Abstracts tagged "SLE"

Abstract Number: 1858 • 2014 ACR/ARHP Annual Meeting
Standardized Mortality Ratios for Cause-Specific Deaths in Lupus Patients Followed Prospectively at a Single Centre Lupus Clinic
Barry J. Sheane¹, Dominique Ibanez², Dafna D. Gladman³ and Murray B. Urowitz³, ¹Division of Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ³University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Background/Purpose Despite the significant improvement in survival rates of patients with systemic lupus erythematosus (SLE) over the last four decades, mortality rates have remained at…
Abstract Number: 1310 • 2014 ACR/ARHP Annual Meeting
Predicting Macrophage Activation Syndrome in Pediatric Systemic Lupus Erythematosus Patients at Diagnosis
Maya Gerstein¹, Roberto Ezequiel Borgia², Brian Feldman¹, Deborah M. Levy³, Sharon Sukhdeo⁴, Susanne M. Benseler⁵, Lawrence W.K. Ng¹, Mohamed Abdelhaleem⁶, Earl D. Silverman² and Linda T Hiraki⁷, ¹Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ³Rheumatology, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ⁴Rheumatology, The Hospital For Sick Children, Toronto, ON, Canada, ⁵Rheumatology, Alberta Children's Hospital, University of Calgary, Calgary, AB, Canada, ⁶Department of Paediatric Laboratory Medicine, Division of Haematopathology, The Hospital for Sick Children, Toronto, ON, Canada, ⁷The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose It can be difficult to differentiate macrophage activation syndrome (MAS) from active pediatric systemic lupus erythematosus (pSLE). However, this differentiation is in determining correct…
Abstract Number: 676 • 2014 ACR/ARHP Annual Meeting
Response to Rituximab in Patients with Refractory Systemic Lupus Erythematosus (SLE): Results from a National Multicentre Register
Emily Sutton¹, Kath D. Watson², David A. Isenberg³, Anisur Rahman⁴, David Jayne⁵, Caroline Gordon⁶, Ben Parker⁷, David P. D'Cruz⁸, Munther A. Khamashta⁹, Pamela Lutalo¹⁰, Peter Lanyon¹¹, Benjamin Rhodes¹², Bridget Griffiths¹³, Edward M. Vital¹⁴, Chee-Seng Yee¹⁵, Christopher Edwards¹⁶, Mohammed Akil¹⁷, Nicola Erb¹⁸, Athiveer Prabu¹⁹, Asad A. Zoma²⁰, Neil McHugh²¹, Hazem Youssef²², Lee-Suan Teh²³, Michael W. Beresford²⁴ and Ian N. Bruce²⁵, ¹University of Manchester, Manchester Academic Health Science Centre, Arthritis Research UK Centre for Epidemiology, Manchester, United Kingdom, ²Arthritis Research UK Centre for Epidemiology, University of Manchester, Manchester, United Kingdom, ³Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁴Centre for Rheumatology Research, University College London, London, United Kingdom, ⁵Vasculitis and Lupus Clinic, Addenbrookes Hospital University of Cambridge, Cambridge, United Kingdom, ⁶Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ⁷Institute of Inflammation and Repair School of Translation Medicine The University of Manchester, Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁸Louise Coote Lupus Unit, Guy's and St Thomas' Hospital, London, United Kingdom, ⁹Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ¹⁰Peter Gorer Department of Immunobiology, King's College London School of Medicine, London, United Kingdom, ¹¹Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom, ¹²Rheumatology, Queen Elizabeth Hospital, Birmingham, United Kingdom, ¹³Rheumatology, Freeman Hospital, Newcastle Upon Tyne, United Kingdom, ¹⁴NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds., United Kingdom, Leeds, United Kingdom, ¹⁵Department of Rheumatology, Doncaster and Bassetlaw Hospitals NHS Foundation Trust, Doncaster, United Kingdom, ¹⁶Tremona Road, NIHR Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom, ¹⁷Rheumatology Department, Sheffield South Yorkshire, United Kingdom, ¹⁸Rheumatology, Russells Hall Hospital, Dudley, United Kingdom, ¹⁹Department of Rheumatology, Worcester Acute Hospitals NHS Trust, Worcester, United Kingdom, ²⁰Rheumatology, Hairmyres Hospital, East Kilbride, United Kingdom, ²¹Rheumatology, Royal National Hospital, Bath, United Kingdom, ²²Department of Rheumatology, NHS Grampian, Aberdeen, United Kingdom, ²³Department of Rhuematology, Royal Blackburn Hospital, Blackburn, United Kingdom, ²⁴Alder Hey Children's NHS Foundation Trust Hospital, Institute of Translational Medicine (Child Health), University of Liverpool, Liverpool, United Kingdom, ²⁵Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Published efficacy data for rituximab in SLE are complex with positive single-centre case series and negative randomised controlled trials. This may be due to…
Abstract Number: 2840 • 2014 ACR/ARHP Annual Meeting
Targeting the RhoA-Rock Pathway to Reverse T Cell Dysfunction in SLE
Cristina T. Rozo¹, Laura Leuenberger², Kyriakos A. Kirou³, Margaret Robotham¹, Sanjay Gupta⁴, Reena Khianey², Alessandra B. Pernis⁴ and Jane E. Salmon², ¹535 East 70th Street, Hospital for Special Surgery, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³Hospital for Special Surgery, New York, NY, ⁴Autoimmunity & Inflammation Research Program, Hospital for Special Surgery, New York, NY
Background/Purpose Aberrant expansion of TH-17 cells and deregulated production of IL-17 and IL-21 are involved in the pathogenesis of SLE. Production of IL-17 and IL-21…
Abstract Number: 2631 • 2014 ACR/ARHP Annual Meeting
Overall Cause and Cause-Specific Mortality in a Multinational Inception Cohort of SLE
Murray B. Urowitz¹, Dafna D. Gladman¹, Nicole Anderson², Dominique Ibanez³ and Systemic Lupus International Collaborating Clinics (SLICC)⁴, ¹University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ²Rheumatology, Toronto Western Hospital Research Institute, Toronto, ON, Canada, ³Rheumatology, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Toronto Western Hospital, Division of Rheumatology, University of Toronto, Toronto Western Hospital (Coordinating Center), Toronto, ON, Canada
Background/Purpose: A large multicenter multinational inception cohort was established initially to study risk factors for atherosclerosis (AS) in SLE. The aim of this study was…
Abstract Number: 1828 • 2014 ACR/ARHP Annual Meeting
Adverse Pregnancy Outcomes in Adolescents and Young Women with Systemic Lupus Erythematosus: A National Estimate
Nicole Ling¹, Isabel E. Allen², Erica F. Lawson¹ and Emily von Scheven³, ¹Pediatrics, University of California, San Francisco, San Francisco, CA, ²Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, ³Pediatric Rheumatology, University of California, San Francisco, San Francisco, CA
Background/Purpose: Pregnant women with SLE have increased risk of adverse outcomes including lupus flare, spontaneous abortion, preeclampsia/eclampsia, premature birth and maternal death, but pregnancy outcomes…
Abstract Number: 1294 • 2014 ACR/ARHP Annual Meeting
Gender Differences in the Lupus Nephritis Biomarkers in Children
Khalid Abulaban¹, Hermine Brunner², Michael Bennett³, Shannen L. Nelson⁴, Jun Ying⁵ and Prasad Devarajan³, ¹Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Nephrology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁴Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵University of Cincinnati, Cincinnati, OH
Background/Purpose: Lupus nephritis (LN) is frequently associated with a poor long-term prognosis. The non-invasive traditional measures of LN (LN-TM) currently used to monitor LN have…
Abstract Number: 674 • 2014 ACR/ARHP Annual Meeting
A Novel Strategy to Identify and Evaluate Approved Drugs and Treatments for Repositioning As Therapies for Systemic Lupus Erythematosus (SLE)
Peter E. Lipsky, Matthew Ryals, Jacob Smearman, Victoria Soler and Amrie Grammer, AMPEL BioSolutions, Charlottesville, VA
Background/Purpose: Development of new SLE treatments has been slow with only one new treatment approved in the past half century. One way to increase the…
Abstract Number: 2841 • 2014 ACR/ARHP Annual Meeting
Identifying Novel Lupus Severity Risk Variants through Identification of Alleles with High Ethnic Variability Worldwide
Belinda A. Waltman¹, Kimberly E. Taylor², Julio Molineros³, Sarah French⁴, Joanne Nitiham¹, Jennifer Kelly³, Adam Adler⁵, Judith A. James³, Swapan Nath⁶, Marta Alarcon-Riquelme^3,7 and Lindsey A. Criswell¹, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Department of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴School of Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁶Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁷GENYO. Center for Genomics and Oncological Research, Granada, Spain
Background/Purpose: Substantial epidemiologic evidence demonstrates that SLE disproportionately affects minority patients in terms of incidence, prevalence, and disease severity. European ancestry has been associated with…
Abstract Number: 2623 • 2014 ACR/ARHP Annual Meeting
Treatment Patterns and Resource Utilization of Systemic Lupus Erythematosus Patients Newly Initiating Standard of Care: United States Commercial and Medicare Supplemental Claims Analysis
Shonda A Foster¹, Emily Durden², Brett Maiese², Sarah Al Sawah¹ and Kathleen Solotkin¹, ¹Eli Lilly and Company, Indianapolis, IN, ²Truven Health Analytics, Bethesda, MD
Background/Purpose: Currently, there is not a standard treatment algorithm for the management of Systemic Lupus Erythematosus (SLE); however, there are medications that may be considered…
Abstract Number: 1813 • 2014 ACR/ARHP Annual Meeting
DNA Sensors Regulate Inflammation in a Model of Autoimmune Arthritis
Rebecca Baum¹, Shruti Sharma², Sudesh Pawaria³, Susan Carpenter⁴, Katherine A. Fitzgerald⁵, Ann Marshak-Rothstein⁶ and Ellen M. Gravallese⁷, ¹Cell Biology, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine - Infectious Diseases Division, University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ⁴University of California, San Francisco, San Francisco, CA, ⁵Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁶Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Innate immune sensors such as cytosolic DNA sensors and toll-like receptors (TLRs) detect viral or bacterial DNA, resulting in production of proinflammatory cytokines and…
Abstract Number: 1209 • 2014 ACR/ARHP Annual Meeting
Anti-Scavenger Receptor Autoantibodies Disrupted Marginal Zone Macrophage Integrity Via Bruton’s Tyrosine Kinase
Hao Li^1,2, Qi Wu¹, PingAr Yang¹, Zheng Wang³, Jun Li¹, Bao Luo¹, Jeffrey C. Edberg¹, Hui-Chen Hsu¹, John D. Mountz^1,4 and Robert P. Kimberly on behalf of PROFILE investigators⁵, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²Department of Medicine, Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ³Med - Pulmonary/Allergy/Critical Care, University of Alabama at Birmingham, Birmingham, AL, ⁴Birmingham VA Medical Center, Birmingham, AL, ⁵Clinical Immun & Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose Ibrutinib, a Btk kinase activity inhibitor, is a novel inhibitor under development for autoimmune disease therapy. We have shown that Btk was significantly upregulated…
Abstract Number: 673 • 2014 ACR/ARHP Annual Meeting
A Comparison of Rheumatoid Arthritis and Systemic Lupus Erythematosus Trial Design: Ways to Improve Positive Trials in Systemic Lupus Erythematosus
Amy Miles¹ and Janet E. Pope², ¹Medicine, University of Western Ontario and U of Toronto, London, ON, Canada, ²St Joseph Health Care, London, ON, Canada
Background/Purpose: Recent SLE RCTs were examined and compared to rheumatoid arthritis (RA) RCT to suggest modifications to SLE RCTs that could improve the future success…
Abstract Number: 2842 • 2014 ACR/ARHP Annual Meeting
An Anti CD123 Monoclonal Antibody (CSL362) Depletes Plasmacytoid Dendritic Cells and Inhibits CpG Upregulated IFNα Production and IFNα-Inducible Gene Expression in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus
Shereen Oon^1,2,3, Nicholas Wilson^4,5 and Ian Wicks^1,2,3, ¹Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia, ²Rheumatology, The Royal Melbourne Hospital, Melbourne, Australia, ³Medical Biology, The University of Melbourne, Melbourne, Australia, ⁴Cell Biology and Physiology, CSL Limited, Melbourne, Australia, ⁵Honorary appointment, The University of Melbourne, Melbourne, Australia
Background/Purpose Plasmacytoid dendritic cells (pDCs) contribute to systemic lupus erythematosus (SLE) pathogenesis by producing Type 1 interferon (IFN), most likely induced by endosomal Toll like…
Abstract Number: 2432 • 2014 ACR/ARHP Annual Meeting
Nutritional Assessment in Patients with Systemic Lupus Erythematosus and Systemic Sclerosis
Sabrina Vagnani¹, Chiara Tani², Linda Carli³, Francesca Querci³, Alessandra Della Rossa³, Anna d'Ascanio^3,4, Ilaria Ermini⁵, Marco Ceroti⁵, Saverio Caini⁵, Domenico Palli⁵, Stefano Bombardieri⁶ and Marta Mosca³, ¹Department of Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ²Clinical and Experimental Medicine, Rheumatology Unit, University of Pisa, Pisa, Italy, ³Rheumatology Unit, University of Pisa, Pisa, Italy, ⁴Internal Medicine, University of Pisa, Pisa, Italy, ⁵Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, ISPO, Florence, Itay., Florence, Italy, ⁶Rheumatology Unit, Pisa, Italy
Background/Purpose Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc) can be both associated with various degrees and types of malnutrition, with different pathogenetic mechanisms. It’s…

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