organic inhalant exposures such as those…
  • Abstract Number: 928 • 2018 ACR/ARHP Annual Meeting

    Single Cell RNA-Sequencing of Rheumatoid Synovial Fibroblasts Reveals a Disease-Associated Spatial Gradient Modulated By Inductive Notch Signaling

    Kevin Wei1, Ilya Korsunsky2, Jennifer Marshall3, Gerald Watts4, Anqi Gao5, Philip Blazar6, Jeffrey Lange6, Thomas Thornhill6, Chris Buckley7, Soumya Raychaudhuri8 and Michael Brenner9, 1Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 2Division of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 3Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 4Brigham and Women's Hospital, Boston, MA, 5Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, 6Orthopaedic Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 7University of Birmingham, Birmingham, United Kingdom, 8Medical and Population Genetics Program, Broad Institute of MIT and Harvard, Cambridge, MA, 9Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: In rheumatoid arthritis (RA), tissue resident fibroblasts orchestrate chronic inflammation and regulate pathologic bone and cartilage remodeling that causes irreversible joint damage. Recently, we…
  • Abstract Number: 1045 • 2018 ACR/ARHP Annual Meeting

    The Coll2-1 Peptide of Collagen Type II: A New Actor of Synovitis in Osteoarthritis

    Cécile Lambert1, Didier Borderie2, Jean-Emile Dubuc3, François Rannou2 and Yves Henrotin4,5, 1Bone and Cartilage Research Unit, University of Liege, Liege, Belgium, 2Inserm umr 1124, Laboratory of pharmacology, toxicology and cell signaling, University Paris Descartes, Paris, France, 3Orthopaedic Department, University Clinics St Luc, Brussels, Belgium, 4Physical Therapy and Rehabilitation, Princess Paola Hospital, Marche-en-Famenne, Belgium, 5Bone and Cartilage Research Unit, University of Liege, Liège, Belgium

    Background/Purpose: We evaluated the inflammatory effect of Coll2-1 peptide in osteoarthritic synoviocytes and rats by comparing peptide-induced inflammatory reaction with the one induced by bovine…
  • Abstract Number: 1020 • 2017 ACR/ARHP Annual Meeting

    The Inflammatory and Proliferative Synovial Lesion in Post-Infectious Lyme Arthritis Results from Impaired Wound Healing

    Robert Lochhead1,2, David Ordonez-Del Valle1,2, Klemen Strle2,3, Sheila Arvikar1,2, John Aversa4 and Allen Steere1,2, 1Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, 2Department of Medicine, Harvard Medical School, BOSTON, MA, 3Department of Immunology and Inflammatory Diseases, Massachusetts General Hospital, BOSTON, MA, 4School of Medicine, Yale University, New Haven, CT

    Background/Purpose: Lyme arthritis (LA) is initially triggered by Borrelia burgdorferi infection, but in some patients, the synovitis persists despite 2-3 months of antibiotic therapy and…
  • Abstract Number: 1063 • 2017 ACR/ARHP Annual Meeting

    Activation of Toll-like Receptor 2 in Human Synovium Explants Increase Tissue Turnover and Secretion of Interleukin-6

    Neha Sharma1,2, Ashref Kayed3,4, Cecilie F. Kjelgaard-Petersen2,5, Thorbjørn G. Christiansen6, Morten Karsdal7, Christian S. Thudium2 and Anne-C. Bay-Jensen8, 1Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, 2Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 3Biomolecular Sciences, University of Copenhagen, Copenhagen, Denmark, 4Research and Biomarkers, Nordic Bioscience, Herlev, Denmark, 5Bioengineering, Technical University of Denmark, Kgs. Lyngby, Denmark, 6Gentofte University Hospital, Orthopaedicsurgery unit, Gentofte, Denmark, 7Biomarkers and Reseacrh, Nordic Bioscience, Herlev, Denmark, 8Biomarkers and Reseach, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: The innate immune system is important for initiation and development of OA. Increased degradation of the cartilage release fragments into the synovial fluid, which…
  • Abstract Number: 1339 • 2017 ACR/ARHP Annual Meeting

    Role of Hexokinase-2 in Synovial Lining Hypertrophy in Murine Arthritis

    Marta Fernandez Bustmanate1, Jeffrey Smith2, Adam Paul Croft3, Gary S. Firestein4, Chris Buckley5, Shigeki Miyamoto2 and Monica Guma6, 1Medicine, UCSD, San Diego, CA, 2Pharmacology, UCSD, La Jolla, CA, 3Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 4Medicine, University of California San Diego, La Jolla, CA, 5University of Birmingham, Birmingham, United Kingdom, 6Medicine, UCSD, La Jolla, CA

    Background/Purpose: Recent studies indicate that fibroblast-like synoviocyte (FLS) glucose metabolism is altered in rheumatoid arthritis (RA). Hexokinases (HKs) catalyze the first step in glucose metabolism.…
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