Abstracts tagged "spondyloarthritis"

Abstract Number: 0981 • ACR Convergence 2023
Time Trends in Overall Infection Risk in Patients with Inflammatory Arthritides Treated with Tumor Necrosis Factor Inhibitors
Aron Hjalti Bjornsson¹, Telma Thrastardottir², Bjorn Gudbjornsson³ and Thorvardur Love⁴, ¹Landspitali University Hospital and the University of Iceland, Reykjavík, Iceland, ²University of Iceland, Reykjavik, Iceland, ³Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland, ⁴Landspitali University Hospital and the University of Iceland, Reykjavik, Iceland
Background/Purpose: Infections are a known complication of disease-modifying therapy in rheumatic patients but have also been associated with the diseases being treated. Biosimilars have increased…
Abstract Number: 1402 • ACR Convergence 2023
Exceeding Activity Targets but Missing the Mark with Sleep: Mapping 24-Hour Movement Guidelines in Axial Spondyloarthritis
Laura Passalent¹, Tina Ko¹, Yangqing Deng², Sunita Mathur³, Mark Abovsky⁴, Igor Jurisica⁵, Nigil Haroon⁶ and Robert Inman⁷, ¹Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, ²Department of Biostatistics, University Health Network, Toronto, ON, Canada, ³School of Rehabilitation Therapy, Queen's University, Kingston, ON, Canada, ⁴Krembil Research Institute, University Health Network, Toronto, ON, Canada, ⁵Schroeder Arthritis Institute, Krembil Research Institute and Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, ⁶University of Toronto, University Health Network, Schroeder Arthritis Institute, Department of Medicine/Rheumatology, Toronto, ON, Canada, ⁷University Health Network, Toronto, ON, Canada
Background/Purpose: The Canadian 24-Hour Movement Guidelines were recently published in 2022 and integrate evidence-based targets for physical activity, sleep and sedentary behaviours, with recommendations regarding…
Abstract Number: 1783 • ACR Convergence 2023
Integrative Functional Genomics Points to Natural Killer Cells as Key Drivers in the Pathogenesis of Ankylosing Spondylitis
Marcos Chiñas¹, Daniela Fernandez-Salinas¹, Vitor Aguiar¹, Victor Caballero-Nieto², Micah Lefton³, Joerg Ermann⁴ and Maria Gutierrez-Arcelus¹, ¹Boston Children's Hospital, Boston, MA, ²Boston Children's Hospital, Montpellier, France, ³Brigham and Women's Hospital, Boston, MA, ⁴Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Multiple lines of evidence indicate that ankylosing spondylitis (AS) is a lymphocyte-driven disease. However, which lymphocyte populations are critical in AS pathogenesis is not…
Abstract Number: 2145 • ACR Convergence 2023
Patterns of Use, Effectiveness, Persistence and Cardiovascular Risk in Patients with Rheumatic Diseases Treated with Upadacitinib in a Real-world Setting. UPAREAL Study
Alicia Garcia Dorta¹, Andrea Hernández Martín², Cristina Rodríguez Regalado³, Sonia Isis Peña Montelongo⁴, Cristina Martínez González⁵, Elena Naveda-González², Enrique González-Dávila⁶, Jose Federico Diaz-Gonzalez⁷ and maría Vanesa Hernández Hernández⁵, ¹Rheumatology Unit, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, ²Rheumatology Unit, Hospital Universitario Dr Negrín, Las Palmas de Gran Canaria, Spain, ³Rheumatology Unit, Hospital Universitario Ntra Sra de la Candelaria, Santa Cruz de Tenerife, Spain, ⁴Rheumatology Unit, Hospital Virgen de la Peña, Fuerteventura, Spain, ⁵Rheumatology Unit, Hospital Universitario de Canarias, San Cristobal de la Laguna, Spain, ⁶Department of Mathematics, Statistics and Operation Reseach La Laguna University, La Laguna, Spain, ⁷Hospital Universitario de Canarias, La Laguna, Spain
Background/Purpose: Based mainly on results from a randomized clinical trial (RCT) in rheumatoid arthritis (RA) patients (ORAL Surveillance), major regulatory agencies have concluded that JAK…
Abstract Number: 2212 • ACR Convergence 2023
Interpretation of Disease-specific Questionnaires on Disease Activity, Functional Capacity and Quality of Life in Daily Practice in Axial Spondyloarthritis
Styliani Tsiami¹, Kalliopi Klavdianou², Imke Redeker³, Yaren Elif Özdemir⁴, Philipp Sewerin¹, David Kiefer¹, Ioana Andreica⁵, Uta Kiltz⁶ and Xenofon Baraliakos⁴, ¹Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, ²Asklepieion' General Hospital, Department of Rheumatology, Voula, Kaisariani Athens, Greece, ³Ruhr Universität Bochum, Bochum, Germany, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany
Background/Purpose: In axial spondyloarthritis (axSpA), assessment of disease activity and physical function in clinical studies relies on patient-reported outcomes (PRO) such as patient's global, BASDAI,…
Abstract Number: 2437 • ACR Convergence 2023
Translocation of Intestinal Bacteria to Axial and Peripheral Joints in a Model of Spondyloarthropathy
Benjamin Cai¹, Rabina Giri², Helen Benham³, Linda Rehaume¹, Geoffery Strutton³, Anne-Sophie Bergot¹ and Ranjeny Thomas⁴, ¹Frazer Institute, The University of Queensland, Woolloongabba, Australia, ²Mater Research Institute-UQ, Woolloongabba, Australia, ³Princess Alexandra Hospital, Woolloongabba, Australia, ⁴Frazer Institute, The University of Queensland, Brisbane, Australia
Background/Purpose: In spondylarthropathy (SpA), such as psoriatic arthritis (PsA) and ankylosing spondylitis (AS), arthritis is often associated with gut inflammation. After systemic β-1,3-glucan (curdlan) injection,…
Abstract Number: 0501 • ACR Convergence 2023
Multicentre Study of Uveitis in Spondyloarthritis: Prevalence, Characteristics, and Prognosis
Nikolaos Kougkas¹, Konstantina Magiouf², Chrysoula Gialouri³, Gerasimos Evangelatos⁴, Maria Pappa², Afroditi Mpitouli⁵, Alexios Iliopoulos⁶, Theodoros Dimitroulas⁷, Anastasios Karamanakos⁸, Aikaterini Dimouli⁸, Maria Tektonidou², Petros Sfikakis⁹ and George Fragoulis¹⁰, ¹4th Internal Department, Ippokratio Hospital, Aristotle University of Thesaaloniki, Thessaloniki, Greece, ²Joint Academic Rheumatology Program, First Department of Propedeutic and Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece, ³National and Kapodistrian University of Athens, Zografou, Greece, ⁴Rheumatology Department, 417 Army Share Found Hospital (NIMTS), Athens, Greece, ⁵Fourth Department of Internal Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece, ⁶NIMTS Veterans Hospital, Zografou, Greece, ⁷Aristotle University of Thessaloniki - School of Medicine, Thessaloniki, Greece, ⁸“Evangelismos” General Hospital, Rheumatology Department, Athens, Greece, ⁹National Kapodistrian University of Athens Medical School, Athens, Greece, ¹⁰"Laiko" Hospital - First Department of Propaedeutic and Internal Medicine, Athens, Greece
Background/Purpose: Data are still scarce about risk factors predicting the occurrence and course of uveitis in spondyloarthritis (SpA). We aimed to examine associations between demographic,…
Abstract Number: 0533 • ACR Convergence 2023
Remission in Axial Spondyloarthritis: Is There a Difference Between NSAIDs and b/tsDMARDs in Daily Practice?
Francesco Natalucci¹, Pauline KRUG², Angela DE SOUSA LEITE², Tatiana Sokolova³, Patrick Durez⁴, Maria S. Stoenoiu² and Adrien NZEUSSEU TOUKAP⁵, ¹UCLouvain University, Sermoneta, Italy, ²Cliniques Universitaires Saint-Luc, Brussels, Belgium, ³Université Catholique de Louvain, Brussels, Belgium, ⁴UCLouvain, Brussels, Belgium, ⁵Cliniques universitaires Saint-Luc, St.-Lambrechts-Woluwe, Belgium
Background/Purpose: Randomized-controlled trials (RCTs) done in axial spondyloarthritis (axSpA) patients have shown that remission in axSpA (including nonradiographic axSpA) patients treated without b/tsDMARDs (TNFα blockers,…
Abstract Number: 0991 • ACR Convergence 2023
Trends in Arthroplasty Utilization for Inflammatory Arthritis Including Rheumatoid Arthritis and Spondyloarthritis in China: Analysis of a Large National Database
Dongxing Xie¹, Qiao Jiang², Yuqing Wang², Huizhong Long², Hu Chen³, Jie Wei⁴, Xiaoxiao Li⁵, Haibo Wang⁶, Chao Zeng⁷ and Guanghua Lei⁷, ¹Xiangya Hospital, Central South University, Changsha, China, ²Xiangya Hospital, Changsha, China, ³Tibet Autonomous Region People’s Hospital, Lhasa, China, ⁴Health Management Center, Xiangya Hospital Central South University, Changsha, China, ⁵Key Laboratory of Aging-related Bone and Joint Diseases Prevention and Treatment, Ministry of Education, Xiangya Hospital, Central South University, Changsha, China, ⁶China Standard Medical Information Research Center, Shenzhen, China, ⁷Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: For end-stage inflammatory arthritis (IA) including rheumatoid arthritis (RA) and spondyloarthritis (SpA), joint arthroplasty is the only treatment option, but is considered to be…
Abstract Number: 1403 • ACR Convergence 2023
MRI-defined Sacroiliitis in First Degree Relatives of Ankylosing Spondylitis Patients
Kristyna Bubova¹, Lenka Hasikova², Katerina Mintalova², Monika Gregova², Sarka Forejtova², Ladislav Senolt³ and Karel Pavelka⁴, ¹Institute of Rheumatology, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Prague, Czech Republic, ³Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Praha, Czech Republic, ⁴Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic
Background/Purpose: Sacroiliitis is a main radiographic finding in axial spondyloarthritis (axSpA) - the inflammatory rheumatic disease with a strong genetic background. The aim of this…
Abstract Number: 1785 • ACR Convergence 2023
Machine Learning Models Identify Gut Microbiota That Predict Chronicity in Reactive Arthritis
Prakashini MV¹, Soumendu Mahapatra², Krushna Chandra Murmu², Rasmita Mishra², Prasanta Padhan¹, Punit Prasad², Ramnath Misra³ and Sakir Ahmed⁴, ¹Kalinga Institute of Medical Sciences, KIIT University, Bhubaneswar, India, ²Institute of Life Sciences, Bhubaneswar, India, ³Kalinga Institute of Medical Sciences, KIIT University, Lucknow, India, ⁴Kalinga Institute of Medical Sciences, Bhubaneswar, India
Background/Purpose: Reactive arthritis (ReA) is the unique infection-triggered spondyloarthritis (SpA). Undifferentiated peripheral SpA (UpSpA) is similar but without previous infection, or psoriasis or inflammatory bowel…
Abstract Number: 2195 • ACR Convergence 2023
Regional Differences in Clinical Phenotype of Axial Spondyloarthritis. Results from the International Map of Axial Spondyloarthritis (IMAS)
Denis Poddubnyy¹, Fernando Sommerfleck², Victoria Navarro-Compán³, Christine Bundy⁴, Souzi Makri⁵, Shashank Murlidhar Akerkar⁶, Lillann Wermskog⁷, Elie Karam⁸, Jose Correa Fernandez⁹, Asif Siddiqui¹⁰ and Marco Garrido-Cumbrera¹¹, ¹Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ²Sanatorio Julio Mendez, Buenos Aires, Argentina, ³Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁴Cardiff University, Cardiff, United Kingdom, ⁵Cyprus League for People with Rheumatism (CYLPER), Nicosia, Cyprus, ⁶Mumbai Arthritis Clinic, Mumbai, India, ⁷Spondyloarthritis Association of Norwary (SPAFO);Axial Spondyloarthritis International Federation (ASIF), Oslo, Norway, ⁸Canadian Spondylitis Association (CSA), Toronto, ON, Canada, ⁹Universidad de Sevilla, Health & Territory Research (HTR), Sevilla, Spain, ¹⁰Novartis Pharma AG, Basel, Switzerland, ¹¹University of Seville, Sevilla, Spain
Background/Purpose: Previous studies have suggested there could be regional differences in clinical phenotype of axial spondyloarthritis (axSpA). This analysis aims to explore differences in axSpA…
Abstract Number: 2213 • ACR Convergence 2023
Identification of a Diagnostic Model for Axial Spondyloarthritis in Daily Clinical Practice Using a Random Forest Machine Learning Approach
Imke Redeker¹, Styliani Tsiami², Jan Eicker³, Uta Kiltz⁴, David Kiefer², Ioana Andreica⁵, Philipp Sewerin² and Xenofon Baraliakos⁶, ¹Ruhr Universität Bochum, Bochum, Germany, ²Ruhr-Universität Bochum and Rheumazentrum Ruhrgebiet, Herne, Germany, ³Rheumazentrum Ruhrgebiet Herne and Ruhr-University Bochum, Herne, Germany, ⁴Rheumazentrum Ruhrgebiet, Herne, Germany, ⁵Rheumazentrum Ruhrgebiet Herne, Herne, Germany, ⁶Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany
Background/Purpose: In axial spondyloarthritis (axSpA), early diagnosis plays a key role in preventing disease progression. However, a validated diagnostic algorithm does not exist, while classification…
Abstract Number: 2545 • ACR Convergence 2023
Efficacy and Safety of Intravenous Secukinumab for the Treatment of Active Axial Spondyloarthritis: Results from a Randomized, Double-Blind, Phase 3 Study
Atul Deodhar¹, Jerzy Supronik², Alan Kivitz³, Guillermo Valenzuela⁴, Karen Kapur⁵, Susanne Rohrer⁶, Eva Dokoupilova⁷, Hanno Richards⁶ and Karel Pavelka⁸, ¹Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, ²OsteoMedic sc A Racewicz J Supronik, Bialystok, Poland, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴Integral Rheumatology & Immunology Specialists, Plantation, FL, ⁵Novartis Pharmaceuticals Corporation, East Hanover, NJ, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Masaryk University, Faculty of Pharmacy, Department of Pharmaceutical Technology; MEDICAL PLUS sro, Brno, Czech Republic, ⁸Institut of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Praha, Czech Republic
Background/Purpose: While subcutaneous secukinumab (SEC) is approved for the treatment of axial spondyloarthritis (axSpA), some patients may benefit more from intravenous (IV) administration. This study…
Abstract Number: 0506 • ACR Convergence 2023
Patient and Physician Global Assessment of Psoriatic Arthritis Disease Activity: High Concordance in an ArLAR Multinational Study
Nelly Ziade¹, Noura Abbas², Lina El Kibbi³, Avin Maroof⁴, Bassel Elzorkany⁵, Nizar Ani⁶, ASAL ADNAN⁷, NABAA IHSAN JAWAD AWADH⁷, Faiq Gorial⁸, Nada Alchama⁹, Chafika Haouichat¹⁰, Fatima Alnaimat¹¹, Suad Hannawi¹², Saed Atawnah¹³, HUSSEIN HALABI¹⁴, Manal Al-Mashaleh¹⁵, Laila Aljazwi¹⁶, Ahmed Abogamal¹⁷, laila Ayoub¹⁸, Elyes Bouajina¹⁹, Rachid Bahiri²⁰, Sahar Saad²¹, Maha Sabkar²¹, Krystel Aouad²², Laure Gossec²³ and Ihsane Hmamouchi²⁴, ¹Saint-Joseph University, Beirut, Lebanon, ²Saint Joseph University Beirut, Beirut, Lebanon, ³Specialized Medical Center, Riyadh, Saudi Arabia, ⁴Kurdistan University Hawler, Erbil, Iraq, ⁵Private (BZRC), Cairo, Egypt, ⁶Baghdad College of Medicine, Baghdad, Iraq, ⁷Baghdad Teaching Hospital, Baghdad, Iraq, ⁸University of Baghdad, Baghdad, Iraq, ⁹Ebn Al Nafiss Hospital, Damascus, Syria, ¹⁰Faculty of Medicine El Mahdi Si Ahmed, Blida, Algeria, ¹¹University of Jordan, Amman, Jordan, ¹²Kuwait Hospital, Department of Rheumatology, Dubai, United Arab Emirates, ¹³Al ahli hospital, Hebron, Palestine, Hebron, Palestinian Territories, ¹⁴King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia, ¹⁵Royal Medical Services, Amman, Jordan, ¹⁶Tripoli, Tripoli, Libya, ¹⁷Saudi German Hospital Dubai, Dubai, United Arab Emirates, ¹⁸University of Tripoli, Tripoli, Libya, ¹⁹Farhat Hached Hospital of Sousse, Sousse, Tunisia, ²⁰Department of Rheumatology, El Ayachi Hospital Medical University, Sale, Morocco, ²¹King Hamad University Hospital, Bahrain, Bahrain, ²²Saint George Hospital University Medical Center, Beirut, Lebanon, ²³Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France, ²⁴Rheumatology Unit, Lalla Aicha Temara Hospital, Temara, Morocco
Background/Purpose: In patients with psoriatic arthritis (PsA), discordance between physicians and patients when assessing disease activity has been described as frequent, mainly in European and…

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