ACR Meeting Abstracts

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Abstracts tagged "Statistical methods"

  • Abstract Number: 0965 • ACR Convergence 2023

    Comparing Predictors of DAPSA28, DAPSA66/68 and DAS28-CRP Remission at 6 Months in Bio-naive Patients with Psoriatic Arthritis Initiating a TNFi in Clinical Practice – Results from the EuroSpA Collaboration

    Stylianos Georgiadis1, Louise Linde2, Lykke Ørnbjerg1, Simon Horskjær Rasmussen1, Johan Askling3, Brigitte Michelsen4, Daniela Di Giuseppe3, Johan Karlsson Wallman5, Bente Glintborg6, Anne Gitte Loft7, Miguel Bernardes8, Carolina Ochôa Matos9, Dan Nordstrom10, Laura Kuusalo11, Burkhard Moeller12, Michael Nissen13, Bjorn Gudbjornsson14, Thorvardur Love15, Florenzo Iannone16, Tore Kvien17, Ziga Rotar18, Isabel Castrejon19, Gary Macfarlane20, Marleen van de Sande21, Merete Hetland1 and Mikkel Østergaard22, 1Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, 2Rigshospitalet Glostrup, Glostrup, Denmark, 3Karolinska Institutet, Stockholm, Sweden, 4Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, 5Lund University and Skåne University Hospital, Lund, Sweden, 6Rigshospitalet Glostrup, University of Copenhagen, Virum, Denmark, 7Aarhus University, Horsens, Denmark, 8Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal, 9Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 10Helsinki University Hospital, Helsinki, Finland, 11Centre for Rheumatology and Clinical Immunology, University of Turku and Turku University Hospital, Turku, Finland, 12Inselspital - University Hospital Bern, Bern, Switzerland, 13Geneva University Hospitals, Geneva, Switzerland, 14Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland, 15Landspitali University Hospital and the University of Iceland, Reykjavik, Iceland, 16Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, 17Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 18University Medical Centre Ljubljana, Ljubljana, Slovenia, 19Universitario Gregorio Marañón, Madrid, Spain, 20Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 21Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology and Department of Experimental Immunology, Amsterdam Infection & Immunity Institute; Amsterdam Rheumatology & Immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, 22Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: The Disease Activity index for PSoriatic Arthritis based on 66/68 joints (DAPSA66/68) and the Disease Activity Score in 28 joints with C-reactive protein (DAS28-CRP)…
  • Abstract Number: 1164 • ACR Convergence 2023

    Can We Differentiate Patients with Dysferlinopathies and Inflammatory Myopathies by Muscle Ultrasound? A Discriminant Analysis Study

    Carina Soto-Fajardo1, Sinthia Solorzano Flores1, Abish Angeles-Acuña1, Fabian Carranza Enriquez1, Rosa-Elena Escobar-Cedillo2, Saul Renan-Leon2, Karina Arias Callejas3, Alejandra Enriquez-Luna2, Graciliano Ramon-Diaz2 and Carlos Pineda2, 1Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico, 2Instituto Nacional de Rehabilitacion, Mexico City, Mexico, 3Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico

    Background/Purpose: Immune-mediated myopathies (IMM) are a heterogeneous group of diseases characterized by inflammation and muscle weakness; among their differential diagnoses are the dysferlinopathies, which are…
  • Abstract Number: 1253 • ACR Convergence 2023

    The Novel Florida Scoring System: A Machine Learning-Based Stratification of Clinical and Laboratory Features in Children with Suspected Sjögren’s Disease

    Akaluck Thatayatikom1, Wenjie Zeng2, Tyler Lovelace3, Nicole Winn4, Ankit Shah5, Thomas Schrepfer6, Indraneel Bhattacharyya7, Renato Gonik8, Panayiotis Benos2 and Seunghee Cha9, 1AdventHealth for Children, Orlando, FL, Orlando, FL, 2University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, 3Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Division of Oral Medicine, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, 5Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, 6Division of Pediatric Otolaryngology, University of Florida College of Medicine, Gainesville, FL, 7Department of Oral & Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, 8Division of Pediatric Neurology, University of Florida College of Medicine, Gainesville, FL, 9Department of Oral & Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry and Center for Orphaned Autoimmune Disorders (COAD), Gainesville, FL

    Background/Purpose: Childhood Sjögren 's disease (cSjD) is a poorly defined systemic autoimmune disorder. Due to the absence of diagnostic criteria, heterogeneous presentations, and the dissimilarity…
  • Abstract Number: 1881 • ACR Convergence 2023

    Deep Learning Approaches to Rheumatoid Arthritis Severity Prognosis

    Zhong-Yuan Lai1, Aditya Varna Iyer2, Isaac Zachary To1, Ivano Lodato1, Simran Hiranandani1, Tommy LAM3, Ho So4 and Lai-Shan Tam5, 1Allos AI, London, United Kingdom, 2Allos AI, University of Oxford, Oxford, United Kingdom, 3Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, 4Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 5The Chinese University of Hong Kong, New Territories, China

    Background/Purpose: Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis affecting a large sector of the global population. The disease is associated with…
  • Abstract Number: 1894 • ACR Convergence 2023

    3-Dimensional Regional Variation in Inter-rater Reliability of Bone Marrow Lesion Scoring in the Knee

    Stephanie Wichuk1, Walter P. Maksymowych1, Joel Paschke2, Abhilash Hareendranathan3 and Jacob Jaremko1, 1University of Alberta, Edmonton, AB, Canada, 2CARE Arthritis, Edmonton, AB, Canada, 3Radiology and Diagnostic Imaging, Edmonton, AB, Canada

    Background/Purpose: Bone marrow lesions (BML) are an important scoring feature on magnetic resonance imaging (MRI) of knee osteoarthritis (OA), and their presence in certain anatomical…
  • Abstract Number: 1901 • ACR Convergence 2023

    Which ASDAS-ESR Cut-offs for Disease Activity Correspond to ASDAS-CRP Cut-offs in Axial Spondyloarthritis? – Results from the EuroSpA Collaboration

    Stylianos Georgiadis1, Lykke Ørnbjerg1, Brigitte Michelsen2, Tore Kvien3, Daniela Di Giuseppe4, Johan Karlsson Wallman5, Jakub Zavada6, Sella Provan7, Ana Maria Rodrigues8, Maria Jose Santos9, Ziga Rotar10, Dan Nordstrom11, Anna-Mari Hokkanen12, Gary Macfarlane13, Gareth T. Jones13, Irene van der Horst-Bruinsma14, Pasoon Hellamand15, Mikkel Østergaard16 and Merete Hetland1, 1Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, 2Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, 3Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 4Karolinska Institutet, Stockholm, Sweden, 5Lund University and Skåne University Hospital, Lund, Sweden, 6Institute of Rheumatology; Charles University, Prague, Czech Republic, 7Diakonhjemmet Hospital, Oslo, Norway, 8Sociedade Portuguesa de Reumatologia; Nova Medical School; Hospital dos Lusíadas, Lisbon, Portugal, 9Hospital Garcia de Orta, Almada, Lisboa, Portugal, 10University Medical Centre Ljubljana, Ljubljana, Slovenia, 11Helsinki University Hospital, Helsinki, Finland, 12Helsinki University and Helsinki University Hospital, Helsinki, Finland, 13Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 14Radboud University Medical Centre, Department of Rheumatology, Nijmegen, Netherlands, 15Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 16Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: When assessing disease activity in patients with axial spondyloarthritis (axSpA), the Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) is recommended over ASDAS…
  • Abstract Number: 1989 • ACR Convergence 2023

    Shared Variation Among Cartilage Thickness Change Maps and Baseline Clinical Features at the Initiation of Structural Knee Osteoarthritis

    Thomas Keefe1, Marc Niethammer1, Boqi Chen1, Zhengyang Shen1, Daniel Nissman1, Mary Catherine Minnig2, Yvonne Golightly3, J.S. Marron1 and Amanda Nelson1, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina at Chapel Hill, Durham, NC, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: To identify features of cartilage thickness change and baseline clinical indicators associated with the transition from normal to mildly reduced joint space as an…
  • Abstract Number: 2213 • ACR Convergence 2023

    Identification of a Diagnostic Model for Axial Spondyloarthritis in Daily Clinical Practice Using a Random Forest Machine Learning Approach

    Imke Redeker1, Styliani Tsiami2, Jan Eicker3, Uta Kiltz4, David Kiefer2, Ioana Andreica5, Philipp Sewerin2 and Xenofon Baraliakos6, 1Ruhr Universität Bochum, Bochum, Germany, 2Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, 3Rheumazentrum Ruhrgebiet Herne and Ruhr-University Bochum, Herne, Germany, 4Rheumazentrum Ruhrgebiet, Herne, Germany, 5Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 6Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany

    Background/Purpose: In axial spondyloarthritis (axSpA), early diagnosis plays a key role in preventing disease progression. However, a validated diagnostic algorithm does not exist, while classification…
  • Abstract Number: 0450 • ACR Convergence 2022

    Incidence of Solid and Hematologic Tumors in Patients with ANCA: A 10-year Retrospective Cohort Study

    Enrico Brunetta1, Giacomo Ramponi2, marco folci2, Maria De Santis3, Giacomo Maria Guidelli1, Angela Ceribelli4, Nicoletta Luciano1, Marta Caprioli5, Arianna Sonaglia1 and Carlo Selmi6, 1IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, 2IRCCS Humanitas Research Hospital, Internal Medicine, Rozzano, Italy, 3Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, 4Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 5IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, 6IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy

    Background/Purpose: Serum antineutrophil cytoplasmic antibodies (ANCA) are significantly associated with the development of ANCA-associated vasculitides (AAV) but may also be detected in patients with other…
  • Abstract Number: 0552 • ACR Convergence 2022

    Identifying Subgroups of Patients Undergoing Knee Replacement

    Brooke McGinley1, Gabriela Rabasa2, Tuhina Neogi3, David Felson2 and Michael LaValley4, 1Boston University School of Public Health, Boston, MA, 2Boston University, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Boston University School of Public Health, Arlington, MA

    Background/Purpose: Knee replacement surgery (KR) is prevalent in the US with estimated lifetime risk from age 25 of 7% for males and 9.5% for females,…
  • Abstract Number: 0643 • ACR Convergence 2022

    Subsetting SLE Patients Based on DNA Methylation at the Time of Disease Flare

    Mary Horton1, Joanne Nitithalm2, Kimberly Taylor3, Laura Trupin4, Patricia Katz5, Jinoos Yazdany6, Maria Dall'Era7, Lisa Barcellos8, Lindsey Criswell9 and Cristina M Lanata10, 1NIH/NHGRI, Oakland, CA, 2NIH/NHGRI, Bethesda, MD, 3University of Californi, San Francisco, San Francisco, CA, 4UC San Francisco, San Francisco, CA, 5UCSF, San Rafael, CA, 6UCSF, San Francisco, CA, 7University of California, Division of Rheumatology, San Francisco, CA, 8School of Public Health, UC Berkeley; National Human Genome Research Institute, National Institutes of Health, Berkeley, CA, 9National Human Genome Research Institute, NIH, Bethesda, MD, 10NIH/NHGRI, Washington, DC

    Background/Purpose: Current treatments for SLE do not adequately prevent disease progression. This lack of efficacy, in part, relates to the molecular heterogeneity of disease. The…
  • Abstract Number: 0768 • ACR Convergence 2022

    Reevaluating Clinical Outcomes of Patients on Combination Biologics

    Ryan Mathew1, Alexa Meara2, ChienWei Chiang3, Komal Paradakar3, Ambra Burrell3 and Gabriel Kirsch3, 1The Ohio State University Medical Center, Skokie, IL, 2The Ohio State University Wexner Medical Center, Columbus, OH, 3The Ohio State University Medical Center, Columbus, OH

    Background/Purpose: Biologic treatments such as monoclonal antibodies have become first line treatment for many autoimmune diseases and now monoclonal antibodies are being used to treated…
  • Abstract Number: 0870 • ACR Convergence 2022

    Knee Acoustic Emissions as a Noninvasive Biomarker of Articular Health in Juvenile Idiopathic Arthritis

    Sevda Gharehbaghi1, Emily Moise1, Priya Brito2, Lori Ponder3, Omer Inan1 and Sampath Prahalad4, 1Georgia Institute of Technology, Atlanta, GA, 2Emory University, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA, 4Emory + Children's Pediatric Institute, Atlanta, GA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) refers to all forms of autoimmune arthritis in children with undetermined etiology, and thus it is the most prevalent chronic…
  • Abstract Number: 1317 • ACR Convergence 2022

    The Epidemiology of Old versus Young Males Referred for BMD Assessment

    Muhammed Aqib Khan1, Rabie Hamad1, Hamzah Amin1 and Marwan Bukhari2, 1Royal Lancaster Infirmary, Lancaster, United Kingdom, 2University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom

    Background/Purpose: Data on osteoporosis in men are scarce. The World Health Organisation's (WHO) definition of a T-score less than 2.5 has only been described for…
  • Abstract Number: 1606 • ACR Convergence 2022

    An Expanded Anti-citrullinated Protein Antibody Profile Derived Using Unsupervised Machine Learning Predicts Treatment Responses to Biologic Therapies in Rheumatoid Arthritis

    nozima Aripova1, George Reed2, Bryant England1, William Robinson3, Dimitrios Pappas4, Joel Kremer5, Geoffrey Thiele1 and Ted Mikuls6, 1University of Nebraska Medical Center, Omaha, NE, 2The Corrona Research Foundation and University of Massachusetts, Albany, NY, 3Stanford University School of Medicine, Palo Alto, CA, 4CorEvitas, LLC, Waltham, MA, 5The Corrona Research Foundation, Delray Beach, FL, 6Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) treatments have advanced with the availability of biologic therapies. Despite these advances, 30-40% of patients receiving a biologic do not adequately…
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