Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 1467 • 2019 ACR/ARP Annual Meeting
Clinical Characteristics of Primary Sjögren’s Syndrome in Adult Patients Diagnosed at Age Less Than or Equal to 35 Years versus Those over 35 Years of Age
Noel Agustin Callahuara Goiburu¹, Patricia Sasaki ¹, Anastasia Secco ², Catalan Pellet ³, Nadia Riscanevo ⁴, Janet Flores ⁵, Francisco Caeiro ⁵, cristina Amitrano ⁶, Cecilia Asnal ⁷, Alejandro Nitsche ⁸, Carolina Segura Escobar ⁹, Julia Demarchi ¹⁰, Damian Duartes ¹⁰, Lida santiago ¹¹, Laura Raiti ¹², Vanesa Cruzat ¹³, Carla Gobbi ¹⁴, Paula Alba ¹⁵, Silvia Papasidero ¹⁶, Sofia Velez ¹⁷, Vicente Juarez ¹⁸ and Gabriela Salvatierra ¹⁹, ¹Rivadavia, CABA, Ciudad Autonoma de Buenos Aires, Argentina, ²Hospital Rivadavia, Caba, Buenos Aires, Argentina, ³Rivadavia, CABA, Argentina, ⁴Hospital Privado de Córdoba, Cordoba, Cordoba, Argentina, ⁵Hospital Privado de Córdoba, Cordoba, Argentina, ⁶Hospital Aleman, CABA, Argentina, ⁷Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, ⁸Hospital Aleman, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ⁹Hospital Británico, Buenos Aires, Buenos Aires, Argentina, ¹⁰Hospital Británico, Ciudad Autonoma de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina, ¹¹OMI, Ciudad Autonoma de Buenos Aires, Argentina, ¹²Clinica Bessone, Buenos Aires, Buenos Aires, Argentina, ¹³Clinica Bessone, Buenos Aires, Argentina, ¹⁴CÁTEDRA DE CLÍNICA MÉDICA I, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ¹⁵UNIDAD DE REUMATOLOGÍA, CÁTEDRA DE SEMIOLOGÍA, HOSPITAL CÓRDOBA, FACULTAD DE CIENCIAS MÉDICAS, UNIVERSIDAD NACIONAL DE CÓRDOBA, ARGENTINA, Cordoba, Cordoba, Argentina, ¹⁶Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, ¹⁷Consultorio Privado S.V, Buenos Aires, Buenos Aires, Argentina, ¹⁸Hospital Milagros de Salta, Salta, Salta, Argentina, ¹⁹IPRI, Santiago del estero, Santiago del Estero, Argentina
Background/Purpose: Although there is little information, the debut of primary Sjögren's syndrome in adult patients aged less than or equal to 35 years, would be…
Abstract Number: 2421 • 2019 ACR/ARP Annual Meeting
Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren’s Syndrome
Ji-Won Kim¹, Jaeseon Lee ², Ui Hong Jung ¹, Sung-Hoon Park ¹, Jennifer Lee ³, Seung-Ki Kwok ³ and Sung-Hwan Park ³, ¹Catholic University of Daegu School of Medicine, Daegu, Republic of Korea, ²Catholic University of Korea, College of Medicine, Seoul, Republic of Korea, ³Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
Background/Purpose: Since primary Sjögren’s syndrome (pSS) is an autoummune disease of B cell hyperactivity and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular…
Abstract Number: 976 • 2019 ACR/ARP Annual Meeting
Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome
Jun Inamo¹, Katsuya Suzuki ², Masaru Takeshita ², Yoshiaki Kassai ³, Maiko Takigchi ⁴, Rina Kurisu ⁴, Yuumi Okuzono ⁴, Shinya Tasaki ⁵ and Tsutomu Takeuchi ⁶, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ³Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Tokyo, Japan, ⁴Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁵Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁶Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Dysregulation of B cells play a critical role in the pathogenesis of primary Sjögren’s syndrome (pSS). Long non-coding RNAs (lncRNAs), which have become the…
Abstract Number: 1468 • 2019 ACR/ARP Annual Meeting
Effects of Resistive Exercise on Fatigue and Disease Activity in Women with Primary Sjogren’s Syndrome
Luciana Paula Dardin ¹, Fernanda Gazoni ¹, Ana Beatriz Garcia ¹, Paulo Alexandre Minali ² and Virginia Fernandes Moça Trevisani³, ¹Sao Paulo Federal University - Brazil, Sao Paulo, Sao Paulo, Brazil, ²Sao Paulo Federal University - Brazil, Sao Paulo, Brazil, ³Department of Evidence-Based Medicine, Brazilian Cochrane Centre, Federal University of São Paulo, Sao Paulo, Brazil, Sao Paulo, Brazil
Background/Purpose: Fatigue is a frequent symptom of pSS, considered debilitating and the most important cause of dysfunction in these patients. The present study aimed to…
Abstract Number: 2423 • 2019 ACR/ARP Annual Meeting
In Primary Sjogren’s Syndrome (pSS) IL7 Promotes the Crosstalk Between T Lymphocytes and Salivary Gland Epithelial Cells and Participates to IFN Signature
Gaetane Nocturne¹, Juliette Pascaud ², Elodie Rivière ³, Alexandre Virone ⁴, Anastasia Dupré ², Vanessa Gauttier ⁵, Nicolas Poirier ⁵ and Xavier Mariette ⁶, ¹Université Paris Sud, Le Kremlin Bicetre, France, ²IMVA - IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre, Paris, France, ³IDMIT, CEA - Université Paris Sud - INSERM U1184, Le Kremlin Bicêtre ; Arthritis R&D, France, Paris, France, ⁴Université Paris Sud, Le Kremlin Bicetre, ⁵OSE Immunotherapeutics, Nantes, France, ⁶Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: pSS is characterized by lymphocytic infiltration of salivary gland epithelial cells (SGEC). This infiltrate is made of T (TL) and B (BL) lymphocytes. SGEC…
Abstract Number: 1395 • 2019 ACR/ARP Annual Meeting
Risk of Immunization to Rituximab in Systemic Autoimmune Diseases and Rheumatoid Arthritis: Frequency and Risk Factors. Analysis of the Efficacy of an Alternative Treatment by Ofatumumab
Alice Combier¹, Gaetane Nocturne ², Julien Henry ³, Rakiba Belkhir ¹, Stephan Pavy ⁴, Clotilde Le Tiec ⁵, Elise Descamps ⁴, Raphaele Seror ⁶ and Xavier Mariette ⁷, ¹Rheumatology Departement - Bicêtre Hospital, Paris, France, ²Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France., Paris, France, ³Rheumatology Departement - Bicêtre Hospital, Paris, ⁴Rheumatology Departement - Bicètre Hospital, Paris, France, ⁵Pharmacy Departement - Bicètre Hospital, Paris, France, ⁶Hopitaux universitaires Paris Sud, Kremlin-Bicetre, France, ⁷Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France
Background/Purpose: The most widely used B cell targeted therapies in auto-immune diseases (AID) is Rituximab (RTX), a murine chimeric monoclonal antibody. Among RTX’s side effects,…
Abstract Number: 1470 • 2019 ACR/ARP Annual Meeting
Health-Related Quality of Life in Primary Sjogren’s Syndrome: Insights from Using PROMIS and Comparison to ESSPRI
Dana DiRenzo¹, Susan Robinson ², Clifton Bingham ¹ and Thomas Grader-Beck ², ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins University, Baltimore
Background/Purpose: Background. Sjogren’s Syndrome (SS) is a chronic, autoimmune disease affecting the exocrine glands that may negatively affect health-related quality of life (HRQL). The importance…
Abstract Number: 2424 • 2019 ACR/ARP Annual Meeting
RORγt Antagonist Attenuates Experimental Sialadenitis Like Sjögren’s Syndrome via Inhibition of CD25 Expression on CD4+ T Cells
Yuko Ono¹, Hiroto Tsuboi ², Masafumi Moriyama ³, Hiroyuki Takahashi ², Fumika Honda ², Saori Abe ², Yuya Kondo ², Isao Matsumoto ², Seiji Nakamura ⁴ and Takayuki Sumida ², ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyushu University, Tsukuba, Japan, ²Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ³Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyusyu University, Fukuoka, Japan, ⁴Section of Oral and Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Science, Faculty of Dental Science, Kyusyu University, Fukuoka
Background/Purpose: Our previous study demonstrated that T cells specific RORγt transgenic-mice under human CD2 promoter (RORγt-Tg mice) developed severe spontaneous sialadenitis like Sjögren’s syndrome (SS)…
Abstract Number: 20 • 2018 ACR/ARHP Annual Meeting
Expression and Functions of the Transcription Factors Ikaros and Aiolos in Sjogren’s Syndrome and Systemic Lupus Erythematosus
Felice Rivellese^1,2, Daniele Mauro¹, Mattia Congia³, Elena Pontarini¹, Peter Schafer⁴, Michele Bombardieri^1,2, Costantino Pitzalis^1,5 and Myles J. Lewis^1,2, ¹Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kindgdom, London, United Kingdom, ²Barts Health NHS Trust & Barts and the London School of Medicine & Dentistry, London, United Kingdom, London, United Kingdom, ³Rheumatology and Rheumatology Unit, University Clinic and AOU of Cagliari, Cagliari, Italy, Cagliari, Italy, ⁴Celgene Corporation, Summit, NJ, ⁵Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
Background/Purpose: Polymorphisms of the transcription factors Ikaros (IKZF1) and Aiolos (IKZF3), which are essential for the maturation, differentiation and survival of B cells, have been…
Abstract Number: 1565 • 2018 ACR/ARHP Annual Meeting
Comorbidity Burden in Primary Sjögren’s Syndrome: A Long-Term Observation in Clinical Practice
Chiara Baldini¹, Francesco Ferro¹, Nicoletta Luciano¹, Emanuele Calabresi¹, Antonella Cecchettini², Marta Mosca¹, Enzo Grossi¹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²IFC, CNR, Pisa, Italy
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex disorder that may affect any organ and system. In this new era of personalized medicine, a growing…
Abstract Number: 1654 • 2018 ACR/ARHP Annual Meeting
Improvement of Cytological Grade and Tear Production in Ankylosing Spondylitis Patients Under Anti-TNF Therapy: A Long-Term Follow-up
Fany Usuba¹, Carla GS Saad², Priscila Novaes¹, Ruth Santo¹, Julio CB Moraes², Eloisa Bonfa³ and Milton Alves⁴, ¹Ophtalmology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Ophtalmolgy Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: Clinical expression and pathophysiology of dry eye disease (DED) have recently changed and pro-inflammatory cytokines, such as TNF-α, may play a role in the…
Abstract Number: 21 • 2018 ACR/ARHP Annual Meeting
Elevated EPSTI1 Promote B Cells Hyperactivation through NF-Kb Signaling in Patients with Sjögren ’s Syndrome
Jin-Lei Sun¹, Zhi-Lei Chen², Chao-Feng Lian³, Ti-Hong Shao², Hao-Ze Zhang², Hua Chen³ and Feng-Chun Zhang², ¹Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Sjogren's syndrome (SS) is a common systemic autoimmune disease characterized with aberrant B cells activation. B cells play a key role in the pathogenesis…
Abstract Number: 1566 • 2018 ACR/ARHP Annual Meeting
Prevalence and Prognosis of Interstitial Lung Disease in a Large Cohort of Chinese Primary Sjögren’s Syndrome Patients
Hui Gao^1,2, Xuewu Zhang¹, Jing He³, Jing Zhang⁴, Ye Sun⁵ and Zhan-Guo Li¹, ¹Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China, ³Rheumatology, Peking University People's Hospital, Beijing, China, ⁴Peking University International Hospital, Beijing, China, ⁵Department of Radiology, Peking University People's Hospital, Beijing, China
Background/Purpose: To determine the prevalence and identify the prognosis associated with pulmonary involvement in pSS patients. Methods: A total of 1341 hospitalized patients (853 with…
Abstract Number: 1826 • 2018 ACR/ARHP Annual Meeting
From Cancer to Autoimmunity : A New Model of Rheumatoid Arthritis Emerging from a Constitutional Genetic Approach Used in Low Penetrance Cancers
Geraldine Falgarone^1,2, Morad El Bouchtaoui³, Marcio Do Cruzeiro⁴, Christophe Leboeuf^5,6,7, Irmine Loisel-Ferreira^5,6, Carèle Frédonie⁷, Chrystophe Ferreira⁸, Rachida Ait El Far⁵, Marc Espié⁹, Bruno Cassinat¹⁰, Jean-Jacques Kiladjian¹¹, Jean-Paul Feugeas^12,13, Anne Janin^5,6,14 and Guilhem Bousquet^2,5,15, ¹HUPSSD, Avicenne Hospital, Rheumatology, APHP, Bobigny, France, ²Paris 13 University, SMBH, Bobigny, France, ³INSERM UMR-S 1165, PARIS, France, ⁴Plateforme de Recombinaison Homologue, Institut Cochin, INSERM U1016, Paris, France, ⁵INSERM UMR-S 1165, Paris, France, ⁶Université Paris Diderot, Paris, France, ⁷INSERM U944, Paris, France, ⁸Plateforme ANIMA5, Université Paris Descartes, Paris, France, ⁹Centre des Maladies du Sein, APHP, Hôpital Saint-Louis, Paris, France, ¹⁰Laboratoire de BIologie Cellulaire, APHP, Hôpital Saint-Louis, Paris, France, ¹¹Centre d'Inverstigation Clinique, APHP, Hôpital Saint-Louis, Paris, France, ¹²INSERM U1137, Paris, France, ¹³Département de Biologie, Université Franche-Comté, Besançon, France, ¹⁴Service de Pathologie, APHP, Hôpital Saint-Louis, Paris, France, ¹⁵Service d'Oncologie médicale, APHP, Hôpital Avicenne, Bobigny, France
Background/Purpose: High-speed technologies for genome sequencing have completely changed the study of disease genetics, but with limited knowledge of the functional value of most genetic…
Abstract Number: 140 • 2018 ACR/ARHP Annual Meeting
Inhibition of Cathepsin S Leads to Suppression of SS-a/SS-B Specific T Cells from Patients with Primary Sjøgren Syndrome
Patrick Hargreaves^1,2, Michel Theron¹, Fabrice Kolb¹, Marianne Manchester¹, Bernhard Reis¹, Andre Tiaden², Diego Kyburz² and Tobias Manigold², ¹Hoffmann La Roche, Basel, Switzerland, ²Rheumatology, University Hospital Basel, Basel, Switzerland
Background/Purpose: Primary Sjögren syndrome (pSS) is an autoimmune disease characterised by an infiltration of T and B cells into exocrine gland tissue and its subsequent…

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