Abstracts tagged "spondyloarthritis"

Abstract Number: 2221 • ACR Convergence 2023
Clinical and Molecular Patterns Associated with Persistence of Inflammation in Spondyloarthritis Patients: Unveiling Potential Biomarkers
Lourdes Ladehesa Pineda¹, Ivan Arias de la Rosa², Laura Cuesta-López³, Clementina López Medina⁴, María Ángeles Puche Larrubia⁵, Miriam Ruiz-Ponce³, María del carmen Ábalos Aguilera³, Pedro Ortiz Buitrago³, Yasin Hanaee³, Carlos Perez-Sanchez⁶, Chary López-Pedrera³, Alejandro Escudero-Contreras⁷, Eduardo Collantes Estévez⁸ and Nuria Barbarroja⁹, ¹Rheumatology Department Reina Sofia Universitary Hospital, Cordoba, Spain, ²IMIBIC/Reina Sofia Hospital/University of Cordoba. Rheumatology service. Cordoba. Spain, Cordoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain, ⁵Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain, ⁶IMIBIC, Córdoba, Spain, ⁷Rheumatology Department, Reina Sofia University Hospital, Cordoba/Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Córdoba, Spain, ⁸Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, ⁹University of Cordoba, Córdoba, Spain
Background/Purpose: Chronic inflammation is closely associated with an increased risk of cardiovascular diseases (CVD) through the activation of the immune system and the release of…
Abstract Number: 0338 • ACR Convergence 2023
Comparative Disease Burden in Patients with Rheumatoid Arthritis, Psoriatic Arthritis or Ankylosing Spondylitis: Data from COVAD Patient-reported E-survey
Diego Benavent¹, Marco Fornaro², Florenzo Iannone³, Lorenzo Cavagna⁴, Masataka Kuwana⁵, Naveen R⁶, Vishwesh Agarwal⁷, Jessica Day⁸, Mrudula Joshi⁹, Sreoshy Saha¹⁰, Kshitij Jagtap¹¹, Wanruchada Katchamart¹², Phonpen Akarawatcharangura Goo¹³, Binit Vaidya¹⁴, Tsvetelina Velikova¹⁵, Parikshit Sen¹⁶, Samuel Shinjo¹⁷, Ai Lyn Tan¹⁸, Nelly Ziade¹⁹, Marcin Milchert²⁰, Abraham Edgar Gracia-Ramos²¹, Carlo Caballero²², Hector Chinoy²³, Vikas Agarwal⁶, Rohit Aggarwal²⁴, Latika Gupta²⁵ and Vincenzo Venerito²⁶, ¹Hospital la Paz, Madrid, Spain, ²University of Bari, Grottaglie, Italy, ³Rheumatology Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", Bari, Italy, ⁴Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ⁵Nippon Medical School Graduate School of Medicine, Tokyo, Japan, ⁶Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, ⁷Mahatma Gandhi Missions Medical College, Lucknow, India, ⁸Walter and Eliza Hall Institute, Melbourne, Australia, ⁹Byramjee Jeejeebhoy Government Medical College and Sassoon General Hospitals, Pune, India, ¹⁰Mymensingh Medical College, Faridpur, Bangladesh, ¹¹Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, India, ¹²Mahidol University, Bangkok, Thailand, ¹³Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand, ¹⁴National Center for Rheumatic Diseases (NCRD), Ratopul, Kathmandu, Nepal., Kathmandu, India, ¹⁵Department of Clinical Immunology, Medical Faculty, University Hospital "Lozenetz", Sofia University St. Kliment Ohridski, Sofia, Bulgaria, ¹⁶Maulana Azad Medical College, 2-Bahadurshah Zafar Marg, New Delhi, Delhi-110002, India., Dalhi, India, ¹⁷Faculdade de Medicina FMUSP, Universidade de Sao Paulo, São Paulo, Brazil, ¹⁸University of Leeds, Leeds, United Kingdom, ¹⁹Saint-Joseph University, Beirut, Lebanon, ²⁰Department of Internal Medicine, Rheumatology, Diabetology, Geriatrics and Clinical Immunology, Pomeranian Medical University in Szczecin, Szczecin, Poland, ²¹Department of Internal Medicine, General Hospital, National Medical Center "La Raza", Instituto Mexicano del Seguro Social, Av. Jacaranda S/N, Col. La Raza, Del. Azcapotzalco, C.P. 02990, Mexico City, Mexico, ²²Universidad del Norte, Barranquilla, Colombia, ²³The University of Manchester, Sale, United Kingdom, ²⁴University of Pittsburgh, Pittsburgh, PA, ²⁵Royal Wolverhampton Trust, Wolverhampton/University of Manchester, United Kingdom, ²⁶Rheumatology Department, Università degli Studi di Bari, Bari, Italy
Background/Purpose: Rheumatoid arthritis (RA) and spondyloarthritis (SpA), including either Psoriatic Arthritis (PsA) and Ankylosing Spondylitis (AS), are some of the most commonly diagnosed autoimmune rheumatic…
Abstract Number: 0519 • ACR Convergence 2023
Long-Term Safety and Efficacy of Bimekizumab in Patients with Active Ankylosing Spondylitis: 5-Year Results from a Phase 2b Study and Its Open-Label Extension
Atul Deodhar¹, Victoria Navarro-Compán², Denis Poddubnyy³, Lianne Gensler⁴, Sofia Ramiro⁵, Tetsuya Tomita⁶, Helena Marzo-Ortega⁷, Carmen Fleurinck⁸, Thomas Vaux⁹, Ute Massow¹⁰, Désirée van der Heijde⁵ and Xenofon Baraliakos¹¹, ¹Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, ²Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ³Department of Gastroenterology, Infectious Diseases and Rheumatology, Charité – Universitätsmedizin Berlin, Berlin, Germany, ⁴University of California San Francisco, Department of Medicine, Division of Rheumatology, San Francisco, CA, ⁵Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁶Graduate School of Health Science, Morinomiya University of Medical Science, Osaka, Japan, ⁷NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁸UCB Pharma, Oosterzele, Belgium, ⁹UCB Pharma, Slough, United Kingdom, ¹⁰UCB Pharma, Monheim am Rhein, Germany, ¹¹Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany
Background/Purpose: Bimekizumab (BKZ), a monoclonal IgG1 antibody, selectively inhibits IL-17F in addition to IL17A. BKZ has demonstrated clinical efficacy and safety up to 3 years…
Abstract Number: 0746 • ACR Convergence 2023
The Association Between Sonographic Imaging Phenotype and Response to Treatment in Patients with Psoriatic Arthritis
Jessica Gutierrez Manjarrez¹, Sydney Thib², Richard J. Cook³ and Lihi Eder⁴, ¹Women’s College Research Institute / Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Women’s College Research Institute, Toronto, ON, Canada, ³Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada, ⁴Women’s College Research Institute, Division of Rheumatology, University of Toronto, Toronto, ON, Canada
Background/Purpose: Ultrasound (US) may improve characterization of psoriatic arthritis (PsA) phenotypes and help predict disease outcomes. We aimed to assess whether US phenotypes are associated…
Abstract Number: 1385 • ACR Convergence 2023
Where Are We with Implementing Axial Spondyloarthritis Treatment Recommendations and Disease Activity Monitoring in Clinical Practice – Results of an Online Survey Amongst Rheumatology Care Providers
Joerg Ermann¹, Stephanie Sinnappan² and Alexandra Forte³, ¹Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Memorial Sloan Kettering Cancer Center, New York, NY
Background/Purpose: Several sets of treatment recommendations for axial spondyloarthritis and ankylosing spondylitis (axSpA/AS) have been published. Clinical practice guidelines are not followed consistently by health…
Abstract Number: 1415 • ACR Convergence 2023
Bimekizumab Treatment Impact on Work Productivity in Biologic DMARD‑Naïve and TNFi-IR Patients with Active Psoriatic Arthritis: Results up to 1 Year from Two Phase 3 Studies
Philip J. Mease¹, Dafna Gladman², Laure Gossec³, Peter Nash⁴, Barbara Ink⁵, Jason Coarse⁶, Nikos Lyris⁵, Damon Willems⁷ and William R Tillett⁸, ¹Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA, ²Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada, ³Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France, ⁴School of Medicine, Griffith University, Brisbane, Australia, ⁵UCB Pharma, Slough, United Kingdom, ⁶UCB Pharma, Morrisville, NC, ⁷UCB Pharma, Brussels, Belgium, ⁸Department of Rheumatology, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom
Background/Purpose: PsA impacts the physical health and functional ability of patients (pts),which can contribute to reduced work productivity.1 Bimekizumab (BKZ) is a monoclonal IgG1 antibody…
Abstract Number: 1872 • ACR Convergence 2023
Performance Analysis of a Deep Learning Algorithm to Detect Positive SIJ MRI According to the ASAS Definition in axSpA Patients
Joeri Nicolaes¹, Evi Tselenti², Theodore Aouad³, Clementina López Medina⁴, Antoine Feydy⁵, Hugues Talbot³, Bengt Hoepken⁶, Natasha De Peyrecave⁷ and Maxime Dougados⁸, ¹KU Leuven, Department of Electrical Engineering (ESAT), Center for Processing Speech and Images; UCB Pharma, Anderlecht, Belgium, ²Veramed, London, United Kingdom, ³CentraleSupélec, Universite Paris-Saclay, Inria, Gif-sur-Yvette, France, ⁴Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain, ⁵INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Radiology Department, Cochin Hospital, Paris, France, ⁶UCB Pharma, Monheim, Germany, ⁷UCB Pharma, Brussels, Belgium, ⁸Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris, Paris, France
Background/Purpose: Magnetic resonance imaging (MRI) of the sacroiliac joints (SIJ) is an essential tool in the evaluation of patients with axial spondyloarthritis (axSpA). In-depth knowledge…
Abstract Number: 2204 • ACR Convergence 2023
Residual Disease Activity in Canadian Patients with Axial Spondyloarthritis: Results from a Multi-registry Analysis (UNISON-Axial SpA)
Denis Choquette¹, Walter P. Maksymowych², Proton Rahman³, Robert Inman⁴, Marie-Claude Laliberté⁵, Pierre-Andre Fournier⁶, Tanya Girard⁵ and Dafna Gladman⁷, ¹Centre hospitalier de l'Université de Montréal (CHUM), Université de Montréal, Montréal, QC, Canada, ²University of Alberta, Edmonton, AB, Canada, ³Craig Dobbin Research Institute, Memorial University, St. John's, NL, Canada, ⁴University Health Network, Toronto, ON, Canada, ⁵AbbVie, Inc., Saint-Laurent, QC, Canada, ⁶AbbVie, Inc., Montréal, QC, Canada, ⁷Schroeder Arthritis Institute, Krembil Research Institute, Toronto Western Hospital, Department of Medicine, University of Toronto, Toronto, ON, Canada
Background/Purpose: In patients with axial spondyloarthritis (axSpA), treatment goals consist of achieving remission or low disease activity (LDA) to alleviate symptoms, improve function, decrease disease…
Abstract Number: 2222 • ACR Convergence 2023
Association Spondyloarthritis and Inflammatory Bowel Disease, More Severe Diseases on Both Sides
Juliane Michel¹, Clément Prati², Lucine Vuitton³, Eric Toussirot⁴, Charline Vauchy⁵, Daniel Wendling⁶ and frank Verhoeven², ¹Rheumatology, CHU Besancon, Besançon, France, ²Service de rhumatologie, CHU de Besançon, Besançon, France, ³Gastroenterology, CHU Besancon, Besançon, France, ⁴University Hospital of Besancon, Besançon, France, ⁵INSERM CIC-1431, Besançon, France, ⁶Besançon University Hospital, Besançon, France
Background/Purpose: There is a pathophysiological link between spondyloarthritis (SpA) and Inflammatory Bowel Disease (IBD), so that 10% of IBD is estimated to have SpA and…
Abstract Number: 0356 • ACR Convergence 2023
PRINTO Provisional Enthesitis/Spondylitis-Related JIA Criteria: Performance in Youth Classified as Axial Disease in Juvenile Spondyloarthritis
Pamela F. Weiss¹, Timothy G. Brandon², Amita Aggarwal³, RUBEN BURGOS-VARGAS⁴, Robert Colbert⁵, Gerd Horneff⁶, Rik Joos⁷, Ronald Laxer⁸, Kirsten Minden⁹, Angelo Ravelli¹⁰, Nicolino Ruperto¹¹, Judith Smith¹², Matthew Stoll¹³, Shirley Tse⁸, Filip Van den Bosch¹⁴, Walter P. Maksymowych¹⁵, Robert Lambert¹⁶, David Biko², Nancy A. Chauvin¹⁷, Michael L. Francavilla¹⁸, Jacob Jaremko¹⁵, Nele Herregods¹⁹, Ozgur Kasapcopur²⁰, Mehmet YILDIZ²¹, Hemalatha Srinivasalu²², Ray Naden²³ and Alison Hendry²⁴, ¹Children's Hospital of Philadelphia, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS), Lucknow, India, ⁴Hospital General de Mexico, Ciudad de México, Mexico, ⁵NIH/NIAMS, Bethesda, MD, ⁶Asklepios Klinik Sankt Augustin GmbH, Bonn, Germany, ⁷Ghent University, Basel, Switzerland, ⁸The Hospital for Sick Children, Toronto, ON, Canada, ⁹Charité University Medicine and German Rheumatism Research Center Berlin, Berlin, Germany, ¹⁰Direzione Scientifica, IRCCS Istituto Giannina Gaslini, Genova, Italy, ¹¹IRCCS Istituto Giannina Gaslini, UOSID Centro Trial, Genova, Italy, ¹²University of Wisconsin, Madison, WI, ¹³University of Alabama at Birmingham, Birmingham, AL, ¹⁴Department of Internal Medicine and Pediatrics, Ghent University and VIB Center for Inflammation Research, Ghent, Belgium, ¹⁵University of Alberta, Edmonton, AB, Canada, ¹⁶Department of Radiology and Diagnostic Imaging, University of Alberta, Edmonton, AB, Canada, ¹⁷The Cleveland Clinic, Hummelstown, PA, ¹⁸University of South Alabama College of Medicine, Mobile, AL, ¹⁹Ghent University Hospital, Ghent, Belgium, ²⁰Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey, ²¹Istanbul University-Cerrahpasa Department of Pediatric Rheumatology, Istanbul, Turkey, ²²Children's National Hospital, Washington, DC, ²³Auckland City Hospital, Auckland, New Zealand, ²⁴Te Whatu Ora, Counties Manukau District, Middlemore Hospital, Auckland, New Zealand
Background/Purpose: The Paediatric Rheumatology International Trials Organisation (PRINTO) recently undertook an effort to better harmonize the pediatric and adult arthritis criteria. These provisional criteria are…
Abstract Number: 0521 • ACR Convergence 2023
Work Productivity Improved in Patients with Axial Spondyloarthritis Receiving Bimekizumab Treatment over 52 Weeks: Results from Two Phase 3 Studies
Martin Rudwaleit¹, Victoria Navarro-Compán², Atul Deodhar³, Maureen Dubreuil⁴, Michael Frank Mørup⁵, Vanessa Taieb⁶, Christine de la Loge⁷, Carmen Fleurinck⁸, Ute Massow⁹, Thomas Vaux¹⁰ and Annelies Boonen¹¹, ¹University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany, ²Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ³Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, ⁴Department of Rheumatology, Boston University School of Medicine, Milton, MA, ⁵UCB Pharma, Copenhagen, Denmark, ⁶UCB Pharma, Colombes, France, ⁷UCB Pharma, Brussels, Belgium, ⁸UCB Pharma, Oosterzele, Belgium, ⁹UCB Pharma, Monheim am Rhein, Germany, ¹⁰UCB Pharma, Slough, United Kingdom, ¹¹Care and Public Health Research Institute (Caphri), Maastricht University, Maastricht, Netherlands
Background/Purpose: The clinical manifestations of axial spondyloarthritis (axSpA) limit physical function and work productivity, posing an economic burden to patients (pts) and society.1 Bimekizumab (BKZ),…
Abstract Number: 0824 • ACR Convergence 2023
Defining Poor Global Functioning and Health in Axial Spondyloarthritis, Using the EQ-5D-3L Questionnaire, When the ASAS-Health Index Is Not Available Is Feasible. an Analysis of 2651 Patients from the PERSPA Study
Juliette Drouet¹, Clementina López Medina², Anna Molto³, Benjamin Granger¹, Bruno Fautrel⁴, Cécile Gaujoux Viala⁵, Uta Kiltz⁶, Maxime Dougados⁷ and Laure Gossec⁸, ¹Sorbonne Université, INSERM, and Pitié Salpêtrière Hospital, Paris, France, ²Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain, ³HOPITAL COCHIN AP-HP, Service de Rhumatologie, Paris, France, ⁴Sorbonne Université APHP, Paris, France, ⁵IDESP Univ Montpellier, INSERM, Rheumatology, CHU Nîmes, Montpellier, France, ⁶Rheumazentrum Ruhrgebiet, Herne, Germany, ⁷Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris, Paris, France, ⁸Sorbonne Université and Pitié Salpêtrière Hospital, Paris, France
Background/Purpose: In axial Spondyloarthritis (axSpA) it is recommended to assess global functioning and health, a concept close to health-related quality of life (HR-QoL), using the…
Abstract Number: 1389 • ACR Convergence 2023
Low Spinal Radiographic Progression After a Mean of 15 Years of Follow-up in a Cohort of Patients with Axial Spondyloarthritis
raquel granados¹, Santiago Dans-Caballero¹, Lourdes Ladehesa Pineda², María Ángeles Puche Larrubia³, Desiree Ruiz Vilchez⁴, Maria del Carmen Abalos-Aguilera⁴, Alejandro Escudero-Contreras⁵, Eduardo Collantes Estévez⁶ and Clementina López Medina⁷, ¹Rheumatology Department, Reina Sofia University Hospital, Cordoba/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Cordoba, Spain, ²Rheumatology Department Reina Sofia Universitary Hospital, Cordoba, Spain, ³Department of Rheumatology, Reina Sofia University Hospital, Cordoba, Spain, ⁴Rheumatology Department, Reina Sofia University Hospital/Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Córdoba, Spain, ⁵Rheumatology Department, Reina Sofia University Hospital, Cordoba/Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Córdoba, Spain, ⁶Maimonides Biomedical Research Institute of Cordoba (IMIBIC)/University of Cordoba, Cordoba, Spain, ⁷Rheumatology Department, Cochin Hospital; INSERM (U1153): Clinical Epidemiology and Biostatistics, University of Paris; Rheumatology Department, Reina Sofia Hospital, Cordoba / IMIBIC / University of Cordoba, Cordoba, Spain
Background/Purpose: Axial spondyloarthritis (axSpA) is characterized by progressive structural damage on the sacroiliac joints and/or the spine. Conventional radiology allows to assess radiology through available…
Abstract Number: 1433 • ACR Convergence 2023
Bimekizumab Impact on Core Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) Domains for Patients with Psoriatic Arthritis: 52-Week Results from Four Phase 3 Studies
Joseph Merola¹, Philip J. Mease², Atul Deodhar³, Barbara Ink⁴, Carmen Fleurinck⁵, Rajan Bajracharya⁴, Jason Coarse⁶ and Laura Coates⁷, ¹Harvard Medical School, Brigham and Women's Hospital, Newton, MA, ²Swedish Medical Center/Providence St. Joseph Health and University of Washington School of Medicine, Seattle, WA, ³Division of Arthritis and Rheumatic Disease, Oregon Health & Science University, Portland, OR, ⁴UCB Pharma, Slough, United Kingdom, ⁵UCB Pharma, Oosterzele, Belgium, ⁶UCB Pharma, Morrisville, NC, ⁷University of Oxford, Oxford, United Kingdom
Background/Purpose: The Group for Research and Assessment of Psoriasis and PsA (GRAPPA) domain‑based treatment recommendations for PsA focus on six key domains: peripheral arthritis, axial…
Abstract Number: 1873 • ACR Convergence 2023
Cervical Spine Involvement in Axial Spondyloarthritis. Radiographic Characteristics and Associated Factors
pol Maymó¹, Laura Berbel Arcobé², Xabi Michelena³, José Antonio Narvaez², Joan Miquel Nolla⁴, Lídia Valencia², Judith Palacios⁴ and Xavier Juanola Roura¹, ¹Hospital Universitari de Bellvitge, Barcelona, Spain, ²H.U. Bellvitge, Barcelona, Spain, ³Vall Hebron University Hospital, Rheumatology Department, Barcelona, Spain, ⁴Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain
Background/Purpose: The study of the cervical spine (CS) in axial spondyloarthritis (axSpA) and its radiographic characteristics including the zygapophyseal joints (ZJ) may be helpful for…

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