Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 2954 • 2015 ACR/ARHP Annual Meeting
Serum and CSF Biomarkers of Neuropsychiatric Involvement in Primary Sjogren Syndrome and Systemic Lupus Erythematosus
Maria Boge Lauvsnes¹, Anne Bolette Tjensvoll², Ingeborg Kvivik³, Roald Omdal⁴ and Chaim Putterman⁵, ¹Clinical Immunology Unit, Stavanger University Hospital, Stavanger, Norway, ²Department of Neurology, Stavanger University Hospital, Stavanger, Norway, ³Reasearch Department, Stavanger University Hospital, Stavanger, Norway, ⁴Clinical Immunology Unit, Department of Internal Medicine, Stavanger University Hospital, Stavanger, Norway, ⁵Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Neuropsychiatric manifestations are commonly observed in both SLE and primary Sjšgren's syndrome (pSS). However, making an accurate diagnosis can be challenging. Multiple serum and…
Abstract Number: 625 • 2015 ACR/ARHP Annual Meeting
Sjögren’s Syndrome Foundation Clinical Practice Guidelines for Management of Systemic Disease
Frederick B Vivino¹, Steven E. Carsons², Ann Parke³, Nancy Carteron⁴, Vidya Sankar⁵, Richard Brasington⁶, Robert Fox⁷, William Ehlers³, Michael Brennan⁸, Robert Hal Scofield⁹, Katherine M Hammitt¹⁰ and Sjogren's Syndrome Foundation Clinical Practice Guidelines Committee, ¹Rheumatology, University of Pennsylvania, Philadelphia, PA, ²Rheumatology, Allergy and Immunology, Winthrop University Hospital, Mineola, NY, ³University of Connecticut, Farmington, CT, ⁴University of California, San Francisco, CA, ⁵Univeristy of Texas, San Antonio, TX, ⁶Washington University, St Louis, MO, ⁷Rheumatology Clinic, La Jolla, CA, ⁸Carolinas Medical Center, Charlotte, NC, ⁹Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ¹⁰Vice President of Medical and Scientific Affairs, Sjögren's Syndrome Foundation, Bethesda, MD
Background/Purpose: There are currently no FDA approved immunomodulating agents available for treatment of the extraglandular manifestations of Sjogren’s (SS). Clinical practice guidelines were developed for…
Abstract Number: 647 • 2015 ACR/ARHP Annual Meeting
Involvement of Peripheral Nervous System in Primary Sjögren Syndrome, a Gessar Analysis
M. Mayer¹, S. Velez², F. Zazzetti², J. C. Barreira², L. Galvan¹, G. Bennasar³, L. R. Carlevaris³, A. Secco³, C. Asnal⁴, P. Pucci⁴, C. Amitrano⁴, A. Nitsche⁴, M. C. Khoury⁵, F. Caeiro⁶, N. Benzaquén⁶, J.P. Pirola⁶, M. Colazo⁶, O.L. Rillo⁷, S. Papasidero⁷, J. Demarchi⁷, L. Raitti⁸, M. N. Tamborenea⁹, M. L. Santiago⁹, P. Alba¹⁰, B. Busamia¹⁰, G. Salvatierra¹¹ and A. Catalán Pellet³, ¹Rheumatology, Buenos Aires British Hospital, CABA, Argentina, ²Rheumatology, Buenos Aires British Hospital, Buenos Aires, Argentina, ³Rivadavia Hospital, CABA, Argentina, ⁴German Hospital, CABA, Argentina, ⁵Statistics, Buenos Aires British Hospital, CABA, Argentina, ⁶Private Hospital of Cordoba, Cordoba, Argentina, ⁷Tornú Hospital, CABA, Argentina, ⁸Bessone Clinic, CABA, Argentina, ⁹OMI, Buenos Aires, CABA, Argentina, ¹⁰Córdoba Hospital, Cordoba, Argentina, ¹¹IPRI, Santiago del Estero, Santiago del Estero, Argentina
Background/Purpose: Primary Sjögren's syndrome (pSS) is an autoimmune disease characterized by dysfunction of the exocrine glands. The frequency of neurological manifestations in pSS ranges from…
Abstract Number: 2282 • 2015 ACR/ARHP Annual Meeting
“Doing Every-Day Life” with Primary Sjögren’s Syndrome: Factors Predicting Difficulties Performing Daily Activities and Taking on Life Roles
Katie Hackett¹, Dennis W Lendrem², Tim Rapley³, Katherine Deane⁴, Vincent Deary⁵, Simon Bowman⁶, Julia Newton⁷, Wan-Fai Ng⁸ and on behalf of the United Kingdom Primary Sjogren's Syndrome Registry, ¹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ²Institute of Cellular Medicine (Musculoskeletal Research Group), NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals Foundation Trust and Newcastle University, Newcastle upon Tyne, United Kingdom, ³Institute of Health and Society, Newcastle University, Newcastle upon Tyne, United Kingdom, ⁴University of East Anglia, Norwich, United Kingdom, ⁵School of Health Psychology, Northumbia University, Newcastle upon Tyne, United Kingdom, ⁶Rheumatology Dept, University Hospital Birmingham, Birmingham, United Kingdom, ⁷Newcastle University, Newcastle upon Tyne, United Kingdom, ⁸Newcastle-upon-Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is an autoimmune disease which targets secretory glands and results in dryness. In addition pSS patients frequently experience symptoms of…
Abstract Number: 3200 • 2015 ACR/ARHP Annual Meeting
Characterization of Early and Progressive Autoimmunity in Sjogrens Syndrome: The Incomplete Sjogrens Syndrome Model
Astrid Rasmussen¹, Christopher J Lessard², Indra Adrianto¹, Graham B. Wiley¹, Donald U Stone^3,4, C. Erick Kaufman⁵, Lida Radfar⁶, David M. Lewis⁷, Stephen K Young⁸, Michael H. Weisman⁹, Daniel J Wallace¹⁰, Swamy Venuturupalli¹¹, Barbara M. Segal¹², John A. Ice¹, Juan-Manuel Anaya¹³, Michael D. Rohrer¹⁴, Raj Gopalakrishnan¹⁵, Glen D Houston¹⁶, James Chodosh¹⁷, Pamela J Hughes¹⁸, Nelson L. Rhodus¹⁹, Jennifer A. Kelly²⁰, Kiely Grundahl²¹, Kimberly Hefner²², R. Hal Scofield^1,23,24 and Kathy L. Sivils¹, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ³Research Department, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁴Department of Ophthalmology, Johns Hopkins University, Riyadh, Saudi Arabia, ⁵College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ⁷College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹¹Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹³Center for Autoimmune Diseases Research (CREA), Universidad del Rosario., Bogota, Colombia, ¹⁴Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ¹⁵Diagnostic and Biological Sciences, Division of Oral Pathology, University of Minnesota, Minneapolis, MN, ¹⁶Heartland Pathology, Oklahoma City, OK, ¹⁷Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹⁸Division of Oral and Maxillofacial Surgery, University of Minnesota, Minneapolis, MN, ¹⁹Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁰Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ²¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma CIty, OK, ²²Hefner Eye Care and Optical Center, Oklahoma City, OK, ²³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²⁴US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Autoimmune diseases are often preceded by subclinical serologic and functional abnormalities that predate diagnosis by several years. The insidious and progressive nature of these…
Abstract Number: 626 • 2015 ACR/ARHP Annual Meeting
Efficacy of Belimumab and Targeting of Rheumatoid Factor Positive B-Cells in Sjögren’s Syndrome: Follow-up of the Open-Label Phase II Study
Luca Quartuccio¹, Sara Salvin², Laura Corazza¹, Saviana Gandolfo², Martina Fabris³ and Salvatore De Vita⁴, ¹S. Maria della Misericordia, University of Udine, Italy, Udine, Italy, ²Rheumatology Clinic, University of Udine, Udine, Italy, ³Clinic of Rheumatology, University of Udine, Udine, Italy, ⁴Santa Maria della Misericordia Hospital, University of Udine, Udine, Italy
Background/Purpose: Belimumab, a monoclonal anti-B lymphocyte Stimulator (BLyS) antibody is preliminary found to be effective in Sjögren’s syndrome (SS) patients with moderate to high systemic…
Abstract Number: 648 • 2015 ACR/ARHP Annual Meeting
Klinefelter’s Syndrome (47,XXY) Among Men with Sjögren’s Syndrome
Valerie M Harris¹, Joshua Cavett², Biji Kurien³, Ke Liu⁴, Kristi A. Koelsch⁵, Lida Radfar⁶, David M. Lewis⁷, Donald U. Stone⁸, Shibo Li⁹, Barbara Segal¹⁰, Daniel J Wallace¹¹, Michael H. Weisman¹², Jennifer A. Kelly¹³, Marta Alarcon-Riquelme¹⁴, Bernado Pons-Estel¹⁵, Roland Jonsson¹⁶, Xianglan Lu⁹, Jacques Gottenberg¹⁷, Juan-Manuel Anaya¹⁸, Deborah S. Cunninghame-Graham¹⁹, Edward C. Keystone²⁰, Andrew J.W. Huang²¹, Michael T. Brennan²², Pamela Hughes²³, G Illei²⁴, Corinne Miceli²⁵, VP Bykerk²⁶, Gideon Hirschfield²⁷, Gang Xie²⁸, Wan-Fai Ng²⁹, Gunnel Nordmark³⁰, Per Eriksson³¹, Roald Omdal³², Nelson L. Rhodus³³, Maureen Rischmueller³⁴, Michael D. Rohrer³⁵, Marie Wahren-Herlenius³⁶, Torsten Witte³⁷, Xavier Mariette³⁸, Christopher Lessard³⁹, John B. Harley⁴⁰, Kathy L. Sivils³⁹ and Robert Hal Scofield⁴¹, ¹Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ³Arthritis and Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴3333 Burnet Ave., University of Cincinnati & Cincinnati Childre, Cincinnati, OH, ⁵Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma Health Sciences Center College of Dentistry, Oklahoma City, OK, ⁷College of Dentistry, Department of Oral and Maxillofacial Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁸King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ⁹Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ¹⁰Rheumatology, Univ of Minnesota, Minneapolis, MN, ¹¹Cedars-Sinai Medical Center, West Hollywood, CA, ¹²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹³Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁴Arthritis & Clinical Immunology, Oklahoma Medical REsearch Foundtion, Oklahoma City, OK, ¹⁵Hospital Provincial de Rosario, Rosario, Argentina, ¹⁶Broegelmann research laboratory, Bergen, Norway, ¹⁷Hautepierre, Strasbourg, France, ¹⁸Cell Biol and Immunogenetics, CIB-Rosario University, Medellin, Colombia, ¹⁹Department of Medical and Molecular Genetics, King's College London, London, United Kingdom, ²⁰Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada, ²¹Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO, ²²Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ²³Division of Oral and Maxillofacial Surgery, Department of Developmental and Surgical Science, University of Minnesota School of Dentistry, Minneapolis, MN, ²⁴Sjögren's Clinic, NIDCR/NIH, Bethesda, MD, ²⁵Rheumatology, PARIS, France, ²⁶University of Toronto, Toronto, ON, Canada, ²⁷Centre for Liver Research, Institute of Biomedical Research, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ²⁸Mount Sinai Hospital, Toronto, ON, Canada, ²⁹Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom, ³⁰Medical Sciences, Uppsala University, Uppsala, Sweden, ³¹University Hospital, Rheumatology clinic, Linköping, Sweden, ³²Department of internal medicine, Clinical Immunology unit, Stavanger, Norway, ³³Department of Oral Surgery, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁴Rheumatology, Queen Elizabeth Hospital, Adelaide, Australia, ³⁵Hard Tissue Research Laboratory, University of Minnesota School of Dentistry, Minneapolis, MN, ³⁶Department of Medicine, Experimental Rheumatology Unit, Solna, Sweden, ³⁷Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany, ³⁸Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ³⁹Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴⁰Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴¹Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation; Department of Medicine, University of Oklahoma Health Sciences Center; US Department of Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Primary Sjögren’s syndrome (pSS) has a strong female bias of greater than 10 to 1. This difference in risk of disease between the sexes…
Abstract Number: 2516 • 2015 ACR/ARHP Annual Meeting
Association Between Primary Sjögren’s Syndrome and Pregnancy Outcome: A Systematic Review and Meta-Analysis
Sikarin Upala¹ and Anawin Sanguankeo², ¹Internal Medicine, Bassett Medical Center, Cooperstown, NY, ²Bassett Medical Center, Cooperstown, NY
Background/Purpose: Systemic autoimmune disorders may interfere with normal reproductive function resulting in negative outcome of pregnancy. Primary Sjögren's syndrome (pSS) is a common rheumatic disease…
Abstract Number: 3201 • 2015 ACR/ARHP Annual Meeting
IL-7 Drives Cytokine Secretion of IL-7Rabright CCR9-Expressing T-Follicular Helper-like Cells: Potential New Axis in Lymphoid Neogenesis in Salivary Glands of Primary Sjogren s Syndrome Patients
S.L.M. Blokland^1,2, M.R. Hillen^1,2, A.A. Kruize¹, A. Kislat³, S. Meller³, B. Homey³, G.M. Smithson⁴, J. Zalevsky⁵, T.R.D.J. Radstake^1,2 and J.A.G. van Roon^1,6, ¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ²Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands, ³Department of Dermatology, University of Düsseldorf, Medical Faculty, Düsseldorf, Germany, ⁴Takeda Pharmaceuticals International, Chicago, IL, ⁵Takeda California, San Diego, CA, ⁶Laboratory for Translational immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: In primary Sjögren’s syndrome (pSS) B cell hyperactivity including autoantibody secretion and lymphoma development are hallmark immunopathological features. Specific lymphoid organization (including germinal centers)…
Abstract Number: 2929 • 2014 ACR/ARHP Annual Meeting
Molecular Diagnostics for Patient Subsetting in Sjögren’s Syndrome
John C. Hall¹, Alan N. Baer¹, Mi Y. Lam², Lindsey A. Criswell³, Antony Rosen¹ and Livia Casciola Rosen¹, ¹Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Orofacial Sciences, University of California San Francisco, San Francisco, CA, ³Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA
Background/Purpose Sjögren’s syndrome (SS) is a chronic autoimmune disease which targets exocrine glands, particularly salivary and lacrimal glands. While all SS patients have abnormal secretory…
Abstract Number: 2543 • 2014 ACR/ARHP Annual Meeting
Anti-Ro/SSA Positive Incomplete Sjögren’s Syndrome
R. Hal Scofield¹, Anne Igoe², Donald U Stone³, Lida Radfar⁴, Kimberly S. Hefner⁵, David M. Lewis⁶, Stephen Young⁶, Judy Harris⁷, Kiely Grundahl⁷, Biji T. Kurien⁸, Jacen Maier-Moore⁹, Kristi A. Koelsch¹⁰, James Chodosh¹¹, Nelson L. Rhodus¹², Raj Gopalakrishnan¹³, Barbara M. Segal¹⁴, A. Darise Farris¹⁵, Courtney G. Montgomery¹⁶, Christopher J. Lessard¹⁷, Kathy L. Sivils¹⁸ and Astrid Rasmussen⁷, ¹US Department of Veterans Affairs Medical Center, Oklahoma City, OK, ²Metro Health, Cleveland, OH, ³Dean McGee Eye Institute, Oklahoma City, OK, ⁴College of Dentristry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁵Hefner Eye Care and Optical Center, Oklahoma City, OK, ⁶College of Dentistry, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁷Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁸U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ⁹Dept. of Clinical Laboratory Science, University of Texas at El Paso, El Paso, TX, ¹⁰Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Okalahoma City, OK, ¹¹Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, ¹²University of Minnesota, Minneapolis, MN, ¹³Diagnostic and Biological Sciences, University of Minnesota, Minneapolis, MN, ¹⁴Rheumatology, Hennepin County Medical Center, Minneapolis, MN, ¹⁵Arthritis and Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶Arthritis & Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁷825 N.E. 13th St., Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁸Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK
Background/Purpose: Sjögren’s syndrome (SS) is a systemic disease characterized by dry eyes and mouth resulting from immune mediated damage and dysfunction of the lacrimal and…
Abstract Number: 526 • 2014 ACR/ARHP Annual Meeting
A Descriptive and Comparative Study of the Transcriptome from Salivary Exosomes of Sjögren’s Syndrome Patients Using RNA-Seq
Alessia Gallo¹, Mayank Tandon², Shyh-Ing Jang³, Ana Paola Cotrim⁴ and Ilias Alevizos⁵, ¹NIH, Bethesda, MD, ²Sjogren's Clinic, NIDCR, Bethesda, MD, ³Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD, ⁴NIDCR, NIH, Bethesda, MD, ⁵Sjogren's Clinic, NIDCR/ NIH #10 1N110, Bethesda, MD
Background/Purpose Saliva is a biofluid secreted by the salivary glands (SGs) that is critical for the health of the oral cavity. In Sjögren’s Syndrome (SS),…
Abstract Number: 2932 • 2014 ACR/ARHP Annual Meeting
Increased Risk of Deep Vein Thrombosis and Pulmonary Embolism in Sjögren’s Syndrome: A General Population-Based Cohort Study
Marko Yurkovich¹, Hyon K. Choi², Eric C. Sayre³, Kamran Shojania⁴ and J. Antonio Avina-Zubieta⁵, ¹Department of Medicine, University of British Columbia, Vancouver, BC, Canada, ²Boston University School of Medicine, Boston, MA, ³Arthritis Research Centre of Canada, Richmond, BC, Canada, ⁴Rheumatology, University of British Columbia, Vancouver, BC, Canada, ⁵Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada
Background/Purpose: There is limited data available on the risk of deep venous thrombosis (DVT) and pulmonary embolism (PE) in Sjögren's Syndrome (SjS). We estimated the…
Abstract Number: 2541 • 2014 ACR/ARHP Annual Meeting
Autoantibodies in Pediatric Sjogren’s Patients
Lakshmanan Suresh¹, Minako Tomiita², Akira Hoshioka³, Long Shen⁴, Kishore Malyavantham⁵ and Julian Ambrus⁶, ¹60 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, ²Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba, Japan, ³Department of Allergy and Rheumatology,, Chiba Children’s Hospital,, Chiba, Japan, ⁴Department of Medicine, SUNY at Buffalo, Buffalo, NY, ⁵Research and Development, IMMCO Diagnostics Inc ., Amherst, NY, ⁶100 High St., University Of Buffalo, Buffalo, NY
Background/Purpose Sjogren’s syndrome (SS) is a common autoimmune disease involving the salivary and lacrimal glands along with various other organs. It is generally seen in…
Abstract Number: 525 • 2014 ACR/ARHP Annual Meeting
The Genetic Basis of Sjögren’s Syndrome (SS) Clinical Manifestations from Genome-Wide Association Analysis of Subphenotype Extremes in an International Cohort
Lindsey A. Criswell¹, Kimberly E. Taylor^2,3, Quenna Wong⁴, David M. Levine⁴, Caitlin McHugh⁴, Cathy Laurie⁴, Kimberly Doheny⁵, Mi Y. Lam⁶, Alan N. Baer⁷, Stephen Challacombe⁸, Yi Dong⁹, Hector Lanfranchi¹⁰, Morten Schiødt¹¹, M. Srinivasan¹², Susumu Sugai¹³, Hisanori Umehara¹⁴, Frederick B. Vivino¹⁵, Zhao Yan¹⁶, Stephen Shiboski¹⁷, Troy Daniels¹⁸, John S. Greenspan⁶, Caroline H. Shiboski⁶ and Sjögren's Syndrome Collaborative Clinical Alliance (SICCA)¹⁹, ¹Medicine, University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ²Medicine, University of California San Francisco, San Francisco, CA, ³University of California, San Francisco, Rosalind Russell / Ephraim P. Engleman Rheumatology Research Center, San Francisco, CA, ⁴University of Washington, Biostatistics, Seattle, WA, ⁵Center for Inherited Disease Research, Baltimore, MD, ⁶Orofacial Sciences, University of California San Francisco, San Francisco, CA, ⁷Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸Kings College London, London, United Kingdom, ⁹Dept of Rheumatology, Peking Univ Med Coll Hospital, East City Beijing, China, ¹⁰University of Buenos Aires, Buenos Aires, Argentina, ¹¹Oral and Maxillofacial Surgery, Rigshospitalet, Copenhagen, Denmark, ¹²Aravind Eye Hospital, Madurai, India, ¹³Kanazawa Medical University, Ishikawa, Japan, ¹⁴Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan, ¹⁵Medicine, Penn Presbyt Med Ctr, Philadelphia, PA, ¹⁶Department of Rheumatology, Peking Union Medical College Hospital, Beijing, China, ¹⁷Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, ¹⁸Orofacial Sciences, Box 0422, University of California San Francisco, San Francisco, CA, ¹⁹University of California San Francisco, San Francisco, CA
Background/Purpose Our goal is to define the contribution of genetic factors to two hallmark manifestations of SS, keratoconjunctivitis sicca (KCS) and focal lymphocytic sialadenitis (FLS),…

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