Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 513 • 2013 ACR/ARHP Annual Meeting
Diagnostic Value Of Labial Minor Salivary Gland Biopsy For Primary Sjögren’s Syndrome
Raquel Altoe¹, Valeria Valim², Maria Carmem S. Santos³, Erica V. Serrano¹ and Samira T. Miyamoto⁴, ¹Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ²Clínica Médica - Reumatologia, Universidade Federal do Espírito Santo, Vitória, Brazil, ³Farmacologia, Universidade de Vila Velha, Vitória, Brazil, ⁴Educação Integrada em Saúde - Reumatologia, Universidade Federal do Espírito Santo, Vitoria, Brazil
Background/Purpose: The presence of lymphocytic infiltrate with ≥ 1 focus score/4mm2 in minor salivary gland is a useful tool for the diagnosis of Sjögren's syndrome…
Abstract Number: 1490 • 2013 ACR/ARHP Annual Meeting
Comparative Study Of The Transcriptome Of Minor Salivary Gland Of Sjögren’s Syndrome Patients Versus Healthy Controls Based On RNA-Seq
Alessia Gallo¹, Shih-Ing Jang², Stamatina Danielides³, Ana Paola Cotrim² and Ilias Alevizos⁴, ¹Sjogren's Clinic, NIDCR, Bethesda, MD, ²NIDCR, NIH, Bethesda, MD, ³Nidcr, NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a complex autoimmune disease characterized by a progressive hypofunction of the salivary and lachrymal glands. In order to better…
Abstract Number: 517 • 2013 ACR/ARHP Annual Meeting
Antibody Responses To Oral Bacteria In Patients With Primary Sjögren’s Syndrome and Comparison With Rheumatoid Arthritis and Periodontitis
Bozo Lugonja¹, Michael Milward², Diana Pearson³, Thomas Dietrich⁴, Iain Chapple⁵, John Hamburger⁶, Francesca Barone¹, Saaeha Rauz⁷, Lorraine Yeo⁸, Ana Povedo-Gallego⁹, Geraint Williams⁷, Paola de Pablo¹, Andrea Richards⁹, Christopher D. Buckley¹, Dagmar Scheel-Toellner⁸ and Simon J. Bowman¹⁰, ¹Rheumatology Research Group, University of Birmingham Research Laboratories, University of Birmingham, Birmingham, United Kingdom, ²Dept of Periodontology, University of Birmingham, Birmingham, United Kingdom, ³Dept of Periodontology, Birmingham Dental Hospital, Birmingham, United Kingdom, ⁴School of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ⁵Periodontology Dept, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, ⁶Dept of Oral Medicine, School of Dentistry, University of Birmingham, Birmingham, United Kingdom, ⁷Academic Unit of Ophthalmology, University of Birmingham, Birmingham, United Kingdom, ⁸Rheumatology Research Group, Centre for Translational Inflammation Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK, Birmingham, United Kingdom, ⁹Dept of Oral Medicine, Birmingham Dental Hospital, Birmingham, United Kingdom, ¹⁰Department of Rheumatology, Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom
Background/Purpose: We set out to examine peripheral blood antibody ELISA responses to common oral bacteria in primary Sjögren’s syndrome (pSS) to identify potential bacterial triggers…
Abstract Number: 2879 • 2013 ACR/ARHP Annual Meeting
Prognostic Value Of Minor Salivary Gland Assessments In Primary Sjögren’s Syndrome
Anna Risselada¹, A.a. Kruize², J.A.G. van Roon³, F.P.J.G. Lafeber⁴ and J.W.J. Bijlsma⁴, ¹Clinical immunology and Rheumatology, University Medical Center Utrecht, Utrecht, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Rheumatology & Clinical Immunology/Lab Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ⁴Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Salivary gland assessment is important for diagnosing primary Sjögren’s syndrome (pSS), as the lymphocytic focus score (LFS) is part of pSS classification criteria. Quantitative…
Abstract Number: 1497 • 2013 ACR/ARHP Annual Meeting
Endosomal TLR Triggering Of B Cells In Sjögren’s Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production
Marie Wahren-Herlenius¹, Susanna Brauner¹, Marika Kvarnström¹, Lasse Folkersen¹, Sabrina Görgen¹, Christina Trollmo², Vivianne Malmström³ and Gunnel Nordmark⁴, ¹Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ²Department of Medicine, Karolinska Institutet, Stochkolm, Sweden, ³Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Background/Purpose: Patients with primary Sjögren’s syndrome have B cell disturbances resulting in hypergammaglobulinemia and autoantibody production. Most patients are not treated by immunomodulatory drugs, enabling…
Abstract Number: 518 • 2013 ACR/ARHP Annual Meeting
Vitamin D In Sjogren’s Syndrome
Suneet Grewal¹, Judith A. James², R. Hal Scofield³, Kathy L. Sivils⁴, Michael H. Weisman⁵ and Swamy Venuturupalli⁶, ¹Division of Rheumatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ²Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁶Cedars-Sinai Medical Center, West Hollywood, CA
Background/Purpose: Unlike other autoimmune diseases in which an association with vitamin D deficiency has been established, the role of vitamin D in Sjogren’s syndrome has…
Abstract Number: 2880 • 2013 ACR/ARHP Annual Meeting
Impact Of Different End Points On The Patient Cohort Size Needed To Demonstrate The Efficacy Of a Therapeutic Intervention In Pss. A Post Hoc Analysis Of The Tears Study (Tolerance and efficacy of Rituximab in primary Sjogren Syndrome study)
Valerie devauchelle-Pensec¹, Sandrine jousse-Joulin², Xavier Mariette³, Jean-Marie Berthelot⁴, Aleth Perdriger⁵, Eric Hachulla⁶, Xavier Puechal⁷, Véronique le Guern⁸, Jean Sibilia⁹, Jacques-Eric Gottenberg¹⁰, Laurent Chiche Sr.¹¹, Vincent Goeb¹², Gilles Hayem¹³, Jacques Morel¹⁴, Charles Zarnitsky¹⁵, Jean Jacques Dubost¹⁶, Jacques-Olivier Pers¹⁷, Divi Cornec¹⁸, Raphaèle Seror¹⁹, Emmanuel Nowak²⁰ and Alain Saraux²¹, ¹Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France, ²Rheumatology/Immunology, CHU de la Cavale Blanche, Brest, France, ³Rheumatology Service, Bicêtre University Hospital, Le Kremlin Bicetre, France, ⁴Rheumatology Unit, Nantes University Hospital, Nantes, France, ⁵Rheumatology, Hôpital Sud, Rennes, France, ⁶Internal Medicine, Lille CEDEX, France, ⁷Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Department of Internal Medicine, Hôpital Cochin, Paris, France, ⁹Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, ¹⁰Strasbourg University Hospital, Strasbourg, France, ¹¹Internal Medicine, CHU Marseille, Marseille, France, ¹²Rheumatology, Amiens University Hospital, Amiens, France, ¹³Rheumatology Unit, Bichat Hospital, Paris, France, ¹⁴Dpartment of Rheumatology, Lapeyronie Hospital, Montpellier, France, ¹⁵Rheumatology, Le Havre General Hospital, Le Havre, France, ¹⁶Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, ¹⁷Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ¹⁸Department of rheumatology, Brest Occidentale University, Brest, France, ¹⁹Rheumatology, Bicetre university hospital, LE Kremlin-Bicetre, France, ²⁰CIC, CHU Brest, Brest, France, ²¹Department of rheumatology and unit of immunology (EA 2216), Université Brest Occidentale, Brest, France
Background/Purpose: To calculate the sample sizes needed in future randomized controlled trials (RCTs) testing a therapeutic intervention in pSS, methodologists usually rely on data obtained…
Abstract Number: 1498 • 2013 ACR/ARHP Annual Meeting
Hypofunction In Intact Cell Lobules Reflect Salivary Flow Rates In Sjogren’s Patients
Leyla Y Teos¹, Bill Swaim², Ana Paola Cotrim¹, Margaret Grisius³, Lolita Bebris⁴, Indu Ambudkar⁵, Gabor G. Illei⁶ and Ilias Alevizos⁷, ¹NIDCR, NIH, Bethesda, MD, ²Mptb, NIH/NIDCR, Bethesda, MD, ³NIH, Bethesda, MD, ⁴Sjogren's Clinic, NIDCR/NIH, Bethesda, MD, ⁵Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD, ⁶Clinical Development, MedImmune, LLC, Gaithersburg, MD, ⁷Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose: Neurotransmitter stimulation of fluid secretion in salivary glands is regulated by increases in intracellular calcium concentration. The increase in cytosolic calcium triggers ion channel…
Abstract Number: 519 • 2013 ACR/ARHP Annual Meeting
Identification Of IgG4-Related Disease and Analysis Of IgG4 Serum Levels In Different Subgroups Of Patients With Sjögren’s Syndrome
Antónia Szántó¹, Gábor Nagy², Csaba Molnár³ and Margit Zeher¹, ¹Clinical Immunology, University of Debrecen, Medical and Health Science Center, Institute for Medicine, Debrecen, Hungary, ²Regional Immunological Laboratory, University of Debrecen, Medical and Health Science Center, Institute for Medicine, Debrecen, Hungary, ³University of Debrecen, Medical and Health Science Center, Institute for Pathology, Debrecen, Hungary
Background/Purpose: In the clinical diagnostic criteria of IgG4-related disease (IgG4-RD), Sjögren’s syndrome (SS) appears as one of the exclusion criteria. However, in Europe, where Mikulicz’s…
Abstract Number: 2881 • 2013 ACR/ARHP Annual Meeting
Ultrasonographic Salivary Glands Response To Rituximab In Primary Sjögren Syndrome Patients In the Tolerance and Efficacy Of Rituximab In Primary Sjogren Syndrome Study Is Not Associated With The Anatomopathology Changes
Sandrine Jousse-Joulin¹, Valerie Devauchelle-Pensec², Divi Cornec³, Simon Gestin⁴, Luc Bressollette⁵, Thierry Marhadour⁶, Jacques-Olivier Pers⁷, Emmanuel Nowak⁸ and Alain Saraux⁹, ¹Rheumatology, Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France, ²Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France, ³Department of rheumatology, Brest Occidentale University, Brest, France, ⁴Vascular medicine, CHU Brest, Brest, France, ⁵Department of ultrasound, Brest Occidentale University, Brest, France, ⁶Rheumatology, CHU de la Cavale Blanche, Brest, France, ⁷Unit of immunology, EA 2216, Brest Occidentale University, Brest, France, ⁸CIC, CHU Brest, Brest, France, ⁹Department of rheumatology and unit of immunology (EA 2216), CHU Brest et Université Bretagne Occidentale, Brest, France
Background/Purpose: We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy of Rituximab (RTX) in active pSS patients in France (TEARS study) and…
Abstract Number: 1499 • 2013 ACR/ARHP Annual Meeting
Detection Of CD4⁺CD25^lowGITR⁺ T Lymphocytes In Sjogren’s Syndrome-Interstitial Lung Disease
Wu Zhenbiao¹ and Chen Lina², ¹Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, Xi'An, China, ²Clinical Immunology, First Affiliated Hospital, Fourth Military Medical University, Xi‘an, China
Background/Purpose: CD4+CD25lowGITR+ T lymphocytes expressing FoxP3 and showing regulatory function have been recently described in healthy donors (HD). The objective of this study was to…
Abstract Number: 400 • 2013 ACR/ARHP Annual Meeting
Parotid Ultrasound Abnormalities Among Rheumatoid Arthritis Patients: Prevalence and Clinical Correlates
Hong Yang¹, Doquyen H. Huynh², Arnold Ceponis³ and Arthur Kavanaugh⁴, ¹Rheumatology, UCSD, San Diego, CA, ²Rheumatology, UC San Diego School of Medicine, San Diego, CA, ³Medicine/Rheumatology, University of California San Diego, La Jolla, CA, ⁴University of California San Diego, San Diego, CA
Background/Purpose: Sjögren's syndrome (SS) occurs commonly among rheumatoid arthritis (RA) patients. It may be an indicator of, and even a contributor to, increased RA disease…
Abstract Number: 2882 • 2013 ACR/ARHP Annual Meeting
B-Cell Depletion Modulates T-Helper Cell Balance In Patients With Primary Sjögren’s Syndrome
WH Abdulahad¹, FGM Kroese², Gwenny Verstappen³, MG Huitema¹, PM Meiners⁴, A Vissink⁵ and H Bootsma¹, ¹Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and clinical immunology, University Medical Center Groningen, Groningen, Netherlands, ³University of Groningen and University Medical Center Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: B-cell depletion therapy with a chimeric anti-human CD20 antibody (rituximab; RTX) is an effective treatment modality for patients with primary Sjögren’s syndrome (pSS). However,…
Abstract Number: 883 • 2013 ACR/ARHP Annual Meeting
Sex Bias In Autoimmune Diseases: Increased Risk Of 47,XXX In Systemic Lupus Erythematosus (SLE) and Sjögren’s Syndrome (SS) Supports The Gene Dose Hypothesis
Ke Liu¹, Kenneth M. Kaufman^2,3, Judith A. James^4,5, Roland Jonsson^6,7, Biji T. Kurien^4,5,8, Xavier Mariette⁹, Joan T. Merrill¹⁰, Roald Omdal¹¹, Maureen Rischmueller^12,13, Timothy J. Vyse¹⁴, Marie Wahren-Herlenius¹⁵, Torsten Witte¹⁶, Christopher J. Lessard^4,5, Sarah L. Zimmerman¹⁷, Susan D. Thompson¹⁸, Gideon Hirschfield¹⁹, Gang Xie^20,21, Courtney G. Montgomery^8,22, Wan-Fai Ng²³, Gunnel Nordmark²⁴, Patrick M. Gaffney^4,8, Katherine A. Siminovitch^20,25, Kathy L. Sivils^4,26, Slegen (International Consortium For The Genetics Of SLE)²⁷ and R. Hal Scofield^4,5,28, ¹Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ²U.S. Department of Veterans Affairs Medical Center, Cincinnati, OH, ³1Center for Autoimmune Genomics and Etiology and Rheumatology Division, Cincinnati Children’s Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁷Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁸U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Paris-Sud University, Paris, France, ¹⁰Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ¹²Rheumatology Department, Queen Elizabeth Hospital, Adelaide, Australia, ¹³Discipline of Medicine, University of Adelaide, Adelaide, Australia, ¹⁴Division of Genetics and Molecular Medicine and Division of Immunology, Infection and Inflammatory Disease, King's College London, London, United Kingdom, ¹⁵Department of Medicine, Karolinska Institutet, Stockholm, Sweden, ¹⁶Clinical Immunology and Rheumatology, Medical University Hannover, Hanover, Germany, ¹⁷Divison of human Genetics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ¹⁸Division and Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ¹⁹Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²⁰Mount Sinai Hospital, Toronto, ON, Canada, ²¹University Of Toronto, Toronto, ON, Canada, ²²Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²³Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle upon Tyne, United Kingdom, ²⁴Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, ²⁵University of Toronto, Toronto, ON, Canada, ²⁶University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁷Center for Autoimmune Genomics and Etiology and Rheumatology Division, International Consortium For The Genetics Of Systemic Lupus Erythematosus, Cincinnati, OH, ²⁸US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Female preponderance is a hallmark of most autoimmune diseases, the mechanism for which is unknown. We hypothesize that this is a consequence of a…
Abstract Number: 218 • 2013 ACR/ARHP Annual Meeting
The Role Of Salivary GLAND Ultrasound In Sjogren Syndrome: A Single Center Experience
Giuseppe Germanò¹, Niccolò Possemato², Olga Addimanda¹, Pierluigi Macchioni¹ and Carlo Salvarani³, ¹Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²S.C. Reumatologia, Arcispedale Santa Maria Nuova, I.R.C.C.S., Reggio Emilia, Italy, ³Rheumatology, Arcispedale S Maria Nuova-IRCCS, Reggio Emilia, Italy
Background/Purpose: There is increasingly scientific evidence of salivary gland ultrasonography accuracy and usefulness in diagnosing Sjogren Syndrome. [1-2] Methods: 82 patients with suspected Sjogren Syndrome…

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