Abstract Number: 1098 • 2015 ACR/ARHP Annual Meeting
Interleukin-1 Reciprocally Regulates Interferon-Gamma Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) and Interleukin-6 in Human Synovial Fibroblasts
Background/Purpose: B cell activating factor of the tumor necrosis factor family (BAFF) and interleukin-6 (IL-6) are cytokines important for the stimulation and survival of autoreactive…Abstract Number: 1142 • 2015 ACR/ARHP Annual Meeting
Joint Specific Function of Synovial Fibroblasts – Integrating Positional Transcriptomes and Anatomic Patterns of Arthritis
Background/Purpose: Synovial fibroblasts (SF) profoundly influence physiological and pathological processes in the joint such as reaction to inflammatory stimuli and production of extracellular matrix. We…Abstract Number: 1265 • 2015 ACR/ARHP Annual Meeting
Genetic and Epigenetic Mapping of Very Early RA Synovial Fibroblasts
Background/Purpose: Genome wide association studies (GWAS) studies from rheumatoid arthritis patients have identified SNPs, which are associated with changes in gene expression levels. Recent studies…Abstract Number: 1616 • 2015 ACR/ARHP Annual Meeting
Identification of Genes Regulating TRAIL-Induced Apoptosis in Rheumatoid Arthritis Fibroblasts-like Synoviocytes (RA FLS)
Background/Purpose: We previously described that sensitivity to TRAIL-induced apoptosis varied in rheumatoid arthritis (RA) fibroblasts-like-synoviocytes (FLS) from one patient to another, and was inversly correlated…Abstract Number: 1627 • 2015 ACR/ARHP Annual Meeting
HIF-1alpha Knockdown Down-Regulates Glycolytic Metabolism and Induces Rheumatoid Synovial Fibroblast Cell Death
Background/Purpose: Intense synovial fibroblast (SF) hyperplasia contributes to the chronic inflammation and osteoarticular destruction that characterizes rheumatoid arthritis (RA). Hypoxia-inducible factor 1α (HIF-1α) plays a…Abstract Number: 2133 • 2015 ACR/ARHP Annual Meeting
Receptor Protein Tyrosine Phosphatase Alpha Enhances Rheumatoid Synovial Fibroblast Signaling and Promotes Arthritis in Mice
Background/Purpose: Rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) promote disease pathogenesis by aggressively invading the joint extracellular matrix. The focal adhesion kinase (FAK) signaling pathway is…Abstract Number: 2446 • 2015 ACR/ARHP Annual Meeting
Synovial Fluid Proteins Differentiate Patients with Oligoarticular Juvenile Idiopathic Arthritis Who Are Destined to Extend from Those Who Will Remain Persistent in Course
Background/Purpose: Children with oligoarticular juvenile idiopathic arthritis (JIA) who have an extended course (recruitment of 5 or more joints after 6 months of disease) have…Abstract Number: 2467 • 2015 ACR/ARHP Annual Meeting
Interaction Between Senescent T Cells and Fibrocyte-like Cells through CD31, TNFα, and IL-17 Create a Tissue Destructive Environment in the Synovium in Juvenile Idiopathic Arthritis
Background/Purpose: T cells are considered effectors of immunopathology in JIA. In previous work, we reported dominance of senescent CD8T cells in synovial fluid of children…Abstract Number: 2546 • 2015 ACR/ARHP Annual Meeting
Targeting Synovial Fibroblasts By the Intra-Articular Delivery of microRNA-140-3p and -5p Ameliorates Experimental Autoimmune Arthritis
Background/Purpose: Synovial fibroblasts (SF) with aberrant expression of microRNAs (miRNA) are critical pathogenic regulators of rheumatoid joint, and studies examining the effect of overexpressing or…Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting
Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis
Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…Abstract Number: 2703 • 2015 ACR/ARHP Annual Meeting
Reduction in Matrix Metalloproteinase-1 and -2 Secretion from Fibroblast-like Synoviocytes after Induction of Adipogenesis By a Natural Peroxisome Proliferator-Activated Receptor Gamma Ligand, Arterpilin-C
Background/Purpose: Fibroblast-like synoviocytes (FLS) play important roles in rheumatoid arthritis (RA) by producing matrix metalloproteinase (MMP) and cytokines, and hence, these cells are a therapeutic…Abstract Number: 2710 • 2015 ACR/ARHP Annual Meeting
Necrox-7 Inhibits Cell Aggressiveness By Suppressing of NF-Kappa B Activation and Reactive Oxygen Species Generation in Human Rheumatoid Arthritis Fibroblast-like Synoviocytes
Background/Purpose: Rheumatoid arthritis (RA) is characterized by hyperplastic synovial pannus tissue, which mediates destruction of cartilage and bone. Fibroblast-like synoviocytes (FLS) are a key component…Abstract Number: 89 • 2014 ACR/ARHP Annual Meeting
Global miRNA Expression Profiling in Peripheral Blood and Synovial Fluid Mononuclear Cells of Patients with Enthesitis Related Arthritis
Background/Purpose: Enthesitis related arthritis (ERA) is the most common category of JIA in India. MicroRNA dysregulation has been associated with arthritis and autoimmune diseases. In…Abstract Number: 2818 • 2014 ACR/ARHP Annual Meeting
SH2 Domain-Containing Phosphatase 2 Promotes Aggressiveness of Rheumatoid Fibroblast-like Synoviocytes
Background/Purpose In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. Although this cell…Abstract Number: 2462 • 2014 ACR/ARHP Annual Meeting
Centrosomal Protein 70kDa Is Down-Regulated By Decoy Receptor 3 in Specifically Rheumatoid Synovial Fibroblasts
Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand, LIGHT, and…
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