ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "Statistical methods"

  • Abstract Number: 0450 • ACR Convergence 2022

    Incidence of Solid and Hematologic Tumors in Patients with ANCA: A 10-year Retrospective Cohort Study

    Enrico Brunetta1, Giacomo Ramponi2, marco folci2, Maria De Santis3, Giacomo Maria Guidelli1, Angela Ceribelli4, Nicoletta Luciano1, Marta Caprioli5, Arianna Sonaglia1 and Carlo Selmi6, 1IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, 2IRCCS Humanitas Research Hospital, Internal Medicine, Rozzano, Italy, 3Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, 4Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, 5IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, 6IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy

    Background/Purpose: Serum antineutrophil cytoplasmic antibodies (ANCA) are significantly associated with the development of ANCA-associated vasculitides (AAV) but may also be detected in patients with other…
  • Abstract Number: 0552 • ACR Convergence 2022

    Identifying Subgroups of Patients Undergoing Knee Replacement

    Brooke McGinley1, Gabriela Rabasa2, Tuhina Neogi3, David Felson2 and Michael LaValley4, 1Boston University School of Public Health, Boston, MA, 2Boston University, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Boston University School of Public Health, Arlington, MA

    Background/Purpose: Knee replacement surgery (KR) is prevalent in the US with estimated lifetime risk from age 25 of 7% for males and 9.5% for females,…
  • Abstract Number: 0643 • ACR Convergence 2022

    Subsetting SLE Patients Based on DNA Methylation at the Time of Disease Flare

    Mary Horton1, Joanne Nitithalm2, Kimberly Taylor3, Laura Trupin4, Patricia Katz5, Jinoos Yazdany6, Maria Dall'Era7, Lisa Barcellos8, Lindsey Criswell9 and Cristina M Lanata10, 1NIH/NHGRI, Oakland, CA, 2NIH/NHGRI, Bethesda, MD, 3University of Californi, San Francisco, San Francisco, CA, 4UC San Francisco, San Francisco, CA, 5UCSF, San Rafael, CA, 6UCSF, San Francisco, CA, 7University of California, Division of Rheumatology, San Francisco, CA, 8School of Public Health, UC Berkeley; National Human Genome Research Institute, National Institutes of Health, Berkeley, CA, 9National Human Genome Research Institute, NIH, Bethesda, MD, 10NIH/NHGRI, Washington, DC

    Background/Purpose: Current treatments for SLE do not adequately prevent disease progression. This lack of efficacy, in part, relates to the molecular heterogeneity of disease. The…
  • Abstract Number: 0768 • ACR Convergence 2022

    Reevaluating Clinical Outcomes of Patients on Combination Biologics

    Ryan Mathew1, Alexa Meara2, ChienWei Chiang3, Komal Paradakar3, Ambra Burrell3 and Gabriel Kirsch3, 1The Ohio State University Medical Center, Skokie, IL, 2The Ohio State University Wexner Medical Center, Columbus, OH, 3The Ohio State University Medical Center, Columbus, OH

    Background/Purpose: Biologic treatments such as monoclonal antibodies have become first line treatment for many autoimmune diseases and now monoclonal antibodies are being used to treated…
  • Abstract Number: 0870 • ACR Convergence 2022

    Knee Acoustic Emissions as a Noninvasive Biomarker of Articular Health in Juvenile Idiopathic Arthritis

    Sevda Gharehbaghi1, Emily Moise1, Priya Brito2, Lori Ponder3, Omer Inan1 and Sampath Prahalad4, 1Georgia Institute of Technology, Atlanta, GA, 2Emory University, Atlanta, GA, 3Children's Healthcare of Atlanta, Atlanta, GA, 4Emory + Children's Pediatric Institute, Atlanta, GA

    Background/Purpose: Juvenile idiopathic arthritis (JIA) refers to all forms of autoimmune arthritis in children with undetermined etiology, and thus it is the most prevalent chronic…
  • Abstract Number: 1317 • ACR Convergence 2022

    The Epidemiology of Old versus Young Males Referred for BMD Assessment

    Muhammed Aqib Khan1, Rabie Hamad1, Hamzah Amin1 and Marwan Bukhari2, 1Royal Lancaster Infirmary, Lancaster, United Kingdom, 2University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom

    Background/Purpose: Data on osteoporosis in men are scarce. The World Health Organisation's (WHO) definition of a T-score less than 2.5 has only been described for…
  • Abstract Number: 1606 • ACR Convergence 2022

    An Expanded Anti-citrullinated Protein Antibody Profile Derived Using Unsupervised Machine Learning Predicts Treatment Responses to Biologic Therapies in Rheumatoid Arthritis

    nozima Aripova1, George Reed2, Bryant England1, William Robinson3, Dimitrios Pappas4, Joel Kremer5, Geoffrey Thiele1 and Ted Mikuls6, 1University of Nebraska Medical Center, Omaha, NE, 2The Corrona Research Foundation and University of Massachusetts, Albany, NY, 3Stanford University School of Medicine, Palo Alto, CA, 4CorEvitas, LLC, Waltham, MA, 5The Corrona Research Foundation, Delray Beach, FL, 6Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA) treatments have advanced with the availability of biologic therapies. Despite these advances, 30-40% of patients receiving a biologic do not adequately…
  • Abstract Number: 1812 • ACR Convergence 2022

    Impact of Misclassification on the US Prevalence of Gout: Bayesian Sensitivity Analysis of the National Health & Nutrition Examination Survey (NHANES)

    Lingxiao Chen1, Yue Zhang2 and Kazuki Yoshida3, 1Kolling Institute, Sydney, Australia, 2University of Utah, Salt Lake City, UT, 3Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Gout is considered the most common inflammatory arthritis in the US with an estimated prevalence of 3.9% based on the National Health and Nutrition…
  • Abstract Number: 2100 • ACR Convergence 2022

    Employment Trajectory of Canadian Young Adults with Systemic Lupus Erythematosus

    Lily Lim1, Menelaos Konstanidis2, Zahi Touma3, Diane Lacaille4, Umut Oguzoglu1, Christine Peschken1, Nicole Anderson3, Ramandeep Kaur1 and Eleanor Pullenayegum2, 1University of Manitoba, Winnipeg, MB, Canada, 2University of Toronto, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, 4Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada

    Background/Purpose: Young adulthood (18-30 years) is a time of many changes. Young adults finish school, enter the labour force, and maybe start their own families.…
  • Abstract Number: 2224 • ACR Convergence 2022

    Genes Causative of Primary Immunodeficiency Are Risk Factors for and Over-expressed in Systemic Lupus Erythematosus

    Haley Davis1, Adam Labonte1, Katherine Owen2, Erika Hubbard1, Jessica Kain1, Brian Kegerreis1, Prathyusha Bachali3, Amrie Grammer4 and Peter Lipsky1, 1AMPEL BioSolutions, Charlottesville, VA, 2RILITE, Crozet, VA, 3AMPEL BioSolutions, Redmond, WA, 4AMPEL LLC, Charlottesville, VA

    Background/Purpose: Systemic lupus erythematosus (SLE) is a polygenic autoimmune disease whose specific causes are incompletely understood and for which there exists no single comprehensive diagnostic…
  • Abstract Number: 0543 • ACR Convergence 2021

    Novel Insights into Systemic Sclerosis Using a Sensitive Computational Method to Analyze Whole-genome Bisulfite Sequencing Data

    Jeffrey Yu1, Tianyuan Lu1, Kaiqiong Zhao1, Kathleen Oros Klein1, Maximilien Lora2, Ines Colmegna3, Celia MT Greenwood4 and Marie Hudson2, 1Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, 2McGill University, Montréal, QC, Canada, 3The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 4Epidemiology, Biostatistics and Occupational Health / Faculty of Medicine and Health Sciences / McGill University, Montréal, QC, Canada

    Background/Purpose: While the etiology of systemic sclerosis (SSc) remains largely unknown, epigenetic dysregulation including abnormal DNA methylation is thought to contribute to its onset and…
  • Abstract Number: 0759 • ACR Convergence 2021

    The Patient as Assessor of Disease Status: A Graphical Evaluation of Relations Between Patient-Reported Outcomes in Early Rheumatoid Arthritis

    Diederik De Cock1, Gert Verhavert1, Sofia Pazmino1, Delphine Bertrand1, Michal Doumen1, Rene Westhovens2 and Patrick Verschueren3, 1KU Leuven, Leuven, Belgium, 2University Hospitals KU Leuven, Maaseik, Belgium, 3University Hospitals Leuven - KULeuven, Leuven, Belgium

    Background/Purpose: Current EULAR-guidelines recommend treating Rheumatoid Arthritis (RA) early, intensively and to-target. Patient-Reported Outcomes (PROs) can be important contributors for remote monitoring of disease status…
  • Abstract Number: 0850 • ACR Convergence 2021

    Regression Methods for Modeling Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain Scores for Early Stage Knee Osteoarthritis

    Benjamin Sweigart and Michael LaValley, Boston University School of Public Health, Boston, MA

    Background/Purpose: The Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score [range 0-20] is a common outcome measure for clinical trials and observational studies…
  • Abstract Number: 0851 • ACR Convergence 2021

    Application of a Modified Recursive Feature Elimination Machine Learning Algorithm to Select Predictors of Mortality in Those with and Without Osteoarthritis

    Siyeon Kim1, Siqi Xiang1, Liubov Arbeeva1, Carolina Alvarez1, Amanda Nelson1, Yvonne Golightly1, Leigh Callahan2, Michael Kosorok1 and Becki Cleveland3, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC

    Background/Purpose: Radiographic osteoarthritis (rOA) and joint symptoms at the knee and hip are predictors of mortality. However, questions remain about the nature of the relationship…
  • Abstract Number: 1218 • ACR Convergence 2021

    Unsupervised Clustering Identifies Unique Subsets of Patients in a Racially and Ethnically Diverse Rheumatoid Arthritis Cohort

    Gabriella Lui1, Namrata Singh2, James Andrews3, Jonathan Graf4 and Katherine Wysham5, 1University of Washington Department of Bioengineering, Seattle, WA, 2University of Washington, Bellevue, WA, 3University of Washington, Seattle, WA, 4Ucsf, San Francisco, CA, 5VA Puget Sound/University of Washington, Seattle, WA

    Background/Purpose: Single biomarkers have limited utility to date in guiding clinical care in RA. There is growing interest in applying machine learning algorithms to combine…
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