Abstracts tagged "SLE"

Abstract Number: 1650 • 2014 ACR/ARHP Annual Meeting
Prevalence and Prognostic Implications of IgG4 in Membranous Lupus Nephritis
David Herrera Van Oostdam¹, Marco Ulises Martinez-Martinez¹, Cuauhtémoc Oros-Ovalle², David Martínez-Galla², Gerardo Tonatiu Jaimes-Piñón¹, Natalia Alemán-Sánchez² and Carlos Abud-Mendoza¹, ¹Unidad de Investigaciones Reumatológicas, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico, ²Patología, Hospital Central & Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico
Background/Purpose: Patients with membranous lupus nephritis (MLN) have increased risk of thrombosis and different prognosis than other classes of lupus nephritis (LN). Previous studies demonstrated…
Abstract Number: 867 • 2014 ACR/ARHP Annual Meeting
Specific SLE Disease Manifestations in the Six Months Prior to Conception Predict Similar Manifestations during Pregnancy
Sara K. Tedeschi¹, Hongshu Guan¹, Alexander Fine¹, Bonnie L. Bermas² and Karen H. Costenbader², ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Active SLE, in particular lupus nephritis, during the six months prior to conception is associated with disease flare during pregnancy. Previous studies, however, have…
Abstract Number: 657 • 2014 ACR/ARHP Annual Meeting
Distinct Contributions of C1q and C3 in Preventing Immunogenicity of Apoptotic Cells in Lupus
Clayton Sontheimer¹, Yenly Nguyen², Keith B. Elkon³ and YuFeng Peng³, ¹Pediatric Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Rheumatology, University of Washington, Seattle, WA
Background/Purpose: Defective clearance of apoptotic cells (AC) and complement deficiency are important contributors to the pathogenesis of systemic lupus. Dead (sunburn) cells and complement…
Abstract Number: 2737 • 2014 ACR/ARHP Annual Meeting
Microrna-155 Suppresses IL-21 Signaling and Production in Systemic Lupus Erythematosus
Tue K. Rasmussen¹, Thomas Andersen¹, Rasmus Bak¹, Gloria Yiu², Kristian Steengaard-Petersen³, Jacob G. Mikkelsen¹, Paul J. Utz⁴, Christian Holm¹ and Bent Deleuran^3,5, ¹Department of Biomedicine, Aarhus University, Aarhus C, Denmark, ²Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ³Department of Rheumatology, Aarhus University Hospital, Aarhus, Denmark, ⁴Medicine, Stanford University School of Medicine, Stanford, CA, ⁵Department of Biomedicine, Aarhus University, Aarhus, Denmark
Background/Purpose IL-21 is a key regulator of B cells functions and autoantibody production and is mainly produced by follicular T helper cells. The purpose of…
Abstract Number: 2109 • 2014 ACR/ARHP Annual Meeting
Are Patient Ratings of Providers and Health Plans Associated with Technical Quality of Care in SLE?
Edward H. Yelin¹, Laura Trupin², Jinoos Yazdany² and Chris Tonner³, ¹Arthritis Research Group, University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, San Francisco, CA, ³3333 California Street, Box 09, University of California, San Francisco, San Francisco, CA
Background/Purpose . Prior research has shown that the technical quality of SLE care is associated with the degree of subsequent accumulated damage. However, it is…
Abstract Number: 1647 • 2014 ACR/ARHP Annual Meeting
Relationship Between Apom/S1P Levels and Atherosclerosis in Women with Systemic Lupus Erythematosus
Sonali Narain¹, Sylvain Galvani², Christina Christoffersen³, Peiying Yang⁴, Maureen A. McMahon⁵, Timothy Hla² and Jane E. Salmon¹, ¹Rheumatology, Hospital for Special Surgery, New York, NY, ²Vascular Biology, Weill Cornell College of Medicine, New York, NY, ³Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, ⁴Gen Oncology Research, University of Texas MD Anderson Cancer Center, Houston, TX, ⁵Division of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, CA
Background/Purpose: SLE patients are at risk for atherosclerotic cardiovascular disease (ASCVD). In some SLE patients, high density lipoprotein (HDL) has impaired vasoprotective effects, and this…
Abstract Number: 865 • 2014 ACR/ARHP Annual Meeting
Cardiovascular Events Prior to or Early after Diagnosis of SLE
Murray B. Urowitz¹, Dafna D. Gladman¹, Nicole Anderson², Dominique Ibanez³ and Systemic Lupus International Collaborating Clinics (SLICC)⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Toronto Western Hospital, Division of Rheumatology, University of Toronto, Toronto Western Hospital (Coordinating Center), Toronto, ON, Canada
Background/Purpose: A large multicenter multinational inception cohort was established to study risk factors for atherosclerosis (AS) in SLE. Previous studies have shown a history of…
Abstract Number: 651 • 2014 ACR/ARHP Annual Meeting
Inhibiting Tweak (TNF-like weak inducer of apoptosis) Signaling Improves Blood Brain Barrier Integrity and Protects from Neuronal Damage in Murine Neuropsychiatric Lupus
Jing Wen¹, Jessica Doerner¹, Ariel Stock², Jennifer Michaelson³, Linda Burkly³, Maria Gulinello² and Chaim Putterman⁴, ¹Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Biogen Idec, Cambridge, MA, ⁴The Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: While neuropsychiatric involvement in systemic lupus erythematosus (NPSLE) is relatively common and appears early, the underlying mechanisms are not fully understood. The disruption of…
Abstract Number: 2722 • 2014 ACR/ARHP Annual Meeting
Rapamycin Corrects GATA-3 Deficiency in Lupus Treg
Hiroshi Kato¹ and Andras Perl², ¹Internal Medicine, Division of Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ²Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: As demonstrated by the negative correlation between Treg frequency or suppressive function and SLE disease activity index score, it is tempting to speculate that…
Abstract Number: 2112 • 2014 ACR/ARHP Annual Meeting
Patterns of Medication Use Before, During, and After Pregnancy Among Women with Systematic Lupus Erythematosus: A Population-Based Study
Mary De Vera¹, Eric C. Sayre², Corisande Baldwin³, Jessica Galo⁴ and J. Antonio Avina-Zubieta⁵, ¹University of British Columbia Faculty of Pharmaceutical Sciences, Vancouver, BC, Canada, ²Arthritis Research Centre of Canada, Richmond, BC, Canada, ³Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁴Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: Systemic lupus erythematosus (SLE) disproportionately affects women during childbearing years. Given the limited data on perinatal medication use among patients, our objective was…
Abstract Number: 1632 • 2014 ACR/ARHP Annual Meeting
Is Liopxin A4 a Biomarker for Systemic Lupus Erythematosus?
Manal Sedky Abdou¹, Dina Effat², Lamiaa Mansour³, Mona mohsen Abdul Salam³ and Noha abd El Baky⁴, ¹rheumatology and rehabilitation kasr el aini hospital, faculty of medicin, cairo university, cairo, Egypt, ²rheumatology and rehabilitation, faculty of medicin, cairo university, giza, Egypt, ³clinical and chemical pathology, faculty of medicin, cairo university, cairo, Egypt, ⁴rheumatology and rehabilitation, faculty of medicin, cairo university, cairo, Egypt
Background/Purpose : Systemic lupus erythematosus (SLE) is characterized by autoantibody production and immune complex deposition which trigger both a local and systemic inflammatory response. The…
Abstract Number: 859 • 2014 ACR/ARHP Annual Meeting
TGF-β3-Producing CD4⁺CD25^–LAG3⁺ Regulatory T Cells Control B Cell Responses
Tomohisa Okamura¹, Kaoru Morita¹, Mariko Inoue¹, Toshihiko Komai¹, Yukiko Iwasaki¹, Shuji Sumitomo¹, Shinichiro Nakachi¹, Hirofumi Shoda², Keishi Fujio² and Kazuhiko Yamamoto¹, ¹Department of Allergy and Rheumatology, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan, ²Department of Allergy and Rheumatology, The University of Tokyo, Tokyo, Japan
Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and associated with a wide range of clinical manifestations. Recent case-control association…
Abstract Number: 636 • 2014 ACR/ARHP Annual Meeting
Liposomal-Glucocorticoids: A Novel Approach to the Therapy of SLE
Yaakov Naparstek¹, Eli Moallem², Rina Ulmansky³, Erez Koren³ and Yechezkel Barenholz³, ¹Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ²Dept. of Medicine, Hadassah - Hebrew University Medical Center, Jerusalem, Israel, ³Hadassah - Hebrew University Medical Center, Jerusalem, Israel
Background/Purpose Glucocorticoids (GCs) have been known for years to be the most effective therapy in SLE. Their use is however limited by the need of…
Abstract Number: 2696 • 2014 ACR/ARHP Annual Meeting
Relationship Between Soluble sCD23 and B Cell Activation Factor in Patients with Systemic Lupus Erythematosus before and after Rituximab
Laura Heretiu^1,2, Maria J. Leandro³, Venkat Reddy⁴, David A. Isenberg⁵ and Geraldine Cambridge³, ¹Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Rheumatology and Internal Medicine, 'Sf. Maria' Clinical Hospital, Bucharest, Romania, ³Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research, Division of Medicine, University College London, London, United Kingdom, ⁵Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom
Background/Purpose CD23 is the low-affinity receptor for IgE (FceRII). The soluble form, sCD23 is released into the circulation and in vitro this is consistent with…
Abstract Number: 2049 • 2014 ACR/ARHP Annual Meeting
Fatigue Is a Risk Factor for Subsequent Functional Decline in SLE
Patricia P. Katz¹, Laura Trupin¹, Jennifer Barton¹, Gabriela Schmajuk¹, Mary Margaretten² and Edward H. Yelin³, ¹Medicine, University of California, San Francisco, San Francisco, CA, ²Rheumatology, University of California, San Francisco, San Francisco, CA, ³Arthritis Research Group, University of California, San Francisco, San Francisco, CA
Background/Purpose: In geriatrics, fatigue has been shown to be a harbinger of future functional decline. Fatigue is associated with poor function in systemic lupus erythematosus…

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

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