Abstracts tagged "spondyloarthritis"

Abstract Number: 0890 • ACR Convergence 2020
Ixekizumab Treatment Improves Fatigue, Spinal Pain, Stiffness, and Sleep in Patients with Nonradiographic Axial Spondyloarthritis
Philip Mease¹, Atul Deodhar², Proton Rahman³, Helena Marzo-Ortega⁴, Vibeke Strand⁵, Theresa Hunter⁶, David Adams⁷, David Sandoval⁶, Andris Kronbergs⁶, Baojin Zhu⁷, Ann Leung⁸, Soyi Liu-Leage⁷ and Victoria Navarro-Compán⁹, ¹Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ²Oregon Health & Science University, Portland, OR, ³Memorial University of Newfoundland, Department of Medicine, St John's, Canada, ⁴The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ⁵Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA, ⁶Eli Lilly and Company, Indianapolis, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸Syneos Health, Morrisville, ⁹Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain
Background/Purpose: Common symptoms of axial spondyloarthritis (axSpA) include fatigue, spinal pain, stiffness, and sleep problems, which can impair health-related quality of life. Ixekizumab (IXE) treatment…
Abstract Number: 1316 • ACR Convergence 2020
Patient Perceptions of Fibromyalgia Symptoms and the Overlap with Axial Spondyloarthritis
Kelly Gavigan¹, William Nowell², Regan Reynolds¹, Laura Stradford¹, Jeffrey R Curtis³ and Alexis Ogdie⁴, ¹Global Healthy Living Foundation, Upper Nyack, NY, ²Global Healthy Living Foundation, New York City, NY, ³Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: In clinical practice, it is often challenging to distinguish fibromyalgia syndrome (FMS) from axial spondyloarthritis (axSpA), which includes ankylosing spondylitis and non-radiographic axSpA. Early stages…
Abstract Number: 1365 • ACR Convergence 2020
Machine Learning-based Berlin Scoring of Magnetic Resonance Images of the Spine in Patients with Ankylosing Spondylitis: Analysis of Data from a Phase 3 Trial with Secukinumab
Amir Jamaludin¹, Rhydian Windsor¹, Sarim Ather¹, Timor Kadir¹, Andrew Zisserman¹, Juergen Braun², Lianne Gensler³, Pedro Machado⁴, Mikkel Østergaard⁵, Denis Poddubnyy⁶, Thibaud Coroller⁷, Brian Porter⁷, Shephard Mpofu⁸ and Aimee Readie⁷, ¹University of Oxford, Oxford, United Kingdom, ²Rheumazentrum Ruhrgebiet and Ruhr-University, 44649 Herne, Germany, ³University of California San Francisco, San Francisco, CA, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ⁶Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁷Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁸Novartis Pharma AG, Basel, Switzerland
Background/Purpose: Magnetic resonance imaging (MRI) offers a non-invasive and objective method of early diagnosis and classification, monitoring disease burden and treatment response for patients (pts)…
Abstract Number: 1851 • ACR Convergence 2020
Different Disease Activity Trajectories in Early Axial Spondyloarthritis Lead to Significantly Different Long-term Outcomes : A Cluster-based Analysis of the DESIR Cohort
Benattar Leslie¹, Anna Molto², Laure Gossec³ and Resche Rigon Matthieu⁴, ¹Cochin Hospital, Paris, Paris, Ile-de-France, France, ²Rheumatology Department, Cochin Hospital, APHP, Paris, France, Paris, France, ³Sorbonne University, INSERM; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, ⁴INSERM (UFR 1153), Saint Louis Hospital, Paris, Paris, France
Background/Purpose: AxSpA is a heterogeneous disease, leading to different treatment and follow-up modalities depending on the presentation, along with other elements (socio-economic, gender, etc..). In a…
Abstract Number: 1878 • ACR Convergence 2020
Consensus Definitions for MRI Lesions in the Spine of Patients with Axial Spondyloarthritis: First Analysis from the Assessments in SpondyloArthritis International Society Classification Cohort
Walter Maksymowych¹, Iris Eshed², Pedro M Machado³, Susanne J Pedersen⁴, Ulrich Weber⁵, Manouk de Hooge⁶, Joachim Sieper⁷, Stephanie Wichuk¹, Denis Poddubnyy⁸, Martin Rudwaleit⁹, Désirée van der Heijde¹⁰, Robert Landewé¹¹, Robert G Lambert¹², Mikkel Østergaard¹³ and Xenofon Baraliakos¹⁴, ¹University of Alberta, Edmonton, AB, Canada, ²Sheba Medical Center, Tel-Aviv, Israel, ³University College London, London, United Kingdom, ⁴Rigshospitalet University, Copenhagen, Denmark, ⁵University of South Denmark, Odense, Denmark, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Charité Universitätsmedizin Berlin, Berlin, Germany, ⁸Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁹Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, ¹⁰Leiden University Medical Center, Leiden, Netherlands, ¹¹Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ¹²University of Alberta and CARE Arthritis, Edmonton, AB, Canada, ¹³Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ¹⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany
Background/Purpose: A broad spectrum of MRI lesions has been described in the spine of patients with axial spondyloarthritis (axSpA) and a recent consensus from the…
Abstract Number: 2014 • ACR Convergence 2020
The Relative Diagnostic Utility of Inflammatory Back Pain Criteria in an Inception Cohort of Patients with Psoriasis, Iritis, and Colitis Presenting with Undiagnosed Back Pain
Georg Kröber¹, Ulrich Weber², Raj Carmona³, James Yeung⁴, Jon Chan⁵, Sibel Aydin⁶, Liam Martin⁷, Ariel Masetto⁸, Stephanie Keeling⁹, Olga Ziouzina⁷, Sherry Rohekar¹⁰, Rana Dadashova¹¹, Joel Paschke¹¹, Amanda Carapellucci¹¹, Robert G Lambert¹² and Walter Maksymowych⁹, ¹University of Southern Denmark, Sønderborg, Denmark, ²University of South Denmark, Odense, Denmark, ³St. Joseph's Healthcare, Hamilton, ON, Canada, ⁴James Yeung Rheumatology, Vancouver, BC, Canada, ⁵Artus Health Clinic, Vancouver, BC, Canada, ⁶University of Ottawa Faculty of Medicine, Rheumatology, Ottawa, ON, CANADA; The Ottawa Hospital Research Institute, Ottawa, ON, CANADA, Ottawa, ON, Canada, ⁷University of Calgary, Calgary, AB, Canada, ⁸University of Sherbrooke, Sherbrooke, QC, Canada, ⁹University of Alberta, Edmonton, AB, Canada, ¹⁰Lawson Health Research Institute, London, ON, Canada, ¹¹CARE Arthritis, Edmonton, AB, Canada, ¹²University of Alberta and CARE Arthritis, Edmonton, AB, Canada
Background/Purpose: Patients with psoriasis, iritis, or colitis and back pain represent a high-risk population for the presence of axial spondyloarthritis (axSpA). Clinicians rely on the…
Abstract Number: 0448 • ACR Convergence 2020
Disease-related factors associated to atherosclerotic disease in axial spondyloarthritis. A mutlicenter study with 806 patients.
Inigo Gonzalez-Mazon¹, Ivan Ferraz-Amaro², Javier Rueda-Gotor³, Lara Sanchez-Bilbao⁴, David Martinez-Lopez⁵, Mario Agudo-Bilbao³, Fernanda Genre⁶, Sara Remuzgo-Martínez⁶, Veronica Pulito-Cueto⁶, Alfonso Corrales⁷, Leticia Lera-Gómez⁶, Virginia Portilla⁶, Vanesa Calvo-Río³, Cristina Mata⁸, Vanesa Hernández-Hernández⁹, Santos Castañeda¹⁰, Esther Francisca Vicente-Rabaneda¹¹, C Fernandez-Carballido¹², M Paz Martínez-Vidal¹³, David Castro-Corredor¹⁴, Joaquín Anino-Fernández¹⁴, Juan Carlos Quevedo-Abeledo¹⁵, Carlos Rodríguez-Lozano¹⁶, C. Fernandez-Diaz¹⁷, Esther Montes-Perez¹⁸, María Luz García Vivar,¹⁹, Eva Galínez-Agirregoikoa¹⁹, Javier Llorca²⁰, Raquel López-Mejías⁶, Chamaida Plasencia²¹, Diana Peiteado²², Alejandro Balsa-Criado²³, Nuria Barbarroja²⁴, Lourdes Ladehesa-Pineda²⁵, Rafaela Ortega-Castro²⁶, Eduardo Collantes-Estévez²⁵, Ricardo Blanco⁴ and Miguel Ángel González-Gay²⁷, ¹Hospital Universitario Marques de Valdecilla, Bezana, Spain, ²Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, ³H.U. Marques de Valdecilla, Santander, Spain, ⁴Hospital Universitario Marques de Valdecilla, Santander, Spain, ⁵Hospital Universitario Marques de Valdecilla, Santander (SPAIN), Spain, ⁶Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic bone Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ⁷Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic bone diseases of the musculoskeletal system, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ⁸Hospital de Laredo, Santander, Spain, ⁹Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ¹⁰Princesa University Hospital, Universidad Autónoma, Madrid, Madrid, Spain, ¹¹Hospital Universitario de la Princesa, IIS-Princesa, UAM, Madrid, Madrid, Spain, ¹²H San Juan, Alicante, Spain, ¹³Hospital General Universitario de Alicante, Alicante, Spain, ¹⁴Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, ¹⁵Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain, ¹⁶Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, ¹⁷H. Marqués de Valdecilla, Madrid, Spain, ¹⁸Diagnóstico Médico Cantabria (DMC), Santander, Spain, ¹⁹Hospital Universitario Basurto, Bilbao, Spain, ²⁰School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, ²¹Rheumatology, La Paz University Hospital-IdiPAZ, madrid, Spain, ²²Hospital Universitario La Paz-IdiPaz, Madrid, Spain, ²³HOSPITAL UNIVERSITARIO LA PAZ, madrid, Spain, ²⁴Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ²⁵Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, ²⁶Hospital Universitario Reina Sofía, Córdoba, Spain, ²⁷Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
Background/Purpose: Cardiovascular (CV) mortality and morbidity is increased in ankylosing spondylitits (AS) due to a process of accelerated atherosclerosis. The disease-related factors involved in this…
Abstract Number: 0893 • ACR Convergence 2020
Is It Feasible to Achieve Recommended Therapeutic Target Objective in Patients with Axial Spondyloarthritis in Clinical Practice? Data from the SpA-paz Cohort
Karen Franco Gomez¹, Chaimada Plasencia-Rodriguez¹, Marta Novella Navarro¹, Diego Benavent Nunez¹, Patricia Bogas¹, Romina Nieto², Irene Monjo³, Laura Nuño¹, Alejandro Villalba⁴, Diana Peiteado¹, Alejandro Balsa-Criado¹ and Victoria Navarro-Compán⁵, ¹HOSPITAL UNIVERSITARIO LA PAZ, MADRID, Spain, ²hospital intendente carrasco, Rosario, Argentina, ³Rheumatology, La Paz University Hospital- IdiPAZ, Madrid, Spain, ⁴Hospital La Paz - IdiPAZ, Madrid, Spain, ⁵Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain
Background/Purpose: to analyze the frequency of patients with axSpA achieving maintained remission (R) or low disease activity (LDA) after receiving biological therapy. Secondary objectives included:…
Abstract Number: 1317 • ACR Convergence 2020
A Large Agreement Between the Pain Points of the ACR 1990 Fibromyalgia Criteria and the MASES Enthesitis Score Is Observed in Patients with Axial Spondylitis, Including in Patients Without Concomitant Fibromyalgia
Faten Hamitouche¹, Clementina Lopez-Medina², Laure Gossec³, Serge Perrot⁴, Maxime Dougados⁵ and Anna Molto⁶, ¹Rheumatology Department, Cochin Hospital, Paris, Ile-de-France, France, ²Rheumatology Department, Cochin Hospital, Paris, Paris, France, ³Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France, ⁴Paris Descartes University, Paris, Ile-de-France, France, ⁵Université de Paris, Department of Rheumatology, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Paris, France, ⁶Rheumatology Department, Cochin Hospital, APHP, Paris, France, Paris, France
Background/Purpose: Enthesitis is the hallmark lesion in Spondyloarthritis (SpA). The Maastricht Ankylosing Spondylitis Enthesitis score (MASES), which assesses 13 enthesitic sites, is the most widely…
Abstract Number: 1367 • ACR Convergence 2020
Impact of Ixekizumab on Work Productivity in Non-Radiographic Axial Spondyloarthritis Patients: Results from the COAST-X Trial at 52 Weeks
Atul Deodhar¹, Philip Mease², Lianne Gensler³, Proton Rahman⁴, Victoria Navarro-Compán⁵, Helena Marzo-Ortega⁶, Theresa Hunter⁷, David Sandoval⁷, Andris Kronbergs⁷, Baojin Zhu⁸, Ann Leung⁹ and Vibeke Strand¹⁰, ¹Oregon Health & Science University, Portland, OR, ²Seattle Rheumatology Associates, P.L.L.C., Seattle, WA, ³University of California San Francisco, San Francisco, CA, ⁴Memorial University of Newfoundland, Department of Medicine, St John's, Canada, ⁵Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ⁶The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, ⁷Eli Lilly and Company, Indianapolis, ⁸Eli Lilly and Company, Indianapolis, IN, ⁹Syneos Health, Morrisville, ¹⁰Division of Immunology/Rheumatology, Stanford University, Palo Alto, CA
Background/Purpose: Patients with non-radiographic axial spondyloarthritis (nr-axSpA) experience impairments in health-related quality of life comparable to those seen in ankylosing spondylitis, including impacts on work…
Abstract Number: 1852 • ACR Convergence 2020
Intestinal Permeability in the Adjuvant Induced Arthritis Model: Preliminary Study and Impact of NSAIDs
Sophie Hecquet¹, Romain Bordy², Clement Prati¹, Daniel Wendling³, Céline Demougeot² and Frank Verhoeven¹, ¹Rheumatology, University Teaching Hospital, Besançon, France, ²EA4267 Laboratory, Besançon, France, ³CHU Besançon, department of rheumatology, Besancon, France
Background/Purpose: The gut is no longer considered as a simple element associated with spondyloarthritis but as a real actor of the disease. In patients with…
Abstract Number: 1879 • ACR Convergence 2020
Development of a Deep Learning Algorithm to Predict Positive MRI of the Sacroiliac Joints According to the ASAS Definition in Patients with Recent Axial Spondyloarthritis
Théodore Aouad¹, Clementina Lopez-Medina², Anna Molto², Antoine Feydy³, Charlotte Martin-Peltier³, Hugues Talbot⁴ and Maxime Dougados⁵, ¹Université Paris-Saclay, CentraleSupelec, Inria, Gif-Sur-Yvette, France, ²Rheumatology Department, Cochin Hospital, Paris, Paris, France, ³Radiology Department, Cochin Hospital, Paris, France, ⁴CVN, CentraleSupelec, Paris, France, ⁵Department of Rheumatology, Hopital Cochin, Université de Paris, Paris, France
Background/Purpose: The magnetic resonance imaging (MRI) of the sacroiliac joints (MRI-SIJ) represents an essential tool in the evaluation of patients with spondyloarthritis (SpA). However, despite…
Abstract Number: 2015 • ACR Convergence 2020
Prevalence and Distribution of Peripheral Musculoskeletal Manifestations in Axial Spondyloarthritis, Peripheral Spondyloarthritis and Psoriatic Arthritis: Results of the International, Cross-sectional ASAS-PerSpA Study
Clementina Lopez-Medina¹, Anna Molto¹, Joachim Sieper², Mehmet Tuncay Duruöz³, Uta Kiltz⁴, Bassel El-Zorkany⁵, Najia Hajjaj-Hassouni⁶, Ruben Burgos-Vargas⁷, Jose Maldonado-Cocco⁸, Nelly Ziade⁹, Meghna Gavali¹⁰, Victoria Navarro-Compán¹¹, Shue Fen Luo¹², Sara Monti¹³, Tae-Jong Kim¹⁴, Mitsumasa Kishimoto¹⁵, Fernando Pimentel-Santos¹⁶, Jieruo Gu¹⁷, Ruxandra Schiotis¹⁸, Floris van Gaalen¹⁹, Pál Géher²⁰, Marina Magrey²¹, Sebastian Ibanez²², Wilson Bautista-Molano²³, Walter Maksymowych²⁴, Pedro M Machado²⁵, Robert Landewé²⁶, Désirée van der Heijde²⁷ and Maxime Dougados²⁸, ¹Rheumatology Department, Cochin Hospital, Paris, Paris, France, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, ⁴Rheumazentrum Ruhrgebiet, Ruhr-University Bochum, Herne, Germany, ⁵Cairo University, Cairo, Egypt, ⁶Health Sciences College, International University of Rabat (UIR), Rabat, Morocco, ⁷Department of Rheumatology, General Hospital of Mexico, Ciudad de Mexico, Mexico, ⁸Buenos Aires School of Medicine, Buenos Aires, Argentina, ⁹Saint-Joseph University, Beirut, Lebanon, Beirut, Lebanon, ¹⁰Nizam’s Institute of Medical Sciences, Hyderabad, India, ¹¹Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ¹²Chang Gung Memorial Hospital-Linkou, Taoyuan, Taipei, Taiwan (Republic of China), ¹³Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy, ¹⁴Department of Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Republic of Korea, ¹⁵Department Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ¹⁶3.CEDOC, NOVA Medical School, Faculdade de Ciências Médicas da Universidade NOVA de Lisboa, Lisboa, Portugal; 7.Hospital Egas Moniz (CHLO) (Rheumatology Department), Lisboa, Portugal, Lisbon, Portugal, ¹⁷Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, guangzhou, China (People's Republic), ¹⁸Pharmacology Department Department, Iuliu Hatieganu University of Medicine and Pharmacy, SCBI-Rheumatology Department, Cluj-Napoca, Romania, ¹⁹Leiden University Medical Center (LUMC), Leiden, Netherlands, ²⁰Semmelweis University, Budapest, Hungary, ²¹Case Western Reserve University School of Medicine, Cleveland, OH, ²²Facultad de Medicina Clínica Alemana – Universidad del Desarrollo, Santiago, Region Metropolitana, Chile, ²³University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia, ²⁴University of Alberta, Edmonton, AB, Canada, ²⁵University College London, London, United Kingdom, ²⁶Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands, ²⁷Leiden University Medical Center, Leiden, Netherlands, ²⁸Department of Rheumatology, Hopital Cochin, Université de Paris, Paris, France
Background/Purpose: Peripheral musculoskeletal manifestations in patients with Psoriatic Arthritis (PsA) have been widely studied. However, there is a lack of knowledge on the distribution of…
Abstract Number: 0455 • ACR Convergence 2020
HLA-B27 and Host Immune Response: Lessons from Reactive Arthritis
Sophie Wojcik¹, Davina Morris², Gillian Fitzgerald³, Steve Ramkissoon⁴, Nigil Haroon² and Robert Inman⁵, ¹UHN, Montreal, QC, Canada, ²University of Toronto, Toronto, ON, Canada, ³Toronto Western Hospital, Toronto, ON, Canada, ⁴UHN, Toronto, ON, Canada, ⁵University Health Network, Toronto, ON, Canada
Background/Purpose: The natural history of reactive arthritis (ReA) remains poorly understood. Certain patients with ReA will go on to develop a chronic course while others…
Abstract Number: 0897 • ACR Convergence 2020
Temporal Achievement of Clinical Response and Inactive Disease Status in Patients with Axial Spondyloarthritis Treated with Etanercept
Xenofon Baraliakos¹, Annette Szumski², Kenneth Kwok³ and Bonnie Vlahos⁴, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ²Syneos Health, Princeton, ³Pfizer, New York, NY, ⁴Pfizer, Collegeville, PA
Background/Purpose: Treatment with etanercept (ETN) is effective and well tolerated in patients with axial spondyloarthritis (AS), but the time frames within which patients tend to…

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