ACR Meeting Abstracts

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Abstracts tagged "synovial fluid"

  • Abstract Number: 2177 • 2014 ACR/ARHP Annual Meeting

    Class a Scavenger Receptor(SR-a)Exacerbated Synovial Fibroblasts-Mediated Inflammation in Rheumatoid Arthritis

    Yingni Li1, Fanlei Hu2, Li Zheng1, Linchong Su3, Lianjie Shi2, Pei Song1 and Zhanguo Li2, 1Peking University People's Hospital, Beijing, China, 2Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, 3Hubei Minzu University, Enshi, China

    Background/Purpose Class A scavenger receptor (SR-A/CD204), mainly expressed on macrophages, plays an important role in the pathogenesis of atherosclerosis and in the pattern recognition of…
  • Abstract Number: 1969 • 2014 ACR/ARHP Annual Meeting

    Neurotrophin Receptor p75 (CD271) Defines a Distinct Synovial Fibroblast Subset in Rheumatoid and Osteoarthritic Synovial Tissues with Enhanced Proinflammatory Potential

    Manuel J. Del Rey1, Regina Faré1, Gabriel Criado2, Alicia Usategui1, Vanessa Miranda1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose Synovial mesenchynmal or stromal cells constitute a heterogeneous cell population difficult to characterize ex vivo due to a paucity of cell markers and are…
  • Abstract Number: 1739 • 2014 ACR/ARHP Annual Meeting

    Immunomodulatory Properties of CD271+ and CD271- Synovial Mesenchymal Cells

    Alicia Usategui1, Manuel J. Del Rey1, Regina Faré1, Gabriel Criado2, Vanessa Miranda1, Juan D. Cañete3 and Jose L. Pablos1, 1Servicio de Reumatología, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Grupo de Enfermedades Inflamatorias y Autoinmunes, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 3Arthritis Unit. Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain

    Background/Purpose Mesenchymal stem cells (MSC) have been isolated from synovium and represent a fraction of synovial fibroblast (SF) cultures. CD271+ is considered a MSC surface…
  • Abstract Number: 1461 • 2014 ACR/ARHP Annual Meeting

    Quantitave Analysis of Cadherin-11 and Beta-Catenin Signaling during Proliferation of Rheumatoid Arthritis-Derived Synovial Fibroblast Cells

    Ryosuke Yoshioka, Yasuhiro Kita, Asako Nagahira, Atsushi Manno, Naoyuki Makita, Urara Tomita and Masao Murakawa, Asubio Pharma Co., Ltd., Kobe, Japan

    [Background/Purpose ] Cadherin-11 (CDH11) is a cadherin adhesion molecule that anchors b-catenin, and is involved with various functions of synovial fibroblast cells (SFCs) during the development…
  • Abstract Number: 1460 • 2014 ACR/ARHP Annual Meeting

    Midkine, a Growth Factor, May Play a Pathophysiological Role in Patients with Rheumatoid Arthritis

    Emiko Shindo, Tomoko Hasunuma, Shotaro Masuoka, Mai Kawazoe, Hiroshi Sato, Natsuki Fujio, Kotaro Shikano, Makoto Kaburaki, Sei Muraoka, Nahoko Tanaka, Kaichi Kaneko, Tatsuhiro Yamamoto, Kenji Takagi, Natsuko Kusunoki and Shinichi Kawai, Division of Rheumatology, Department of Internal Medicine, School of Medicine, Faculty of Medicine, Toho University, Tokyo, Japan

    Background/Purpose: Midkine (MK) is known as a heparin-binding growth factor.  Recent studies revealed that MK has various functions such as cell proliferation, differentiation, and apoptosis…
  • Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting

    Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis

    Lenka Pleštilová1, Niharika Gaur1, Mária Filková2, Borbala Aradi-Vegh1, Ladislav Senolt3, Adrian Ciurea1, Renate E. Gay4, Jiri Vencovsky3, Michel Neidhart5, Steffen Gay5 and Astrid Juengel1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich Schlieren, Switzerland, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 3Institute of Rheumatology and Clinic of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 4Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 5Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…
  • Abstract Number: 1031 • 2014 ACR/ARHP Annual Meeting

    Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a

    Salahuddin Ahmed1, Laura Walsh2, Anil Singh1, Maria Beamer3, Kuladeep Sudini4 and Douglas Leaman4, 1Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, 2Department of Pharmacology, University of Toledo, Toledo, OH, 3Department of Pharmacology, Department of Pharmacology, University of Toledo, Toledo, OH, 4Department of Biological Sciences, University of Toledo, Toledo, OH

    Background/Purpose:  In rheumatoid arthritis (RA), the paucity of pro-apoptotic protein expression may significantly contribute to the resistance of synovial fibroblasts (FLS) to apoptosis. In the…
  • Abstract Number: 1029 • 2014 ACR/ARHP Annual Meeting

    Anandamide and Related Eicosanoids Decrease the Production of Pro-Inflammatory Cytokines in Synovial Fibroblasts By a COX-2 Dependent Mechanism: Involvement of Calcium and TRP Channels

    Torsten Lowin1, Tanja Späth2, Angelika Graeber1 and Rainer Straub3, 1Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, 2Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, Regensburg, Germany, 3Internal Medicine, University Hospital Regensburg, Regensburg, Germany

    Background/Purpose: Endocannabinoids are immunomodulatory lipid compounds that act on cannabinoid receptors type 1 and 2 but also on transient receptor potential (TRP) channels. Their action…
  • Abstract Number: 1025 • 2014 ACR/ARHP Annual Meeting

    Leptin Production By Osteoarthritis Synovial Fibroblasts: Stimulation By Glucocorticoids and Mineralocorticoids through the Glucocorticoid Receptor and GILZ (Glucocorticoid-Induced Leucine Zipper) Protein 

    Olivier Malaise1, Biserka Relic1, Sophie Neuville2, Edith Charlier1, Dominique de Seny1 and Michel G. Malaise1, 1Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 2GIGA Research - University of Liège - CHU of Liège, Liège, Belgium

    Background/Purpose: Osteoarthritis (OA) is a metabolic disorder for which leptin is playing a catabolic role on cartilage. In mice, obesity due to impaired leptin did…
  • Abstract Number: 89 • 2014 ACR/ARHP Annual Meeting

    Global miRNA Expression Profiling in Peripheral Blood and Synovial Fluid Mononuclear Cells of Patients with Enthesitis Related Arthritis

    Sushma Singh, Ramnath Misra and Amita Aggarwal, Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in India. MicroRNA dysregulation has been associated with arthritis and autoimmune diseases. In…
  • Abstract Number: 1835 • 2013 ACR/ARHP Annual Meeting

    Dynamic Visualization Of Monocyte Migration In 3D Synovial Micromass Tissue Cultures

    Clemens Scheinecker1, Ruth Byrne1, Karolina Dalwigk2, Anastasiya Hladik1, Gunter Steiner3, Josef S. Smolen4 and Hans Peter Kiener1, 1Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Medicine 3, Division of Rheumatology, Medical University of Vienna and Hietzing Hospital, Vienna, Austria

    Background/Purpose: Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated…
  • Abstract Number: 1728 • 2013 ACR/ARHP Annual Meeting

    Amelioration Of Collagen-Induced Arthritis By Modulation Of Inhibitory Apoptosis Stimulating Protein Of p53 To Activate Transcription Factor p73

    Chrong-Reen Wang1, Shih-Yao Chen2, Ai-Li Shiau3, Yuan-Tsung Li4, Chia-Tse Weng5, I-Ming Jou6, Ming-Fei Liu7 and Chao-Liang Wu2, 1Section of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 2Biochemistry and Molecular Biology, National Cheng Kung University Medical College, Tainan, Taiwan, 3Microbiology and Immunology, National Cheng Kung University Medical College, Tainan, Taiwan, 4Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, 5Internal Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, 6Orthopedics, National Cheng Kung University Medical College, Tainan, Taiwan, 7Internal Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

    Background/Purpose: Our previous studies have demonstrated p53 mutations competent for the inactivation of wild type p53 in synovial fibroblasts (SF) from either rheumatoid arthritis patients…
  • Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting

    Novel Role For Ly6C– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis

    Alexander Misharin1, Carla M. Cuda2, Rana Saber3, Angelica K. Gierut4, G. Kenneth Haines III5, Steffen Jung6 and Harris R. Perlman7, 1Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/Rheumatology, Northwestern University, Chicago, IL, 4Rheumatology, Northwestern Med Faculty Found, Chicago, IL, 5Department of Pathology, Yale University, New Haven, CT, 6Immunology, Weizmann Institute, Rehovot, Israel, 7Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…
  • Abstract Number: 1426 • 2013 ACR/ARHP Annual Meeting

    Inhibition Of Spermidine/Spermine N1-Acetyltransferase Activity – a New Therapeutical Concept In Rheumatoid Arthritis

    Emmanuel Karouzakis1, Astrid Jungel1, Beat A. Michel2, Renate E. Gay3, Steffen Gay1 and Michel Neidhart4, 1Center of Experimental Rheumatology, University Hospital Zurich and Zurich Center of Integrative Human Physiology (ZIHP), Zurich, Switzerland, 2Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 3Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 4Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: Spermine/spermidine N1-acetyltransferase (SSAT1) and polyamine modulating factor 1 (PMF1) are increased in rheumatoid arthritis synovial fibroblasts (RASF). Since PMF1 regulates the expression of SSAT1,…
  • Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting

    Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis

    Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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ACR Abstract Embargo Policy

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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