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Abstracts tagged "Spondyloarthropathies"

  • Abstract Number: 1007 • ACR Convergence 2022

    Metabolic Disorders and Abnormal Dietary Patterns and Their Association with Psoriatic Arthritis Activity: The Dietary Intervention in PsA (DIPSA) Study

    Lihi Eder1, Charlene Compher2, Helen Emanoilidis3, Ryan F. Quinn2, Dafna Gladman4, Vinod Chandran5, Jose Scher6 and Alexis Ogdie7, 1Women’s College Research Institute, Department of Medicine, University of Toronto, Toronto, ON, Canada, 2University of Pennsylvania, Philadelphia, PA, 3Women's College Hospital, Toronto, ON, Canada, 4Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 5Departments of Medicine and Laboratory Medicine and Pathobiology, University of Toronto/ Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 6New York University School of Medicine, New York, NY, 7Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Psoriatic Arthritis (PsA) is associated with obesity and its related metabolic abnormalities. The role of diet as an adjunct therapy in PsA remains unclear.…
  • Abstract Number: 1255 • ACR Convergence 2022

    Rheumatologists Overcall Sacroiliitis on X-ray and MRI in Axial Spondyloarthritis Patients: Data from the BelGian Inflammatory Arthritis and SpoNdylitis cohorT (Be-GIANT)

    Ann-Sophie Kathleen De Craemer1, Manouk de Hooge2, Thomas Renson3, Liselotte Deroo4, Gaelle Varkas3, Liesbet Van Praet5, Rik Joos6, Jan Lenaerts7, Mieke Devinck8, Lieve Gyselbrecht9, isabelle peene3, Kristof Thevissen10, Philippe Carron3, Filip Van den bosch11 and Dirk Elewaut12, 1Ghent University Hospital, Gent, Belgium, 2Ghent University Hospital, Luxembourg, Luxembourg, 3Ghent University Hospital, Ghent, Belgium, 4Ghent University, Gent, Belgium, 5AZ Maria Middelares, Ghent, Belgium, 6Ghent University Hospital, Basel, Switzerland, 7Reuma Instituut Hasselt, Hasselt, Belgium, 8AZ Sint-Lucas, Brugge, Belgium, 9ASZ Aalst, Aalst, Belgium, 10Reumacentrum Genk, Genk, Belgium, 11Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 12Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium

    Background/Purpose: To investigate (1) agreement between local and central reading of sacroiliac joint images (X-ray and magnetic resonance imaging [MRI]) from axial spondylarthritis (axSpA) patients,…
  • Abstract Number: 2147 • ACR Convergence 2022

    Cumulative Dose and Exposure Time to Methotrexate Were Not Shown to Be Predictors of Hepatic Fibrosis by Elastography – A Monocentric Cohort Study

    Filipe Pinheiro1, Rui Gaspar2, Bruno Fernandes3, Armando Peixoto2, Guilherme Macedo2 and Iva Brito4, 1Rheumatology Department, Centro Hospitalar Universitário de São João, Porto, Portugal, 2Gastroenterology Deparment, Centro Hospitalar e Universitário de São João, Porto, Portugal, 3Rheumatology Deparment, Centro Hospitalar e Universitário de São João, Porto, Portugal, 4Pediatric and Young Adult Rheumatology Unit, Centro Hospitalar Universitário de São João, Porto, Portugal

    Background/Purpose: Methotrexate is an immunomodulatory agentu sed in several inflammatory diseases, such as rheumatoid arthritis (RA), spondyloarthritis (SpA) or inflammatory bowel disease (IBD). Despite being…
  • Abstract Number: 0386 • ACR Convergence 2022

    Quantitative Proteomic Screening Uncovers Diagnostic and Monitoring Serum Biomarkers of Ankylosing Spondylitis

    Mark Hwang1, Jessica Castillo2, kamala Vanarsa2, Jim Zheng3, Shervin Assassi4, Chandra Mohan2 and John Reveille5, 1McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, 2University of Houston, Houston, TX, 3UTHealth School of Bioinformatics, Houston, TX, 4McGovern Medical School, University of Texas, Houston, TX, 5University of Texas McGovern Medical School, Houston, TX

    Background/Purpose: We sought to discover novel serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity. Methods: We used biologic-treatment naïve AS and…
  • Abstract Number: 1022 • ACR Convergence 2022

    Validation of the SPARCCRETIC E-Tool for Ensuring Scoring Proficiency of MRI Lesions in Axial Spondyloarthritis

    Walter P Maksymowych1, Anna Hadsbjerg2, Mikkel Østergaard3, Raphael Micheroli4, Susanne J. Pedersen5, Adrian Ciurea6, Nora Vladimirova2, Michael Nissen7, Kristyna Bubova8, Stephanie Wichuk9, Manouk de Hooge10, Ashish J Mathew11, Karlo Pintaric12, Monika gregova13, Ziga Snoj12, Marie Wetterslev14, Karel Gorican15, Joel Paschke16, Iris Eshed17 and Robert G Lambert9, 1Department of Medicine, University of Alberta, Edmonton, AB, Canada, 2Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 3Rigshospitalet, University of Copenhagen, Glostrup, Denmark, 4University Hospital Zurich, Department of Rheumatology, Zürich, Switzerland, 5Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, 6University Hospital Zurich, Zürich, Switzerland, 7Hopitaux Universitaires de Genève, Geneva, Switzerland, 8First Faculty of Medicine, Charles University,, Prague, Czech Republic, 9University of Alberta, Edmonton, AB, Canada, 10Ghent University Hospital, Luxembourg, Luxembourg, 11Rigshospitalet, Copenhagen, Denmark, 12Radiology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 13Institue of Rheumatology, Prague, 14Rigshospitalet, Copenhagen, Glostrup, Denmark, 15MSK radiology unit, Radiology section – Diagnostic department, Geneva University Hospitals, Geneva, Switzerland, 16CARE Arthritis LTD, Edmonton, AB, Canada, 17Sheba Medical Center, Tel Aviv, Israel

    Background/Purpose: Quantification of inflammatory and structural lesions in the sacroiliac joints (SIJ) on MRI scans from patients with axial spondyloarthritis (axSpA) has a growing list…
  • Abstract Number: 1503 • ACR Convergence 2022

    Is Inflammation-driven Bone Loss Associated with Two-year Bone Formation at the Same Vertebra in Axial Spondyloarthritis? – a Multilevel MRI and Low Dose CT Analysis from the Sensitive Imaging of Axial Spondyloarthritis (SIAS) Cohort

    Mary Lucy Marques1, Nuno Pereira da Silva2, Désirée van der Heijde3, Rosalinde Stal4, Xenofon Baraliakos5, Juergen Braun6, Monique Reijnierse4, Caroline Bastiaenen7, Sofia Ramiro4 and floris van Gaalen4, 1Leiden University Medical Center, Coimbra, Portugal, 2Radiology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 3Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, 4Leiden University Medical Center, Leiden, Netherlands, 5Rheumazentrum Ruhrgebiet Herne, Herne, Germany, 6Rheumazentrum Ruhrgebiet, Herne, Germany, 7Department of Epidemiology, Maastricht University, Maastricht, Netherlands

    Background/Purpose: In radiographic axial spondyloarthritis (r-axSpA), inflammation-driven trabecular bone loss is hypothesised to trigger bone repair at an anatomically distinct site of the same vertebra…
  • Abstract Number: 2199 • ACR Convergence 2022

    Primary Non-adherence to Biologics and Immunomodulatory Therapies for Rheumatoid Arthritis, Psoriatic Arthritis, and Spondyloarthritis Using Linked EHR and Pharmacy Claims Data

    Jeffrey Curtis1, Yujie Su2, Cassie Clinton2, Patrick Stewart3, Bryant England4, Tim Buekelman5 and Fenglong Xie2, 1Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Birmingham, AL, 3Bendcare, Boca Raton, FL, 4University of Nebraska Medical Center, Omaha, NE, 5FASTER, Hoover, AL

    Background/Purpose: Many patients with autoimmune and inflammatory conditions discontinue biologics and other immunomodulatory medications prematurely, but many fail to even start (primary non-adherence). We examined…
  • Abstract Number: 0840 • ACR Convergence 2021

    Modelling of Disease Activity in Patients with Inflammatory Arthropathies Treated with Etanercept Originator or Biosimilar as First-Line Biologic: A Real-World Observational Study Using the OPAL Dataset

    Claire Deakin1, Geoffrey Littlejohn2, Hedley Griffiths3, Tegan Smith4, Catherine OSullivan5 and Paul Bird6, 1OPAL Rheumatology Ltd, Sydney, Australia, 2Monash University, Melbourne, Australia, 3Barwon Rheumatology Service, Geelong, Australia, 4OPAL Rheumatology Ltd, Kogarah, Australia, 5OPAL Rheumatology Ltd, Queenscliff, Australia, 6University of New South Wales, Sydney, Australia

    Background/Purpose: The availability of biosimilars as non-proprietary versions of established biologic disease-modifying anti-rheumatic drugs (bDMARDs) has increased around the world. Since April 2017 both the…
  • Abstract Number: 0905 • ACR Convergence 2021

    Artificial Neural Network for the Recognition of Active Inflammatory Changes Compatible with Axial Spondyloarthritis on Magnetic Resonance Imaging of Sacroiliac Joints

    Denis Poddubnyy1, Janis Vahldiek2, Lisa Adams2, Torsten Diekhoff2, Fabian Proft2, Mikhail Protopopov2, Judith Rademacher2, Valeria Rios Rodriguez2, Murat Torgutalp2, Stefan Niehues2 and Keno Bressem2, 1Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 2Charité University Medicine Berlin, Berlin, Germany

    Background/Purpose: Active inflammatory changes in sacroiliac joints (SIJ) compatible with axial spondyloarthritis - axSpA (first of all, subchondral bone marrow edema – BME / osteitis)…
  • Abstract Number: 0922 • ACR Convergence 2021

    Bimekizumab Shows Sustained and Meaningful Long-Term Improvements in Health-Related Quality of Life in Ankylosing Spondylitis: Interim Results After 3 Years of Treatment in an Ongoing Phase 2b Study

    Atul Deodhar1, Maxime Dougados2, Karl Gaffney3, Raj Sengupta4, Marina Magrey5, Natasha de Peyrecave6, Marga Oortgiesen7, Thomas Vaux8, Carmen Fleurinck6, Vanessa Taieb8, Christine de la Loge9 and Xenofon Baraliakos10, 1Oregon Health & Science University, Portland, OR, 2Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, 3Norfolk and Norwich University Hospital NHS Trust, Norwich, United Kingdom, 4The Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 5Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, USA, Richfield, OH, 6UCB Pharma, Brussels, Belgium, 7UCB Pharma, Raleigh, NC, 8UCB Pharma, Slough, United Kingdom, 9PCOM Analytics, Avallon, France, Avallon, France, 10Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany

    Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits both interleukin (IL)-17F and IL­-17A, has been demonstrated to be efficacious and well tolerated in…
  • Abstract Number: 0923 • ACR Convergence 2021

    Minimal Impact of the COVID-19 Pandemic on Patient-Reported Disease Activity and Health-Related Quality of Life in Patients with Ankylosing Spondylitis Receiving Bimekizumab: Post Hoc Analyses from a Phase 2b Study

    Philip Robinson1, Pedro Machado2, Nigil Haroon3, Lianne Gensler4, John Reveille5, Vanessa Taieb6, Thomas Vaux6, Carmen Fleurinck7, Marga Oortgiesen8, Natasha de Peyrecave7 and Atul Deodhar9, 1University of Queensland School of Clinical Medicine, Brisbane, Queensland, Australia, Herston, Australia, 2Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 3Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, 4Department of Rheumatology, University of California San Francisco, San Francisco, CA, 5Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, 6UCB Pharma, Slough, United Kingdom, 7UCB Pharma, Brussels, Belgium, 8UCB Pharma, Raleigh, NC, 9Oregon Health & Science University, Portland, OR

    Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that inhibits both interleukin (IL)-17A and IL-17F, has been demonstrated to be efficacious and well tolerated in patients…
  • Abstract Number: 0250 • ACR Convergence 2021

    Is There a Need for a New Classification Criteria in Juvenile Spondyloarthritis?

    Maria Martha Katsicas1, Maria Cecilia Bertinotti2 and Maria Giselle Villarreal2, 1Hospital de Pediatria J.P Garrahan, Buenos Aires, Argentina, 2Garrahan, Buenos Aires, Argentina

    Background/Purpose: Juvenile SpA (JSpA) involve enthesitis related arthritis (ERA), juvenile psoriatic arthritis and undifferentiated arthritis (UA) according to the ILAR criteria. Two different patterns have…
  • Abstract Number: 0932 • ACR Convergence 2021

    Sequential Treatment in Axial Spondyloarthritis – Real World Data from a Network of German Rheumatologists

    Stefan Kleinert1, Peter Bartz-Bazzanella2, Cay Von der Decken3, Kirsten Karberg4, Florian Schuch5, Georg Gauler6, Patrick Wurth7, Susanna Späthling-Mestekemper8, Christoph Kuhn9, Fabian Proft10, Denis Poddubnyy11, Mathias Englbrecht12 and Wolfgang Vorbrüggen13, 1Praxisgemeinschaft Rheumatologie - Nephrologie (PGRN), Erlangen, Germany, 2Rhein-Maas Klinikum, Wuerselen, Germany, 3Klinik für Internistische Rheumatologie, Rhein-Maas-Klinikum, Würselen, Germany, 4Praxis für Rheumatologie und Innere Medizin, Berlin, Germany, Berlin, Germany, 5Praxisgemeinschaft Rheumatologie-Nephrologie, Erlangen, Germany, 6rheumapraxis, Osnabrck, Germany, 7Rheumatologische Schwerpunktpraxis, Osnabrück, Germany, 8Rheumapraxis München, München, Germany, 9Praxis für Rheumatologie, Karlsruhe, Germany, Karlsruhe, Germany, 10Charité University Medicine Berlin, Berlin, Germany, 11Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 12Freelance Healthcare Data Scientist, Eckental, Germany., Eckental, Germany, 13Verein zur Förderung der Rheumatologie e.V., Würselen, Germany

    Background/Purpose: Increasing immunmodulatory treatment options are available for axial spondyloarthritis. Little is known about sequential treatment in clinical routine.Methods: The pseudonymized RHADAR database (Kleinert, S.…
  • Abstract Number: 0285 • ACR Convergence 2021

    Risk of Cardiovascular Disease in Newly Diagnosed Rheumatoid Arthritis: A Current Risk Assessment

    Reinder Raadsen1, Romy Hansildaar1, Maaike Heslinga2, Arno van Kuijk1 and Michael Nurmohamed3, 1Reade, Amsterdam, Netherlands, 2Amsterdam University Medical Center, location VUmc, Amsterdam, Netherlands, 3Reade and Amsterdam University Medical Center, location VUmc, Amsterdam, Netherlands

    Background/Purpose: Patients with rheumatoid arthritis (RA) are known to have an increased risk of developing, mainly ischemic cardiovascular diseases (CVD). This is partly explained by…
  • Abstract Number: 0937 • ACR Convergence 2021

    Evaluation of the Safety of Vedolizumab in Combination with Other Immunosuppression Biological Therapy in Patients with Inflammatory Bowel Disease

    Gino Chesini1, Elizabeth Parrott1, Lauren Fox1, Jenna Beatty1, Cassandra Effken1, Na Yu1, Florence Hosseini-Aslinia1 and Megan Krause2, 1University of Kansas Medical Center, Kansas City, KS, 2University of Kansas, Kansas City, KS

    Background/Purpose: Inflammatory bowel disease (IBD) causes a wide range of symptomology frequently leading to co-management of disease activity between gastroenterologist and rheumatologists. Recently in efforts…
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