Abstracts tagged "spondyloarthritis"

Abstract Number: 0469 • ACR Convergence 2021
Imaging Characteristics in Patients with Spondyloarthritis Using a Novel Heel Enthesitis Magnetic Resonance Imaging Scoring (HEMRIS) System: Post-hoc Analysis of a Phase 3 Secukinumab Trial
Xenofon Baraliakos¹, Philipp Sewerin², Eugenio De Miguel³, Effie Pournara⁴, Christine Kleinmond⁵, Ankita Shekhawat⁶, Annette Wiedon⁷ and Frank Behrens⁸, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, ²Department and Hiller Research Unit of Rheumatology, Heinrich Heine University Duesseldorf, Duesseldorf, Germany, ³Hospital Universitario La Paz, Madrid, Spain, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵ClinProject GmbH, Eurasburg, Germany, ⁶Novartis Healthcare Private Limited, Hyderabad, India, ⁷Novartis Pharma GmbH, Nürnberg, Germany, ⁸Rheumatology & Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Fraunhofer Cluster Immune-Mediated Diseases (CIMD), Fraunhofer Cluster Immune-Mediated Diseases (CIMD), Frankfurt/Main, Germany
Background/Purpose: The heel is a frequently affected anatomical site for enthesitis in spondyloarthritis (SpA).1 Recently, the Outcome Measures in Rheumatology (OMERACT) group developed and validated…
Abstract Number: 0914 • ACR Convergence 2021
Response to Certolizumab Pegol in Patients with Non-Radiographic Axial Spondyloarthritis by Baseline C-Reactive Protein Cut-Offs: Post-Hoc Analysis from a Phase 3 Multicenter Study
Philip Robinson¹, Stephen Hall², Bengt Hoepken³, Lars Bauer³, Eleni Demas⁴, Mindy Kim⁵ and Atul Deodhar⁶, ¹University of Queensland School of Clinical Medicine, Brisbane, Queensland, Australia, Herston, Australia, ²Emeritus Research and Monash University, Melbourne, Australia, Melbourne, Australia, ³UCB Pharma, Monheim am Rhein, Germany, ⁴UCB Pharma, Slough, United Kingdom, ⁵UCB Pharma, Smyrna, GA, ⁶Oregon Health & Science University, Portland, OR
Background/Purpose: Certolizumab pegol (CZP), an Fc-free, PEGylated tumor necrosis factor (TNF) inhibitor, has previously demonstrated efficacy and safety in patients with radiographic (r) and non-radiographic…
Abstract Number: 0947 • ACR Convergence 2021
Cytokine Competent Gut-joint Migratory T Cells Contribute to Inflammation in the Joint
Adam Lefferts¹, David Claypool¹, Eric Norman¹, Uma Kantheti¹ and Kristine Kuhn², ¹University of Colorado, Anschutz Medical Campus, Aurora, CO, ²University of Colorado Anschutz Medical Campus, Aurora, CO
Background/Purpose: Although studies have identified the presence of gut-associated cells in the enthesis of joints affected by spondyloarthritis, a direct link through cellular transit between…
Abstract Number: 1320 • ACR Convergence 2021
Obesity and Its Associations with Clinical Manifestations and Disease Burden of Patients with Spondyloarthritis: An Ancillary Study from the ASAS-perSpA Project
Mehmet Tuncay Duruoz¹, Sevtap Acer Kasman², Halise Hande Gezer¹, Clementina López Medina³ and Maxime Dougados⁴, ¹Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, Istanbul, Turkey, ²Marmara University School of Medicine, PMR Department, Rheumatology Division, Istanbul, Turkey, ³Department of Rheumatology, Reina Sofia Hospital, IMIBIC, University of Cordoba, Cordoba, Spain/ Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France, ⁴Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France
Background/Purpose: Obese patients with spondyloarthritis (SpA) had more functional limitations, higher subjective disease activity, fewer benefits of exercise, and showed less response to drug therapy.…
Abstract Number: 1797 • ACR Convergence 2021
Are Smoking and Alcohol Associated with Peripheral Musculoskeletal Involvement in Patients with Spondyloarthritis? Results from the ASAS-PerSpA Study
M.Lourdes Ladehesa-Pineda¹, Rafaela Ortega², Mara ngeles Puche Larrubia¹, Maxime Dougados³, Eduardo Collantes-Estevez² and Clementina López Medina⁴, ¹Hospital Universitario Reina Sofía, Córdoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Córdoba, Córdoba, Spain, ³Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁴Department of Rheumatology, Reina Sofia Hospital, IMIBIC, University of Cordoba, Cordoba, Spain/ Department of Rheumatology, University of Paris, Cochin Hospital, Paris, France
Background/Purpose: There are controversies around the role of smoking in manifestations of axial spondyloarthritis (axSpA) such as peripheral involvement. It has been observed an inverse…
Abstract Number: 0096 • ACR Convergence 2021
The True Prevalence of SARS-CoV-2 Infection in an Italian Cohort of Patients with Inflammatory Arthritis: A Seroepidemiological Study
Gabriella Maioli¹, Ennio Giulio Favalli², Elisa Pesce³, Martina Biggioggero², Mauro Bombaci³, Elena Agape², Martina Martinovic³, Tanya Fabbris³, Elena Zagato³, Andrea Favalli³, Andrea Gobbini³, Sergio Abrignani³, Renata Grifantini³ and Roberto Caporali⁴, ¹Università degli Studi di Milano, Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Milan, Italy, Milan, Italy, ²ASST Gaetano Pini-CTO Institute, Division of Clinical Rheumatology, Milan, Italy, Milan, Italy, ³Istituto Nazionale Genetica Molecolare, Padiglione Romeo ed Enrica Invernizzi, Milan, Italy, ⁴Policlinico S. Matteo University, Pavia, Italy
Background/Purpose: Observational data have shown that rheumatic patients seem not to be more susceptible to SARS-CoV-2 infection neither to worse outcomes. However, the true prevalence…
Abstract Number: 0370 • ACR Convergence 2021
Awareness and Attitudes Regarding Axial Spondyloarthritis Among Primary Care Providers
Yuliya Afinogenova¹, Swetha Ann Alexander², Narinder Maheshwari³, Sonam Kiwalkar⁴ and Abhijeet Danve⁵, ¹Yale School of Medicine, Hamden, CT, ²University of Connecticut, Hartford, CT, ³UConn Health, West Hartford, CT, ⁴The Vancouver Clinic, Portland, OR, ⁵Yale University, Rocky Hill, CT
Background/Purpose: There is significant discrepancy between population and diagnostic prevalence of axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS) in the US. Delayed and missed diagnosis…
Abstract Number: 0491 • ACR Convergence 2021
Bimekizumab Long-Term Safety and Efficacy in Patients with Ankylosing Spondylitis: Interim Results After 3 Years of Treatment in an Ongoing Phase 2b Study
Lianne Gensler¹, Atul Deodhar², Désirée van der Heijde³, Denis Poddubnyy⁴, Alan Kivitz⁵, Maxime Dougados⁶, Natasha de Peyrecave⁷, Marga Oortgiesen⁸, Thomas Vaux⁹, Carmen Fleurinck⁷ and Xenofon Baraliakos¹⁰, ¹Department of Rheumatology, University of California San Francisco, San Francisco, CA, ²Oregon Health & Science University, Portland, OR, ³Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands, ⁴Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, ⁵Altoona Center for Clinical Research, Duncansville, PA, ⁶Université de Paris . Department of Rheumatology - Hôpital Cochin. Assistance Publique - Hôpitaux de Paris . INSERM (U1153): Clinical epidemiology and biostatistics, PRES Sorbonne Paris-Cité. Paris, France., Paris, France, ⁷UCB Pharma, Brussels, Belgium, ⁸UCB Pharma, Raleigh, NC, ⁹UCB Pharma, Slough, United Kingdom, ¹⁰Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany
Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody that selectively inhibits both interleukin (IL)-17F and IL-17A, has been demonstrated to be efficacious and well tolerated in…
Abstract Number: 0915 • ACR Convergence 2021
Biomarkers of Extracellular Matrix Turnover Reflect Treatment Response and Pharmacodynamic Effects of TNF-α Inhibitory Therapy in Patients with Axial Spondyloarthritis
Helena Port Linares¹, Signe Holm Nielsen², Peder Frederiksen³, Sofie Falkenløve Madsen⁴, Anne-Christine Bay-Jensen⁵, Morten Karsdal⁵, Inge Juul Sørensen⁶, Bente Jensen⁷, Anne Gitte Loft⁸, Ole Rintek Madsen⁷, Mikkel Ostergaard⁹ and Susanne Pedersen¹⁰, ¹Nordic Bioscience and University of Copenhagen, School of Health and Medical Sciences, Copenhagen, Denmark, ²Nordic Bioscience and Technical University of Denmark, Biomedicine and Biotechnology, Kgs. Lyngby, Herlev, Denmark, ³Nordic Bioscience, Herlev, Copenhagen, Denmark, ⁴University of Copenhagen, School of Health and Medical Sciences, Herlev, Copenhagen, Denmark, ⁵Nordic Bioscience, Herlev, Denmark, ⁶Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, ⁷Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, ⁸Aarhus University Hospital, Aarhus, Denmark, ⁹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark, ¹⁰Rigshospitalet, Center for Arthritis Research, Glostrup, Denmark
Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory disease associated with extracellular matrix (ECM) remodeling of the cartilage, bone, and connective tissues. Quantification of ECM-mediated…
Abstract Number: 0975 • ACR Convergence 2021
Data-driven MRI Definitions for Active and Structural Sacroiliac Joint Lesions in Juvenile Spondyloarthritis Typical of Axial Disease
Pamela Weiss¹, Timothy Brandon¹, Amita Aggarwal², Ruben Burgos-Vargas³, Robert Colbert⁴, Gerd Horneff⁵, Rik Joos⁶, Ronald Laxer⁷, Kirsten Minden⁸, Angelo Ravelli⁹, Nicolino Ruperto¹⁰, Judith Smith¹¹, Matthew Stoll¹², Shirley Tse⁷, Filip Van den Bosch¹³, Robert Lambert¹⁴, David Biko¹⁵, Nancy Chauvin¹⁶, Michael Francavilla¹⁵, Jacob Jaremko¹⁴, Nele Herregods¹⁷, Ozgur Kasapcopur¹⁸, Mehmet YILDIZ¹⁹, Alison Hendry²⁰ and Walter Maksymowych²¹, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, ³Department of Rheumatology, General Hospital of Mexico, Ciudad de Mxico, Mexico, ⁴NIH/NIAMS, Bethesda, MD, ⁵Paediatric Rheumatology International Trials Organisation (PRINTO), Sankt Augustin, Germany, ⁶Ghent University, Ghent, Belgium, ⁷SickKids, Toronto, ON, Canada, ⁸German Rheumatism Research Center, Berlin, Germany, ⁹Istituto Giannina Gaslini, Genoa, Italy, ¹⁰IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy, ¹¹University of Wisconsin, Madison, WI, ¹²University of Alabama at Birmingham, Birmingham, AL, ¹³Dept. of Rheumatology - Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, ¹⁴University of Alberta, Edmonton, AB, Canada, ¹⁵University of Pennsylvania, Philadelphia, PA, ¹⁶Penn State Health, Hershey, PA, ¹⁷Universitair Ziekenhuis Ghent, Ghent, Belgium, ¹⁸Istanbul University-Cerrahpasa, Cerrahpasa Medical School, İstanbul, Turkey, ¹⁹Istanbul University-Cerrahpasa, Faculty of Medicine, Pediatric Rheumatology, İstanbul, Turkey, ²⁰NZ Familial GI Cancer Service, Auckland, New Zealand, ²¹Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada
Background/Purpose: Determining optimal cut-offs for active and structural imaging lesions of juvenile spondyloarthritis (JSpA) with axial disease is important for diagnosis, therapeutic management, and classification.…
Abstract Number: 1322 • ACR Convergence 2021
Body Mass Index (BMI) Underestimates Obesity in Females with Axial Spondyloarthropathy
Sinead Maguire¹, Wilson Fiona², Phil Gallagher³ and Finbar (Barry) O'Shea¹, ¹St James's Hospital, Dublin, Ireland, ²Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland, ³St Vincent's Hospital, Dublin, Ireland
Background/Purpose: Worldwide prevalence of obesity has been steadily increasing, despite public health campaigns to raise awareness. In axial spondyloarthropathy (axSpA) obesity has been shown to…
Abstract Number: 1802 • ACR Convergence 2021
Comparison of Axial and Peripheral Manifestations in Patients with Psoriatic Arthritis and Ankylosing Spondylitis in Upadacitinib Clinical Trials
Xenofon Baraliakos¹, Atul Deodhar², Roberto Ranza³, Simona Rednic⁴, Francesco Ciccia⁵, Fabiana Ganz⁶, Tianming Gao⁶, Apinya Lertratanakul⁶, In-Ho Song⁶, Andrew Ostor⁷ and Laura Coates⁸, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, ²Oregon Health & Science University, Portland, OR, ³Hospital de Clinicas, Universidade Federal de Uberlândia, Uberlandia, MG, Brazil, ⁴Emergency Clinical County Hospital, Rheumatology and Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania, ⁵University of Campania “Luigi Vanvitelli", Naples, Italy, ⁶Abbvie Inc., North Chicago, IL, ⁷Monash University, Cabrini Hospital, and Emertius Research, Malvern, Australia, ⁸Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom
Background/Purpose: Axial, peripheral, and other disease manifestations often overlap between psoriatic arthritis (PsA) and ankylosing spondylitis (AS). Upadacitinib (UPA) is an oral Janus kinase inhibitor…
Abstract Number: 0099 • ACR Convergence 2021
First Results of the BELCOMID Study: BELgian Cohort Study of COVID-19 in Immune Mediated Inflammatory Diseases (IMID)
Kurt de Vlam¹, Jeroen Geldhof², Marie Truyens³, Joao Sabino⁴, Marc ferrante⁴, Jo Lambert³, Hilde lapeere³, Tom hillary⁴, an Van Laethem⁴, Triana Lobaton³, severine vermeire⁴, Barbara Neerinckx¹ and Patrick Verschueren⁵, ¹University Hospitals Leuven, Leuven, Belgium, ²University Hospital Gent, Gent, Belgium, ³university hospital gent, gent, ⁴university hospitals leuven, leuven, ⁵University Hospitals Leuven - KULeuven, Leuven, Belgium
Background/Purpose: It has been suggested that 100% of SARS-CoV2 infections leads to development of specific IgG antibodies that remain detectable for a long period of…
Abstract Number: 0371 • ACR Convergence 2021
Self-referral Strategy for Early Diagnosis of Axial Spondyloarthritis- Preliminary Analysis from Finding Axial Spondyloarthritis Study
Yuliya Afinogenova¹, Swetha Ann Alexander², Andrew Haims³ and Abhijeet Danve⁴, ¹Yale School of Medicine, Hamden, CT, ²University of Connecticut, Hartford, CT, ³Yale School of Medicine, New Haven, CT, ⁴Yale University, Rocky Hill, CT
Background/Purpose: Lack of timely rheumatology referral for suspected axial spondyloarthritis (axSpA) is a major contributor to delayed diagnosis in patients with chronic back pain (CBP).…
Abstract Number: 0567 • ACR Convergence 2021
Determinants of Health-Related Quality of Life in Spondyloarthritis and Comparison with Chronic Low Back Pain – Results from a Nation-Wide Study
Helena Santos¹, Ana Rita Henriques², Ana Maria Rodrigues³, Jaime Branco³ and Helena Canhao³, ¹Portuguese Institute of Rheumatology, Lisbon, Portugal, ²EpiDoC Unit, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal, ³EpiDoC Unit, CEDOC, NOVA Medical School, Comprehensive Health Research Centre (CHRC), Lisbon, Portugal
Background/Purpose: Spondyloarthritis (SpA) causes pain, fatigue, stiffness, loss of physical function and impaired health-related quality of life (HRQoL).This study aims to: 1) to compare HRQoL…

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