Abstracts tagged "SLE"

Abstract Number: 197 • 2015 ACR/ARHP Annual Meeting
Synergy Between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of Dnase II Deficient Mice
Rebecca Baum¹, Kerstin Nundel¹, Sudesh Pawaria^1,2, Shruti Sharma¹, Patricia Busto¹, Tara Robidoux¹, Katherine A. Fitzgerald¹, Ellen M. Gravallese³ and Ann Marshak-Rothstein¹, ¹Medicine, University of Massachusetts Medical School, Worcester, MA, ²Department of Medicine, University of Massachusetts Medical School, Worcester, MA, ³Lazare Research Bldg Ste 223, University of Massachusetts Medical School, Worcester, MA
Background/Purpose: Toll-like receptors (TLRs) dependent on Unc93b1 and cytosolic sensors dependent on STING detect microbial and endogenous nucleic acids to initiate inflammatory responses that resolve…
Abstract Number: 796 • 2015 ACR/ARHP Annual Meeting
Single Cell Gene Expression Studies in Lupus Patient Monocytes Reveal a Unique Anti-Inflammatory Population of Non-Classical Monocytes Associated with Clinical Quiescence
Zhongbo Jin¹, Wei Fan^2,3, Mark A. Jensen⁴, Jessica M. Dorschner¹, Danielle Vsetecka¹, Shreyasee Amin⁵, Ashima Makol⁶, Floranne C. Ernste⁷, Thomas Osborn⁷, Kevin G. Moder⁵, Vaidehi Chowdhary⁵ and Timothy B. Niewold¹, ¹Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ²Department of Rheumatology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China, Shanghai, China, ³Mayo Clinic, Rochester, MN, ⁴Divsion of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁵Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ⁷Division of Rheumatology, Mayo Clinic, Rochester, MN
Background/Purpose: Our previous gene expression studies in sorted immune cell populations in SLE has shown that different cell types from the same blood sample demonstrate…
Abstract Number: 1120 • 2015 ACR/ARHP Annual Meeting
Analysis of SLE Plasmablasts By High Throughput Pairing of the Immunoglobulin Heavy and Light Chain (VH-VL)
Deepak Tomar¹, Christopher Tipton¹ and Ignacio Sanz², ¹Medicine/Rheumatology, Emory University School of Medicine, Atlanta, GA, ²Rheumatology, Emory University School of Medicine, Atlanta, GA
Background/Purpose: In-depth analysis of the molecular and antigenic properties of antibody secreting cells (ASC) is critical for our understanding of autoimmune diseases. This goal however…
Abstract Number: 1837 • 2015 ACR/ARHP Annual Meeting
Predictability of Musculoskeletal Flares and Hand Deformities in Systemic Lupus Erythematosus By High Resolution Ultrasound : 5-Year Clinical and Imaging Prospective Follow-up Study
Matteo Piga¹, Alessandra Gabba¹, Mattia Congia¹, Fabiana Figus¹, Alberto Floris^1,2, Alberto Cauli¹ and Alessandro Mathieu¹, ¹University of Cagliari, Cagliari, Italy, ²University of Oxford, Oxford, United Kingdom
Background/Purpose: SLE patients develop non-deforming non-erosive (NDNE) arthritis in 70-80%, but 5-15% of cases progresses into Jaccoud's arthropathy (JA) a non-erosive deforming arthritis. This study…
Abstract Number: 2785 • 2015 ACR/ARHP Annual Meeting
Association of Anti-Glutamate Receptor Subunit NR2 Antibody and Psychiatric Disorder in Patients with Primary Sjögren Syndrome
Yoshiyuki Arinuma^1,2, Yuko Sakuma³, Eisuke Ogawa², Tatsuhiko Wada⁴, Tatsuo Nagai², Sumiaki Tanaka² and Shunsei Hirohata², ¹Center for Autoimmune and Musculoskeletal Diseases, The Feinstein Institute for Medical Research, Manhasset, NY, ²Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ³Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan, ⁴Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Sjögren syndrome (SjS) is one of the autoimmune disease characterized by the production of autoantibodies. Patients with SjS frequently observe psychiatric manifestation such as…
Abstract Number: 3212 • 2015 ACR/ARHP Annual Meeting
Characterizing the Effects of the G-CSF-R Coding rs13377964 SNP Located within Murine Lupus Susceptibility Locus Sle2c2
Ramya Sivakumar¹ and Laurence Morel², ¹Pathology, University of Florida, Gainesville, FL, ²Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL
Background/Purpose: The genetic analysis of the lupus prone NZM2410 mouse has identified a suppressor locus, Sle2c2, which confers resistance to both spontaneous and chronic graft-vs.-host…
Abstract Number: 408 • 2015 ACR/ARHP Annual Meeting
Characterization of Pediatric Systemic Lupus Erythematosus with Acquired Angioedema
Marietta De Guzman¹, Diana Bayer², Roshni Sambasivan³, Debra Canter⁴, Martha Curry⁵ and Anna Carmela Sagcal-Gironella⁶, ¹Pediatric Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ²Division of Allergy, Immunology andPulmonology, University of Iowa Carver College of Medicine, Iowa, IA, ³Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, ⁴Pediatric Immuology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁵Pediatric Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, ⁶Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX
Background/Purpose: Acquired angioedema, defined as non-hereditary angioedema without associated urticaria, is an uncommon but potentially life-threatening feature among adults with systemic lupus erythematosus (SLE). Although…
Abstract Number: 803 • 2015 ACR/ARHP Annual Meeting
Interferon-Alpha Mediated Lowering of Pentraxin-3 Levels in Systemic Lupus Erythematosus?
Lina Wirestam¹, Helena Enocsson², Christopher Sjöwall², Thomas Skogh², Maija-Leena Eloranta³, Lars Rönnblom³ and Jonas Wetterö², ¹Department of Clinical & Experimental Medicine, Rheumatology/AIR, Linkoping, Sweden, ²Department of Clinical and Experimental Medicine, Rheumatology/AIR, Linköping, Sweden, ³Medical Sciences, Rheumatology clinic, Uppsala, Sweden
Background/Purpose: The type I interferon (IFN) system is important in the pathogenesis of systemic lupus erythematosus (SLE). We have previously shown an inhibitory effect of…
Abstract Number: 1172 • 2015 ACR/ARHP Annual Meeting
Single Cell Sequencing of Non-Lesional Non-Sun Exposed Skin from SLE Patients with Proteinuria Supports Widespread Endothelial Activation
Robert Clancy¹, Evan Der², Kemal Akat³, Anna R. Broder⁴, H. Michael Belmont⁵, Peter M. Izmirly⁶, Beatrice Goilav⁷, Thomas Tuschl³, Chaim Putterman⁸ and Jill P. Buyon¹, ¹Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Albert Einstein College of Medicine, Bronx, NY, ³Rockefeller University, New York, NY, ⁴Rheumatology-Forchheimer 701N, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, ⁵New York University School of Medicine, New York, NY, ⁶Rheumatology, NYU School of Medicine, New York, NY, ⁷Division of Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁸Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Given the widespread vasculopathy present in SLE, endothelial cell activation in the renal tubulointerstitium in lupus nephritis (LN) may be accompanied by similar activation…
Abstract Number: 1846 • 2015 ACR/ARHP Annual Meeting
IGFBP-2 As a Novel Biomarker for Disease Activity and Renal Pathology in Lupus Nephritis
Huihua Ding¹, Chandra Mohan¹ and Tianfu Wu², ¹Biomedical Engineering, University of Houston, Houston, TX, ²Department of Biomedical Engineering, University of Houston, Houston, TX
Background/Purpose: Lupus nephritis (LN) is one of the most serious manifestations of systemic lupus erythematosus. Invasive renal biopsy remains the golden standard for the diagnosis…
Abstract Number: 2901 • 2015 ACR/ARHP Annual Meeting
Anti-dsDNA Antibodies Measured By Chemiluminescent Immunoassay Show Strong Association with Active Lupus Nephritis
Gabriella Lakos¹, John G. Hanly², Peter Martis¹, Chelsea Bentow¹, Milagros Garcia³, Odette Viñas³, Gerard Espinosa⁴, Ricard Cervera⁴ and Michael Mahler⁵, ¹Research, Inova Diagnostics, San Diego, CA, ²Rheumatology, Division of Rheumatology, Capital Health and Dalhousie University, Halifax, NS, Canada, ³Immunology, Hospital Clinic of Barcelona, Barcelona, Spain, ⁴Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Spain, ⁵Inova Diagnostics, San Diego, CA
Background/Purpose: Anti-dsDNA antibodies support the diagnosis of systemic lupus erythematosus (SLE), and their quantification is useful for the assessment of lupus nephritis (LN) and the…
Abstract Number: 3214 • 2015 ACR/ARHP Annual Meeting
Impaired Phagocytosis of Apoptotic Cells in Pristane-Induced Lupus Simulates the Clearance Defect in Human SLE
Shuhong Han¹, Haoyang Zuang¹, Ravil Khaybullin², Stepan Shumyak³, Anan Afaneh⁴, Xin Qi⁵, Lijun yang⁶ and Westley H. Reeves⁷, ¹Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL, ²medicinal chemistry, University of Flordia, gainesville, FL, ³division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁴Division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁵medicinal chemistry, University of Florida, gainesville, FL, ⁶Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, ⁷Medicine, University of Florida, Gainesville, FL
Background/Purpose: Defective phagocytosis of dead cells is seen in SLE patients’ monocytes. Pristane-induced lupus causes accumulation of dead cells in tissues resembling that in SLE…
Abstract Number: 718 • 2015 ACR/ARHP Annual Meeting
Urinary MBL : A Promising Biomarker for Predicting Flare in Lupus Nephritis
Sarit sekhar Pattanaik¹, Madhukara HM¹, Aditya kumar Panda², Rashmi ranjan Sahoo¹, Rina Tripathy³ and Bidyut kumar Das¹, ¹Medicine, SCB Medical College, Cuttack, India, ²Centre for Life science, Central University of Jharkand, Ranchi, India, ³Biochemistry, SCB Medical College, Cuttack, India
Background/Purpose: Nephritis is the most common cause of mortality and morbidity in SLE, develops in 40 to 70% of cases in 5-10 years with 60%…
Abstract Number: 804 • 2015 ACR/ARHP Annual Meeting
Prolactin Induces Interferon Regulatory Factor 1 Activation and Histone H4 Hyperacetylation in Primary Monocytes Comparable to Changes Seen in Monocytes from Systemic Lupus Erythematosus Patients
Yiu Tak Leung¹, Kathleen E. Sullivan², Kelly Maurer³, Li Song⁴ and Lihua Shi³, ¹Medicine/Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Allergy Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, ³Immunology ARC 1216, The Children's Hospital of Philadelphia, Philadelphia, PA, ⁴Allergy Immunology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: : Epigenetic changes have been described in systemic lupus erythematosus (SLE) and offer a potential explanation for the chronicity of disease. We previously found…
Abstract Number: 1263 • 2015 ACR/ARHP Annual Meeting
Applications of Protein Microarray for Saliva Diagnostics in Autoimmune Diseases
Yeon-Ah Lee¹, Yong-Gil Kim², Seung-Jae Hong¹ and Paul J. Utz³, ¹Division of Rheumatology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea, ³Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: There have been many reports showing that saliva could be a source of biomarkers capable of detecting certain diseases. However, very few studies have…

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