ACR Meeting Abstracts

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Abstracts tagged "Statistical methods"

  • Abstract Number: 1404 • ACR Convergence 2024

    Modeling Diversity in Systemic Lupus Erythematosus (SLE) Clinical Trials Using Real-world Data (RWD) Sources

    Andrew Bevan1 and Nora Carroll2, 1Integrated Project Solutions, PPD, part of Thermo Fisher Scientific, Cambridge, United Kingdom, 2Cardiovascular and General Medicine, Thermo Fisher Scientific, Athlone, Ireland

    Background/Purpose: The FDA places emphasis on studying clinically relevant trial populations but does not address how these might be defined. SLE disproportionately affects women and…
  • Abstract Number: 1409 • ACR Convergence 2024

    Salivary Organoids Contain More Diverse Epithelial and Less Mesenchymal Cells Than Adherent Cultures: Choose Your Sjögren’s Disease Research Tool Carefully

    Ting Yang1, Abel Soto Gamez1, Janneke Terpstra1, Hendrika Bootsma2, Arjan Vissink1, Frans Kroese3 and Sarah Pringle3, 1UMCG, Groningen, Netherlands, 2Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 3University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: The majority of the critical pieces of work probing the involvement of the salivary gland (SG) epithelium in Sjogren’s Disease (SjD) employ salivary gland…
  • Abstract Number: 1728 • ACR Convergence 2024

    Higher Oral Steroid Dose Is Associated with Worse Survival in Immune Checkpoint Inhibitor-Treated Rheumatoid Arthritis Patients with Metastatic Non-Small Cell Lung Cancer

    Deanna Jannat-Khah1, Jeffrey Curtis2, Fenglong Xie3, Ashish Saxena4 and Anne Bass5, 1Hospital For Special Surgery, New York, NY, 2The University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Weill Cornell Medicine, New York, NY, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: It is unknown if steroid use for RA patients could interfere with the benefits of immune checkpoint inhibitors (ICI) as cancer therapies. Additionally, it…
  • Abstract Number: 0479 • ACR Convergence 2024

    Constructing and Using a Novel Nucleotide Transformer for Patients with Rheumatoid Arthritis

    Shant Ayanian, Collin Osborne, Marc Blasi, Daniel Darveaux, Eric Klee and Elena Myasoedova, Mayo Clinic, Rochester, MN

    Background/Purpose: Applying the methods of artificial intelligence (AI) to genomic data for clinical outcome prediction in rheumatoid arthritis (RA) is an area of growing research.…
  • Abstract Number: 0492 • ACR Convergence 2024

    A Machine Learning Model for the Early Identification of Rheumatoid Arthritis: Development and Validation

    Michael Dreyfuss1, Yonatan Jenudi2, Dan Riesel3, Or Ramni3, Daniel Underberger4, Benjamin Getz5, Shlomit Steinberg-Koch3, Douglas White6 and Elena Myasoedova7, 1Predicta Med, Ramat Gan, Israel, 2[email protected], Ramat Gan, Israel, 3Predicta Med Analytics Ltd., Ramat Gan, Israel, 4Predicta Med Analytics Ltd., Bridgeport, CT, 5CTO, Ramat Gan, Israel, 6Gundersen Health System, Onalaska, WI, 7Mayo Clinic, Rochester, MN

    Background/Purpose: Patients with rheumatoid arthritis often experience clinically significant delays in diagnosis (Sørensen et al., 2015; Raza et al., 2011). RA can present similarly to…
  • Abstract Number: 0545 • ACR Convergence 2024

    Missing Data in Observational Studies: Investigating Cross-sectional Single Imputation Methods for Assessing Disease Activity in Axial Spondyloarthritis

    Stylianos Georgiadis1, Marion Pons2, Simon Horskjær Rasmussen2, Merete Hetland3, Louise Linde2, Daniela DiGuiseppe4, Brigitte Michelsen5, Johan Karlsson Wallman6, Tor Olofsson7, Karel Pavelka8, Jakub Závada8, Bente Glintborg9, Anne Gitte Loft10, Catalin Codreanu11, Daniel Melim12, Diogo Esperança Almeida13, Tore K. Kvien14, Vappu Rantalaiho15, Ritva Peltomaa16, Bjorn Gudbjornsson17, Olafur Palsson18, Ovidiu Rotariu19, Ross MacDonald19, Ziga Rotar20, Katja Perdan-Pikmajer20, Karin Laas21, Florenzo Iannone22, Adrian Ciurea23, Mikkel Ostergaard24 and Lykke Oernbjerg1, 1Rigshospitalet Glostrup, Glostrup, Hovedstaden, Denmark, 2Rigshospitalet Glostrup, Glostrup, Denmark, 3Rigshospitalet Glostrup and University of Copenhagen, Glostrup, Denmark, 4Karolinska Institutet, Stockholm, 5Rigshospitalet Glostrup, Diakonhjemmet Hospital and Sørlandet Hospital, Copenhagen, Denmark, 6Lund University, Department of Clinical Sciences Lund, Section of Rheumatology and Skåne University Hospital, Lund, Sweden, Lund, Skane Lan, Sweden, 7Lund University, Department of Clinical Sciences Lund, Section of Rheumatology and Skåne University Hospital, Lund, Sweden, Lund, Sweden, 8Institute of Rheumatology and Charles University, Praha, Czech Republic, 9DANBIO, Rigshospitalet Glostrup and University of Copenhagen, Virum, Denmark, 10Aarhus University Hospital and Aarhus University, Horsens, Denmark, 11University of Medicine and Pharmacy, Bucharest, Romania, 12Hospital Egas Moniz, Lisbon, Portugal, 13Hospital de Braga, Braga, Portugal, 14Center for treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway and University of Oslo (UiO), Institute of Clinical Medicine, Oslo, Norway, Oslo, Norway, 15Tampere University Hospital, Tampere University and Kanta-Häme Central Hospital, Tampere, Finland, 16Helsinki University Hospital and University of Helsinki, Helsinki, Finland, 17Landspitali University Hospital and University of Iceland, Reykjavik, Iceland, 18University of Iceland and Skåne University Hospital, Reykjavik, Iceland, 19University of Aberdeen, Aberdeen, United Kingdom, 20University Medical Centre Ljubljana and University of Ljubljana, Ljubljana, Slovenia, 21East-Tallinn Central Hospital, Tallinn, Estonia, 22Rheumatology Unit- University of Bari "Aldo Moro", IT, Bari, Italy, 23University Hospital Zurich, Zürich, Switzerland, 24Department of Clinical Medicine, University of Copenhagen and Center for Rheumatology, Copenhagen Center for Arthritis Research, Glostrup, Denmark

    Background/Purpose: In observational studies, several longitudinal methods have been proposed to impute missing data of an individual by using the available information of the same…
  • Abstract Number: 0754 • ACR Convergence 2024

    Clinical Characterization of Aortitis and Periaortitis in a Cohort of 134 Patients from a Single Universitary Center. A Model-based Cluster Analysis

    Carmen Secada Gómez1, Javier Loricera2, Adrián Martín-Gutiérrez3, Fernando Lopez-Gutierrez4, María Nuñez-Sayar5, Ander Ucelay-Aristi5, Isabel Martinez-Rodriguez6, ivan Ferraz-Amaro7, Santos Castañeda8 and Ricardo Blanco-Alonso9, 1Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 2Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain, 3Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Cantabria, Spain, 5Cardiovascular Surgery, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 6Nuclear Medicine, Hospital Universitario Marques de Valdecilla,IDIVAL, Santander, Cantabria, Spain, 7Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 8Hospital Universitario de la Princesa, Madrid, Spain, 9Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain

    Background/Purpose: Aortitis and periaortitis represent the inflammation of the aortic wall and the surrounding periaortic tissues, respectively. Both can be idiopathic or secondary to infectious…
  • Abstract Number: 0885 • ACR Convergence 2024

    Reproducible Single Cell Annotation of Programs Underlying T-cell Subsets, Activation States, and Functions

    Dylan Kotliar1, Michelle Curtis1, Ryan Agnew1, Kathryn Weinand1, Aparna Nathan2, Yuriy Baglaenko1, Yu Zhao1, Pardis Sabeti3, Deepak Rao4 and Soumya Raychaudhuri1, 1Brigham and Women's Hospital, Boston, MA, 2Harvard Medical School, Boston, MA, 3Broad Institute, Boston, MA, 4Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: T-cells play a key role in the pathogenesis of autoimmune disease and in protection against cancer and infection. Consequently, there is widespread interest in…
  • Abstract Number: 1109 • ACR Convergence 2024

    Differences Between Correlation and Causal Inference in Detecting Predictors of Undefined Crystal Arthropathy in Women

    Laura Scagnellato1, Antonio Collesei2, Sonia farah3, Carlomaurizio Montecucco4, Francesca Oliviero5, Bernd raffeiner6, Marta favero5, Amelia Damasco5, doria Andrea5, Fausto Salaffi3 and Roberta Ramonda7, and SIR Study Group on Crystal Arthropaties, 1Rheumatology Unit, University of Padova, Padova, Italy, 2IRCCS Istituto Oncologico Veneto IOV, Padova, Italy, 3Polytechnic University of Marche, Jesi (AN), Italy, 4IRCCS policlinico S. Matteo foundation, University of Pavia, Pavia, Italy, 5University of Padova, Padova, Italy, 6General Hospital of Bolzano, Bolzano, Italy, 7Rheumatology Unit, University of Padova, Italy, Padova, Italy

    Background/Purpose: Crystal arthropaties, including gout and calcium pyrophosphate deposition disease (CPPD), are prevalent and burdensome conditions. The ALLSTAR model allows the identification of reliable causal,…
  • Abstract Number: 1191 • ACR Convergence 2024

    Discordant Associations Among Chronological and Biological Age with Multi-joint Osteoarthritis and Symptom Burden: The Johnston County Health Study

    Liubov Arbeeva1, Yvonne Golightly2, Cameron Kurz3, Matlock Jeffries4, Virginia Kraus5, Richard Loeser6, Duncan Lascelles7 and Amanda Nelson3, 1University of North Carolina, Chapel Hill, Carrboro, NC, 2University of Nebraska Medical Center, Omaha, NE, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, 4Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Duke University, Durham, NC, 6University of North Carolina, Chapel Hill, NC, 7North Carolina State University, Raleigh, NC

    Background/Purpose: Biological age (BA) may be superior to chronological age (CA) in predicting mortality and age-related conditions such as diabetes and cognitive/functional decline (PMID35715611), as…
  • Abstract Number: 1207 • ACR Convergence 2024

    Patterns of Shared Variation in Knee Ultrasound for Osteoarthritis: A Machine Learning Approach

    Sahar Sawani1, Liubov Arbeeva2, Katherine Yates3, Carolina Alvarez4, Todd Schwartz1, Serena Savage-Guin5, Jordan Renner6, Catherine Bakewell7, Minna Kohler8, Janice Lin9, Jonathan Samuels10 and Amanda Nelson1, 1University of North Carolina at Chapel Hill, Chapel Hill, NC, 2University of North Carolina, Chapel Hill, Carrboro, NC, 3University of North Carolina Medical Center, Chapel Hill, NC, 4University of North Carolina at Chapel Hill, Miami, FL, 5Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, 6Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Intermountain Health Care, Salt Lake City, UT, 8Massachusetts General Hospital, Boston, MA, 9Stanford University, Palo Alto, CA, 10NYU Langone, Rye Brook, NY

    Background/Purpose: The aim of this study was to utilize a machine learning (ML) approach to identify phenotypes of knee OA (KOA) based on demographic variables,…
  • Abstract Number: 0965 • ACR Convergence 2023

    Comparing Predictors of DAPSA28, DAPSA66/68 and DAS28-CRP Remission at 6 Months in Bio-naive Patients with Psoriatic Arthritis Initiating a TNFi in Clinical Practice – Results from the EuroSpA Collaboration

    Stylianos Georgiadis1, Louise Linde2, Lykke Ørnbjerg1, Simon Horskjær Rasmussen1, Johan Askling3, Brigitte Michelsen4, Daniela Di Giuseppe3, Johan Karlsson Wallman5, Bente Glintborg6, Anne Gitte Loft7, Miguel Bernardes8, Carolina Ochôa Matos9, Dan Nordstrom10, Laura Kuusalo11, Burkhard Moeller12, Michael Nissen13, Bjorn Gudbjornsson14, Thorvardur Love15, Florenzo Iannone16, Tore Kvien17, Ziga Rotar18, Isabel Castrejon19, Gary Macfarlane20, Marleen van de Sande21, Merete Hetland1 and Mikkel Østergaard22, 1Copenhagen Center for Arthritis Research, Rigshospitalet, Copenhagen, Denmark, 2Rigshospitalet Glostrup, Glostrup, Denmark, 3Karolinska Institutet, Stockholm, Sweden, 4Rigshospitalet Glostrup; Diakonhjemmet Hospital; Sørlandet Hospital, Copenhagen, Denmark, 5Lund University and Skåne University Hospital, Lund, Sweden, 6Rigshospitalet Glostrup, University of Copenhagen, Virum, Denmark, 7Aarhus University, Horsens, Denmark, 8Rheumatology Department, Centro Hospitalar e Universitário de São João, Porto, Portugal, 9Centro Académico de Medicina de Lisboa, Lisbon, Portugal, 10Helsinki University Hospital, Helsinki, Finland, 11Centre for Rheumatology and Clinical Immunology, University of Turku and Turku University Hospital, Turku, Finland, 12Inselspital - University Hospital Bern, Bern, Switzerland, 13Geneva University Hospitals, Geneva, Switzerland, 14Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland, 15Landspitali University Hospital and the University of Iceland, Reykjavik, Iceland, 16Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, 17Center for Treatment of Rheumatic and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital, Oslo, Norway, 18University Medical Centre Ljubljana, Ljubljana, Slovenia, 19Universitario Gregorio Marañón, Madrid, Spain, 20Aberdeen Centre for Arthritis and Musculoskeletal Health (Epidemiology Group), University of Aberdeen, Aberdeen, United Kingdom, 21Amsterdam UMC, University of Amsterdam, Department of Rheumatology & Clinical Immunology and Department of Experimental Immunology, Amsterdam Infection & Immunity Institute; Amsterdam Rheumatology & Immunology Center (ARC), Academic Medical Center, Amsterdam, Netherlands, 22Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet; University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: The Disease Activity index for PSoriatic Arthritis based on 66/68 joints (DAPSA66/68) and the Disease Activity Score in 28 joints with C-reactive protein (DAS28-CRP)…
  • Abstract Number: 1164 • ACR Convergence 2023

    Can We Differentiate Patients with Dysferlinopathies and Inflammatory Myopathies by Muscle Ultrasound? A Discriminant Analysis Study

    Carina Soto-Fajardo1, Sinthia Solorzano Flores1, Abish Angeles-Acuña1, Fabian Carranza Enriquez1, Rosa-Elena Escobar-Cedillo2, Saul Renan-Leon2, Karina Arias Callejas3, Alejandra Enriquez-Luna2, Graciliano Ramon-Diaz2 and Carlos Pineda2, 1Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico, 2Instituto Nacional de Rehabilitacion, Mexico City, Mexico, 3Instituto Nacional de Rehabilitación "Luis Guillermo Ibarra Ibarra", Mexico City, Mexico

    Background/Purpose: Immune-mediated myopathies (IMM) are a heterogeneous group of diseases characterized by inflammation and muscle weakness; among their differential diagnoses are the dysferlinopathies, which are…
  • Abstract Number: 1253 • ACR Convergence 2023

    The Novel Florida Scoring System: A Machine Learning-Based Stratification of Clinical and Laboratory Features in Children with Suspected Sjögren’s Disease

    Akaluck Thatayatikom1, Wenjie Zeng2, Tyler Lovelace3, Nicole Winn4, Ankit Shah5, Thomas Schrepfer6, Indraneel Bhattacharyya7, Renato Gonik8, Panayiotis Benos2 and Seunghee Cha9, 1AdventHealth for Children, Orlando, FL, Orlando, FL, 2University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, 3Department of Computational & Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 4Division of Oral Medicine, Department of Oral and Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, 5Department of Ophthalmology, University of Florida College of Medicine, Gainesville, FL, 6Division of Pediatric Otolaryngology, University of Florida College of Medicine, Gainesville, FL, 7Department of Oral & Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry, Gainesville, FL, 8Division of Pediatric Neurology, University of Florida College of Medicine, Gainesville, FL, 9Department of Oral & Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry and Center for Orphaned Autoimmune Disorders (COAD), Gainesville, FL

    Background/Purpose: Childhood Sjögren 's disease (cSjD) is a poorly defined systemic autoimmune disorder. Due to the absence of diagnostic criteria, heterogeneous presentations, and the dissimilarity…
  • Abstract Number: 1881 • ACR Convergence 2023

    Deep Learning Approaches to Rheumatoid Arthritis Severity Prognosis

    Zhong-Yuan Lai1, Aditya Varna Iyer2, Isaac Zachary To1, Ivano Lodato1, Simran Hiranandani1, Tommy LAM3, Ho So4 and Lai-Shan Tam5, 1Allos AI, London, United Kingdom, 2Allos AI, University of Oxford, Oxford, United Kingdom, 3Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong, Hong Kong, 4Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 5The Chinese University of Hong Kong, New Territories, China

    Background/Purpose: Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis affecting a large sector of the global population. The disease is associated with…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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