Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1564 • 2018 ACR/ARHP Annual Meeting
Severe, Life-Threatening Phenotype of Primary Sjögren Syndrome: Clinical Characterization and Outcomes in 1580 Patients (GEAS-SS Registry)
Soledad Retamozo^1,2,3, Alejandra Flores-Chavez⁴, Belchin Kostov⁵, Roser Solans⁶, Guadalupe Fraile⁷, Brenda Maure⁸, Carlos Feijoo⁹, Francisco-Javier Rascón¹⁰, Roberto Pérez-Alvarez¹¹, Mónica Zamora¹², Alicia García-Pérez¹³, Miguel Lopez-Dupla¹⁴, Jesús Canora¹⁵, Mar Ripoll¹⁶, Eva Fonseca¹⁷, Pablo Guisado¹⁸, Blanca Pinilla¹⁹, Gloria de-la-Red²⁰, Antonio-J. Chamorro²¹, César Morcillo²², Patricia Fanlo²³, Mª José Soto-Cárdenas²⁴, Manuel Ramos-Casals²⁵ and Pilar Brito-Zerón^4,22, ¹Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, ²Laboratory of Systemic Autoimmune Diseases “Josep Font”, CELLEX, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Department of Systemic Autoimmune Diseases, ICMID, Hospital Clinic, Barcelona, Barcelona, Spain, ³Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, ⁴Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, ICMiD, Hospital Clínic, Barcelona, Spain, Barcelona, Spain, ⁵Primary Care Research Group, IDIBAPS, Centre d’Assistència Primària ABS Les Corts, GESCLINIC, Barcelona, Spain., Barcelona, Spain, ⁶Systemic Autoimmune Diseases Unit, Hospital Vall d’Hebron, Barcelona, Barcelona, Spain, ⁷Systemic Autoimmune Diseases Unit, Hospital Ramón y Cajal, Madrid, Madrid, Spain, ⁸Department of Internal Medicine, Complejo Hospitalario Universitario, Vigo, Vigo, Spain, ⁹Systemic Autoimmune Diseases Unit, Hospital Parc Taulí, Sabadell, Sabadell, Spain, ¹⁰Systemic Autoimmune Diseases Unit, Hospital Son Espases, Palma de Mallorca, Palma de Mallorca, Spain, ¹¹Department of Internal Medicine, Hospital do Meixoeiro, Vigo, Vigo, Spain, ¹²Systemic Autoimmune Diseases Unit, Hospital Virgen de las Nieves, Granada, Granada, Spain, ¹³Systemic Autoimmune Diseases Unit, Hospital Universitario Central de Asturias, Oviedo, Oviedo, Spain, ¹⁴Systemic Autoimmune Diseases Unit, Hospital Joan XXIII, Tarragona, Tarragona, Spain, ¹⁵Systemic Autoimmune Diseases Unit, Hospital de Fuenlabrada, Madrid, Madrid, Spain, ¹⁶Department of Internal Medicine, Hospital Infanta Sofía, Madrid, Madrid, Spain, ¹⁷Systemic Autoimmune Diseases Unit, Hospital de Cabueñes, Gijón, Gijón, Spain, ¹⁸Department of Internal Medicine, Complejo Hospitalario Ruber Juan Bravo, Madrid, Madrid, Spain, ¹⁹Systemic Autoimmune Diseases Unit Medicine, Hospital Gregorio Marañón, Madrid, Madrid, Spain, ²⁰Systemic Autoimmune Diseases Unit, Hospital Esperit Sant, Santa Coloma de Gramenet, Santa Coloma de Gramenet, Spain, ²¹Systemic Autoimmune Diseases Unit, Hospital Universitario de Salamanca, Salamanca, Salamanca, Spain, ²²Systemic Autoimmune Diseases Unit, Hospital CIMA-Sanitas, Barcelona, Barcelona, Spain, ²³Systemic Autoimmune Diseases Unit, Hospital Virgen del Camino, Pamplona, Pamplona, Spain, ²⁴Department of Medicine, University of Cadiz, Cadiz, Cadiz, Spain, ²⁵University of Barcelona, Hospital Clínic, Barcelona, Barcelona, Spain
Background/Purpose: To analyse the clinical features and outcomes of patients presenting with life-threatening systemic disease in a large cohort of Spanish patients with primary Sjogren…
Abstract Number: 1587 • 2018 ACR/ARHP Annual Meeting
Pathogenic Role of Interleukin 27 in the Nonobese Diabetic Mouse Model of Sjögren Syndrome
Scott Lieberman¹, Jennifer Barr², Xiaofang Wang² and Yi-Guang Chen³, ¹Division of Rheumatology, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, ²Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, ³Pediatrics, Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Sjögren syndrome is an immunologically complex autoimmune disease characteristically targeting the lacrimal and salivary glands leading to progressively worsening oral and ocular health and…
Abstract Number: 20 • 2018 ACR/ARHP Annual Meeting
Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren’s Syndrome and Systemic Lupus Erythematosus
Felice Rivellese^1,2, Daniele Mauro¹, Mattia Congia³, Elena Pontarini¹, Peter Schafer⁴, Michele Bombardieri^1,2, Costantino Pitzalis^1,5 and Myles J. Lewis^1,2, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ²Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, United Kingdom, London, United Kingdom, ³Rheumatology and Rheumatology Unit, University Clinic and AOU of Cagliari, Cagliari, Italy, Cagliari, Italy, ⁴Celgene Corporation, Summit, NJ, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Polymorphisms of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which are essential for the maturation, differentiation and survival of B cells, have been…
Abstract Number: 1565 • 2018 ACR/ARHP Annual Meeting
Comorbidity Burden in Primary Sjögren’s Syndrome: A Long-Term Observation in Clinical Practice
Chiara Baldini¹, Francesco Ferro¹, Nicoletta Luciano¹, Emanuele Calabresi¹, Antonella Cecchettini², Marta Mosca¹, Enzo Grossi¹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²IFC, CNR, Pisa, Italy
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex disorder that may affect any organ and system. In this new era of personalized medicine, a growing…
Abstract Number: 1654 • 2018 ACR/ARHP Annual Meeting
Improvement of Cytological Grade and Tear Production in Ankylosing Spondylitis Patients Under Anti-TNF Therapy: A Long-Term Follow-up
Fany Usuba¹, Carla GS Saad², Priscila Novaes¹, Ruth Santo¹, Julio CB Moraes², Eloisa Bonfa³ and Milton Alves⁴, ¹Ophtalmology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Ophtalmolgy Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Clinical expression and pathophysiology of dry eye disease (DED) have recently changed and pro-inflammatory cytokines, such as TNF-α, may play a role in the…
Abstract Number: 21 • 2018 ACR/ARHP Annual Meeting
Elevated EPSTI1 Promote B Cells Hyperactivation through NF-Kb Signaling in Patients with Sjögren ’s Syndrome
Jin-Lei Sun¹, Zhi-Lei Chen², Chao-Feng Lian³, Ti-Hong Shao², Hao-Ze Zhang², Hua Chen³ and Feng-Chun Zhang², ¹Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Sjogren's syndrome (SS) is a common systemic autoimmune disease characterized with aberrant B cells activation. B cells play a key role in the pathogenesis…
Abstract Number: 1566 • 2018 ACR/ARHP Annual Meeting
Prevalence and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren’s Syndrome Patients
Hui Gao^1,2, Xuewu Zhang¹, Jing He³, Jing Zhang⁴, Ye Sun⁵ and Zhan-Guo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China, ³Rheumatology, Peking University People's Hospital, Beijing, China, ⁴Peking University International Hospital, Beijing, China, ⁵Department of Radiology, Peking University People's Hospital, Beijing, China
Background/Purpose: To determine the prevalence and identify the prognosis associated with pulmonary involvement in pSS patients. Methods: A total of 1341 hospitalized patients (853 with…
Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting
From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers
Geraldine Falgarone^1,2, Morad El Bouchtaoui³, Marcio Do Cruzeiro⁴, Christophe Leboeuf^5,6,7, Irmine Loisel-Ferreira^5,6, Carèle Frédonie⁷, Chrystophe Ferreira⁸, Rachida Ait El Far⁵, Marc Espié⁹, Bruno Cassinat¹⁰, Jean-Jacques Kiladjian¹¹, Jean-Paul Feugeas^12,13, Anne Janin^5,6,14 and Guilhem Bousquet^2,5,15, ¹HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, ²Paris 13 University, SMBH, Bobigny, France, ³INSERM UMR-S 1165, PARIS, France, ⁴Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM UMR-S 1165, Paris, France, ⁶Université Paris Diderot, Paris, France, ⁷INSERM U944, Paris, France, ⁸Plateforme ANIMA5, Université Paris Descartes, Paris, France, ⁹Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, ¹⁰Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, ¹¹Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, ¹²INSERM U1137, Paris, France, ¹³Département de Biologie, Université Franche-Comté, Besançon, France, ¹⁴Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, ¹⁵Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France
Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
Abstract Number: 140 • 2018 ACR/ARHP Annual Meeting
Inhibition of Cathepsin S Leads to Suppression of SS-a/SS-B Specific T Cells from Patients with Primary Sjøgren Syndrome
Patrick Hargreaves^1,2, Michel Theron¹, Fabrice Kolb¹, Marianne Manchester¹, Bernhard Reis¹, Andre Tiaden², Diego Kyburz² and Tobias Manigold², ¹Hoffmann La Roche, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland
Background/Purpose: Primary Sjögren syndrome (pSS) is an autoimmune disease characterised by an infiltration of T and B cells into exocrine gland tissue and its subsequent…
Abstract Number: 1568 • 2018 ACR/ARHP Annual Meeting
Azathioprine and Mycophenolate for Management of Sjögren’s Syndrome-Related Interstitial Lung Disease: A Retrospective Cohort Study
Barkha Amlani¹, Umang Barvalia², Ghada Metwally Ahmed Elsayed³, Jeffrey P. Kanne⁴, Zhanhai Li⁵ and Sara S. McCoy⁶, ¹Rheumatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ²Pulmonary And Critical Care, university of wisconsin Hospital and clinics, Madison, WI, ³Rheumatology, University of Wisconsin Hospital and clinics, Madison, WI, ⁴Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁵University of Wisconsin School of Medicine and Public Health, Madison, WI, ⁶Department of Medicine, Rheumatology Division, University of Wisconsin School of Medicine and Public Health, Madison, WI
Background/Purpose: Interstitial lung disease (ILD) is a common extraglandular manifestation of Sjögren’s syndrome (SS). There is a paucity of literature on the management of SS-ILD.…
Abstract Number: 2158 • 2018 ACR/ARHP Annual Meeting
Clinical Significance of Anti-Ro52 Antibody in Chinese Patients with Connective Tissue Diseases: A Single-Center Experience
Si Wu, Xiaojun Tang and Xuebing Feng, Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Autoantibody targeting Ro52 has been implied as a unique antibody with distinct clinical properties. However, its relations with anti-Ro60 antibody and various connective tissue…
Abstract Number: 365 • 2018 ACR/ARHP Annual Meeting
Monoclonal Gammopathy in Rheumatic Diseases
Yue Yang, Yuan Jia, Shi Chen, Yin Su and Zhan-Guo Li, Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China
Background/Purpose: To analyze the clinical spectrum, laboratory characteristics, and outcomes of monoclonal gammopathy (MG) in patients with rheumatic diseases. Methods: Screening for the presence of…
Abstract Number: 1569 • 2018 ACR/ARHP Annual Meeting
Diagnostic Performance of Labial Salivary Gland Biosy, Serological and Clinical Data in Sjogrens Syndrome. in Argentinian Multicenter
Janet Flores¹, Diego Baenas², Maria Jezabel Haye Salinas³, Soledad Retamozo⁴, Juan Pablo Pirola⁵, Nadia Benzaquén³, Nadia Riscanevo⁶, María Flavia Ceballos⁷, Ana C. Alvarez³, Verónica Saurit⁸, Alejandro Alvarellos⁹, Priscila Serravalle¹⁰, Alberto Ortiz¹¹, Sergio Paira¹¹ and Francisco Caeiro⁵, ¹Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, ²Reumatologia, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ³Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Córdoba, Argentina, ⁴Sociedad Argentina de Reumatologia, Córdoba, Argentina, ⁵Rheumatology, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, ⁶Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba, Cordoba, Argentina, ⁷Rheumatology, Rheumatology Unit, Hospital privado Universitario de Córdoba., Cordoba, Argentina, ⁸Hospital Privado Centro Médico de Córdoba, Cordoba, Argentina, ⁹Rheumatology, Rheumatology Unit, Hospital Privado Universitario de Córdoba, Cordoba, Argentina, ¹⁰Hospital Cullen, Santa Fe, Argentina, ¹¹Reumatologia, Hospital J M Cullen, Santa Fe, Argentina
Background/Purpose:Labial salivary gland biopsy (LSGB) is a safe and minimally invasive procedure used in the diagnostic evaluation of Sjogren’s Syndrome (SS). The objectives of this…
Abstract Number: 2162 • 2018 ACR/ARHP Annual Meeting
The Prevalence, Incidence, and Determinants of Depression and Anxiety in Less Common Systemic Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis
Alyssa Howren^1,2,3, Enav Z. Zusman^1,2,3, J. Antonio Avina-Zubieta^2,4 and Mary A. De Vera^1,2,3, ¹Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada, ²Arthritis Research Canada, Richmond, BC, Canada, ³Collaboration for Outcomes Research and Evaluation (CORE), Vancouver, BC, Canada, ⁴Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Individuals with systemic autoimmune rheumatic diseases (SARDs), including systemic lupus erythematosus (SLE), systemic sclerosis/scleroderma (SSc), Sjogren’s syndrome (SjS), dermatomyositis/polymyositis (DM/PM), and systemic vasculitides (SV),…
Abstract Number: 541 • 2018 ACR/ARHP Annual Meeting
Prevalence of Sjögren’s Syndrome in Patients with RA Enrolled in a Large Observational US Registry
Leslie R Harrold¹, Ying Shan², Sabrina Rebello², Neil Kramer³, Sean E. Connolly⁴, Evo Alemao⁴, Sheila Kelly⁴, Tammy Curtice⁴, Joel Kremer⁵ and Elliot Rosenstein³, ¹University of Massachusetts, Worcester, MA, ²Corrona, LLC, Southborough, MA, ³Overlook Medical Center, Institute for Rheumatic & Autoimmune Diseases, Summit, NJ, ⁴Bristol-Myers Squibb, Princeton, NJ, ⁵Albany Medical College and the Center for Rheumatology, Albany, NY
Background/Purpose: Sjögren’s syndrome is a known co-existing autoimmune disease in patients with RA, but its prevalence and impact on RA are poorly understood. The aims…

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