Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1577 • 2018 ACR/ARHP Annual Meeting
Soluble Siglec-5 Is a Novel Salivary Biomarker for Primary Sjogren’s Syndrome
Jennifer Lee¹, Hong-Ki Min², Ji-Won Kim³, Seung-Ki Kwok⁴ and Sung-Hwan Park⁵, ¹Rheumatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ³Medicine, Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), ⁵Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South)
Background/Purpose: Despite advances in the understanding of the pathogenesis, disease-specific biomarkers have not been included in the classification criteria for Primary Sjogren's syndrome (pSS). Based…
Abstract Number: 2507 • 2018 ACR/ARHP Annual Meeting
Healthcare Resource Utilization in Patients with Secondary Sjögren’s Syndrome Associated with RA Compared with Patients with RA in an Insured Population
Evo Alemao¹, Aarti Rao², Chidananda Samal² and Robert Wong¹, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is a rheumatic disease that may coexist with RA. Joint disease is more severe in patients (pts) with RA with…
Abstract Number: 1214 • 2018 ACR/ARHP Annual Meeting
Comparison of Ultrasound Features of Major Salivary Glands in Sarcoidosis, Amyloidosis, and Sjögren’s Syndrome
Shing Law¹, Praveen Govender², S. Reza Jafarzadeh³, Xianbang Sun⁴, Vaishali Sanchorawala⁵ and Eugene Y. Kissin⁶, ¹Rheumatology, Boston Medical Center, Boston, MA, ²The Pulmonary Center, Sarcoidosis Center, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Boston University, Boston, MA, ⁵Division of Hematology and Oncology, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Boston University, Boston, MA
Background/Purpose: Salivary gland enlargement occurs in conditions such as Sjögren’s syndrome (SS), sarcoidosis (SAR), and AL amyloidosis (AL). Salivary gland ultrasound (US) has been shown…
Abstract Number: 1578 • 2018 ACR/ARHP Annual Meeting
Exercise Increases Aerobic Capacity in Primary Sjögren´s Syndrome: A Randomized Controlled Trial
Ana Beatriz Andreo Garcia, MD¹, Virginia Fernandes Moça Trevisani², Luciana Dardin³ and Paulo Alexandre Minali⁴, ¹Evidence-based Health, UNIFESP, São Paulo, Brazil, São Paulo, Brazil, ²UNIFESP, Sao Paulo, Brazil, San Paulo, Brazil, ³Emergency Medicine and Evidence-Based Medicine Department, UNIFESP, São Paulo Brazil, SÃO PAULO, Brazil, ⁴UNIFESP, São Paulo, Brazil, São Paulo, Brazil
Background/Purpose: Recent studies have shown increased cardiovascular risk in patients with primary Sjögren's syndrome (pSS). As physical exercise is one of the pillars in primary…
Abstract Number: 2663 • 2018 ACR/ARHP Annual Meeting
Comparison of Clinical and Laboratory Profiles in 3575 Systemic Lupus Erythematosus Patients with and without Sjögren’s Syndrome: Data from the Spanish Society for Rheumatology Lupus Registry
Juan Gabriel Ovalles-Bonilla^1,2, Francisco Javier López Longo³, Iñigo Rúa-Figueroa⁴, María Galindo⁵, Jaime Calvo-Alén⁶, Juan Carlos Nieto², Julia Martínez-Barrio³, Roberto González⁷, Belen Serrano⁸, Iustina Janta², Carlos M Gonzalez⁹, Indalecio Monteagudo² and JM Pego-Reigosa¹⁰, ¹Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain, ²Rheumatology, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ³Rheumatology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ⁴Rheumatology Division, Hospital Doctor Negrin, Las Palmas GC, Spain, ⁵Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ⁶Rheumatology Department, Hospital Universitario Araba. Vitoria-Gasteiz, Alava, Spain, ⁷Rheumatology, Hospital general Universitario Gregorio Marañón, Madrid, Spain, ⁸Rheumatology, Hospital General Universitario Gregorio Marañón, Genoa, Italy, ⁹Servicio de Reumatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain, ¹⁰Complexo Hospitalario Universitario de Vigo, Vigo, Spain
Background/Purpose: The clinical coexistence of Systemic Lupus Erythematosus (SLE) and Sjögren's Syndrome (SS) was recognized in 1959. The prevalence of SS among patients with SLE…
Abstract Number: 1463 • 2018 ACR/ARHP Annual Meeting
Do Anti-Citrullinated Protein Antibodies and Anti-Sjögren’s-Syndrome-Related Antigen a Double Positive Patients with Secondary Sjögren’s Syndrome and RA Have Higher Joint Disease Activity?
Evo Alemao¹, Yogesh Saini², Ying Bao¹, Aarti Rao², Christine K Iannaccone³, Michelle Frits³, Michael E Weinblatt³ and Nancy A. Shadick³, ¹Bristol-Myers Squibb, Princeton, NJ, ²Mu Sigma, Bangalore, India, ³Brigham and Women's Hospital, Boston, MA
Background/Purpose: Secondary Sjögren’s syndrome (sSS) is considered an extra-articular manifestation of RA and is an autoantibody-mediated condition similar to RA. Thus, patients (pts) with sSS…
Abstract Number: 1580 • 2018 ACR/ARHP Annual Meeting
Persistent Serological Activity in Primary Sjögren’s Syndrome
Jorge Lopez-Morales, Daniel Cortes-Muñoz and Gabriela Hernandez-Molina, Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición SZ, Mexico City, Mexico
Background/Purpose: To assess presence of persistent serological activity and its association with clinical outcomes in a cohort of patients with primary Sjögren’s syndrome (pSS). Methods:…
Abstract Number: 2881 • 2018 ACR/ARHP Annual Meeting
How Immunological Profile Drives Clinical Phenotype of Primary Sjögren’s Syndrome at Diagnosis: Analysis of 10.500 Patients (Sjögren Big Data Project)
Soledad Retamozo^1,2, Nihan Acar-Denizli³, Wan-Fai Ng⁴, Margit Zeher⁵, Astrid Rasmussen⁶, Thomas Mandl⁷, Raphaele Seror⁸, Xiaomei Li⁹, Chiara Baldini¹⁰, Jacques-Eric Gottenberg¹¹, Debashish Danda¹², Luca Quartuccio¹³, Roberta Priori¹⁴, Gabriela Hernandez-Molina¹⁵, Berkan Armagan¹⁶, Aike A. Kruize¹⁷, Seung-Ki Kwok¹⁸, Marika Kvarnström¹⁹, Sonja Praprotnik²⁰, Damien Sène²¹, Elena Bartoloni²², Roser Solans²³, Maureen Rischmueller²⁴, Yasunori Suzuki²⁵, David A. Isenberg²⁶, Valeria Valim²⁷, Piotr Wiland²⁸, Gunnel Nordmark²⁹, Guadalupe Fraile³⁰, Hendrika Bootsma³¹, Takashi Nakamura³², Roberto Giacomelli³³, Valérie Devauchelle-Pensec³⁴, Andreas Knopf³⁵, Michele Bombardieri³⁶, Virginia Fernandes Trevisani³⁷, Daniel S. Hammenfors³⁸, Sandra G Pasoto³⁹, Tamer A. Gheita⁴⁰, Fabiola Atzeni⁴¹, Jacques Morel⁴², Cristina Vollenveider⁴³, Ildiko-Fanny Horvath⁵, Kathy L. Sivils⁴⁴, Peter Olsson⁴⁵, Salvatore De Vita⁴⁶, Jorge Sánchez-Guerrero⁴⁷, Levent Kilic¹⁶, Marie Wahren-Herlenius⁴⁸, Xavier Mariette⁸, Manuel Ramos-Casals⁴⁹ and Pilar Brito-Zerón^50,51, ¹Instituto de Investigaciones en Ciencias de la Salud, Universidad Nacional de Córdoba, Consejo Nacional de Investigaciones Científicas y Técnicas (INICSA-UNC-CONICET), Cordoba, Argentina, ²Rheumatology Unit, Hospital Privado Universitario de Córdoba, Institute University of Biomedical Sciences University of Córdoba (IUCBC), Cordoba, Argentina, ³Department of Statistics, Faculty of Science and Letters, Mimar Sinan Fine Arts University, Istanbul, Turkey, Istanbul, Turkey, ⁴Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, Newcastle, United Kingdom, ⁵Division of Clinical Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary, ⁶Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ⁷Department of Rheumatology, Skåne University Hospital, Malmö, Sweden, Lund, Sweden, ⁸Rheumatology department, Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique- Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, Paris, France, ⁹Department of Rheumatology and Immunology, Anhui Provincial Hospital, Hefei., Hefei, China, ¹⁰Rheumatology Unit, University of Pisa, Pisa, Italy, ¹¹Rhumatologie, Hôpitaux universitaires de Strasbourg, Strasbourg, France, ¹²Clinical Immunology & Rheumatology, Christian Medical College, Vellore, India, Vellore, India, ¹³Clinic of Rheumatology, Department of Medical Area (DAME), University Hospital “Santa Maria della Misericordia”, Udine., Udine, Italy, ¹⁴Department of Internal Medicine and Medical Specialties, Rheumatology Clinic, Sapienza University of Rome., Rome, Italy, ¹⁵Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, ¹⁶Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, ¹⁷Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ¹⁸Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul., Seoul, Korea, Republic of (South), ¹⁹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²⁰Department of Rheumatology, University Medical Centre, Ljubljana., Ljubljana, Slovenia, ²¹Lariboisière Hospital, Paris Diderot University, Paris, France, ²²Rheumatology Unit, University of Perugia, Perugia, Italy, ²³Department of Internal Medicine, Hospital Vall d’Hebron, Barcelona, Barcelona, Spain, ²⁴The Queen Elizabeth Hospital and University of Adelaide, Adelaide, Australia, ²⁵Ishikawa, Division of Rheumatology, Kanazawa University Hospital, Kanazawa, Ishikawa, Ishikawa, Japan, ²⁶Centre for Rheumatology Research, University College Hospital London, UK, London, United Kingdom, ²⁷Department of Medicine, Federal University of Espírito Santo and University Hospital HUCAM/EBSERH, Vitória, Vitoria, Brazil, ²⁸Department of Rheumatology and Internal Medicine, Wroclaw Medical Hospital, Wroclaw, Wroclaw, Poland, ²⁹Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ³⁰Department of Internal Medicine, Hospital Ramón y Cajal, Madrid, Madrid, Spain, ³¹Department of Rheumatology & Clinical Immunology, University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, ³²Department of Radiology and Cancer Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³³Clinical Unit of Rheumatology, University of l’Aquila, School of Medicine, L’Aquila, L’Aquila, Italy, ³⁴Rheumatology Department, Brest University Hospital, Brest, Brest, France, ³⁵Otorhinolaryngology/ Head and Neck Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany, ³⁶Centre for Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, ³⁷Federal University of São Paulo, São Paulo, Brazil, ³⁸Department of Rheumatology, Haukeland University Hospital, University of Bergen, Bergen, Norway, ³⁹Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, Brazil, ⁴⁰Rheumatology Department, Kasr Al Ainy School of Medicine, Cairo University, Cairo, Egypt, ⁴¹IRCCS Galeazzi Orthopaedic Institute, Milan, and Rheumatology Unit, University of Messina, Messina, Italy, ⁴²Department of Rheumatology, Montpellier University Hospital and University of Montpellier, Montpellier, France, ⁴³German Hospital, Buenos Aires, Buenos Aires, Argentina, ⁴⁴Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma, OK, ⁴⁵Department of Rheumatology, Skane University Hospital Malmö, Lund University, Malmö, Malmö, Sweden, ⁴⁶Clinic of Rheumatology, Department of Medical Area (DAME), University Hospital “Santa Maria della Misericordia”, Udine, Udine, Italy, ⁴⁷Immunology and Rheumatology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México City, Mexico, Mexico, ⁴⁸Department of Medicine, Solna, Unit of Experimental Rheumatology, Karolinska Institutet, and Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ⁴⁹University of Barcelona, Hospital Clínic, Barcelona, Barcelona, Spain, ⁵⁰Sjögren’s Syndrome Research Group (AGAUR), Laboratory of Autoimmune Diseases Josep Font, IDIBAPS-CELLEX, Department of Autoimmune Diseases, ICMiD, University of Barcelona, Hospital Clínic, Barcelona, Bercelona, Spain, ⁵¹Autoimmune Diseases Unit, Department of Medicine, Hospital CIMA Sanitas, Barcelona, Barcelona, Spain
Background/Purpose: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary…
Abstract Number: 1468 • 2018 ACR/ARHP Annual Meeting
Minor Salivary Gland Biopsy: Its Importance in Rheumatoid Arthritis and Secondary Sjögren’s Syndrom
Maria Florencia Rodriguez¹, Cristian Troitiño², Emmanuel Guerra³, Fernando Melo⁴, Anastasia Secco⁵, Natalia Tamborenea³, María Victoria Martire⁶ and Marta Mamani⁴, ¹Reumatologia, Hospital Bernardino Rivadavia, Ciudad Autónoma de Buenos Aires, Argentina, ²Reumatologia, Hospital Bernardino Rivadavia, CAPITAL FEDERAL, Argentina, ³Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁴Rheumatology Department, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ⁶Instituto Médico Platense, La Plata, Argentina
Background/Purpose: Secondary Sjögren's Syndrome (sSS) is a common extraarticular manifestation in patients with Rheumatoid Arthritis (RA). According to the 2002 European American criteria (EA 2002)…
Abstract Number: 1581 • 2018 ACR/ARHP Annual Meeting
Lack of Specificity in Testing for Murine Tissue Specific Autoantibodies for the Diagnosis of Sjogren’s Syndrome
Frederick B Vivino¹, Michael D. George², Chadwick Johr³, Nora Sandorfi⁴, Vatinee Bunya⁵, Giacomina Massaro-Giordano⁵, Andrew Diederich⁶, Brandon Eilberg⁶, Lakshmanan Suresh⁷ and Long Shen⁷, ¹Rheumatolgy Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA, ²Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, ³University of Pennsylvania, Philadelphia, PA, ⁴Rheumatology, University of Pennsylvania, Philadelphia, PA, ⁵Ophthalmology, University of Pennsylvania, Philadelphia, PA, ⁶Orthopedic Surgery, University of Pennsylvania, Philadelphia, PA, ⁷Trinity Biotech, Inc., Buffalo, NY
Background/Purpose: A group of murine parotid tissue specific autoantibodies (TSAs) which includes anti-SP1 (salivary protein 1), anti-PSP (parotid secretory protein) and anti-CA6 (carbonic anhydrase) are…
Abstract Number: 2882 • 2018 ACR/ARHP Annual Meeting
Minimal Progression of Disease Manifestation in Patients with Sjögren’s Syndrome Re-Evaluated Multiple Years after Initial Disease Classification
Astrid Rasmussen¹, Lida Radfar², Kimberly Hefner³, David M. Lewis⁴, C. Erick Kaufman⁵, Donald U. Stone⁶, Kerry M. Leehan¹, Kiely Grundahl⁷, Christopher J. Lessard¹, A. Darise Farris⁸, R. Hal Scofield⁹ and Kathy L. Sivils¹⁰, ¹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Department of Oral Diagnosis and Radiology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ³Hefner Eye Care Center, Oklahoma City, OK, ⁴Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁵Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁶Ophthalmology, Johns Hopkins University, Baltimore, MD, ⁷Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ⁸Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Classical connective tissue diseases, such as SLE and RA have well documented progression of disease and damage accrual. However, the natural history of Sjögren’s…
Abstract Number: 1557 • 2018 ACR/ARHP Annual Meeting
Visualization of Dorsal Root Ganglionitis with Three-Tesla Magnetic Resonance Neurography in Sensory Ataxic Neuropathy Associated with Sjögren’s Syndrome
Takeshi Yoshida¹, Takeshi Sueyoshi², Mitsuyo Kinjo³, Shugo Suwazono⁴ and Hiroyuki Nodera⁵, ¹Rheumatology, Chikamori Hospital, Kochi, Japan, ²Radiology, Minei Daiichi Hospital, Urasoe, Japan, ³Rheumatology, Okinawa Chubu Hospital, Uruma, Japan, ⁴Brain-Nerve-Muscle Research Center, National Hospital Organization Okinawa Hospital, Uruma, Japan, ⁵Neurology, Tokushima University School of Medicine, Tokushima, Japan
Background/Purpose: Sjögrenfs syndrome (SS)-associated neuropathy manifests as various forms of neuropathy, including sensory ataxic neuropathy (SAN). Dorsal root ganglionitis, pathologically defined as the lymphocytic infiltration…
Abstract Number: 1582 • 2018 ACR/ARHP Annual Meeting
Clinical Correlations and Expression Pattern of the Autoimmunity Susceptibility Factor Diora-1 in Primary Sjögren’s Syndrome
Lauro Meneghel¹, Lara Aqrawi^1,2,3, Lara Mentlein¹, Albin Björk¹, Gudny Ella Thorlacius¹, Margarita Ivanchenko¹, Jorge Ramírez¹, Kathrine Skarstein^2,4, Marika Kvarnström¹, Susanna Brauner¹, Alexander Espinosa¹ and Marie Wahren-Herlenius¹, ¹Unit of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Sweden, ²The Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, Bergen, Norway, ³Department of Oral Surgery and Oral Medicine, Institute of Clinical Odontology, University of Oslo, Oslo, Norway, Oslo, Norway, ⁴Department of Pathology, Haukeland University Hospital, Bergen, Bergen, Norway
Background/Purpose: Genome-wide association studies of multiple autoimmune diseases, including primary Sjögren’s syndrome (pSS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have revealed an association…
Abstract Number: 2883 • 2018 ACR/ARHP Annual Meeting
Testing for Anti-Microbial Antibodies with Cross-Reactivity to Human Tissue in Autoimmune Diseases
Peilin Zhang, Lawrence Minardi, J. Todd Kuenstner and Stephen Zekan, PZM Diagnostics, LLC, Charleston, WV
Background/Purpose: Autoantibodies are defining features of autoimmune diseases. How and why the autoantibodies are produced and how these autoantibodies relate to pathogenesis is poorly understood.…
Abstract Number: 1558 • 2018 ACR/ARHP Annual Meeting
Intravenous Immunoglobulin Efficacy for Primary Sjögren’s Syndrome Associated Small Fiber Neuropathy
Antoine Gaillet¹, Karine Champion¹, Jean-Pascal Lefaucheur², Herve Trout³, Jean-François Bergmann¹ and Damien Sène⁴, ¹Internal Medicine Department, Lariboisière Hospital, Paris, France, ²Clinical Neurophysiology Unit,, Henri-Mondor Hospital, Créteil, France, ³Pharmacy Department, Lariboisière Hospital, Paris, France, ⁴Lariboisière Hospital, Paris Diderot University, Paris, France
Background/Purpose: To analyze the efficacy and tolerance of intravenous immunoglobulin (IVIG) therapy in 11 patients with primary Sjögren's syndrome (pSS)-associated small-fiber neuropathy (SFN).Methods: Retrospective, single-center…

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