ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 2541

Autoantibodies in Pediatric Sjogren’s Patients

Lakshmanan Suresh1, Minako Tomiita2, Akira Hoshioka3, Long Shen4, Kishore Malyavantham5 and Julian Ambrus6, 160 Pineview Drive, State University of New York/Buffalo, Buffalo, NY, 2Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba, Japan, 3Department of Allergy and Rheumatology,, Chiba Children’s Hospital,, Chiba, Japan, 4Department of Medicine, SUNY at Buffalo, Buffalo, NY, 5Research and Development, IMMCO Diagnostics Inc ., Amherst, NY, 6100 High St., University Of Buffalo, Buffalo, NY

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: antibodies and pediatrics, Sjogren's syndrome

  • Tweet
  • Email
  • Print
Session Information

Session Title: Sjogren's Syndrome: Clinical Science

Session Type: Abstract Submissions (ACR)

Background/Purpose

Sjogren’s syndrome (SS) is a common autoimmune disease involving the salivary and lacrimal glands along with various other organs. It is generally seen in adult females and it is considered ‘rare’ in children. However, there are not a few pediatric SS patients, and their clinical features are different from those of adults. It is because pediatric patients are in early stages of the disease. The current studies were designed to characterize SS in a population of pediatric patients and whether anti-SP1, anti-CA6 and anti-PSP antibodies could be a new disease marker of early stages of SS.

Methods

Sera were obtained from 15 patients, 4 fulfilled the revised Japanese diagnostic criteria for SS and 11 who probably have SS from the Department of Allergy and Rheumatology, Chiba Children’s Hospital, Chiba City, Japan.  Their age range was 3-18 years with a mean age of 10.98 years. Fifty pediatric normal controls who were age and sex matched were obtained from Promedx Corporation, USA.  ANA was evaluated by HEp2-IFA (Immunofluorescence), RF (Rheumatoid Factor), anti-Ro, anti-La, anti-SP1, anti-CA6 and anti-PSP by ELISA as previously described.

Results

Of the 15 pediatric patients, 11 were females (73%), 2 had SS secondary to SLE and 1 had MCTD. The majority of the patients (80%) expressed ANA and 40% RF. Anti-Ro was expressed by 7 patients of whom 2 also expressed anti-La and 1 also expressed anti-SP1 whose sialography was negative. One 6 year-old patient expressed anti-CA6 and anti-PSP without anti-Ro or anti-La.  Of the 50 pediatric normal controls, ANA, anti-Ro, anti-La, anti-CA6 were all negative. Four normal controls expressed RF, 1 had a low titer for anti-PSP and one a low titer for anti-SP1.

Conclusion

Pediatric patients with SS are frequently ANA and anti-Ro positive. One patient lacking these autoantibodies expressed anti-CA6 and anti-PSP and one patient whose sialography was negative expressed anti-SP1. These antibodies may be new disease markers of SS in early stages. In general, a larger percentage of pediatric Sjogren’s patients compared to adult patients were male.

The pattern of autoantibody expression in pediatric Sjogren’s patients was different from what has been historically seen in adult Sjogren’s patents. Further studies will be necessary to look at a larger population of pediatric Sjogren’s patients over time to evaluate the progression of their disease and the pattern of their autoantibody expression.


Disclosure:

L. Suresh,
None;

M. Tomiita,
None;

A. Hoshioka,
None;

L. Shen,
None;

K. Malyavantham,
None;

J. Ambrus,
None.

  • Tweet
  • Email
  • Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/autoantibodies-in-pediatric-sjogrens-patients/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2023 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences