Abstracts tagged "SLE"

Abstract Number: 1856 • 2015 ACR/ARHP Annual Meeting
Exosomes from Patients with Active Systemic Lupus Erythematosus Induce a Strong Inflammatory Response
Joo Youn Lee¹, Jin Kyun Park^1,2, Eun Young Lee³, Eun Bong Lee³ and Yeong Wook Song^1,2, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine Seoul National University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
Background/Purpose: Exosomes are 60–150 nm membrane vesicles that are secreted by various cells into surrounding body fluids including blood and urine. As vehicles for intercellular…
Abstract Number: 2925 • 2015 ACR/ARHP Annual Meeting
Factors Associated with Early Damage Accrual in Patients with Systemic Lupus Erythematosus: 12-Month Preliminary Results from the Inception Cohort of the Multicenter Early Lupus Project
Matteo Piga¹, Fabiana Figus¹, Francesca Bellisai², Silvano Bettio³, Alessandra Bortoluzzi⁴, Laura Coladonato⁵, Fabrizio Conti⁶, Andrea Doria³, Mauro Galeazzi², Marcello Govoni⁴, Florenzo Iannone⁷, Annamaria Iuliano⁸, Marta Mosca⁹, Imma Prevete⁸, Gian Domenico Sebastiani⁸, Francesca Romana Spinelli¹⁰, Chiara Tani⁹ and Alessandro Mathieu¹, ¹University of Cagliari, Cagliari, Italy, ²University of Siena, Siena, Italy, ³Department of Medicine-DIMED, University of Padova, Padova, Italy, ⁴University of Ferrara, Ferrara, Italy, ⁵DIM, Rheumatology Unit, Bari, Italy, ⁶Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, ⁷Interdisciplinary Department of Medicine (DIM), Rheumatology Unit, University of Bari, Bari, Italy, ⁸Osp. San Camillo, Roma, Italy, ⁹University of Pisa, Pisa, Italy, ¹⁰Sapienza University of Rome, Rome, Italy
Background/Purpose: Preventing organ damage is a major challenge in management of Systemic Lupus Erythematosus (SLE). Few data are available on factors related to development of…
Abstract Number: 3222 • 2015 ACR/ARHP Annual Meeting
Repeated Administration of Dapirolizumab Pegol (DZP) Appears Safe and Well Tolerated in Patients with Systemic Lupus Erythematosus (SLE) and Is Accompanied By an Improvement in Disease Activity: Results from a Phase 1 Study
Chris Chamberlain¹, Murray Urowitz^2,3, Julie Soranson¹, Mark Watling¹, Peter Colman¹, Olivier Harari¹, Thomas Dorner⁴ and Falk Hiepe⁴, ¹UCB Pharma, Slough, United Kingdom, ²University of Toronto, Toronto, ON, Canada, ³Rheumatology, U of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ⁴Charité – Universitätsmedizin, Berlin, Germany
Background/Purpose: CD40 ligand (CD40L) regulates interactions between T cells, B cells, and antigen presenting cells. Considerable evidence suggests CD40L blockade might provide an effective treatment…
Abstract Number: 722 • 2015 ACR/ARHP Annual Meeting
Biomarkers/Pathways Discovery of Lupus Nephritis By Urine Proteomics
Michelle Petri¹, Wei Fu², Adnan Kiani¹, Lauren DeVine¹, Conover Talbot Jr.¹ and Robert Cole¹, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: We have previously validated several urine proteomic biomarkers for Lupus Nephritis (osteoprotegerin, MCP-1, VCAM-1 and urine TWEAK). In this discovery effort we looked for…
Abstract Number: 808 • 2015 ACR/ARHP Annual Meeting
Heritable Endotheliopathy and ApolipoproteinL1 Risk Traits in SLE
Ashira Blazer¹, Andrew Markham², Sara Rasmussen³, Jill P. Buyon⁴, H. Michael Belmont⁵, Shilpi Mehta-Lee⁶, Janet Nwaukoni⁴, Peter M. Izmirly⁷ and Robert Clancy⁴, ¹Division of Rheumatology, NYU School of Medicine, New York, NY, ²Medicine, New York University School of Medicine, New York, NY, ³Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Hosp for Joint Disease, New York, NY, ⁶Obstetrics and Gynecology, New York University School of Medicine, New York, NY, ⁷Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: With higher prevalence of renal and cardiovascular diseases (CVD), as well as HTN, African American (AA) SLE patients experience accelerated damage accrual and excess…
Abstract Number: 1754 • 2015 ACR/ARHP Annual Meeting
BANK1 Controls the Development of SLE By Modulating TLR7 Signaling and Type I IFN-Induced Translation Initiation Pathway in B Cells
Ying-Yu Wu¹, Ramesh Kumar², Harini Bagavant¹ and Marta E. Alarcon Riquelme³, ¹Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma Cty, OK, ³Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
Background/Purpose: BANK1 is a susceptibility gene for SLE, and we have shown that stimulation of TLR9 agonist leads to a reduction in the activation of…
Abstract Number: 1858 • 2015 ACR/ARHP Annual Meeting
Serum Tartrate Resistant Acid Phosphatase (TRAP) Levels Are Decreased and Associated with Anti-Maa Antibodies in Systemic Lupus Erythematosus (SLE) Patients
Kathleen Borghoff¹, Andy Hollins², Michael J. Duryee¹, Ted R. Mikuls², Zhixin Zhang³, Kaihong Su⁴, Michelene Hearth-Holmes⁵ and Geoffrey M. Thiele⁶, ¹Internal Medicine Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, ²University of Nebraska Medical Center, Omaha, NE, ³Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ⁴Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, ⁵Division of Rheumatology, University of Nebraska College of Medicine and VA Nebraska Western Iowa Health Care System, Omaha, NE, ⁶Omaha VA Medical Center and University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Previous studies have shown that patients with systemic lupus erythematosus (SLE) are prone to systemic osteoporosis, bone loss and fracture. Paradoxically, previous studies…
Abstract Number: 2929 • 2015 ACR/ARHP Annual Meeting
Diet and Glucocorticoid Treatment in Patients with SLE
Cecilia Lourdudoss¹, Johan Frostegård² and Ronald F. van Vollenhoven³, ¹Dept. of Medicine, ClinTRID, Karolinska institutet, Stockholm, Sweden, ²Karolinska Institutet, Section of Immunology and chronic disease, Institute of Environmental Medicine, Stockholm, Sweden, ³Department of Medicine, Unit for Clinical Therapy Research, Inflammatory Diseases (ClinTRID), The Karolinska Institute, Stockholm, Sweden
Background/Purpose: Relatively little is known about the link between diet and treatment results in SLE. Glucocorticoids (GC) are used to control active SLE but minimized…
Abstract Number: 3223 • 2015 ACR/ARHP Annual Meeting
Anifrolumab, an Anti-Interferon Alpha Receptor Monoclonal Antibody, in Moderate to Severe Systemic Lupus Erythematosus (SLE)
Richard Furie¹, JT Merrill², VP Werth^3,4, M Khamashta⁵, K Kalunian⁶, P Brohawn⁷, G Illei⁷, J Drappa⁷, L Wang⁷ and S Yoo⁸, ¹North Shore-LIJ Health System, New York, NY, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Philadelphia V.A. Medical Center, Philidelphia, PA, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Graham Hughes Lupus Research Laboratory, The Rayne Institute, St Thomas' Hospital, London, United Kingdom, ⁶UCSD School of Medicine, La Jolla, CA, ⁷MedImmune, Gaithersburg, MD, ⁸Regenx Bio, Rockville, MD
Background/Purpose: The efficacy and safety of anifrolumab (ANIFR), a type I IFN receptor antagonist, were assessed in a Phase II, randomized, double-blind, placebo-controlled study in…
Abstract Number: 726 • 2015 ACR/ARHP Annual Meeting
Associates of Pleurisy of Pericarditis in Systemic Lupus Erythematosus (SLE)
Seungwon Ryu¹ and Michelle Petri², ¹Konkuk University School of Medicine, Seoul, South Korea, ²Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Serositis is one of the classification criteria for systemic lupus erythematosus and a common type of extra renal flare. Comparison of associates of pleurisy…
Abstract Number: 810 • 2015 ACR/ARHP Annual Meeting
Human Parvovirus B19 Nonstructural Protein 1 (NS1) Helicase Breaks Tolerance to Self dsDNA: A Model for Viral Induction of Autoimmunity
Heidi Pirttinen¹, Kanoktip Puttaraksa¹, Robert J. Lagier², Stanley J. Naides³ and Leona Gilbert¹, ¹Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland, ²Research Support, Alameda, Quest Diagnostics Alameda, Alameda, CA, ³Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano, CA
Background/Purpose: B19 virus (B19V) is common, infects all ages, and is associated with various clinical syndromes including SLE-like autoimmunity. We previously demonstrated that B19 NS1,…
Abstract Number: 1760 • 2015 ACR/ARHP Annual Meeting
PD-1 Signaling Interferes with OX40 to Alter the Suppressive Function and Proliferation of CD4+ Regulatory T Cells in Lupus Mice
Maida Wong¹ and Bevra H. Hahn^2,3, ¹Division of Rheumatology, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, ²Medicine, UCLA David Geffen School of Medicine, Division of Rheumatology, Los Angeles, CA, ³Rheumatology, Professor Emeritus, Department of Medicine/Rheumatology, David Geffen School of Medicine UCLA, Los Angeles, CA
Background/Purpose: In systemic lupus erythematosus (SLE), the dysregulated production of autoantibodies is a consequence of disrupted T cell homeostasis. Programmed death-1 (PD1), a negative regulatory…
Abstract Number: 1859 • 2015 ACR/ARHP Annual Meeting
Anti-Interferon Autoantibodies in Systemic Lupus Erythematosus Are Biologically Active and Have Distinct Functions
Sarthak Gupta^1,2, Ioanna P. Tatouli³, Lindsey B. Rosen¹, Sarfaraz Hasni², Illias Alevizos⁴, Zerai G. Manna², Juan Rivera², Chao Jiang^2,5, Richard M. Siegel⁶, Steven M. Holland¹, Haralampos M. Moutsopoulos³ and Sarah K. Browne^1,7, ¹Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ³Department of Pathophysiology, School of Medicine, National University of Athens, Athens, Greece, ⁴National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁵National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, MD, ⁶NIAMS, Immunoregulation Section, Autoimmunity Branch, Bethesda, MD, ⁷Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, US Food and Drug Administration, Silver Spring, MD
Background/Purpose: Anticytokine autoantibodies are pathogenic in many hematologic, pulmonary and infectious diseases. However, a systematic investigation of their presence and significance in autoimmune diseases is…
Abstract Number: 2933 • 2015 ACR/ARHP Annual Meeting
Low Prevalence of PCP in Hospitalized Patients with SLE: Review of a Clinical Database Warehouse
Teja Kapoor¹, Jianhua Li², Sameer Malhotra³, Joan Bathon⁴ and Anca Askanase⁵, ¹Columbia University, New York, NY, ²Columbia University Medical Center, New York, NY, ³Weill Cornell Medical Center, New York, NY, ⁴Rheumatology, Columbia University Medical Center, NY, NY, ⁵Columbia University College of Physicians & Surgeons, New York, NY
Background/Purpose : The risk of Pneumocystis carinii pneumonia (PCP) in Systemic Lupus Erythematosus (SLE) is not well-established. Accordingly, this study aims to establish the prevalence…
Abstract Number: 733 • 2015 ACR/ARHP Annual Meeting
Late Onset Systemic Lupus Erythematosus: A Different Disease Subset?
Anne Riveros Frutos¹, Melania Martínez-Morillo¹, Irma Casas^2,3, Iñigo Rúa-Figueroa⁴, JM Pego-Reigosa⁵, M. Jesús García de Yebenes⁶, Alejandro Olivé¹, José Rosas⁷, Paloma Vela Casasempere⁸, Monica Ibanez Barcelo⁹, Vicente Torrente¹⁰, Ivan Castellvi¹¹, Javier Narváez¹², Mireia Moreno¹³, Ricardo Blanco¹⁴, Víctor Martínez Taboada¹⁵, Jaime Calvo¹⁶, Ángeles Aguirre Zamorano¹⁷, Mercedes Freire¹⁸, Enrique Raya¹⁹, Celia Erausquin²⁰, Esther Uriarte²¹, Elvira Diez Alvarez²², Tomás Vázquez Rodríguez²³, Antonio Fernandez-Nebro²⁴, Eva Tomero²⁵, Paloma García de la Peña²⁶, Ana Sánchez Atrio²⁷, Monica Fernandez Castro²⁸, Antonio Zea²⁹, Patricia Richi³⁰, Francisco Javier López Longo³¹, María Galindo³², Patricia E. Carreira³³, Gema Bonilla³⁴, Carlos Marras Fernandez-Cid³⁵, Maria Loreto Horcada³⁶, Carlos Alberto Montilla Morales³⁷, Blanca Hernández-Cruz³⁸, José Luis Marenco de la Fuente³⁹, Marian Gantes⁴⁰, Olaia Fernández Berrizbeitia⁴¹, Juan José Alegre⁴², Ángela Pecondón Español⁴³, Manuel Rodríguez-Gómez⁴⁴, Victor Quevedo⁴⁵, José Hernández Beiraín⁴⁶ and Lucía Silva Fernández⁴⁷, ¹Rheumatology, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ²Preventive Medicine, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain, ³preventive medicine, Hospital Universitari Germans Trias i Pujol, barcelona, Spain, ⁴Rheumatology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canarias, Spain, ⁵Rheumatology, Hospital Meixoeiro, Vigo, Spain, ⁶Research Unit of the SER, Madrid, Spain, ⁷Rheumatology, Hospital Marina Baixa, Villajoyosa, Spain, ⁸Rheumatology, Hospital General de Alicante, Alicante, Spain, ⁹H. Son Llatzer, Palma de Mallorca, Spain, ¹⁰Hospital Sant Joan de Déu, Esplugues de Llobregat, Spain, ¹¹Unitat de Reumatologia., Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, ¹²Rheumatology Department, Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain, ¹³Rheumatology, Hospital Parc Taulí, Sabadell, Spain, ¹⁴Reumatologia, Hospital Universitario Marques de Valdecilla, Santander, Spain, ¹⁵Rheumatology, Hospital Marqués de Valdecilla, Santander, Spain, ¹⁶Rheumatology, Hospital de Sierrallana, Torrelavega, Spain, ¹⁷Rheumatology, IMIBIC-Reina Sofia Hospital, Cordoba, Spain, ¹⁸Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain, ¹⁹Rheumatology, Hospital Clínico San Cecilio, Granada, Spain, ²⁰Rheumatology, Hospital de Gran Canaria Dr Negrin, Las Palmas GC, Spain, ²¹Reumatología, Hospital de Donosti, Donosti, Spain, ²²Rheumatology, Hospital de León, León, Spain, ²³Rheumatology, Hospital Lucus Augusti, Lugo, Spain, ²⁴Rheumatology, Hospital Universitario Carlos Haya, Malaga, Spain, ²⁵Hospital La Princesa. Madrid., Madrid, Spain, ²⁶Rheumatology, Hospital Universitario Madrid Norte Sanchinarro, Madrid, Spain, ²⁷Hospital Principe de Asturias. Madrid, Madrid, Spain, ²⁸Rheumatology, Hospital Puerta de Hierro, Madrid, Spain, ²⁹Hospital Ramón y Cajal, Madrid, Spain, ³⁰Hospital Infanta Sofía, Madrid, Spain, ³¹Hospital Gregorio Marañón, Madrid, Spain, ³²Rheumatology, Hospital 12 de octubre, Madrid, Spain, ³³Hospital 12 de Octubre, Madrid, Spain, ³⁴Rheumatology, Hospital La Paz, Madrid, Spain, ³⁵Hospital Virgen de la Arrixaca, Murcia, Spain, ³⁶Rheumatology, Complejo Hospitalario de Navarra, Pamplona, Spain, ³⁷Hospital Clínico Universitario de Salamanca, Salamanca, Spain, ³⁸Rheumatology, Hospital Universitario Virgen Macarena, Sevilla, Spain, ³⁹Rheumatology, Hospital de Valme, Seville, Spain, ⁴⁰Hospital Universitario de Canarias, Tenerife, Spain, ⁴¹Rheumatology, Basurto University Hospital, Bilbao, Spain, ⁴²Rheumatology Department, Hospital Universitario Doctor Peset, Valencia, Spain, ⁴³Rheumatology, Hospital Miguel Servet, Zaragoza, Spain, ⁴⁴Complejo Hospitalario Universitario de Ourense, Ourense, Spain, ⁴⁵Rheumatology, Hospital de Monforte, Lugo, Spain, ⁴⁶Rheumatology, Hospital Insular de Gran Canaria, Las palmas Gran Canarias, Spain, ⁴⁷Hospital Universitario de Guadalajara, Guadalajara, Spain
Background/Purpose: To describe the demographic, clinical and immunological manifestations in patients with late onset systemic lupus erythematosus (SLE) Methods: Patients diagnosed of SLE in the RELESSER data…

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