Abstracts tagged "Statistical methods"

Abstract Number: 0450 • ACR Convergence 2022
Incidence of Solid and Hematologic Tumors in Patients with ANCA: A 10-year Retrospective Cohort Study
Enrico Brunetta¹, Giacomo Ramponi², marco folci², Maria De Santis³, Giacomo Maria Guidelli¹, Angela Ceribelli⁴, Nicoletta Luciano¹, Marta Caprioli⁵, Arianna Sonaglia¹ and Carlo Selmi⁶, ¹IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Rozzano, Italy, ²IRCCS Humanitas Research Hospital, Internal Medicine, Rozzano, Italy, ³Humanitas University, IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pieve Emanuele, Italy, ⁴Humanitas Research Hospital, Humanitas University, Rozzano (MI) Italy, Borgo San Giacomo, Italy, ⁵IRCCS Humanitas Research Hospital, Rheumatology and Clinical Immunology, Pavia, Italy, ⁶IRCCS Humanitas Research Hospital, Humanitas University, Rozzano (MI), Italy, Rozzano, Italy
Background/Purpose: Serum antineutrophil cytoplasmic antibodies (ANCA) are significantly associated with the development of ANCA-associated vasculitides (AAV) but may also be detected in patients with other…
Abstract Number: 0552 • ACR Convergence 2022
Identifying Subgroups of Patients Undergoing Knee Replacement
Brooke McGinley¹, Gabriela Rabasa², Tuhina Neogi³, David Felson² and Michael LaValley⁴, ¹Boston University School of Public Health, Boston, MA, ²Boston University, Boston, MA, ³Boston University School of Medicine, Boston, MA, ⁴Boston University School of Public Health, Arlington, MA
Background/Purpose: Knee replacement surgery (KR) is prevalent in the US with estimated lifetime risk from age 25 of 7% for males and 9.5% for females,…
Abstract Number: 0643 • ACR Convergence 2022
Subsetting SLE Patients Based on DNA Methylation at the Time of Disease Flare
Mary Horton¹, Joanne Nitithalm², Kimberly Taylor³, Laura Trupin⁴, Patricia Katz⁵, Jinoos Yazdany⁶, Maria Dall'Era⁷, Lisa Barcellos⁸, Lindsey Criswell⁹ and Cristina M Lanata¹⁰, ¹NIH/NHGRI, Oakland, CA, ²NIH/NHGRI, Bethesda, MD, ³University of Californi, San Francisco, San Francisco, CA, ⁴UC San Francisco, San Francisco, CA, ⁵UCSF, San Rafael, CA, ⁶UCSF, San Francisco, CA, ⁷University of California, Division of Rheumatology, San Francisco, CA, ⁸School of Public Health, UC Berkeley; National Human Genome Research Institute, National Institutes of Health, Berkeley, CA, ⁹National Human Genome Research Institute, NIH, Bethesda, MD, ¹⁰NIH/NHGRI, Washington, DC
Background/Purpose: Current treatments for SLE do not adequately prevent disease progression. This lack of efficacy, in part, relates to the molecular heterogeneity of disease. The…
Abstract Number: 0768 • ACR Convergence 2022
Reevaluating Clinical Outcomes of Patients on Combination Biologics
Ryan Mathew¹, Alexa Meara², ChienWei Chiang³, Komal Paradakar³, Ambra Burrell³ and Gabriel Kirsch³, ¹The Ohio State University Medical Center, Skokie, IL, ²The Ohio State University Wexner Medical Center, Columbus, OH, ³The Ohio State University Medical Center, Columbus, OH
Background/Purpose: Biologic treatments such as monoclonal antibodies have become first line treatment for many autoimmune diseases and now monoclonal antibodies are being used to treated…
Abstract Number: 0870 • ACR Convergence 2022
Knee Acoustic Emissions as a Noninvasive Biomarker of Articular Health in Juvenile Idiopathic Arthritis
Sevda Gharehbaghi¹, Emily Moise¹, Priya Brito², Lori Ponder³, Omer Inan¹ and Sampath Prahalad⁴, ¹Georgia Institute of Technology, Atlanta, GA, ²Emory University, Atlanta, GA, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Juvenile idiopathic arthritis (JIA) refers to all forms of autoimmune arthritis in children with undetermined etiology, and thus it is the most prevalent chronic…
Abstract Number: 1317 • ACR Convergence 2022
The Epidemiology of Old versus Young Males Referred for BMD Assessment
Muhammed Aqib Khan¹, Rabie Hamad¹, Hamzah Amin¹ and Marwan Bukhari², ¹Royal Lancaster Infirmary, Lancaster, United Kingdom, ²University Hospitals of Morecambe Bay NHS Trust, Lancaster, United Kingdom
Background/Purpose: Data on osteoporosis in men are scarce. The World Health Organisation's (WHO) definition of a T-score less than 2.5 has only been described for…
Abstract Number: 1606 • ACR Convergence 2022
An Expanded Anti-citrullinated Protein Antibody Profile Derived Using Unsupervised Machine Learning Predicts Treatment Responses to Biologic Therapies in Rheumatoid Arthritis
nozima Aripova¹, George Reed², Bryant England¹, William Robinson³, Dimitrios Pappas⁴, Joel Kremer⁵, Geoffrey Thiele¹ and Ted Mikuls⁶, ¹University of Nebraska Medical Center, Omaha, NE, ²The Corrona Research Foundation and University of Massachusetts, Albany, NY, ³Stanford University School of Medicine, Palo Alto, CA, ⁴CorEvitas, LLC, Waltham, MA, ⁵The Corrona Research Foundation, Delray Beach, FL, ⁶Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Rheumatoid arthritis (RA) treatments have advanced with the availability of biologic therapies. Despite these advances, 30-40% of patients receiving a biologic do not adequately…
Abstract Number: 1812 • ACR Convergence 2022
Impact of Misclassification on the US Prevalence of Gout: Bayesian Sensitivity Analysis of the National Health & Nutrition Examination Survey (NHANES)
Lingxiao Chen¹, Yue Zhang² and Kazuki Yoshida³, ¹Kolling Institute, Sydney, Australia, ²University of Utah, Salt Lake City, UT, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Gout is considered the most common inflammatory arthritis in the US with an estimated prevalence of 3.9% based on the National Health and Nutrition…
Abstract Number: 2100 • ACR Convergence 2022
Employment Trajectory of Canadian Young Adults with Systemic Lupus Erythematosus
Lily Lim¹, Menelaos Konstanidis², Zahi Touma³, Diane Lacaille⁴, Umut Oguzoglu¹, Christine Peschken¹, Nicole Anderson³, Ramandeep Kaur¹ and Eleanor Pullenayegum², ¹University of Manitoba, Winnipeg, MB, Canada, ²University of Toronto, Toronto, ON, Canada, ³Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ⁴Arthritis Research Canada, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Young adulthood (18-30 years) is a time of many changes. Young adults finish school, enter the labour force, and maybe start their own families.…
Abstract Number: 2224 • ACR Convergence 2022
Genes Causative of Primary Immunodeficiency Are Risk Factors for and Over-expressed in Systemic Lupus Erythematosus
Haley Davis¹, Adam Labonte¹, Katherine Owen², Erika Hubbard¹, Jessica Kain¹, Brian Kegerreis¹, Prathyusha Bachali³, Amrie Grammer⁴ and Peter Lipsky¹, ¹AMPEL BioSolutions, Charlottesville, VA, ²RILITE, Crozet, VA, ³AMPEL BioSolutions, Redmond, WA, ⁴AMPEL LLC, Charlottesville, VA
Background/Purpose: Systemic lupus erythematosus (SLE) is a polygenic autoimmune disease whose specific causes are incompletely understood and for which there exists no single comprehensive diagnostic…
Abstract Number: 0543 • ACR Convergence 2021
Novel Insights into Systemic Sclerosis Using a Sensitive Computational Method to Analyze Whole-genome Bisulfite Sequencing Data
Jeffrey Yu¹, Tianyuan Lu¹, Kaiqiong Zhao¹, Kathleen Oros Klein¹, Maximilien Lora², Ines Colmegna³, Celia MT Greenwood⁴ and Marie Hudson², ¹Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, ⁴Epidemiology, Biostatistics and Occupational Health / Faculty of Medicine and Health Sciences / McGill University, Montréal, QC, Canada
Background/Purpose: While the etiology of systemic sclerosis (SSc) remains largely unknown, epigenetic dysregulation including abnormal DNA methylation is thought to contribute to its onset and…
Abstract Number: 0759 • ACR Convergence 2021
The Patient as Assessor of Disease Status: A Graphical Evaluation of Relations Between Patient-Reported Outcomes in Early Rheumatoid Arthritis
Diederik De Cock¹, Gert Verhavert¹, Sofia Pazmino¹, Delphine Bertrand¹, Michal Doumen¹, Rene Westhovens² and Patrick Verschueren³, ¹KU Leuven, Leuven, Belgium, ²University Hospitals KU Leuven, Maaseik, Belgium, ³University Hospitals Leuven - KULeuven, Leuven, Belgium
Background/Purpose: Current EULAR-guidelines recommend treating Rheumatoid Arthritis (RA) early, intensively and to-target. Patient-Reported Outcomes (PROs) can be important contributors for remote monitoring of disease status…
Abstract Number: 0850 • ACR Convergence 2021
Regression Methods for Modeling Western Ontario and McMaster Universities Arthritis Index (WOMAC) Pain Scores for Early Stage Knee Osteoarthritis
Benjamin Sweigart and Michael LaValley, Boston University School of Public Health, Boston, MA
Background/Purpose: The Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score [range 0-20] is a common outcome measure for clinical trials and observational studies…
Abstract Number: 0851 • ACR Convergence 2021
Application of a Modified Recursive Feature Elimination Machine Learning Algorithm to Select Predictors of Mortality in Those with and Without Osteoarthritis
Siyeon Kim¹, Siqi Xiang¹, Liubov Arbeeva¹, Carolina Alvarez¹, Amanda Nelson¹, Yvonne Golightly¹, Leigh Callahan², Michael Kosorok¹ and Becki Cleveland³, ¹University of North Carolina at Chapel Hill, Chapel Hill, NC, ²University of North Carolina Thurston Arthritis Research Center, Chapel Hill, NC, ³Thurston Arthritis Research Center, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC
Background/Purpose: Radiographic osteoarthritis (rOA) and joint symptoms at the knee and hip are predictors of mortality. However, questions remain about the nature of the relationship…
Abstract Number: 1218 • ACR Convergence 2021
Unsupervised Clustering Identifies Unique Subsets of Patients in a Racially and Ethnically Diverse Rheumatoid Arthritis Cohort
Gabriella Lui¹, Namrata Singh², James Andrews³, Jonathan Graf⁴ and Katherine Wysham⁵, ¹University of Washington Department of Bioengineering, Seattle, WA, ²University of Washington, Bellevue, WA, ³University of Washington, Seattle, WA, ⁴Ucsf, San Francisco, CA, ⁵VA Puget Sound/University of Washington, Seattle, WA
Background/Purpose: Single biomarkers have limited utility to date in guiding clinical care in RA. There is growing interest in applying machine learning algorithms to combine…