Abstracts tagged "Spondylarthropathy"

Abstract Number: 560 • 2019 ACR/ARP Annual Meeting
Dactylitis Occurrence in Early Spondyloarthritis: Five Years Data from a French National Prospective Cohort
Daniel WENDLING¹, Clément PRATI ², Alain Saraux ³, Anna Moltó ⁴, Thao PHAM ⁵, Maxime Dougados ⁶ and Xavier GUILLOT ⁷, ¹Rheumatology, University Teaching Hospital (CHRU), Besançon, France, ²University Teaching Hospital (CHRU), Besançon, France, ³CHU de la Cavale-Blanche Brest, Brest, France, ⁴Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, ⁵CHU, Marseille, France, ⁶Cochin Hospital, Paris, France, ⁷CHU, Saint Denis de la Réunion, Reunion
Background/Purpose: Dactylitis is a particular feature shared across the several phenotypical forms of spondyloarthritis (SpA), part of the classification criteria. There are only few data…
Abstract Number: 589 • 2019 ACR/ARP Annual Meeting
Smoking, Alcohol Intake and Body Mass Index in Prediction of Disease Activity over Time in Early Axial Spondyloarthritis – Results from the SPondyloArthritis Caught Early (SPACE) Cohort
Sofia Exarchou ¹, Carl Turesson¹, Ulf Lindström ², Roberta Ramonda ³, Robert B.M. Landewé ⁴, Hanne Dagfinrud ⁵, Floris van Gaalen ⁶, Désirée van der Heijde ⁶ and Lennart Jacobsson ⁷, ¹Lund University, Malmö, Sweden, ²University of Gothenburg, Gothenburg, Sweden, ³University of Padova, Padova, Italy, ⁴Amsterdam University Medical Center, Amsterdam, Netherlands, ⁵University of Oslo, Oslo, Norway, ⁶Leiden University Medical Center, Leiden, Netherlands, ⁷Dept of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden,, Gothenburg, Sweden
Background/Purpose: In ankylosing spondylitis (AS), smokers have been found to have both higher disease activity and greater syndesmophyte progression, and a higher body mass index…
Abstract Number: 1247 • 2019 ACR/ARP Annual Meeting
Adult-Onset Still’s Disease and Spondyloarthritis: Overlapping Syndrome or Incidental Association? A Series of 5 Cases
Aly Kamissoko ¹, Nolan Hassold ², Alexis Mathian ³, Edouard Pertuiset ⁴, Gaetane Nocturne ², Bruno Fautrel ⁵ and Stéphane Mitrovic⁶, ¹AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Paris, France, Paris, France, ²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ³AP-HP, Service de Médecine Interne 2, Hôpital Universitaire Pitié-Salpêtrière, Paris, France, Paris, France, ⁴Rheumatology Department, Pontoise Hospital, Pontoise, France, Pontoise, France, ⁵Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, ⁶AP-HP, Department of Rheumatology, Pitié-Salpêtrière University Hospital, Sorbonne Université, GRC 08, Pierre Louis Institute of Epidemiology and Public Health, Paris, France - Centre d’Etude et de Référence sur les Maladies AutoInflammatoires et les Amyloses (CEREMAIA), FAI2R network, Paris, France - Institut Mutualiste Montsouris, Paris, France, Paris, France
Background/Purpose: Some forms of spondyloarthritis (SpA) such as SAPHO syndrome are classified as auto-inflammatory disorders. Association with adult onset Still’s disease (AoSD) has never been…
Abstract Number: 2092 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of the Adjuvanted Recombinant Zoster Vaccine in Adults with Pre-existing Potential Immune Mediated Diseases: A Pooled Post-hoc Analysis on Two Parallel Randomized Trials
Alemnew Dagnew¹, Debora Rausch ², Caroline Hervé ³, Toufik Zahaf ⁴ and Anne Schuind ¹, ¹GSK, Rockville, MD, ²GSK, Philadelphia, PA, ³GSK, Wavre, Belgium, ⁴GSK, Rixensart, Belgium
Background/Purpose: The increased risk of herpes zoster (HZ) in older adults is attributable to age-related decline in immunity. In 2 pivotal studies, ZOE-50 (NCT01165177) and…
Abstract Number: 2716 • 2016 ACR/ARHP Annual Meeting
Does Secretory Immunoglobulin a Influence Disease Activity in Patients with Reactive Arthritis and Undifferentiated Spondylarthritis?
fabian Alexander salas-Cuestas¹, Consuelo Romero Sanchez^2,3, WILSON BAUTISTA-MOLANO⁴, Juan Manuel Bello-Gualtero^5,6, Ivonne Arias C⁷, Daniel Herrera⁸ and Rafael Valle-Oñate^6,9, ¹School of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, Bogota DC, Colombia, ²Rheumatology, School of Medicine HMC / UMNG, Bogota, Colombia, ³Rheumatology and Immunology, Hospital Militar Central, Bogota DC, Colombia, ⁴Rheumatology Department, School of Medicine, UMNG / HMC, Bogotá, Colombia, ⁵Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, Colombia, ⁶Rheumatology and Immunology Department,Hospital Militar Central, Bogota, Colombia, ⁷3. Instituto de Genética Humana, School of Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia., Bogota DC, Colombia, ⁸Genetic, Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia, ⁹School of Medicine, Universidad Militar Nueva Granada, Bogota, Colombia
Background/Purpose: Spondylarthropathies (SpA) comprise a group of rheumatic diseases such as ankylosing spondylitis (AS), arthritis/spondylitis with inflammatory bowel disease, arthritis/spondylitis with psoriasis (PsA), reactive arthritis…
Abstract Number: 2492 • 2012 ACR/ARHP Annual Meeting
Protective and Pathogenic Effects of the IL-23 Family of Cytokines in Spondyloarthropathy in SKG Mice
Helen Benham¹, Linda Rehaume¹, Merja Ruutu¹, Jared Velasco¹, Kristine Kikly², Geoffrey Strutton³, Michael McGuckin⁴ and Ranjeny Thomas¹, ¹Diamantina Institute, Diamantina Institute University of Queensland, Brisbane, Australia, ²Biotechnology Discovery Research, Eli Lilly and Co., Indianapolis, ³Dept of Pathology, Department of Pathology, Princess Alexandra Hospital, Brisbane, Australia, ⁴Mater Medical Research Institute, Brisbane, Australia
Background/Purpose: , IL-23 is required for the expansion and maintenance of T cells and innate cells secreting IL-17 and IL-22. These cytokines are important for…
Abstract Number: 2493 • 2012 ACR/ARHP Annual Meeting
The Presence of HLA-B27 Shapes Gut Microbiome Composition in Rats
Mary H. Bach¹, Russell N. Van Gelder², Joel D. Taurog³ and James T. Rosenbaum⁴, ¹Rheumatology, University of Washington Medical Center, Seattle, WA, ²Ophthalmology, University of Washington Medical Center, Seattle, WA, ³Internal Medicine, Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, ⁴Arthritis and Rheumatic diseases, Oregon Health and Science University, Portland, OR
Background/Purpose: The association of spondyloarthropathies (SpA) with HLA-B27 was first described in 1973. However, the mechanism remains unknown. The HLA-B27-human beta2 microglobulin (B27/hβ2m) transgenic (TG)…
Abstract Number: 2494 • 2012 ACR/ARHP Annual Meeting
Incidence and Severity of Spondyloarthritis and Crohn’s Ileitis Are Determined by Interaction Between the Microbiota and Genetic Susceptibility in Beta-Glucan-Treated SKG Mice
Ranjeny Thomas¹, Linda Rehaume¹, Daniel Aguirre de Cárcer², Stan Mondot², Jared Velasco¹, Helen Benham¹, Merja Ruutu¹, Mark Morrison² and Michael McGuckin³, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²CSIRO Livestock Industries, Brisbane, Australia, ³Mater Medical Research Institute, Brisbane, Australia
Background/Purpose: Spondyloarthritis and inflammatory bowel disease (IBD) or microscopic gut inflammation co-exist in many patients. These conditions share genetic associations in the IL23R signaling pathway.…
Abstract Number: 2409 • 2012 ACR/ARHP Annual Meeting
Work Productivity in a Population Based Cohort of Patients with Spondyloarthritis
Emma Haglund¹, Ann B. I. Bremander², Stefan Bergman¹, Lennart TH Jacobsson³, Britta Strömbeck⁴ and Ingemar F. Petersson⁴, ¹Spenshult Hospital, R&D Center Spenshult, Oskarstrom, Sweden, ²Department of Exercise Physiology, Biomechanics and Health, Halmstad University School of Business and Engineering,, Halmstad, Sweden, ³Rheumatology/Lund University, Department of Rheumatology, Clinical sciences, Skane University Hospital, Malmö, Sweden, ⁴Musculoskeletal Sciences, Department of Orthopedics, Clinical Sciences, Lund, Sweden
Background/Purpose: Spondyloarthritis (SpA) often causes impaired function, activity limitations, affected health related quality of life and work disability. Work disability has been shown to be…
Abstract Number: 2232 • 2012 ACR/ARHP Annual Meeting
Performance of Berlin Criteria in Patients with EARLY Spondyloarthritis
Beatriz E. Joven¹, Milena Gobbo², Miguel A. Descalzo³, Eugenio De Miguel⁴ and Esperanza Group⁵, ¹Rheumatology, HOSPITAL UNIVERSITARIO 12 DE OCTUBRE, Madrid, Spain, ²Research Unit, Spanish Society of Rheumatology., Madrid, Spain, ³Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ⁴Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ⁵Madrid
Background/Purpose: Berlin criteria are a diagnostic algorithm based on calculation of the likelihood ratio (LR) product of currently available diagnostic test for spondyloarthritis (SpA). However,…
Abstract Number: 1701 • 2012 ACR/ARHP Annual Meeting
Validation of the New ASAS Criteria for Classification of Early Spondyloarthritis in the Esperanza Cohort
Eva Tomero¹, Loreto Carmona², Juan Mulero³, Eugenio De Miguel⁴, Milena Gobbo⁵, Carmen Martínez⁶, Miguel A. Descalzo⁶, Pedro Zarco⁷, Eduardo Collantes-Estevez⁸ and Esperanza Group⁹, ¹Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, ²Health Sciences School, Universidad Camilo José Cela, Villanueva de la Cañada, Spain, ³Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda (Madrid), Spain, ⁴Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ⁵Research Unit, Spanish Society of Rheumatology., Madrid, Spain, ⁶Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ⁷Unit Rheumatology, Fundación Hospital Alcorcon, Alcorcon, Madrid, Spain, ⁸Depatamento de Medicina, IMIBIC-Reina Sofia Hospital, Cordoba 14012, Spain, ⁹Madrid
Background/Purpose: To validate the new axial and peripheral ASAS criteria in patients with early spondyloarthritis (SpA) and the full spectrum of clinical manifestations under clinical…
Abstract Number: 1378 • 2012 ACR/ARHP Annual Meeting
Validity of Ankylosing Spondylitis Disease Activity Score (ASDAS) in Patients with Early Spondyloarthritis
Cruz Fernández-Espartero¹, Eugenio De Miguel², Milena Gobbo³, Carmen Martínez⁴, Miguel A. Descalzo⁴, Estíbaliz Loza Sr.⁵ and Esperanza Group⁶, ¹Servicio de Reumatología, Hospital Universitario de Móstoles, Madrid, Spain, ²Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ³Research Unit, Spanish Society of Rheumatology., Madrid, Spain, ⁴Research Unit, Spanish Society of Rheumatology, Madrid, Spain, ⁵Research Unit. Sociedad Española de Reumatología, Madrid, Spain, ⁶Madrid
Background/Purpose: Recently, a Working Group of the SpondyloArtrhitis International Society (ASAS) has proposed a composite disease activity score, the Ankylosing Spondylitis Disease Activity Score (ASDAS),…
Abstract Number: 1362 • 2012 ACR/ARHP Annual Meeting
Evaluation of Spondyloarthritis activity by the Patients and the Physicians: ASDAS, Basdai, PASS and Flare
Marie Godfrin-Valnet¹, Clément Prati², Marc Puyraveau³, Eric Toussirot⁴, Helene Letho-Gyselinck⁵ and Daniel Wendling⁵, ¹Rheumatology, CHU, Besançon, France, ²Service de Rhumatologie, CHU J Minjoz, Besancon, France, ³Clinical Methodology Center, CHU, Besançon, France, ⁴Université de Franche Comté , CHRU, CIC Biotherapy 506 and Rheumatology and EA 4266 Pathogens and Inflammation, Besançon, France, ⁵Service de Rhumatologie, Minjoz University Hospital, Besancon, France
Background/Purpose: Objectives: to define thresholds of the ASDAS corresponding to the PASS (Pateint Acceptable Symptomatic State) and to the thresholds of activity of the disease…
Abstract Number: 1343 • 2012 ACR/ARHP Annual Meeting
EARLY Improvements in the Lower Limbs Enthesis by Ultrasound Predicting Later Favorable Responses in TNF Inhibotors-Treated Patients with Spondyloarthritis
Kensuke Kume¹, Kanzo Amano¹, Kuniki Amano², Hiroyuki Ohta³ and Noriko Kuwaba⁴, ¹Rheumatology, Hiroshima Clinic, Hiroshima, Japan, ²Rheumatology, Sky Clinic, Hiroshima, Japan, ³Medical Research, hiroshima clinic, Hiroshima, Japan, ⁴Medical Research, Sanki Clinical Link, Hiroshima, Japan
Background/Purpose: Lower limbs enthesis by ultrasound (US) detects inflammatory activity in patients with spondyloarthritis(SpA) and is a diagnostic tool of early SpA. The present objective…
Abstract Number: 593 • 2012 ACR/ARHP Annual Meeting
DKK1 Serum Level Is Increased in Recent Spondyloarthritis and Is Associated with Higher Prevalence of Syndesmophytes. Sclerostin Is Highly Correlated with Age. Data From the DESIR Cohort
Gaetane Nocturne¹, Stephan Pavy², Désirée van der Heijde³, Philipe M. Goupille⁴, Maxime Dougados⁵, Christian Roux⁶, Xavier Mariette⁷ and Corinne Miceli-Richard², ¹INSERM U1012, Université Paris Sud, Le Kremlin Bicêtre, France, ²Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Hopital Trousseau, Tours, France, ⁵Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ⁶Paris Descartes University, Paris, France, ⁷Rheumatology, Université Paris-Sud, Le Kremlin Bicetre, France
Background/Purpose: Dickkopf-1 (DKK-1) and sclerostin (SOST) are 2 inhibitory proteins of the Wnt signalling pathway that could rationally be involved either in AS osteoporosis or…

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