ACR Meeting Abstracts

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Abstracts tagged "SLE"

  • Abstract Number: 779 • 2018 ACR/ARHP Annual Meeting

    Cerebrospinal Fluid Biomarkers for Diagnosing Neuropsychiatric SLE: A Systematic Review and Meta-Analysis

    Seyed-Foad Ahmadi1, Golara Zahmatkesh2, Masoud Majed3 and Sheetal Desai4, 1Department of Medicine, University of California Irvine, Orange, CA, 2Department of Psychiatry, University of New Mexico, Albuquerque, NM, 3Department of Neurology, University of Texas Southwestern Medical Center, Dallas, TX, 4Medicine/Rheumatology, Unviersity of California, Irvine, Orange, CA

    Cerebrospinal Fluid Biomarkers for Diagnosing Neuropsychiatric SLE: A Systematic Review and Meta-analysis Background/Purpose: Current guidelines recommend that in suspected neuropsychiatric SLE (NPSLE), the initial diagnostic workup…
  • Abstract Number: 1666 • 2018 ACR/ARHP Annual Meeting

    The Use of Patient-Reported Outcome Measures to Assess Clinical Features of Fibromyalgia in SLE

    Jennifer Rogers1, Amanda M. Eudy2, Lisa Criscione-Schreiber2, David Pisetsky3, Kai Sun4, Jay Doss4 and Megan E. B. Clowse2, 1Medicine, Divison of Rheumatology, Duke University, Durham, NC, 2Department of Medicine, Division of Rheumatology and Immunology, Duke University, Durham, NC, 3Department of Medicine, Duke University, Durham, NC, 4Division of Rheumatology & Immunology, Duke University, Durham, NC

    Background/Purpose: Patient-reported outcome measures (PROs) in SLE can capture patient specific information and the patient perspective, but clinical use can be challenging due to confounding…
  • Abstract Number: 2105 • 2018 ACR/ARHP Annual Meeting

    Genetic Analysis of a Drosophila Systemic Lupus Erythematosus Model Reveals Lupus Susceptibility Genes

    Pooja KR, Brooklynne Thielen, Xavier Hernandez and Nathan Mortimer, School of Biological Sciences, Illinois State University, Normal, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder with various immunological abnormalities and a diverse range of clinical symptoms. In contrast to the…
  • Abstract Number: 2664 • 2018 ACR/ARHP Annual Meeting

    Long-Term Clinical Outcomes in a Cohort of Adults with Childhood-Onset Systemic Lupus Erythematosus

    Noortje Groot1, Y.K. Onno Teng2, Karina de Leeuw3, Marc Bijl4, Radboud J. E. M. Dolhain5, Els J. Zirkzee6, Ruth D.E. Fritsch-Stork7, Irene E.M. Bultink8 and Sylvia S.M. Kamphuis9, 1Pediatric Rheumatology, Sophia Children's Hospital – Erasmus University Medical Centre, Rotterdam, Netherlands, 2Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands, Leiden, Netherlands, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, 4Internal Medicine and Rheumatology, Martini Hospital, Groningen, Netherlands, 5Rheumatology, Erasmus University Medical Centre, Rotterdam, Netherlands, 6Department of Rheumatology, Maasstad Hospital, Rotterdam, Netherlands, 7Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 8Rheumatology, Amsterdam Rheumatology and immunology Center | VU University Medical Center, Amsterdam, Netherlands, Amsterdam, Netherlands, 9Pediatric Rheumatology, Sophia Children's Hospital – Erasmus University Medical Center, Rotterdam, Netherlands

    Background/Purpose: Childhood-onset SLE (cSLE) is a severe lifelong multisystem autoimmune disease. Long-term outcome data are limited. Here, we report for the first time on the…
  • Abstract Number: 395 • 2018 ACR/ARHP Annual Meeting

    Systemic Lupus Erythematosus (SLE) with Inflammatory Myositis

    Nicole Bitencourt, Elizabeth (Blair) Solow and Bonnie L. Bermas, Division of Rheumatic Diseases, UT Southwestern Medical Center, Dallas, TX

    Background/Purpose: The goal of this study was to identify specific clinical features of patients with SLE who have inflammatory myositis. Methods: A retrospective chart review…
  • Abstract Number: 916 • 2018 ACR/ARHP Annual Meeting

    Integrative Analysis of Multi-Omics Data in an Ethnically Diverse Lupus Cohort Identifies Distinct Molecular Subtypes of SLE

    Cristina Lanata1, Ishan Paranjpe2, Joanne Nitiham3, Kimberly Taylor4, Brooke Rhead5, Milena Gianfrancesco6, Lisa Barcellos7, Louise Murphy8, Patricia Katz9, Laura Trupin6, Jinoos Yazdany2, Maria Dall'Era2, Marina Sirota10 and Lindsey A. Criswell9, 1Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, Division of Rheumatology, University of California, San Francisco, San Francisco, CA, 2University of California, San Francisco, San Francisco, CA, 3Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, University of California, San Francisco, San Francisco, CA, 4University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, 5University of California, Berkeley, Berkeley, CA, 6Medicine/Rheumatology, University of California, San Francisco, San Francisco, CA, 7School of Public Health, UC Berkeley, Berkeley, CA, 8Arthritis Program, Centers for Disease Control and Prevention, Atlanta, GA, 9University of California San Francisco, San Francisco, CA, 10Pediatrics, Institute for Computational Health Sciences, University of California, San Francisco, San Francisco, CA

    Background/Purpose: Systemic Lupus Erythematous (SLE) is a chronic autoimmune disease with heterogeneous disease manifestations and outcomes. We aimed to define how molecular differences underlie this…
  • Abstract Number: 1672 • 2018 ACR/ARHP Annual Meeting

    Poor Sleep Quality Predicts Worsening SLE Disease Activity

    Philip Chu1, Alicia M. Hinze2, Noor Al-Hammadi3, Lacey Feigl4, Nancy Mathis4, Deepali Sen5, Seth Eisen4, Yo-El Ju6 and Alfred Kim7, 1Internal Medicine, Washington University School of Medicine, Saint Louis, MO, 2Rheumatology, Johns Hopkins University, Baltimore, MD, 3Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, 4Rheumatology, Washington University School of Medicine, Saint Louis, MO, 5Rheumatology, Washington University School of Medicine, St. Louis, MO, 6Neurology, Washington University School of Medicine, Saint Louis, MO, 7Medicine/Rheumatology, Washington University School of Medicine, St. Louis, MO

    Background/Purpose: Poor sleep quality is commonly observed in patients with SLE. We hypothesize that poor sleep contributes to worsening SLE. The aims of this study…
  • Abstract Number: 2107 • 2018 ACR/ARHP Annual Meeting

    Lupus-Prone SLE1.2.3. Mice Exhibit Loss of Thymus-Derived CD4+CD25+Helios+ Tregs

    Nick Huang1, Zhi-Wei Lai1, Gourav Choudhary2, Thomas Winans3, Ryan Kelly4, Katalin Banki5, Laurence Morel6 and Andras Perl1, 1Medicine, SUNY Upstate Medical University, Syracuse, NY, 2Department of Biochemistry and Mol. Biology, SUNY Upstate Medical University, Syracuse, NY, 3SUNY Upstate Medical University, Syracuse, NY, 4SUNY, Syracuse, NY, 5Clinical Pathology, SUNY Upstate Medical University, Syracuse, NY, 6Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease that is characterized by the production of autoantibodies against nuclear antigens (ANA) and phospholipids…
  • Abstract Number: 2671 • 2018 ACR/ARHP Annual Meeting

    Development and First-in-Human Characterization of an ICOSL and BAFF Bispecific Inhibitor AMG 570 for SLE Treatment

    Laurence E Cheng1, Hailing Hsu2, Martin Kankam3, Nicholas Siebers4, Randall Stoltz5, Lubna Abuqayyas2, Bella Ertik6, Barbara Sullivan2, Lei Zhou2 and Jane R Parnes2, 1Amgen Inc., South San Francisco, CA, 2Amgen Inc., Thousand Oaks, CA, 3Vince and Associates Clinical Research, Inc.,, Overland Park, KS, 4Covance, Madison, WI, 5Covance, Evansville, IN, 6Amgen Inc, Boston, MA

    Background/Purpose: Autoimmune diseases, including systemic lupus erythematosus (SLE), are associated with dysregulated T cell and B cell responses. AMG 570 is a bispecific molecule targeting…
  • Abstract Number: 464 • 2018 ACR/ARHP Annual Meeting

    The Long Term Outcomes in Chinese Children Diagnosed with Systemic Lupus Erythematosus and Biopsy Proven Lupus Nephritis – a 18-Year Cohort

    Grace Chiang1,2, Sik Nin Wong3, Clara Law4, Kwok Piu Lee5, Cheuk Chun Szeto6, Chi Chiu Mok7, Lai-Shan Tam8 and Ting Fan Leung9, 1Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Sha Tin, Hong Kong, 2Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, 3Paediatrics and Adolescent Medicine, Tune Mun Hospital, Hong Kong, Hong Kong, 4Medicine and Therapeutics, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, Hong Kong, 5Paediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Hong Kong, Hong Kong, 6Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong, 7Medicine and Geriatrics, Tune Mun Hospital, Hong Kong, Hong Kong, Hong Kong, 8Department of Medicine & Therapeutics, The Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China, Hong Kong, Hong Kong, 9Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Renal disease occurs in 50-70% of all childhood onset systemic lupus erythematosus (cSLE).  The prevalence of LN is higher in children and the manifestations…
  • Abstract Number: 936 • 2018 ACR/ARHP Annual Meeting

    Selective Deficiency of Serine Arginine-Rich Splicing Factor 1 (SRSF1) in T Lymphocytes Leads to mTORC1 Activation, Treg Dysfunction and Systemic Autoimmune Disease

    Takayuki Katsuyama1, Hao Li1, Denis Comte2, Michael W. Mosho3, Andrew R. Gillooly3, George C Tsokos4 and Vaishali R. Moulton1, 1Division of Rheumatology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 2Beth Israel Deaconess Medical Center, Harvard Medical School, Division of Rheumatology, Department of Medicine, Boston, MA, 3Medicine/ Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 4Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA

    Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit defects in signaling and cytokine production, and aberrant numbers and/or function of regulatory T…
  • Abstract Number: 1681 • 2018 ACR/ARHP Annual Meeting

    Performance of the Proposed American College of Rheumatology / European League Against Rheumatism 2017 Classification Criteria for SLE in Adult and Juvenile Systemic Lupus Erythematosus and Other Anti-Nuclear Antibody Related Rheumatic Diseases

    Chengappa KG1, Gunjan Kumar2, Swaminathan R P3 and Vir Singh Negi1, 1Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India, 2Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India, 3Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India

    Background/Purpose: A new classification criteria for SLE was proposed at the ACR/ARHP 2017 annual meet. The aim of this study was to compare the performance…
  • Abstract Number: 2111 • 2018 ACR/ARHP Annual Meeting

    Ifnβ Affects Osteogenesis-Adipogenesis Axis in SLE Bone Marrow

    Lin Gao, Mary O'Connell, Jennifer Anolik and R. John Looney, Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY

    Background/Purpose: SLE patients are especially vulnerable to corticosteroid induced avascular necrosis. While it is appreciated that multiple factors contribute to AVN, the bone-fat axis in…
  • Abstract Number: 2683 • 2018 ACR/ARHP Annual Meeting

    Selective Expansion and Targeting of FoxP3+CD127lo Regulatory T Cells By Low-Dose IL-2 Therapy in Active SLE

    Jens Humrich1, Caroline von Spee-Mayer2, Philipp Enghard3, Angelika Rose4, Elise Siegert5, Tobias Alexander5, Falk Hiepe6, Gerd R. Burmester7 and Gabriela Riemekasten8, 1Department of Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany, 2Immunology, University Hospital Freiburg, Freiburg, Germany, 3Department of Nephrology, Charité – University Medicine Berlin, Berlin, Germany, 4Rheumatology and Clinical Immunology, Charité – University Medicine Berlin, Berlin, Germany, 5Rheumatology and Clinical Immunology, Charité - University Medicine Berlin, Berlin, Germany, 6Rheumatology, Charité – University Medicine Berlin, Berlin, Germany, 7Rheumatology and Clinical Immunology, Charité-University Medicine Berlin, Berlin, Germany, 8Rheumatology, University Hospital Schleswig-Holstein - Campus Lübeck, Lübeck, Germany

    Background/Purpose: Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies…
  • Abstract Number: 467 • 2018 ACR/ARHP Annual Meeting

    The Prevalence and Clinical Features of Co-Occurring Autoimmunity in Children with Systemic Lupus Erythematosus: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry

    Ohoud AlAhmed1, Vidya Sivaraman2, Melissa Moore-Clingenpeel3, Stacy P. Ardoin4 and Sharon Bout-Tabaku5, 1Pediatric Rheumatology, Nationwide Children's Hospital, Columbus, OH, 2Pediatrics, The Ohio State University, COLUMBUS, OH, 3Research, Nationwide Children's Hospital, Dublin, OH, 4Division of Rheumatology, Nationwide Children’s Hospital, Columbus, OH, 5Rheumatology, Nationwide Children's Hospital, Columbus, OH

    Background/Purpose: The co-occurrence of autoimmune disorders (AI) with systemic lupus erythematosus (SLE) in adults is associated with poor disease outcomes. We describe the co-occurrence of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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