Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting
Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis
Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting
Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential
Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting
Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells
Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…Abstract Number: 1461 • 2014 ACR/ARHP Annual Meeting
Quantitave Analysis of Cadherin-11 and Beta-Catenin Signaling during Proliferation of Rheumatoid Arthritis-Derived Synovial Fibroblast Cells
[Background/Purpose ] Cadherin-11 (CDH11) is a cadherin adhesion molecule that anchors b-catenin, and is involved with various functions of synovial fibroblast cells (SFCs) during the development…Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting
Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis
Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor. Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting
Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis
Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting
Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a
Background/Purpose: In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…Abstract Number: 1029 • 2014 ACR/ARHP Annual Meeting
Anandamide and Related Eicosanoids Decrease the Production of Pro-Inflammatory Cytokines in Synovial Fibroblasts By a COX-2 Dependent Mechanism: Involvement of Calcium and TRP Channels
Background/Purpose: Endocannabinoids are immunomodulatory lipid compounds that act on cannabinoid receptors type 1 and 2 but also on transient receptor potential (TRP) channels. Their action…Abstract Number: 1025 • 2014 ACR/ARHP Annual Meeting
Leptin Production By Osteoarthritis Synovial Fibroblasts: Stimulation By Glucocorticoids and Mineralocorticoids through the Glucocorticoid Receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) Protein
Background/Purpose: Osteoarthritis (OA) is a metabolic disorder for which leptin is playing a catabolic role on cartilage. In mice, obesity due to impaired leptin did…Abstract Number: 89 • 2014 ACR/ARHP Annual Meeting
Global miRNA Expression Profiling in Peripheral Blood and Synovial Fluid Mononuclear Cells of Patients with Enthesitis Related Arthritis
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in India. MicroRNA dysregulation has been associated with arthritis and autoimmune diseases. In…Abstract Number: 1835 • 2013 ACR/ARHP Annual Meeting
Dynamic Visualization Of Monocyte Migration In 3D Synovial Micromass Tissue Cultures
Background/Purpose: Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated…Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting
Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73
Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting
Novel Role For Ly6C– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis
Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…Abstract Number: 1426 • 2013 ACR/ARHP Annual Meeting
Inhibition Of Spermidine/Spermine N1-Acetyltransferase Activity – a New Therapeutical Concept In Rheumatoid Arthritis
Background/Purpose: Spermine/spermidine N1-acetyltransferase (SSAT1) and polyamine modulating factor 1 (PMF1) are increased in rheumatoid arthritis synovial fibroblasts (RASF). Since PMF1 regulates the expression of SSAT1,…Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting
Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis
Background/Purpose: Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
- « Previous Page
- 1
- …
- 4
- 5
- 6
- 7
- 8
- 9
- Next Page »