Abstracts tagged "spondyloarthritis"

Abstract Number: 0899 • ACR Convergence 2020
Secukinumab Provides Significant Improvement of Spinal Pain and Lowers Disease Activity in Patients with Axial Spondyloarthritis: 24-week Results from a Randomized Controlled Phase 3b Trial
Denis Poddubnyy¹, Effie Pournara², Agnieszka Zielinska³, Asta Baranauskaite⁴, Alejandro Muñoz Jiménez⁵, Sanchayita Sadhu⁶, Barbara Schulz², Michael Rissler², Chiara Perella² and Helena Marzo-Ortega⁷, ¹Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Novartis Pharma AG, Basel, Switzerland, ³Medycyna Kliniczna, Warszawa, Poland, ⁴Lithuanian University of Health Sciences, Kaunas, Lithuania, ⁵H. U. Virgen del Rocío (Sevilla), Sevilla, Spain, ⁶Novartis Healthcare Private Limited, Hyderabad, Telangana, India, ⁷The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom
Background/Purpose: SKIPPAIN (NCT03136861) is the first randomized controlled study involving a biological disease modifying antirheumatic drug, with spinal pain as the primary endpoint as early…
Abstract Number: 1321 • ACR Convergence 2020
Central Sensitization, Disease Perception and Obesity Should Be Taken into Account When Interpreting Disease Activity in Patients with Axial Spondyloarthritis
Stan Kieskamp¹, Davy Paap², Marllies Carbo¹, Freke Wink³, Reinhard Bos⁴, Hendrika Bootsma¹, Suzanne Arends⁵ and Anneke Spoorenberg⁵, ¹University Medical Centre Groningen, Groningen, Netherlands, ², Department of Rehabilitation Medicine, University of Medical Centre Groningen, Groningen, Netherlands, ³Medical Centre Leeuwarden, Leeuwarden, Netherlands, ⁴Medical Centre Leeuwarden, Leeuwarden, ⁵University Medical Centre Groningen and Medical centre Leeuwarden, Groningen, Netherlands
Background/Purpose: Up to 40% of ankylosing spondylitis patients report persistently high pain scores of >4 (scale of 0-10) even after responding to long-term TNF-α blocking…
Abstract Number: 1370 • ACR Convergence 2020
A Delayed Effect of Tumor Necrosis Factor Inhibitors on Radiographic Spinal Progression in Patients with Axial Spondyloarthritis: Long-term Results from the German Spondyloarthritis Inception Cohort
Denis Poddubnyy¹, Valeria Rios Rodriguez², Murat Torgutalp², Ani Dilbaryan², Maryna Verba², Mikhail Protopopov², Fabian Proft², Judith Rademacher², Hildrun Haibel², Joachim Sieper² and Martin Rudwaleit³, ¹Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany
Background/Purpose: There are inconclusive data on the effect of tumor necrosis factor inhibitors (TNFi) on radiographic spinal progression in axial spondyloarthritis (axSpA). Although inflammation and…
Abstract Number: 1853 • ACR Convergence 2020
Association of Gut Dysbiosis with Radiographic and Enthesis Involvement, Disease Activity and Duration in Axial Spondyloarthritis. Data from CASTRO Registry
Ignacio Gómez-García¹, Isabel Moreno-Indias², María-Carmen Abalos-Aguilera¹, Clementina Lopez-Medina³, Lourdes Ladehesa-Pineda⁴, Concepción Aranda-Valera⁴, Carolina Gutierrez-Repiso², Yolanda Jimenez-Gomez⁵, Nuria Barbarroja¹, Chary Lopez-Pedrera¹, Francisco-Jose Tinahones², Eduardo Collantes-Estévez⁴, Alejandro Escudero-Contreras⁴ and Patricia Ruiz-Limon⁶, ¹Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ²Biomedical Research Institute of Malaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain/ CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain, Malaga, Spain, ³Rheumatology Department, Cochin Hospital, Paris, Paris, France, ⁴Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, ⁵Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, ⁶Biomedical Research Institute of Málaga (IBIMA)/ Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Malaga, Spain, Malaga, Spain
Background/Purpose: The etiopathogenesis of axial spondyloarthritis (AxSpA) is multifactorial. The possible role of alteration in gut microbiome (dysbiosis) has been recently suggested. However, the association…
Abstract Number: 1881 • ACR Convergence 2020
In Radiographic Axial Spondyloarthritis, Bridging Syndesmophytes Increase Risk of Facet Joint Ankylosis Development on the Same Vertebral Level While Facet Joint Ankylosis Does Not Increase Risk of Same Level Syndesmophytes Development
Rosalinde Stal¹, Alexandre Sepriano², Floris van Gaalen³, Xenofon Baraliakos⁴, Rosaline van den Berg¹, Monique Reijnierse¹, Juergen Braun⁵, Robert Landewé⁶ and Désirée van der Heijde¹, ¹Leiden University Medical Center, Leiden, Netherlands, ²Leiden University Medical Center, Portela Loures, Portugal, ³Leiden University Medical Center (LUMC), Leiden, Netherlands, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ⁵Rheumazentrum Ruhrgebiet and Ruhr-University, 44649 Herne, Germany, ⁶Amsterdam University Medical Center & Zuyderland Hospital, Amsterdam, Netherlands
Background/Purpose: In radiographic axial spondyloarthritis (r-axSpA), spinal damage manifests as syndesmophytes and facet joint ankylosis (FJA). Whether there is an order in which lesion develops…
Abstract Number: 2016 • ACR Convergence 2020
Baseline Serum Biomarker Levels Predict Spinal Radiographic Progression in Ankylosing Spondylitis Patients on TNF Inhibitor Therapy
Judith Rademacher¹, Mark Siderius², Laura Gellert¹, Freke Wink³, Maryna Verba¹, Fiona Maas⁴, Lorraine M Tietz¹, Denis Poddubnyy⁵, Anneke Spoorenberg³ and Suzanne Arends³, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³University Medical Centre Groningen and Medical centre Leeuwarden, Groningen, Netherlands, ⁴University medical Centre Groningen, Groningen, Netherlands, ⁵Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Radiographic spinal progression determinates functional status and mobility in ankylosing spondylitis (AS) (Poddubnyy et al, 2018). Our objective was to analyze whether biomarker levels…
Abstract Number: 0160 • ACR Convergence 2020
Use of PROMIS29 Across Inflammatory Arthritis: Score Distributions and Impact of Contextual Factors
Alexis Ogdie¹, Kaleb Michaud², Mark Hwang³, Sofia Pedro⁴ and Patricia Katz⁵, ¹University of Pennsylvania, Philadelphia, PA, ²FORWARD-The National Data Bank for Rheumatic Diseases; University of Nebraska Medical Center, Wichita, ³McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁴FORWARD-The National Data Bank for Rheumatic Diseases, Wichita, ⁵University of California, San Francisco, Novato, CA
Background/Purpose: The Patient-Reported Outcome Measure Information System (PROMIS) includes a set of instruments developed to measure physical, mental and social health. PROMIS measures have been…
Abstract Number: 0505 • ACR Convergence 2020
Secukinumab Provides Sustained Improvements in Clinical and Imaging Outcomes in Patients with Psoriatic Arthritis and Axial Manifestations: Results from the MAXIMISE Trial
Xenofon Baraliakos¹, Laure Gossec², Effie Pournara³, Slawomir Jeka⁴, Ricardo Blanco⁵, Salvatore D'Angelo⁶, Georg Schett⁷, Barbara Schulz³, Michael Rissler³, Dermot Whyms⁸, Chiara Perella³ and Laura Coates⁹, ¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ²Sorbonne Université and Hôpital Universitaire Pitié Salpêtrière, Paris, France, ³Novartis Pharma AG, Basel, Switzerland, ⁴2nd Univ Hospital, CM UMK, Bydgoszcz, Poland, ⁵Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ⁶Rheumatology Department of Lucania and Rheumatology Institute of Lucania (IRel), San Carlo Hospital of Potenza, Potenza, Italy, ⁷Friedrich-Alexander-Universität Erlangen- Nuremberg, Erlangen, Germany, ⁸Novartis Ireland Limited, Dublin, Ireland, ⁹University of Oxford, Oxford, United Kingdom
Background/Purpose: Axial disease may affect up to 25–70% of psoriatic arthritis (PsA) patients, depending on the definition used. Current evidence on efficacy of biologics in…
Abstract Number: 0900 • ACR Convergence 2020
Achievement of Low Disease Activity According to BASDAI with Ixekizumab in Patients with Axial Spondyloarthritis: 16-Week Results from the COAST Trials
Denis Poddubnyy¹, Xavier Juanola², Clément Prati³, Hagen Russ⁴, Yves Schymura⁴, Soyi Liu-Leage⁵, Mani Haschemi Nassab⁴ and Jean Dudler⁶, ¹Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Rheumatology Service, University Hospital Bellvitge, IDIBELL, Barcelona, Spain, Barcelona, Spain, ³Service de Rhumatologie, Hôpital Jean-Minjoz , Besançon, France, Besançon, France, ⁴Eli Lilly and Company, Indianapolis, Indiana, USA, Indianapolis, IN, ⁵Eli Lilly and Company, Indianapolis, IN, ⁶Department of Rheumatology, HFR Fribourg - Hospital Cantonal, Fribourg, Switzerland, Fribourg, Switzerland
Background/Purpose: The efficacy of ixekizumab (IXE), a selective interleukin-17A antagonist, was assessed in patients (pts) with axial SpA (axSpA) in three Phase 3, randomized, double-blind,…
Abstract Number: 1322 • ACR Convergence 2020
Prevalence and Associated Factors of Sleep Disorders in Patients with Axial Spondyloarthritis. Results from the European Map of Axial Spondyloarthritis (EMAS)
Marco Garrido-Cumbrera¹, Victoria Navarro-Compán², Laura Christen³, Christine Bundy⁴, Raj Mahapatra⁵, Souzi Makri⁶, Carlos-Jesus Delgado-Domínguez⁷, José Correa-Fernández⁸ and Denis Poddubnyy⁹, ¹Health & Territory Research (HTR), Universidad de Sevilla / Spanish Federation of Spondyloarthritis Associations, Sevilla, Spain, ²Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain, ³Novartis Pharma AG, Basel, Switzerland, ⁴Cardiff University, Cardiff, United Kingdom, ⁵Axial Spondyloarthritis International Federation, London, United Kingdom, ⁶Cyprus League Against Rheumatism, Nicosia, Cyprus, ⁷Health & Territory Research, Seville, Spain, ⁸Health & Territory Research (HTR), Universidad de Sevilla, Sevilla, Spain, ⁹Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Sleep is an essential health aspect that is often impacted in patients with axial spondyloarthritis (axSpA). This analysis aims to assess the prevalence and…
Abstract Number: 1374 • ACR Convergence 2020
Secukinumab in the Treatment of Dactylitis in Patients with Psoriatic Arthritis: Post Hoc Analysis Results from a Randomized Phase 3 Trial
Bruce Kirkham¹, Peter Nash², Sandra Navarra³, Erhard Quebe-Fehling⁴, Corine Gaillez⁴, Carlos Sastre⁴ and Philip Mease⁵, ¹Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom, ²School of Medicine Griffith University, Brisbane, Queensland, Australia, ³University of Santo Tomas, Manila, Philippines, ⁴Novartis Pharma AG, Basel, Switzerland, ⁵Seattle Rheumatology Associates, P.L.L.C., Seattle, WA
Background/Purpose: Dactylitis is a key and frequent clinical manifestation of psoriatic arthritis (PsA)1 associated with significant disease burden and impaired function.2–3 Randomized controlled trials designed…
Abstract Number: 1855 • ACR Convergence 2020
Elevated Calprotectin Levels Reveal Loss of Vascular Pattern and Atrophy of Villi in Ileum Using Digital Chromo-endoscopy and Magnification Colonoscopy in Patients with Spondyloarthritis Without Inflammatory Bowel Disease
Consuelo Romero-Sanchez¹, Cristian Florez-Sarmiento², Valerie Khoury-Rosas³, Wilson Bautista-Molano⁴, Magaly Chamorro-Melo⁵, Diego Alejandro Jaimes⁶, Adriana Beltran-Ostos⁷, Juliette De Avila⁸, Alejandro Ramos-Casallas⁸, Juan Manuel Bello-Gualtero⁹, Jaiber Gutierrez⁵, Cesar Pacheco Tena¹⁰, Philipe Chalem Choueka¹¹ and Viviana Parra-Izquierdo¹², ¹Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada / Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada /Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, ²Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo- / Grastroadvanced SAS, Bogotá D.C., Colombia, ³Universidad EL Bosque / School of Medicine, Bogotá D.C., Colombia, ⁴University Hospital Fundación Santa Fé de Bogotá and Universidad El Bosque, Bogotá, Colombia, ⁵Hospital Militar Central, Rheumatology and Immunology Department, School of Medicine, Bogotá D.C., Colombia, ⁶Clínicos IPS- Universidad de la Sabana, Bogotá D.C., Colombia, ⁷Hospital Militar Central, Subdirección de docencia e Investigación, Bogotá D.C., Colombia, ⁸Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo-, School of Dentistry, Bogotá D.C., Colombia, ⁹Hospital Militar Central, Rheumatology and Immunology Department, Universidad Militar Nueva Granada/ Clinical Immunology Group, Hospital Militar Central, School of Medicine, Universidad Militar Nueva Granada, Bogotá D.C., Colombia, ¹⁰Universidad Autonoma de Chihuahua, Chihuahua, Chihuahua, Mexico, ¹¹Fundacion Instituto de Reumatología Fernando Chalem, Universidad El Rosario, Bogotá D.C., Colombia, ¹².Universidad El Bosque, Cellular and Molecular Immunology Group -InmuBo- / Grastroadvanced SAS, Bogotá D.C., Colombia
Background/Purpose: Fecal calprotectin (FC) is a well bio-marker related to mucosal inflammation. Digital chromo-endoscopy (DCE) with magnification is a technique to identify microscopic inflammation. The…
Abstract Number: 1882 • ACR Convergence 2020
Are There Any Clues to Predict Bamboo Spine in Axial Spondyloarthritis?
Pamir Atagündüz¹, Sedat Kiraz², Servet Akar³, Orhan Küçükşahin⁴, Abdulsamet Erden⁴, Nihan Coşkun⁵, Burcu Yağız⁵, Cemal Bes⁶, Levent Kılıç⁷, Ömer Karadağ⁷, Timuçin Kaşifoğlu⁸, Hakan Emmungil⁹, Muhammet Çınar¹⁰, Gezmiş Kimyon¹¹, Veli Yazısız¹², Askin Ates¹³, Emine Duygu Ersozlu¹⁴, Emel Gönüllü¹⁵, Rıdvan Mercan¹⁶, İhsan Ertenli² and Umut Kalyoncu², ¹Marmara University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, İstanbul, Turkey, ²Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ³Izmir Katip Celebi University, Izmir, Turkey, ⁴Yıldırım Beyazıt University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology,, Ankara, Turkey, ⁵Uludag University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Bursa, Turkey, ⁶Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Bolu, Turkey, ⁷Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara,, Ankara, Turkey, ⁸Eskisehir Osmangazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Eskişehir, Turkey, ⁹Trakya University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Edirne, Turkey, ¹⁰University of Health Sciences, Gulhane Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ¹¹Hatay Mustafa Kemal University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology,, Hatay, Turkey, ¹²Akdeniz University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology,, Antalya, Turkey, ¹³Ankara University, Ankara, Turkey, ¹⁴Ministry of Health Adana City Hospital, Adana, Turkey, ¹⁵Sakarya University, Department of Internal Medicine, Division of Rheumatology, Sakarya, Turkey, ¹⁶Tekirdag Namik Kemal University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology,, Tekirdağ, Turkey
Background/Purpose: Complete ankylosis of the entire spinal column is a severe condition seen in spondyloarthritis. This study aims to investigate the possible risk factors associated…
Abstract Number: 2018 • ACR Convergence 2020
Development and Validation of an Artificial Intelligence Approach for the Detection of Radiographic Sacroiliitis
Keno-Kyrill Bressem¹, Janis Vahldiek¹, Lisa Adams¹, Stefan Niehues¹, Hildrun Haibel¹, Valeria Rios Rodriguez¹, Murat Torgutalp¹, Mikhail Protopopov¹, Fabian Proft¹, Judith Rademacher¹, Joachim Sieper¹, Martin Rudwaleit², Bernd Hamm¹, Markus Makowski¹, Kay-Geert Hermann¹ and Denis Poddubnyy³, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²Department of Internal Medicine and Rheumatology, Klinikum Bielefeld, Germany, ³Charité – Universitätsmedizin Berlin, Berlin, Germany
Background/Purpose: Conventional radiography of the sacroiliac joints is still recommended as the first imaging method if axial spondyloarthritis (axSpA) is suspected. Furthermore, radiographic sacroiliitis is…
Abstract Number: 0182 • ACR Convergence 2020
Chronic Kidney Disease Is Underestimated in Patients with Rheumatoid Arthritis – Real World Data Gathered from a Network of Rheumatologists
Stefan Kleinert¹, Peter Bartz-Bazzanella², Cay von der Decken³, Kirsten Karberg⁴, Florian Schuch⁵, Georg Gauler⁶, Patrick Wurth⁷, Susanna Spaethling-Mestekemper⁸, Christoph Kuhn⁹, Matthias Englbrecht¹⁰, Wolfgang Vorbrueggen¹¹ and Martin Welcker¹², ¹Rheumatology-Nephrology Practice, Erlangen, Germany, ²Department of Rheumatology, Internal Medicine, Rhein-Maas-Hospital, Wuerselen, Germany, ³Medical Centre Stolberg, Stolberg, Germany, ⁴Practice for Rheumatology and Internal Medicine, Berlin, Germany, ⁵Rheumatology-Nephrology Practice, Erlangen, ⁶Rheumatology Practice, Osnabrueck, ⁷Rheumatology Practice, Osnabrueck, Germany, ⁸Rheumatology Group Practice, Muenchen, Germany, ⁹Rheumatology Practice, Karlsruhe, ¹⁰Freelance Healthcare Data Scientist, Eckental, Germany, ¹¹Foundation for fostering rheumatology, Wuerselen, Germany, ¹²MVZ für Rheumatologie Dr. M. Welcker, Planegg, Germany
Background/Purpose: Patient registries have become a common approach to learn from patient-related data by prospectively including large numbers of individuals into a sample followed over…

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