ACR Meeting Abstracts

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Abstracts tagged "Sjogren’s syndrome"

  • Abstract Number: 633 • 2015 ACR/ARHP Annual Meeting

    Anti-Centromere Antibodies Are Associated with More Severe Exocrine Glandular Dysfunction in Primary Sjögren’s Syndrome: An Analysis of the Sjögren’s International Collaborative Clinical Alliance Cohort

    Alan N. Baer1, Leah Medrano2 and Mara McAdams-Demarco3, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD, 3Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

    Background/Purpose: Anti-centromere antibodies (ACA) define a subgroup of Sjögren’s syndrome (SS) patients who are often older, have more frequent Raynaud’s phenomenon, and a lower frequency…
  • Abstract Number: 1253 • 2015 ACR/ARHP Annual Meeting

    Identification and Validation of Novel Putative Salivary Proteomic Biomarkers in Sjögren’s Syndrome and Different Disease Subsets

    Chiara Baldini1, Daniela Martini1, Nadia Ucciferri2, Silvia Rocchiccioli2, Letizia Mattii3, Antonietta Raffaella Maria Sabbatini3, Francesca Sernissi1, Francesco Ferro1, Nicoletta Luciano1, Leonardo Lorenzini1, Marta Mosca4, Stefano Bombardieri1 and Antonella Cecchettini3, 1Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 2Institute of Clinical Physiology, Pisa, Italy, Pisa, Italy, 3Department of Clinical and Experimental Medicine, University of Pisa, Italy, Pisa, Italy, 4University of Pisa, Pisa, Italy

    Background/Purpose: Salivary proteomics has recently appeared as a promising tool for the identification of novel diagnostic biomarkers for primary Sjögren’s syndrome (SS). However, to date…
  • Abstract Number: 2795 • 2015 ACR/ARHP Annual Meeting

    Fatigue in Primary Sjögren’s Syndrome: Clinical, Laboratory, Psychometric and Biological Associations

    Theofanis Karageorgas1, Sofia Fragkioudaki2, Adrianos Nezos3, Dimitris Karaiskos4, Clio Mavragani5 and Haralampos M. Moutsopoulos6, 1Clinical Immunology and Rheumatology, "Attikon" University Hospital of Athens, Athens, Greece, 2Physiology, Medical School of Athens, Department of Physiology, Athens, Greece, 3Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, 4Physiology, School of Medicine, University of Athens, Athens, Greece, Athens, Greece, 5Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, 6Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece

    Background/Purpose: To identify independent predictors of fatigue in primary Sjogren’s Syndrome (pSS) patients taking into account clinical, laboratory and psychological features and to explore the…
  • Abstract Number: 634 • 2015 ACR/ARHP Annual Meeting

    Big Data International Primary Sjögren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria

    Pilar Brito-Zerón1, Soledad Retamozo1,2, Margit Zeher3, Astrid Rasmussen4, Elke Theander5, Jacques Gottenberg6, Chiara Baldini7, Luca Quartuccio8, Roberta Priori9, Valeria Valim10, Marika Kvarnström11, Aike Kruize12, Gabriela Hernandez-Molina13, Elena Bartoloni-Bocci14, Sonja Praprotnik15, David A. Isenberg16, Gunnel Nordmark17, Michele Bombardieri18, Yasunori Suzuki19, Roser Solans20, Roberto Giacomelli21, Daniel S. Hammenfors22, Steven E. Carsons23, Hendrika Boostma24, Cristina F. Vollenweider25, Fabiola Atzeni26, Kathy Sivils27, Thomas Mandl28, Salvatore De Vita29, Marie Wahren-Herlenius11, Mitsuhiro Kawano30, Roberto Gerli31, Arjan Vissink32, Johan G. Brun33, Virginia Trevisani34, Jorge Sánchez-Guerrero35, Xavier Mariette36, Manuel Ramos-Casals1 and on behalf of the EULAR-SS Task Force, 1Department of Autoimmune Diseases, CELLEX-IDIBAPS, Hospital Clínic, Barcelona, Barcelona, Spain, 2Rheumatology Unit, Hospital Privado Centro Médico de Córdoba, Córdoba, Argentina, 3University of Debrecen, Debrecen, Hungary, 4Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 5Skåne University Hospital Malmö, Lund University, Malmo, Sweden, 6Hôpitaux Universitaires de Strasbourg, Strasbourg, France, 7Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, 8Clinic of Rheumatology, Department of Medical and Biological Sciences (DSMB), Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 9Rheumatology Unit, Sapienza University of Rome, Rome, Italy, 10Rheumatology, Universidade Federal do Espírito Santo, Vitória, Brazil, 11Department of medicine, Rheumatology unit, Karolinska Institutet, Stockholm, Sweden, 12Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, 13Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico city, Mexico, 14Department of Medicine, Rheumatology Unit, University of Perugia, Perugia, Italy, 15Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 16Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 17Medical Sciences, Uppsala University, Uppsala, Sweden, 18Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom, 19Kanazawa University Graduate School of Medicine, Kanazawa, Japan, 20Department of Internal Medicine, Hospital Vall d'Hebron, Barcelona, Spain, 21University of L'Aquila, L'Aquila, Italy, 22Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 23Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, 24University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 25Rheumatology, German Hospital, Buenos Aires, Argentina, 26Rheumatology Unit, L. Sacco University Hospital of Milan, Milan, Italy, 27Oklahoma Medical Research Foundation, Oklahoma City, OK, 28Dept of Rheumatology, Skåne University Hospital Malmö, Lund University, Malmo, Sweden, 29Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy, 30Division of Rheumatology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, 31University of Perugia, Perugia, Italy, 32Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 33Haukeland University Hospital, Bergen, Norway, 34Health Evidence Based, Universidade Federal de São Paulo, Sâo Paulo, Brazil, 35Rheumatology, Mount Sinai Hospital and University Health Network, Toronto Canada, Toronto, ON, Canada, 36Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France

    Background/Purpose: To analyse the epidemiological, clinical and immunological characteristics at diagnosis of the largest international cohort of patients diagnosed with primary Sjögren syndrome (SS) according…
  • Abstract Number: 1262 • 2015 ACR/ARHP Annual Meeting

    Epigenome-Wide DNA Methylation Patterns Associated with Fatigue in Primary Sjögren’s Syndrome

    Katrine B Norheim1, Juliana Imgenberg-Kreuz2, Kristin Jonsdottir3, Emiel Janssen4, Ann-Christine Syvänen2, Johanna K Sandling2, Gunnel Nordmark5 and Roald Omdal6, 1Dept of Internal Medicine, Clinical immunology Unit, Stavanger, Norway, 2Molecular Medicine and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 3Dept. of Pathology, Stavanger University Hospital, Stavanger, Norway, 4Dept. of Pathology, Stavanger university Hospital, Stavanger, Norway, 5Rheumatology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden, 6Department of internal medicine, Clinical Immunology unit, Stavanger, Norway

    Background/Purpose: Chronic fatigue is a common, often disabling, and poorly understood phenomenon of many diseases. Recent studies indicate that epigenetic mechanisms may be involved in…
  • Abstract Number: 2796 • 2015 ACR/ARHP Annual Meeting

    Elevated Serum Immunoglobulin G Is a Prognostic Factor for Progression of Interstitial Lung Disease in Primary Sjögren’s Syndrome

    Eriko Ishioka1, Katsuya Suzuki2, Naoshi Nishina2, Hidekata Yasuoka3, Kunihiro Yamaoka2 and Tsutomu Takeuchi2, 1Division of Rheumatology, Department of Internal medicine, Keio University School of Medicine, Tokyo, Japan, 2Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 3Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Lung involvement is a systemic manifestation of primary Sjögren's syndrome (pSS), however, the prevalence in pSS is various (9-75 %) and details are still…
  • Abstract Number: 635 • 2015 ACR/ARHP Annual Meeting

    Seronegative Sjögren’s Syndrome Is Associated with a Higher Frequency of Patient-Reported Neuropathic Pain: An Analysis of the Sjögren’s International Collaborative Clinical Alliance Cohort

    Alan N. Baer1 and Julius Birnbaum2, 1Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 2Medicine (Rheumatology), Johns Hopkins University School of Medicine, Baltimore, MD

    Background/Purpose: Patients with Sjögren’s syndrome (SS) and negative SSA/SSB serology (ie. seronegative SS) have phenotypic characteristics different than seropositive ones, and thus may constitute a…
  • Abstract Number: 1358 • 2015 ACR/ARHP Annual Meeting

    Detection of a Unique Viral Infection in Salivary Glands of Sjögren’s Syndrome Patients and Viral-Mediated Recapitulation of Disease in Vivo

    Melodie Weller1, Matthew Gardner1, Zoe Bogus1, Michael Smith1, Elisa Astorri2, Drew Michael1, Changyu Zheng1, Peter Burbelo3, Paul A. Wilson4, Zhennan Lai1, Bill Swaim1, Beverly Handelman1, Sandra Afione1, Michele Bombardieri2 and John A. Chiorini1, 1Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 2Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom, 3Clinical Dental Research Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 4National Intramural Database, Division of Enterprise and Custom Applications, Center for Information Technology, National Institutes of Health, Bethesda, MD

    Background/Purpose: A viral infection is thought to be one of the triggers in the development of primary Sjögren’s syndrome (pSS).  Multiple studies have shown stimulation…
  • Abstract Number: 2797 • 2015 ACR/ARHP Annual Meeting

    Identification of Serum Biomarker for the Glandular Dysfunction of Primary Sjögren’s Syndrome

    Ayumi Nishikawa1, Katsuya Suzuki1, Yoshiaki Kassai2, Yuumi Gotou3, Takahiro Miyazaki4, Maiko Takiguchi4, Rimpei Morita5, Akihiko Yoshimura5 and Tsutomu Takeuchi1, 1Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, 2Takeda Pharmaceutical Company, Fujisawa, Japan, 3Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Tokyo, Tokyo, Japan, 4Inflammation Drug Discovery Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Ltd., Kanagawa, Japan, 5Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by dry eye and mouth. Measurements of un-stimulated salivary flow and Schirmer’s test are…
  • Abstract Number: 2537 • 2014 ACR/ARHP Annual Meeting

    Diagnostic Accuracies of Sialography and Salivary Ultrasonography in Sjogren’s Syndrome Patients: A Meta-Analysis

    Young Ho Lee1 and Gwan Gyu Song2, 1Internal Medicine, Rheumatology, Korea University Medical Center, Seoul, South Korea, 2Div of Rheum, Dept of Int Medicine, Guro Hospital, Korea Univ College of Medicine, Seoul, South Korea

    Background/Purpose Ultrasonography (US) may come to replace conventional invasive examinations in clinical practice. However, the diagnostic accuracy of salivary US has not been clearly compared…
  • Abstract Number: 1605 • 2014 ACR/ARHP Annual Meeting

    Elevated Regulatory Mediators and Interferon Gamma Associated Responses, but Not Interferon Alpha, BLyS or IP-10, Accompany High-Titer Anti-Ro Autoantibodies in Asymptomatic Mothers of Children with Neonatal Lupus

    Peter M. Izmirly1, Robert M. Clancy2, Melissa Munroe3, Sara Rasmussen2, Amit Saxena2,4, Jose U. Scher2, Aikaterini Thanou5, Stan Kamp6, Joan T. Merrill7, Jill P. Buyon2 and Judith James8, 1Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 2Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, 3Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Rheumatology, New York University School of Medicine, New York, NY, 5Arthritis and Clinical Immunology Reseach Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 6Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 7Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, 8Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Mothers of children with neonatal lupus offer a unique opportunity to study the drivers and consequences of autoantibody production in the absence of ongoing…
  • Abstract Number: L3 • 2014 ACR/ARHP Annual Meeting

    Low Protein A20 Expression in Minor Salivary Glands Is Associated with Lymphoma Development in Primary Sjögren’s Syndrome

    Svein Joar A. Johnsen1, Einar Gudlaugsson2, Ivar Skaland2, Emiel Janssen2, Malin V. Jonsson3, Lars Helgeland4, Ellen Berget5, Roland Jonsson6 and Roald Omdal1, 1Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, 2Stavanger University Hospital, Stavanger, Norway, 3Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, 4Haukeland University Hospital, Bergen, Norway, 5University of Bergen, Bergen, Norway, 6Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway

    Background/Purpose: Patients with primary Sjogrens syndrome (pSS) have an increased risk of developing lymphomas, especially of the subtype mucosa-associated lymphoid tissue (MALT) lymphoma. Chronic antigen…
  • Abstract Number: 2536 • 2014 ACR/ARHP Annual Meeting

    The Sjögren’s Syndrome Responder Index, a Data-Driven Combined Endpoint, Could Detect Biologics Efficacy

    Divi Cornec1, Valerie Devauchelle-Pensec2, Xavier Mariette3, Sandrine Jousse-Joulin4, Jean-Marie Berthelot5, Aleth Perdriger6, Xavier Puéchal7, Véronique le Guern8, Jean Sibilia9, Jacques Gottenberg10, Laurent Chiche11, Eric Hachulla12, Pierre-Yves Hatron13, Vincent Goëb14, Gilles Hayem15, Jacques Morel16, Charles Zarnitsky17, Jean Jacques Dubost18, Raphaèle Seror19, Jacques-Olivier Pers20, Emmanuel Nowak21 and Alain Saraux22, 1Department of rheumatology and unit of immunology, Brest Occidentale University, Brest, France, 2Department of rheumatology and unit of immunology (EA2216), Brest Occidentale university, Brest, France, 3rheumatology, Université Paris-Sud, Le Kremlin Bicêtre, France, 4Rheumatology, CHU Brest, Brest, France, 5Rheumatology, CHU Nantes (Nantes University Hospital), Nantes, France, 6Rhumatologie, Rennes, France, 7National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, Paris, France, 8Department of Internal Medicine, Hôpital Cochin, Paris, France, 9Division of Rheumatology, University Hospital of Strasbourg, Strasbourg, France, 10Rheumatology, Strasbourg University Hospital, Strasbourg, France, 11147 Boulevard Baille, CHU Marseille, Marseille, France, 12Internal Medicine, National Scleroderma Centre, Lille CEDEX, France, 13CHU Lille, Lille, France, 14Rheumatology, Amiens University Hospital, Amiens, France, 15CHU Bichat, Paris, France, 16Department of Rheumatology, Hôpital Lapeyronie, Montpellier, France, 17Rheumatology, Le Havre General Hospital, Le Havre, France, 18Rheumatology, CHU G.-Montpied, Clermont-Ferrand, France, 19Rheumatology, Université Paris Sud, Le Kremlin Bicêtre, France, 20CHU Brest, Brest, France, 21CIC, CHU Brest, Brest, France, 22Rheumatology, CHU de la Cavale Blanche and Université Bretagne occidentale, Brest Cedex, France

    Background/Purpose Efficacy of rituximab remains debated in primary Sjögren’s syndrome (pSS), but that could be partly due to the absence of validated endpoint. To determine…
  • Abstract Number: 1329 • 2014 ACR/ARHP Annual Meeting

    Comparison of Clinical and Serological Features of Childhood Sjögren Syndrome Based on the Presence or Absence of Parotitis

    Jay Mehta1, Namrata Singh2 and Scott Lieberman3, 1Pediatrics, Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY, 2Medicine, University of Iowa, Iowa City, IA, 3Pediatrics (Division of Rheumatology), University of Iowa Children's Hospital, Iowa City, IA

    Background/Purpose: Sjögren syndrome is a complex autoimmune disease that affects lacrimal and salivary glands with the potential to cause damage to other organs. Diagnosis of…
  • Abstract Number: 2534 • 2014 ACR/ARHP Annual Meeting

    Ocular Surface Temperature in Early Sjogren’s Syndrome and Established Disease

    Andreea Coca1, Ranjini Kottaiyan2, Mircea Coca3, Debbie Campbell4, Holly Hindman2 and James Aquavella2, 1Allergy, Immunology and Rheumatology, University of Rochester, Rochester, NY, 2Ophtalmology, University of Rochester, Rochester, NY, 3Ophtalmology, University of Texas Medical Branch, Galveston, TX, 4Allergy, Immunology and Rheumatology, Univerity of Rochester, Rochester, NY

    Background/Purpose Due to a variety of factors it is challenging to make a definite diagnosis in the early stages of Sjögren’s syndrome (SS). The ocular…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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