ACR Meeting Abstracts

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Abstracts tagged "synovial fluid"

  • Abstract Number: 1057 • 2018 ACR/ARHP Annual Meeting

    Autophagy Promotes Citrullination of Vimentin and Its Interaction with Major Histocompatibility Complex Class II in Synovial Fibroblasts

    Eri Sugawara, Masaru Kato, Yuki Kudo, WenShi Lee, Yuichiro Fujieda, Toshiyuki Bohgaki, Olga Amengual, Kenji Oku, Shinsuke Yasuda and Tatsuya Atsumi, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Citrullinated vimentin (cVIM) is one of the major autoantigens in patients with rheumatoid arthritis (RA), recognized by anti-citrullinated peptide antibodies. Autophagy is a self-cannibalism…
  • Abstract Number: 1067 • 2018 ACR/ARHP Annual Meeting

    Simulating the Pathogenesis of Arthritis in Vitro By Developing a Human-Based Multicomponent 3D Joint Model

    Alexandra Damerau1,2, Annemarie Lang1,2, Moritz Pfeiffenberger1,2, Timo Gaber1,3 and Frank Buttgereit1,2, 1Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany, 3Deutsches Rheuma Forschungszentrum (DRFZ) Berlin, Berlin, Germany

    Background/Purpose: Although arthritis is a matter of research since more than 140 years, there is currently no valid 3D model available, which is able to…
  • Abstract Number: 1075 • 2018 ACR/ARHP Annual Meeting

    Automated Multiparameter Microscopy and Image Analysis: Next Generation Synovial Tissue Histology

    William Murray-Brown1, Helen Weedon1, Amanda Aloia2, Susan Lester3, Susanna Proudman4, Malcolm D. Smith5, Jenny Walker1 and Mihir D Wechalekar1,3, 1Rheumatology, Flinders University, Adelaide, Australia, 2Cellular Imaging, Flinders University, Adelaide, Australia, 3Royal Adelaide Hospital, Adelaide, Australia, 4Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, 5Rheumotology, Flinders University, Adelaide, Australia

    Background/Purpose: Currently, histological assessment of synovial tissue (ST) in Rheumatoid Arthritis (RA) is hampered by 3 main factors: 1) tissue is a finite resource, 2)…
  • Abstract Number: 1076 • 2018 ACR/ARHP Annual Meeting

    Phospholipase C-eta2, As a C2 Domain-Containing Protein, Regulate Aggressiveness of Fibroblast‐like Synoviocytes and Ameliorate Arthritis in Experimental Animal Models of Rheumatoid Arthritis

    Mingyo Kim, Hyun Min Jeon, Hae Sook Noh, Sang Mi Yi and Sang-Il Lee, Department of Internal Medicine and Institute of Health Science, Gyeongsang National University School of Medicine, Jinju, Korea, Republic of (South)

    Background/Purpose: The C2 domain is a Ca2+-dependent membrane-targeting motif found in many cellular proteins involved in signal transduction or inflammatory pathway. However, the effects of…
  • Abstract Number: 1832 • 2018 ACR/ARHP Annual Meeting

    Proteomic and Transcriptomic Profiling of Cells in Ankylosing Spondylitis Patients Identifies a Novel, Synovial-Resident CD8+ T Cell

    Zoya Qaiyum1, Eric Gracey2, Yuchen Yao2 and Robert D Inman3, 1Department of Immunology, University of Toronto, Toronto, ON, Canada, 2Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 3Toronto Western Hospital, University of Toronto, Spondylitis Clinic, Toronto, ON, Canada

    Background/Purpose: Current data suggests that immune events in the gut may impact on joint inflammation in ankylosing spondylitis (AS) but what directs cells in the…
  • Abstract Number: 2025 • 2018 ACR/ARHP Annual Meeting

    Fibroblast-like Synoviocytes from Juvenile Idiopathic Arthritis and Controls Influence Expression of Bone Morphogenetic Protein Antagonists in Chondrocytes

    Megan Simonds1, Amanda R. Schlefman2, Suzanne M. McCahan3, Kathleen E. Sullivan4, Carlos D. Rosé5 and AnneMarie C. Brescia5, 1Nemours, Nemours Biomedical Research, Wilmington, DE, 2Pediatric Rheumatology, Nemours/Thomas Jefferson University, Wilmington, DE, 3Nemours Biomedical Research, Wilmington, DE, 4Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, 5Nemours/Thomas Jefferson University, Wilmington, DE

    Background/Purpose: Fibroblast-like synoviocytes (FLS) may play a role in the pathogenesis of Juvenile idiopathic arthritis (JIA) and have chondrogenic potential. Bone morphogenetic proteins (BMP) are…
  • Abstract Number: 2459 • 2018 ACR/ARHP Annual Meeting

    Nivolumab-Induced Synovial Tissue T Cell Infiltration, Sustained PD1 Occupancy and Resolution of Severe Synovitis with Infliximab Therapy

    William Murray-Brown1, Helen Weedon1, Tom Wilsdon2, Susanna Proudman3, Jenny Walker1, Malcolm D. Smith4 and Mihir D Wechalekar1,5, 1Rheumatology, Flinders University, Adelaide, Australia, 2Rheumatology, Flinders Medical Centre, Adelaide, Australia, 3Royal Adelaide Hospital, Rheumatology Unit and University of Adelaide, Discipline of Medicine, Adelaide, Australia, 4Rheumotology, Flinders University, Adelaide, Australia, 5Royal Adelaide Hospital, Adelaide, Australia

    Background/Purpose: Checkpoint inhibitors (CI) for cancer therapy are associated with inflammation that can recapitulate features of autoimmunity, including synovitis resembling rheumatoid arthritis (RA). No reports…
  • Abstract Number: 2801 • 2018 ACR/ARHP Annual Meeting

    A Novel B-Cell-Helper IL-21-Producing CD8+ T Cell Subset Involved in the Pathogenesis of Rheumatoid Arthritis

    Kazuhiko Higashioka1, Masahiro Ayano1, Yasutaka Kimoto2, Hiroki Mitoma1, Mitsuteru Akahoshi1, Yojiro Arinobu1, Koichi Akashi1, Takahiko Horiuchi3 and Hiroaki Niro4, 1Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, 2Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, 3Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, 4Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    Background/Purpose: A plethora of evidence from genome-wide association studies and relevant animal models implicates a pivotal role of T cells in the pathogenesis of rheumatoid…
  • Abstract Number: 1940 • 2017 ACR/ARHP Annual Meeting

    Immunologic Synovitis Score: A New Score for Synovial Membrane Characterization in Inflammatory and Non-Inflammatory Arthritis

    Aurélie Najm1,2, Benoît Le Goff MD PhD2,3, Frédéric Blanchard1, Jérome Amiaud4, Céline Charrier5 and Veit Krenn6, 1INSERM U1238 University of medicine, PHY-OS Laboratory, Nantes, France, 2Rheumatology, Nantes University Hospital, Nantes, France, 3UNR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 4UMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 5UNMR1238 University of medicine, PHY-OS Laboratory, Nantes, France, 6Zytologie und Molekulare Diagnostik, MVZ-Zentrum für Histologie, Trier, Germany

    Background/Purpose: General Synovitis score (GSS) has been developed by Krenn et al in order to discriminate inflammatory arthritis (IA) and non-inflammatory arthritis (NIA) (1). This…
  • Abstract Number: 86 • 2017 ACR/ARHP Annual Meeting

    Regulation of Interleukin-1β Signaling By Inhibition of O-Glc-Nacase in Rheumatoid Arthritis Synovial Fibroblasts

    Mahamudul Haque1, Anil Singh2, Kelly Kopczynski1 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Washington State University, College of Pharmacy, Spokane, WA

    Background/Purpose: O-GlcNAcylation is an important post-translational modification of nuclear and cytosolic proteins involved in the cytokine signaling networks. Studies show both pro- and anti-inflammatory roles…
  • Abstract Number: 299 • 2017 ACR/ARHP Annual Meeting

    Bik Plays an Important Role of Cell Proliferation Caused By Nitric Oxide in Rheumatoid Arthritis Synovium

    Takeshi Ueha1, Yoshitada Sakai1, Kohjin Suzuki2, Koji Fukuda3, Toshihisa Maeda3, Hanako Nishimoto3, Shinya Hayashi4, Yasushi Miura4, Ryosuke Kuroda3 and Akira Hashiramoto2, 1Division of Rehabilitation Medicine, Kobe University Graduate School of Medicine, Kobe, Japan, 2Department of Biophysics, Kobe University Graduate School of Health Sciences, Kobe, Japan, 3Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 4Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

    Background/Purpose: Nitric oxide (NO), a proinflammatory mediator responsible for various physiological processes, plays a central role in the pathogenesis of rheumatoid arthritis (RA). As a…
  • Abstract Number: 481 • 2017 ACR/ARHP Annual Meeting

    Immunocompetent Cells Expressing Citrullinated Proteins in Joint Synovium of Osteoarthritis and Rheumatoid Arthritis

    Kyoko Honne1, Masahiro Iwamoto2, Shunichiro Hanai1, Satoshi Machida3, Hitoshi Sekiya4, Reina Tsuda5, Tatsuhiko Ozawa5, Tadayoshi Karasawa6, Atsushi Muraguchi5, Masafumi Takahashi6, Hiroyuki Kishi5 and Seiji Minota7, 1Division of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 2Deivision of Rheumatology and Clinical Immunology, Jichi Medical University, Shimotsuke, Japan, 3Department of Orthopaedic Surgery, Orthopedics Clinic Medical Papas, Tochigi, Japan, 4Department of orthopedic surgery, Jichi Medical University, Shimotsuke, Japan, 5Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan, 6Division of Inflammation Research Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan, 7Division of Rheumatology and Clinical Immunology, Jichi Medical University, Tochigi, Japan

    Background/Purpose: Human monoclonal ACPA (Human-ACPA) is reported to strongly bind to synovium in RA patients [1]. The aims of our study were 1) To investigate…
  • Abstract Number: 962 • 2017 ACR/ARHP Annual Meeting

    Role of Syndecans in Cytokine Mediated Inflammation in Rheumatoid Arthritis Synovial Fibroblasts

    Solomon Agere1, Nahid Akhtar1, David Fox2 and Salahuddin Ahmed1, 1Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA, 2Department of Medicine [Division of Rheumatology], University of Michigan Medical System, Ann Arbor, MI

    Background/Purpose: Syndecans (SDCs) are type-I transmembrane proteoglycans that prominently interact with heparan sulfate, extracellular matrix (ECM) components and glycoproteins. The present study was carried out…
  • Abstract Number: 965 • 2017 ACR/ARHP Annual Meeting

    Decoy Receptor 3 up-Regulates Cadherin 2 in Rheumatoid Synovial Fibroblasts

    Koji Fukuda1, Yasushi Miura2,3, Shinya Hayashi2, Toshihisa Maeda1,4 and Ryosuke Kuroda1, 1Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 2Orthpaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, 3Department of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, 4Department of Immunology and Rheumatology, Stanford University, Stanford, CA

    Background/Purpose: Decoy receptor 3 (DcR3) is a secreted decoy tumor necrosis factor receptor and competitively binds and inhibits the TNF family including Fas-ligand, LIGHT, and…
  • Abstract Number: 976 • 2017 ACR/ARHP Annual Meeting

    Cannabinoid Receptor 2 Agonist (JWH-015) Inhibits Interleukin-1β-Induced Inflammation in Rheumatoid Arthritis Synovial Fibroblasts

    Sabrina Fechtner and Salahuddin Ahmed, Department of Pharmaceutical Sciences, Washington State University, College of Pharmacy, Spokane, WA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by activated synovial fibroblasts in which pro-inflammatory cytokine interleukin-1β (IL-1β) mediates inflammation. The endocannabinoid system…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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