Abstracts tagged "spondyloarthritis"

Abstract Number: 0417 • ACR Convergence 2022
Treating Spondyloarthritis Early: Does It Matter? Results from a Systematic Literature Review
Dafne Capelusnik¹, Diego Benavent², Désirée van der Heijde³, Robert Landewé⁴, Denis Poddubnyy⁵, Astrid van Tubergen⁶, Louise Falzon⁷, Victoria Navarro-Compán⁸ and Sofia Ramiro⁹, ¹Instituto de Rehabilitación Psicofísica (IREP), Buenos Aires, Argentina, ²La Paz University Hospital, Madrid, Spain, ³Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁶Maastricht UMC+, Maastricht, Netherlands, ⁷Health Economics and Decision Science, School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom, ⁸Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁹Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The ASAS-SPEAR (SPondyloarthritis EARly definition) project aims to develop a consensual definition of early SpA. Therefore, it is important to know whether treatment earlier…
Abstract Number: 0857 • ACR Convergence 2022
Consensus-Driven Definition for Unequivocal Sacroiliitis on Radiographs for Classification in Juvenile Spondyloarthritis
Pamela Weiss¹, Timothy Brandon², Robert G Lambert³, David Biko⁴, Nancy Chauvin⁵, Michael Francavilla⁴, Nele Herregods⁶, Alison Hendry⁷ and Walter P Maksymowych⁸, ¹Children's Hospital of Philadelphia, Glen Mills, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³University of Alberta, Edmonton, AB, Canada, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Penn State Health, Hershey, PA, ⁶Ghent University Hospital, Ghent, Belgium, ⁷Middlemore Hospital, Auckland, ⁸Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Radiographs are neither sensitive nor reliable in assessment of axial disease in juvenile spondyloarthritis (JSpA). However, they are still performed in some areas due…
Abstract Number: 1044 • ACR Convergence 2022
Combined Biological or Targeted Therapy in Spondyloarthritis: Experience from a Multicenter Case Series in Spain
cristina Valero-Martinez¹, Judith Font Urguelles², Meritxell Sallés³, BEATRIZ E. JOVEN⁴, Felipe Julio Ramirez Garcia⁵, Xavier Juanola⁶, Raquel Almodóvar⁷, ana Laiz⁸, Mireia Moreno⁹, Manel Pujol¹⁰, Luis Sala-Icardo¹¹, Santos Castañeda¹² and Rosario Garcia-Vicuña¹, ¹Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain, ²Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Althaia Xarxa Assistencial Universitària, Manresa, Spain, ⁴Hospital Universitario 12 de Octubre, Madrid, Spain, ⁵Hospital Clínic, Barcelona, Spain, ⁶Hospital Universitari Bellvitge, Hospitalet de Llobregat, Barcelona, Spain, ⁷Hospital Universitario Fundación Alcorcón, Madrid, Spain, ⁸Unitat Territorial de Reumatologia Sant Pau-Dos de Maig, Barcelona, Spain, ⁹Hospital Universitari Parc Taulí, Sabadell, Spain, ¹⁰Hospital Universitario MútuaTerrassa, Terrassa, Spain, ¹¹Hospital Universitario de Torrejón de Ardoz, Madrid, Spain, ¹²Division of Rheumatology, Hospital Universitario de La Princesa, IIS-Princesa, Madrid, Spain
Background/Purpose: Combined biological or targeted therapy (CBTT) is rarely considered in clinical practice due to contraindication in guidelines, potential safety concerns and high costs. However,…
Abstract Number: 1294 • ACR Convergence 2022
Translation and Cross-cultural Adaptation of the CORS into Spanish
Victoria Navarro-Compán¹, Diego Benavent², Andrea Jochems³, Dora Pascual-Salcedo³, Gijs Jochems⁴, Sofia Ramiro⁵, Wim van Lankveld⁶ and Chamaida Plasencia-Rodriguez⁷, ¹Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ²La Paz University Hospital, Madrid, Spain, ³Immuno-Rheumatology Group, Hospital Universitario La Paz, Madrid, Spain, ⁴Promega Biotech Ibérica, Madrid, Spain, ⁵Leiden University Medical Center, Leiden, Netherlands, ⁶NA, Amsterdam, Netherlands, ⁷Rheumatology Department, La Paz University Hospital, Madrid, Spain
Background/Purpose: Rheumatic diseases substantially affect the lives of patients, with complex associations between disease severity and self-perceived health status. In this regard, the Coping with…
Abstract Number: 1614 • ACR Convergence 2022
Females with Non-Radiographic but Not with Radiographic Axial Spondyloarthritis Are Less Likely to Achieve Inactive Disease State Than Males: Results from a Multicountry Prospective Observational Study
Denis Poddubnyy¹, Joachim Sieper², Servet Akar³, Santiago Muñoz-Fernández⁴, Hildrun Haibel², Torsten Diekhoff⁵, Mikhail Protopopov⁶, Elisabeth Altmaier⁷, Fabiana Ganz⁸ and Robert Inman⁹, ¹Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Charité - Universitätsmedizin, Berlin, Berlin, Germany, ³Izmir Katip Celebi University School of Medicine, Izmir, Turkey, ⁴Servicio de Reumatología, Hospital Universitario Infanta Sofía, Universidad Europea, Madrid, Spain, ⁵Department of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany, ⁶Charité Universitätsmedizin Berlin, Berlin, Germany, ⁷GKM Gesellschaft für Therapieforschung mbH, Munich, Germany, ⁸AbbVie, Inc., Luzern, Switzerland, ⁹University Health Network, Toronto, ON, Canada
Background/Purpose: Emerging evidence suggests that men and women experience axial spondyloarthritis (axSpA) differently. Some studies suggested that the probability of treatment response was lower in…
Abstract Number: 2254 • ACR Convergence 2022
Detection of Active Inflammatory and Structural Changes Indicative of Axial Spondyloarthritis on MRI of Sacroiliac Joint Using a Deep Learning Framework
Keno Kyrill Bressem¹, Lisa Adams¹, Fabian Proft², Kay-Geert Hermann³, Torsten Diekhoff¹, Laura Spiller¹, Stefan Niehues¹, Marcus Makowski⁴, Bernd Hamm¹, Mikhail Protopopov⁵, valeria Rios-Rodriguez⁶, Hildrun Haibel⁷, Judith Rademacher⁵, Murat Torgutalp⁷, Robert G Lambert⁸, Xenofon Baraliakos⁹, Walter P Maksymowych¹⁰, Janis Vahldiek¹ and Denis Poddubnyy², ¹Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ³Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴Technical University of Munich, Munich, Germany, ⁵Charité Universitätsmedizin Berlin, Berlin, Germany, ⁶Charité-Universitätsmedizin Berlin, Berlin, Germany, ⁷Charité - Universitätsmedizin, Berlin, Berlin, Germany, ⁸University of Alberta, Edmonton, AB, Canada, ⁹Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ¹⁰Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Magnetic resonance tomography (MRI) plays a key role in the early diagnosis of axial spondyloarthritis (axSpA). However, the detection of changes indicative of axSpA…
Abstract Number: 0384 • ACR Convergence 2022
Inflammation Is Associated with Incident Hypertension in Patients with Axial Spondyloarthritis: A Longitudinal Cohort Study
Jenny Lin Hong Shi¹, Steven H Lam², Ho So³, Edmund Li¹, Tena Li¹, Cheuk Chun Szeto¹ and Lai-shan Tam¹, ¹The Chinese University of Hong Kong, Hong Kong, China, ²The Chinese university of Hong Kong, Hong Kong, Hong Kong, ³The Faculty of Medicine, CUHK, Hong Kong, Hong Kong
Background/Purpose: In the general population, hypertension (HT) is reported as one of the most important risk and modifiable factors to develop CVD. It is well…
Abstract Number: 0419 • ACR Convergence 2022
Efficacy of Upadacitinib in Patients with Non-Radiographic Axial Spondyloarthritis Stratified by Objective Signs of Inflammation at Baseline
Walter P Maksymowych¹, Xenofon Baraliakos², Atul Deodhar³, Denis Poddubnyy⁴, Fabiana Ganz⁵, Tianming Gao⁶, Jayne Stigler⁶, Anna K Shmagel⁶, Peter Wung⁶ and Filip Van den bosch⁷, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ³Oregon Health & Science University, Portland, OR, USA, Portland, OR, ⁴Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁵AbbVie, Inc., Luzern, Switzerland, ⁶AbbVie, Inc., North Chicago, IL, ⁷Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium
Background/Purpose: The Phase 3 SELECT-AXIS 2 trial (NCT04169373) assessed the efficacy and safety of upadacitinib (UPA) in patients with non-radiographic axial spondyloarthritis (nr-axSpA). Here, we…
Abstract Number: 0880 • ACR Convergence 2022
Impact of Characteristic Inflammatory and Structural Imaging Lesions on Expert Classification of Axial Juvenile Spondyloarthritis
Adam Mayer¹, Timothy Brandon¹, Amita Aggarwal², Ruben Burgos vargas³, Robert Colbert⁴, Gerd Horneff⁵, Rik Joos⁶, Ronald Laxer⁷, Kirsten Minden⁸, Angelo Ravelli⁹, Nicola Ruperto¹⁰, Judith Smith¹¹, Matthew Stoll¹², Shirley Tse⁷, Filip Van den bosch¹³, Walter P Maksymowych¹⁴, Robert G Lambert¹⁵, David Biko¹⁶, Nancy Chauvin¹⁷, Michael Francavilla¹⁶, Jacob Jaremko¹⁵, Nele Herregods¹⁸, Jennifer Faerber¹, Ozgur Kasapcopur¹⁹, Mehmet YILDIZ²⁰, Alison Hendry²¹ and Pamela Weiss²², ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, ³hospital general de mexico, Ciudad de México, Mexico, ⁴NIH/NIAMS, Bethesda, MD, ⁵Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, ⁶Ghent University Hospital, Basel, Switzerland, ⁷Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁸Charité Universitätsmedizin Berlin, Berlin, Germany, ⁹Department of Neurosciences, Rehabilitation, Ophthalmology, Genetic and Maternal Infantile Sciences (DINOGMI) University of Genoa, Italy,Scientific Direction, IRCCS Istituto Giannina Gaslini, Genova, Italy, ¹⁰IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy, ¹¹University of Wisconsin, Madison, WI, ¹²University of Alabama at Birmingham, Birmingham, AL, ¹³Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, ¹⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada, ¹⁵University of Alberta, Edmonton, AB, Canada, ¹⁶University of Pennsylvania, Philadelphia, PA, ¹⁷Penn State Health, Hershey, PA, ¹⁸Ghent University Hospital, Ghent, Belgium, ¹⁹Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey, ²⁰Istanbul University-Cerrahpaşa, Istanbul, Turkey, ²¹Middlemore Hospital, Auckland, ²²Children's Hospital of Philadelphia, Glen Mills, PA
Background/Purpose: Axial disease in juvenile spondyloarthritis (JSpA) is difficult to assess in children and the role of MRI in rheumatologist diagnosis has not yet been…
Abstract Number: 1045 • ACR Convergence 2022
Quantification of the Enthesic Response to Biological Therapies in Patients with Spondyloarthritis by Computer Analysis of Ultrasound Images
Marina Tortosa Cabanas, CARLOS ANTONIO GUILLEN ASTETE and Africa Andreu Suarez, Ramon y Cajal University Hospital, Madrid, Spain
Background/Purpose: Enthesitis is the base of the pathophysiology of spondyloarthritis. Recently, our research group has shown that computer analysis of static images can be used…
Abstract Number: 1353 • ACR Convergence 2022
Dietary Practices and Beliefs of Patients with Rheumatic Diseases and Relationship with Symptoms: Results of a Multicenter Cross-sectional Study
Domitille RENARD¹, Sophie Tuffet², Philippe Dieude³, Pascal Claudepierre⁴, Laure Gossec⁵, Bruno Fautrel⁶, Anna Molto⁷, Corinne MIceli⁸, Pascal Richette⁹, Emmanuel Maheu¹⁰, Claire Carette¹¹, Sebastien Czernichow¹¹, Chloe JAMAKORZYAN¹², alexandra Rousseau², Francis Berenbaum¹³, Catherine Beauvais¹⁴ and Jérémie SELLAM¹⁵, ¹Sorbonne University Paris- Sant Antoine Hospital, Paris, France, ²Saint Antoine hospital, Paris, Ile-de-France, France, ³Université Paris Cité, Paris, France, ⁴Paris Est Creteil University, Creteil, France, ⁵Sorbonne Université, Paris, France, ⁶Sorbonne University Paris, France and Pierre Louis Institute of Epidemiology and Public Health, Paris, France, Paris, France, ⁷Rheumatology Department, Cochin Hospital, APHP, Paris, France, ⁸APHP, Paris, France, ⁹Department of Rheumatology, Hôpital Lariboisière, Assistance Publique-Hôpitaux de Paris, Paris, France, ¹⁰Hôpital Paris Saint Antoine, Moirans, Auvergne-Rhône-Alpes, France, ¹¹Hôpital Européen Georges Pompidou, Paris, France, ¹²Hopital Begin, Saint-Mandé, France, ¹³Sorbonne University - Saint-Antoine hospital, Paris, France, ¹⁴Saint Antoine hospital, Paris, France, ¹⁵Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France
Background/Purpose: Diet is a subject of questioning and beliefs among patients with rheumatic diseases. They are inclined to change their eating habits and sometimes follow…
Abstract Number: 1673 • ACR Convergence 2022
Preconceptional NSAID Treatment Exposure Is Associated with a Significantly Longer Time-to-conception in Women with Spondyloarthritis: Analysis of the Prospective GR2 Cohort
SABRINA HAMROUN¹, Marion Couderc², Rene-Marc Flipo³, Jérémie SELLAM⁴, Christophe Richez⁵, Emmanuelle Dernis⁶, Aline Frazier-Mironer⁷, Laure Gossec⁸, elisabeth gervais⁹, Hubert Marotte¹⁰, Laetitia Dunogeant¹¹, Cédric Lukas¹², Alban DEROUX¹³, Nathalie Costedoat-Chalumeau¹⁴ and Anna Molto¹⁵, ¹Rheumatology Department, University Hospital of Cochin, Paris, Paris, France, ²University Hospital, Clermont-Ferrand, France, ³CHU Lille, Boulogne-Billancourt, France, ⁴Sorbonne Universite, AP-HP, Saint-Antoine hospital, Paris, France, ⁵Université de Bordeaux, Bordeaux, France, ⁶LE MANS general hospital, LE MANS, France, ⁷APHP Hôpital Lariboisire, Paris, France, ⁸Sorbonne Université, Paris, France, ⁹chu poitiers, Poitiers, France, ¹⁰INSERM 1059, Saint-Etienne, France, ¹¹Hospital of Aix en Provence, Marseille, France, ¹²University Hospital Centre Montpellier, University of Montpellier, Montpellier, France, ¹³CHU Grenoble, Grenoble, France, ¹⁴Inserm DR Paris 5, Paris, France, ¹⁵Rheumatology Department, Cochin Hospital, APHP, Paris, France
Background/Purpose: Spondyloarthritis (SpA) is one of the most common chronic inflammatory diseases and regularly affects women of childbearing age. However, there is limited knowledge about…
Abstract Number: 2257 • ACR Convergence 2022
MRI Spinal Lesions in Patients Without MRI or Radiographic Lesions in the Sacroiliac Joints Typical of Axial Spondyloarthritis
Walter P Maksymowych¹, Mikkel Østergaard², Xenofon Baraliakos³, Pedro Machado⁴, Susanne J. Pedersen⁵, Ulrich Weber⁶, Iris Eshed⁷, Manouk de Hooge⁸, Joachim Sieper⁹, Denis Poddubnyy¹⁰, Martin Rudwaleit¹¹, Désirée van der Heijde¹², Robert Landewé¹³ and Robert G Lambert¹⁴, ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Rigshospitalet, University of Copenhagen, Glostrup, Denmark, ³Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁴University College London, London, United Kingdom, ⁵Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, ⁶Practice Buchsbaum Schaffhausen, Schaffhausen, Switzerland, ⁷Sheba Medical Center, Tel Aviv, Israel, ⁸Ghent University Hospital, Luxembourg, Luxembourg, ⁹Charité - Universitätsmedizin, Berlin, Berlin, Germany, ¹⁰Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ¹¹University of Bielefeld, Klinikum Bielefeld, Bielefeld; Germany Klinikum Bielefeld and Charité Berlin, Germany, and Gent University, Gent, Belgium, ¹²Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ¹³Amsterdam University Medical Center, Meerssen, Netherlands, ¹⁴University of Alberta, Edmonton, AB, Canada
Background/Purpose: There is limited data as to the frequency of spinal lesions on MRI in patients without MRI or radiographic features typical of sacroiliac joint…
Abstract Number: 0386 • ACR Convergence 2022
Quantitative Proteomic Screening Uncovers Diagnostic and Monitoring Serum Biomarkers of Ankylosing Spondylitis
Mark Hwang¹, Jessica Castillo², kamala Vanarsa², Jim Zheng³, Shervin Assassi⁴, Chandra Mohan² and John Reveille⁵, ¹McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ²University of Houston, Houston, TX, ³UTHealth School of Bioinformatics, Houston, TX, ⁴McGovern Medical School, University of Texas, Houston, TX, ⁵University of Texas McGovern Medical School, Houston, TX
Background/Purpose: We sought to discover novel serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity. Methods: We used biologic-treatment naïve AS and…
Abstract Number: 0420 • ACR Convergence 2022
What Does It Mean – A Good Response to NSAIDs? A Systematic Comparison of Patients with Axial Spondyloarthritis and Controls with Chronic Back Pain
Xenofon Baraliakos¹, Imke Redeker², Elena Bergmann³, Styliani Tsiami⁴ and Juergen Braun⁵, ¹Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ²Rheumazentrum Ruhrgebiet Herne, Ruhr University Bochum, Bochum, Germany, ³Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁴Rheumazentrum Ruhrgebiet, Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: A fast response to NSAIDs is an important finding in the evaluation of clinical findings within the items comprising the ASAS classification criteria but…

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