Abstracts tagged "synovial fluid"

Abstract Number: 1766 • 2012 ACR/ARHP Annual Meeting
Synovial Gene Expression and Response to Rituximab: Preliminary Data
Yasser El-Sherbiny¹, Sarah Churchman², Frederique Ponchel³, Paul Emery⁴ and Edward M. Vital¹, ¹Section of Musculoskeletal Disease, NIHR Leeds Biomedical Research Unit, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ²Section of Musculoskeletal Disease, NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁴Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds, United Kingdom
Background/Purpose: Quality and duration of response to rituximab in rheumatoid arthritis have not been completely explained. In the synovium, three studies have indicated a relationship…
Abstract Number: 326 • 2012 ACR/ARHP Annual Meeting
Silencing Intraarticular Snail Expression Ameliorates Rat Collagen-Induced Arthritis Through Induction of Mesenchymal-Epithelial Transition in Synovial Fibroblasts
Chrong-Reen Wang¹, Shih-Yao Chen², Ai-Li Shiau³, Yuan-Tsung Li⁴, Ming-Fei Liu⁵ and Chao-Liang Wu², ¹Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ²Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, ³Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, ⁴Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, ⁵Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan
Background/Purpose: Morphological characteristics of rheumatoid arthritis (RA) synovial fibroblasts (SF) are similar to transformed cells. We hypothesized that epithelial-mesenchymal transition (EMT) of SF regulated by…
Abstract Number: 1768 • 2012 ACR/ARHP Annual Meeting
The Absolute Concentration of Anti Citrullinated Protein Antibodies in Serum and Synovial Fluid in Relation to Total Immunoglobulin-Concentrations
Annemiek Willemze, Jing Shi, Marlies Mulder, Gerrie Stoeken-Rijsbergen, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw, Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The presence of anti-citrullinated protein antibodies (ACPA) is one of the most predictive factors for the development of rheumatoid arthritis (RA). Nonetheless, relatively little…
Abstract Number: 51 • 2012 ACR/ARHP Annual Meeting
Phosphodiesterase 4 Expression in Rheumatoid Arthritis Synovium and Anti-Inflammatory Effects of Apremilast On Synovial Fibroblasts
Lei Wu, Mary Adams, Stacey Parton and Peter Schafer, Department of Translational Development, Celgene Corporation, Summit, NJ
Background/Purpose: Apremilast (APR), a small molecule specific inhibitor of phosphodiesterase 4 (PDE4), works intracellularly to modulate pro- and anti-inflammatory mediator production in both immune and…
Abstract Number: 1659 • 2012 ACR/ARHP Annual Meeting
Ptpome Profile of Rheumatoid Arthritis Fibroblast-Like Synoviocytes: A Novel Role for the Tyrosine Phosphatase SHP-2 As a Modulator of Invasion and Survival
Stephanie Stanford¹, Michael Maestre², Beatrix Bartok³, David L. Boyle⁴, Heather Arnett⁵, Tomas Mustelin⁶, Gary S. Firestein⁷ and Nunzio Bottini², ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁴Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA, ⁵Amgen, Inc., Seattle, WA, ⁶Sanford-Burnham Institute for Medical Research, La Jolla, CA, ⁷Div of Rheumatology, UCSD School of Medicine, La Jolla, CA
Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining are key mediators of inflammation and joint destruction in rheumatoid arthritis (RA). These cells assume a…
Abstract Number: 21 • 2012 ACR/ARHP Annual Meeting
IL-32 and IL-17 Interact and Aggravate Osteoclastogenesis in Rheumatoid Arthritis
Bo Young Yoon¹, Young-Mee Moon², Yang-Mi Her², Hye Jwa Oh², Jae-Seon Lee², Kyoung-Woon Kim³, Seon-Yeong Lee², Yun-Ju Woo², Kyung-Su Park², Sung-Hwan Park⁴, Ho-Youn Kim² and Mi-La Cho², ¹Inje University Ilsan Paik Hospital, Goyang, South Korea, ²Rheumatism Research Center, Catholic Research Institute of Medical Science, Catholic University of Korea, Seoul, South Korea, ³Conversant Research Consortium in Immunologic disease, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea, ⁴Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul St. Mary's Hospital, Seoul, South Korea
Background/Purpose: Interleukin (IL)-32 and IL-17 play critical roles in pro-inflammatory responses and are highly expressed in the synovium of patients with rheumatoid arthritis (RA). We…
Abstract Number: 1601 • 2012 ACR/ARHP Annual Meeting
Role of Focal Adhesion Kinase in Synovial Fibroblast Invasion and Arthritis
Miriam A. Shelef¹, David Bennin² and Anna Huttenlocher³, ¹Medicine, Univ of Wisconsin Schl of Med, Madison, WI, ²Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI, ³Dept of Pediatrics and MMI, Univ of Wisconsin Schl of Med, Madison, WI
Background/Purpose: Rheumatoid arthritis is an inflammatory arthritis characterized by joint erosions and destruction. This damage is mediated in part by invasion of synovial fibroblasts into…
Abstract Number: 4 • 2012 ACR/ARHP Annual Meeting
Pro-Inflammatory Effect of Extracellular RNA On Synovial Fibroblasts From Patients with Rheumatoid Arthritis
Birgit Zimmermann¹, Silvia Fischer², Markus Rickert³, Stefan Rehart⁴, Angela Lehr⁵, Ulf Müller-Ladner⁶, Klaus T. Preissner² and Elena Neumann⁷, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Dept of Biochemistry, Justus-Liebig-University of Giessen, Medical School, Giessen, Germany, ³Dept of Orthopedics and Orthopedic Surgery, University Hospital Giessen and Marburg, Giessen, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Dept Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁶Dept of Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁷Department of Internal Medicine and Rheumatology, Justus-Liebig-University of Gießen, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: Extracellular RNA (exRNA) is present in the serum of patients suffering of different kinds of cancer. exRNA influences physiological processes like blood coagulation and…
Abstract Number: 1196 • 2012 ACR/ARHP Annual Meeting
Analysis of Gene Expression Patterns in Rheumatoid Arthritis (RA) Synovial Macrophages From Patients Undergoing Disease Flare
Karen L. Berg¹, Adedayo Hanidu¹, Jon Hill², Xiaoyu Jiang¹, Tom Freeman², Jennifer Swantek¹, Anna Yarlina³, George D. Kalliolias⁴, Lionel B. Ivashkiv⁵ and Gerald H. Nabozny¹, ¹Immunology and Inflammation, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, ²Scientific Knowledge Discovery, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT, ³Hospital for Special Surgery, New York, NY, ⁴Medicine, Hospital for Special Surgery, New York, NY, ⁵Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Synovial macrophages play a key role in RA pathogenesis. Their numbers are greatly increased in RA synovium, their phenotype is consistent with a pro-inflammatory…
Abstract Number: 1197 • 2012 ACR/ARHP Annual Meeting
Porphyromonas Gingivalis and the Pathogenesis of Rheumatoid Arthritis: Analysis of the Synovial Tissue and of Other Compartments
Michele C. Totaro¹, Sara D'Onghia², Elisa Gremese¹, Luca Petricca¹, Simona Marchetti², Silvia Canestri¹, Barbara Tolusso¹, Stefano Alivernini¹, Paola Cattani² and Gianfranco Ferraccioli¹, ¹Division of Rheumatology, Institute of Rheumatology and Affine Sciences, Catholic University of the Sacred Heart, Rome, Italy, ²Laboratory of Clinical Analyses CIC, Catholic University of the Sacred Heart, Rome, Italy
Background/Purpose: Porphyromonas gingivalis (Pg), a periodontal anaerobic intracellular pathogen, has been recently associated to rheumatoid arthritis (RA) and the pathogenesis of the disease, due to…
Abstract Number: 1208 • 2012 ACR/ARHP Annual Meeting
Stable Synovial Fluid Phenotype for Anti Citrullinated-Protein Antibodies in Established Rheumatoid Arthritis
Vijay Joshua¹, Lena Israelsson², Lars Klareskog³, Anca Catrina¹ and Vivianne Malmström⁴, ¹Department of Medicine, Rheumatology unit, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, ²Department of Medicine, Karolinska Institute, Stockholm, Sweden, ³Department of Medicine, Rheumatology Unit, Karolinska Institute, Stockholm, Sweden, ⁴Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Presence of anti citrullinated-protein antibodies (ACPA) in the peripheral blood of patients with rheumatoid arthritis is a validated disease biomarker. We have previously shown…
Abstract Number: 1189 • 2012 ACR/ARHP Annual Meeting
Stromal Cell Markers in the Synovial Tissue of Patients with Early Arthritis and Preclinical Rheumatoid Arthritis
Yuen Kei Choi¹, Olga N. Karpus², Paul Peter Tak³, Jörg Hamann⁴, Christopher D. Buckley⁵, Andrew Filer⁶ and Danielle M. Gerlag⁷, ¹Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²1Departments of Experimental Immunology and Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, ³Academic Medical Center / University of Amsterdam, Department of Clinical Immunology and Rheumatology & GlaxoSmithKline, Amsterdam, Netherlands, ⁴Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ⁵Center for Translational Inflammation Research, School of Immunity and Infection, MRC Center for Immune Regulation, Birmingham, United Kingdom, ⁶Rheumatology Research Group, MRC Centre for Immune Regulation, School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁷Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands
Background/Purpose: Stromal cells in synovial tissue (ST) of patients with arthritis may have an important role in the initiation and persistence of the inflammatory infiltrate.…

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