ACR Meeting Abstracts

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Abstracts tagged "SLE"

  • Abstract Number: 715 • 2018 ACR/ARHP Annual Meeting

    Septic Shock Among Patients with Systemic Lupus Erythematosus: Short and Long-Term Outcome and Cost. Analysis of the French Nationwide Database

    Arthur Mageau1, Karim Sacre2, Anne Perozziello1, Stephane Ruckly1, Claire Dupuis1, Lila Bouadma1, Thomas Papo1 and Jean Francois Timsit1, 1Université Paris-Diderot, Paris, France, 2Bichat Hospital, Paris Diderot University, Paris, France

    Background/Purpose: Infection is a leading cause of death and ICU admission in systemic lupus erythematosus (SLE) patients. Our aim was to investigate the outcome and…
  • Abstract Number: 1084 • 2018 ACR/ARHP Annual Meeting

    Dysfunction of the DNASE1L3 Pathway and Antigen Accumulation in Lupus Nephritis

    Johannes Hartl1, Robert M. Clancy1, Peter M. Izmirly2, H. Michael Belmont1, Nicole Kaiden3, Nicole Bornkamp3, Vanja Sisirak1, Benjamin Sally1, Jill P. Buyon1 and Boris Reizis1, 1NYU School of Medicine, New York, NY, 2Medicine, Division of Rheumatology, NYU School of Medicine, New York, NY, 3Medicine, NYU School of Medicine, New York, NY

    Background/Purpose: DNASE1L3 is a unique secreted DNase that is capable of degrading DNA complexed with proteins and/or encapsulated in membranes, such as chromatin within microparticles…
  • Abstract Number: 1942 • 2018 ACR/ARHP Annual Meeting

    Anti-NMDA Receptor Antibodies in Systemic Lupus Erythematosus Associate with Decreased White Matter Integrity and Impaired Spatial Memory

    Erik Anderson1, An Vo2, Elisabeth Ploran3, Betty Diamond2, Bruce Volpe4, Cynthia Aranow2, David Eidelberg2 and Meggan Mackay2, 1Autoimmune and Musculoskeletal Disease, The Feinstein Institute for Medical Research, Manhasset, NY, 2The Feinstein Institute for Medical Research, Manhasset, NY, 3Hofstra University, Hempstead, NY, 4Biomedical Sciences, The Feinstein Institute for Medical Research, Manhasset, NY

    Background/Purpose: Cognitive impairment is common in SLE and impacts quality of life; however, causality is limited by incomplete understanding of neurotoxic mechanisms. Diffusion tensor imaging…
  • Abstract Number: 2150 • 2018 ACR/ARHP Annual Meeting

    Association of Poverty Income Ratio with Physical Functioning in a Cohort of Patients with Systemic Lupus Erythematosus

    Courtney Hoge1, C. Barrett Bowling2, S. Sam Lim3, Cristina Drenkard4 and Laura Plantinga5, 1Department of Epidemiology, Emory University, Atlanta, GA, 2Durham Veterans Affairs Medical Center, Durham, NC, 3Emory University School of Medicine, Atlanta, GA, 4Medicine/Rheumatology, Emory University, Atlanta, GA, 5Department of Medicine, Emory University School of Medicine, Atlanta, GA

    Background/Purpose: Lower socioeconomic status (SES) has been shown to be associated with poor physical functioning in systemic lupus erythematosus (SLE) patients; however, previous studies have…
  • Abstract Number: 2894 • 2018 ACR/ARHP Annual Meeting

    Psychosis in Systemic Lupus Erythematosus: Results from an International, Inception Cohort Study

    John G. Hanly1, Qiuju Li2, Li Su3, Murray Urowitz4, Caroline Gordon5, Sang-Cheol Bae6, Juanita Romero-Díaz7, Jorge Sanchez-Guerrero4, Sasha Bernatsky8, Ann E. Clarke9, Daniel J. Wallace10, David A. Isenberg11, Anisur Rahman12, Joan T. Merrill13, Paul R. Fortin14, Dafna D Gladman15, Ian N. Bruce16, Michelle Petri17, Ellen M. Ginzler18, Mary Dooley19, Kristján Steinsson20, Rosalind Ramsey-Goldman21, Asad A Zoma22, Susan Manzi23, Ola Nived24, Andreas Jönsen24, Munther A Khamashta25, Graciela S. Alarcón26, Ronald F van Vollenhoven27, Cynthia Aranow28, Meggan Mackay28, Guillermo Ruiz-Irastorza29, Manuel Ramos-Casals30, S. Sam Lim31, Murat Inanc32, Kenneth C. Kalunian33, Søren Jacobsen34, Christine A. Peschken35, Diane L. Kamen36, Anca Askanase37, Chris Theriault38 and Vernon Farewell39, 1Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 2MRC Biostatistics Unit, Cambridge, United Kingdom, 3Nova Scotia Rehab Site, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, 4University of Toronto Lupus Research Program, Toronto Western Hospital, Toronto, ON, Canada, 5Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom, 6Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), 7Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas y Nutricion, Mexico City, Mexico, 8Divisions of Rheumatology and Clinical Epidemiology, The Research Institute of the McGill University Health Centre, Montreal, QC, Canada, 9Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 10Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, 11University College London, London, United Kingdom, 12Rayne Institute, University College London, London, United Kingdom, 13Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 14Medicine, CHU de Québec - University of Laval, Quebec, QC, Canada, 15Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, 16Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, United Kingdom, 17Johns Hopkins University School of Medicine, Baltimore, MD, 18Rheumatology, SUNY Downstate Medical Center, Brooklyn, NY, 19Dooley Rheumatology, Chapel Hill Doctors, Chapel Hill, NC, 20Rheumatology, Univ. Hospital, Reykjavik, Iceland, 21FSM, Northwestern University, Chicago, IL, 22Lanarkshire Center for Rheumatology, Hairmyres Hospital, East Kilbride, East Kilbride, Scotland, United Kingdom, 23Autoimmunity Institute and Medicine Institute, Allegheny Health Network, Pittsburgh, PA, 24Rheumatology, Lund University, Department of Clinical Sciences, Lund, Sweden, 25Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, 26University of Alabama at Birmingham, Birmingham, AL, 27Unit for clinical therapy research (ClinTRID), Karolinska Institute, Stockholm, Sweden, 28The Feinstein Institute for Medical Research, Manhasset, NY, 29Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain, 30Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Spain, Barcelona, Spain, 31Emory University School of Medicine, Atlanta, GA, 32Department of Internal Medicine, Division of Rheumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey, 33Division of Rheumatology, Allergy and Immunology, UCSD School of Medicine, La Jolla, CA, 34Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, 35RR 149G, University of Manitoba, Winnipeg, MB, Canada, 36Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 37Rheumatology, Columbia University, College of Physician and Surgeons, New York, NY, 38Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada, 39Medicine, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada

    Background/Purpose: Psychosis, one of the rarer neuropsychiatric (NP) events in lupus patients, features in both the ACR and Systemic Lupus International Collaborating Clinics (SLICC) classification…
  • Abstract Number: 27 • 2018 ACR/ARHP Annual Meeting

    Top-Down Proteomics Coupled with Antibody Sequencing from Single B Cells Reveals a Monoclonal Anti-Sm Clone Present in the Serum of an SLE Patient over Three Years

    Zhe Wang1, Jennifer Muther2, Judith A. James3, Si Wu1 and Kenneth Smith2, 1Chemistry and Biochemistry, University of Oklahoma, Norman, OK, 2Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 3University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Proteomics is becoming an increasingly powerful tool to study autoantibodies. Current bottom-up approaches are yielding a plethora of knowledge about public clonotypes and clonal…
  • Abstract Number: 728 • 2018 ACR/ARHP Annual Meeting

    A Higher Activity Index at Initial Renal Biopsy Is Associated with Rapid Progression to Renal Failure in Patients with Refractory Lupus Nephritis

    Shuwei Wang1, Stacy Tanner2, Teja Kapoor3, Thania Perez4, Vivette D D'Agati5, Anca Askanase4, Robert Winchester3 and Laura Geraldino-Pardilla3, 1Rheumatology, Columbia University, College of Physicians & Surgeons, New York City, NY, 2Division of Rheumatology, Columbia University, College of Physicians & Surgeons, Winnipeg, DC, Canada, 3Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, 4Columbia University, College of Physicians & Surgeons, New York, NY, 5Pathology & Cell Biology, Columbia University, College of Physicians & Surgeons, New York City, NY

    Background/Purpose: Lupus nephritis (LN) is a major cause of morbidity and mortality affecting ~50% of systemic lupus erythematosus (SLE) patients.  Up to 30% of patients…
  • Abstract Number: 1091 • 2018 ACR/ARHP Annual Meeting

    Serine Arginine-Rich Splicing Factor 1 (SRSF1) Is Essential for T Lymphocyte Homeostasis and Decreased Levels of SRSF1 Correlate with Lymphopenia in SLE Patients

    Takayuki Katsuyama1, Kotaro Iida2 and Vaishali R. Moulton1, 1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Rheumatology, Department of Medicine, Boston, MA

    Background/Purpose: Lymphopenia is one of the most common clinical features in patients with systemic lupus erythematosus (SLE), and associates with severe disease and comorbidities such…
  • Abstract Number: 1943 • 2018 ACR/ARHP Annual Meeting

    Apolipoprotein L1 Risk Variants Associate with Poor Renal Outcomes, Damage Accrual, and Death: A Prospective Ghanaian SLE Cohort

    Ashira Blazer1, Ida Dzifa Dey2, Margaret Reynolds3, Festus Ankrah3, Nancyanne Schmidt4, Robert M. Clancy5 and Jill P. Buyon6, 1Internal Medicine Division of Rheumatology, NYU School of Medicine, New York, NY, 2Department of Medicine, Rheumatology Unit, School of Medicine and Dentistry,University of Ghana, Accra, Ghana, 3Internal Medicine, The University of Ghana, Accra, Ghana, 4Internal Medicine, New York University School of Medicine, New York, NY, 5NYU School of Medicine, New York, NY, 6Rheumatology, NYU School of Medicine, New York, NY

    Background/Purpose: Two Apolipoprotein L1 (APOL1) risk variants (RV), G1 and G2, are enriched in ancestrally African populations due to a conferred superior resistance to Trypanosoma…
  • Abstract Number: 2170 • 2018 ACR/ARHP Annual Meeting

    Relationship between Short- and Long-Term Periods of Self-Reported Physical Activity Patterns in Individuals with SLE

    Gizem Irem Kinikli1, Susanne Pettersson2, Iva Gunnarsson3, Elisabet Svenungsson3 and Carina Boström4, 1Physiotherapy and Rehabilitation, Hacettepe University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara/TURKEY, Ankara, Turkey, 2Neurobiology, care sciences and society, Karolinska Institutet, Department of Neurobiology, care sciences and society, Karolinska University Hospital, Stockholm/SWEDEN, Stockholm, Sweden, 3Division of Rheumatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden, 4Karolinska University Hospital, Karolinska Institutet, Department of Neurobiology, care sciences and society, Karolinska University Hospital, Stockholm/SWEDEN, Stockholm, Sweden

    Background/Purpose: Physical inactivity is prevalent in Systemic Lupus Erythematosus (SLE). Assessment of physical activity (PA) is vital to manage cardiovascular risk factors in SLE. The…
  • Abstract Number: 2895 • 2018 ACR/ARHP Annual Meeting

    Effect of Vitamin D on Serum Markers of Bone Turnover in SLE in a Randomized Controlled Trial

    Sara K. Tedeschi1, Cynthia Aranow2, Diane L. Kamen3, Meryl S. LeBoff4, Betty Diamond2 and Karen Costenbader5, 1Division of Rheumatology, Immunology and Allergy, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, 2The Feinstein Institute for Medical Research, Manhasset, NY, 3Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 4Division of Endocrinology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 5Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Bone health in SLE is adversely affected by vitamin D deficiency, inflammatory cytokines including interferon (IFN)-α, and glucocorticoid use. We tested the hypothesis that…
  • Abstract Number: 93 • 2018 ACR/ARHP Annual Meeting

    Biomarkers Associating Endothelial Function in Systemic Lupus Erythematous

    Wan-Fang Lee1, Chao-Yi Wu2, Huang-Yu Yang3 and Jing-Long Huang2,4, 1Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, 2Division of Allergy, Asthma and Rheumatology. Department of Pediatrics, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, 3Department of Nephrology,, Chang-Gung Memorial Hospital, Taoyuan city, Taiwan, 4Medicine, Chang-Gung University, Taoyuan city, Taiwan

    Background/Purpose: The endothelium is a key element in the regulation of vascular homeostasis and its alteration is a precursor of vascular disease. Considering SLE is…
  • Abstract Number: 749 • 2018 ACR/ARHP Annual Meeting

    Is Lupus Nephritis Onset Delayed in Older Caucasian Females with Less Aggressive Pathology?

    Cristina Arriens1, Sixia Chen2, David Karp3, Ramesh Saxena4, Joan T. Merrill1 and Judith A. James5, 1Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 3Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, 4Nephrology Division, UT Southwestern Medical Center, Dallas, TX, 5Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Lupus Nephritis (LN) usually presents within 5 years of SLE diagnosis, however the minority of patients with late-occurring nephritis are poorly characterized. Factors associated…
  • Abstract Number: 1095 • 2018 ACR/ARHP Annual Meeting

    IFN Gene Expression Correlates with Frequency of Circulating Switched Memory B-Cells in Patients with Incomplete Systemic Lupus Erythematosus

    Wietske Lambers1, Geert Lanting1, Wayel H. Abdulahad2, Hendrika Bootsma2, Johanna Westra2 and Karina de Leeuw3, 1Rheumatology/Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 2Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Incomplete systemic lupus erythematosus (iSLE) includes patients with typical features of SLE, who do not meet classification criteria. Still, up to 50% will develop…
  • Abstract Number: 2019 • 2018 ACR/ARHP Annual Meeting

    Investigating Urine S100A4 and Podocyte Proteins As Biomarkers of Lupus Nephritis Activity

    Jessica Turnier1, Jianghong Deng2, Pinar Ozge Avar Aydin3, David Witte4, Prasad Devarajan5, Matthew Fenchel6, Michael Bennett7 and Hermine I. Brunner8, 1Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Division of Rheumatology, Beijing Children’s Hospital and Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 3Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Pathology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 5Nephrology, Cincinnati Children`s Hospital Medical Center, Cincinnati, OH, 6Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 7Nephrology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 8Pediatric Rheumatology Collaborative Study Group (PRCSG), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: We lack accurate clinical tools to identify the degree of active renal inflammation in childhood-onset SLE (cSLE). In this study, we investigated urine S100A4…
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