Abstracts tagged "Sjogren’s syndrome"

Abstract Number: 873 • 2017 ACR/ARHP Annual Meeting
Type I High-IFN Gene Signature in Associated with Higher Essdai at Enrollmment and Follow-up in the Prospective Multicenter Assess Cohort of 395 Patients
Jacques-Eric Gottenberg¹, Pierre-Etienne BOST², Benno Schwikowski², Raphaele Seror³, Valérie Devauchelle-Pensec⁴, Philippe Dieudé⁵, Jean-Jacques Dubost⁶, Anne Laure Fauchais⁷, Vincent Goeb⁸, Eric Hachulla⁹, Pierre Yves Hatron¹⁰, Claire Larroche¹¹, Véronique Le-Guern¹², Jacques Morel¹³, Aleth Perdriger¹⁴, Emmanuelle Dernis¹⁵, Stephanie Rist Bouillon¹⁶, Alain Saraux¹⁷, Damien Sène¹⁸, Jean Sibilia¹⁹, Olivier Vittecoq²⁰, Gaetane Nocturne²¹, Sarah TUBIANA²², Philippe Ravaud²³ and Xavier Mariette²⁴, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Pasteur Institute, System biologique, PARIS, France, ³Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, ⁴Department of Rheumatology, Brest University Hospital, Brest, France, ⁵Rheumatology, Hôpital Bichat, Paris, France, ⁶Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ⁷Rheumatology, Limoges, France, ⁸Rheumatologie, Rheumatology Department CHU Teaching Hospital Amiens, Amiens, France, ⁹CHU Lille, Département de Médecine Interne et Immunologie Clinique, F-59000 Lille, France, Lille, France, ¹⁰Internal Medicine, Lille, France, ¹¹Internal Medicine, Paris, France, ¹²service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹³Rheumatology, CHU Lapeyronie and Montpellier University, Montpellier, France, ¹⁴Service de Rhumatologie, CHRU de Rennes, Rennes, France, ¹⁵Service de Rhumatologie, CH du Mans, Le Mans, France, ¹⁶Rhumatologie, Hopital La Source, La Source, France, ¹⁷Rheumatology, Brest University Hospital, Brest, France, ¹⁸Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁰INSERM U905 & Normandy University, Institute for Research and Innovation in Biomedicine, Rouen, France, ²¹INSERM U1184, IMVA, Paris Sud University,LabEx LERMIT, Le Kremlin Bicêtre, France, ²²CRB Bichat, PARIS, France, ²³Hôpital Hôtel Dieu, Paris, France, ²⁴Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France
Background/Purpose: The type I interferon (IFN) signature is a hallmark of the pathogenesis of primary Sjögren’s syndrome (pSS). However, little is known regarding the clinical…
Abstract Number: 1491 • 2017 ACR/ARHP Annual Meeting
Is There a Seasonal Effect on Fatigue, Pain, and Dryness in Primary Sjögren’s Syndrome? Data from the Prospective Assess Cohort and from 3 Randomized Controlled Trials
Pierre-Marie DURET¹, Nicolas MEYER², Alain Saraux³, Valérie Devauchelle-Pensec⁴, Jean Sibilia⁵, Raphaele Seror⁶, Véronique Le-Guern⁷, Claire Larroche⁸, Aleth Perdriger⁹, Xavier Mariette¹⁰ and Jacques-Eric Gottenberg¹¹, ¹Rhumatology, Hautepierre Hospital, STRASBOURG, France, ²clinical research, Hautepierre Hospital, STRASBOURG, France, ³Rheumatology, Brest University Hospital, Brest, France, ⁴Department of Rheumatology, Brest University Hospital, Brest, France, ⁵Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ⁶Center for Immunology of Viral Infections and Autoimmune Diseases, Assistance Publique – Hôpitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin-Bicêtre, Université Paris Sud, INSERM, Paris, France, Paris, France, ⁷service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ⁸Internal Medicine, Paris, France, ⁹Service de Rhumatologie, CHRU de Rennes, Rennes, France, ¹⁰Université Paris-Sud, AP-HP, Hôpitaux Universitaires Paris-Sud, Paris, France, ¹¹CNRS, Immunopathologie et Chimie Thérapeutique/Laboratory of Excellence Medalis, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France
Background/Purpose: A seasonal effect was reported on fatigue and pain in rheumatoid arthritis. We speculated that fall and winter could be associated with increased fatigue…
Abstract Number: 2873 • 2017 ACR/ARHP Annual Meeting
DNA Microarray Analysis Identifies Nuclear Receptor Subfamily 4 Group a Member 2 (NR4A2) As a Novel Molecule Involved in the Pathogenesis of Sjogren’s Syndrome
Hiroyuki Takahashi, Hiroto Tsuboi, Hiromitsu Asashima, Hanae Kudo, Yuko Ono, Saori Abe, Yuya Kondo, Isao Matsumoto and Takayuki Sumida, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
Background/Purpose:Some reports on DNA microarray analysis in labial salivary glands (LSGs) of Sjögren’s syndrome (SS) and healthy controls (HCs) showed that the genes associated with…
Abstract Number: 100 • 2017 Pediatric Rheumatology Symposium
Improvement of Salivary Gland Ultrasound Findings in Juvenile Sjögren’s Syndrome after Systemic Corticosteroid Treatment
Akaluck Thatayatikom¹, Renee F Modica², Daniel S. Hammenfors³, Natalie Jane Shiff¹ and Melissa E Elder², ¹Pediatrics, University of Florida, Gainesville, FL, ²Department of Pediatrics, University of Florida, Gainesville, FL, ³Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
Background/Purpose: Juvenile Sjögren’sSyndrome (jSS) is a rare systemic autoimmune disease affecting predominantly salivary glands (SG) in children who do not meet criteria for SLE or MCTD. Currently, no specific criteria for…
Abstract Number: 661 • 2016 ACR/ARHP Annual Meeting
Epitope Specificity and End-Organ Susceptibility Dictates Anti-Ro52 Mediated Salivary Gland Dysfunction
Magdalena Sroka¹, Indranil Biswas¹, Brian Shepherd¹, Dat C Truong², Harini Bagavant¹ and Umesh S Deshmukh¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²University of Oklahoma, Norman, OK
Background/Purpose: Circulating autoantibodies reactive against Ro52 are detected in the sera of 70% of patients with Sjögren’s syndrome (SS), and their presence has been associated…
Abstract Number: 2660 • 2016 ACR/ARHP Annual Meeting
Do Ultrasonographic Lesions of Salivary Glands Evolve in SjöGren Patients during Follow-up ?
Alain Saraux¹, Valerie Devauchelle², Sandrine Jousse-Joulin³, Divi Cornec⁴, Pierre Gazeau⁵ and Dewi Guellec⁵, ¹Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ²Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ³Rheumatology, CHu La cavle Blanche, Brest, France, ⁴Department of rheumatology, Brest Occidentale University, Brest, France, ⁵Rheumatology, CHU Brest, Brest, France
Background/Purpose: to evaluate if the salivary glands ultrasonographic score (SGUS) is modified during follow-up in primitive Sjögren patients (pSS) and to compare pSS with idiopathic…
Abstract Number: 2688 • 2016 ACR/ARHP Annual Meeting
Characteristics, Treatment and Outcome of Joint Involvement with Synovitis in Primary SjöGren’s Syndrome: French Multicentric Retrospective Case-Control Study
Adrien Mirouse¹, raphaèle seror², Xavier Mariette³, Maxime Dougados⁴, Anne-Laure Fauchais⁵, Alban Deroux⁶, Nathalie Costedoat-Chalumeau⁷, Jeremie Sellam⁸, Jean-Benoit Arlet⁹, Christian Lavigne¹⁰, Dominique Fischer-Dumont¹¹, Arsène Mékinian¹² and Olivier Fain¹², ¹Service de médecine interne, Hôpital Saint-Antoine, Paris, France, ²INSERM U1184, Paris Sud University, Le Kremlin Bicetre, France, ³INSERM U1184, Université Paris-Sud, Paris, France, Le Kremlin Bicetre, France, ⁴Paris Descartes University, Paris, France, ⁵Department of Internal Medicine, CHU de Limoges, Limoges, France, ⁶Internal Medicine, CHU Grenoble, Grenoble, France, ⁷Internal Medicine, Cochin University Hospital, Paris, France, ⁸Rheumatology, Saint-Antoine Hospital, Paris, France, ⁹Service de médecine interne, Hopital Européen Georges Pompidou, Paris, France, ¹⁰CHU Angers, department of Internal Medicine, Angers, France, ¹¹Service de rhumatologie, Hôpital Avicenne, Bobigny, France, ¹²Service de médecine interne. Hôpital Saint-Antoine., Paris, France
Background/Purpose: primary Sjogren’s syndrome (pSS) articular manifestations include often tender joints and more rarely synovitis. The main objective of this study was to describe characteristics,…
Abstract Number: 662 • 2016 ACR/ARHP Annual Meeting
The Unusual Cross-Reactivity of Anti Muscarinic Receptor 3 Monclonal Antibodies Derived from Salivary Glands of Sjögren’s Syndrome Patients to Ro Peptides
Syed M.S. Quadri¹, Kristi A. Koelsch², Biji T Kurien³, Valerie M Harris⁴ and R. Hal Scofield², ¹Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²U.S. Department of Veterans Affairs Medical Center, Oklahoma City, OK, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Sjogrens syndrome (SS) is a chronic autoimmune inflammatory disease the characterisitic features of which includes hypofunction of exocrine glands leading to decrease in salivation…
Abstract Number: 2661 • 2016 ACR/ARHP Annual Meeting
Performance of the Proposed ACR-EULAR Criteria for Sjogren’s Syndrome in a Prospective Multidisciplinary Diagnostic Cohort from Daily Clinical Practice
Jolien F. van Nimwegen¹, Martha S. van Ginkel¹, Suzanne Arends¹, Gwenny M. Verstappen¹, Erlin A. Haacke^1,2, Bert van der Vegt³, Nicole Sillevis Smitt-Kamminga⁴, Fred K.L. Spijkervet⁵, Frans G.M. Kroese¹, Arjan Vissink⁶ and Hendrika Bootsma¹, ¹Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Pathology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Opthalmology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Sjögren’s syndrome (SS) is a systemic auto-immune disease with a heterogeneous clinical presentation. Recently, ACR-EULAR criteria were proposed for classification of SS, which combine…
Abstract Number: 2693 • 2016 ACR/ARHP Annual Meeting
Evolution of Disease Activity over a 5-Year Period in the 395 Patients with Primary SjöGren’s Syndrome of the Assess Prospective Cohort
Jacques-Eric Gottenberg¹, Raphaele Seror², Alain Saraux³, Valerie Devauchelle⁴, Emmanuelle Dernis Labous⁵, Philippe Dieudé⁶, Jean-Jacques Dubost⁷, Anne Laure Fauchais⁸, Vincent Goeb⁹, Claire Larroche¹⁰, Véronique Le-Guern¹¹, Eric Hachulla¹², Pierre Yves Hatron¹³, Jacques Morel¹⁴, Aleth Perdriger¹⁵, Stephanie Rist Bouillon¹⁶, Damien Sène¹⁷, Olivier Vittecoq¹⁸, Jean Sibilia¹⁹, Philippe Ravaud²⁰ and Xavier Mariette²¹, ¹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²Department of Rheumatology, Assistance Publique–Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Le Kremlin Bicêtre, France, ³Rheumatology, Brest University Hospital, Brest, France, ⁴Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ⁵Le Mans Hospital, Le Mans, France, ⁶Rheumatology, Hôpital Bichat, Paris, France, ⁷Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ⁸Rheumatology, Limoges, France, ⁹Rhumatologie, CHU Amiens, Amiens, France, ¹⁰Internal Medicine, Paris, France, ¹¹service de médecine interne, Department of Internal Medicine, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, AP–HP, Université Paris Descartes, Paris, France, ¹²Internal Medicine, Lille University Hospital, Lille, France, ¹³Internal Medicine, Lille, France, ¹⁴Rheumatology, Department of Rheumatology, Montpellier University Hospital, Montpellier, France, ¹⁵C.H.R. Hôpital Sud, Rennes, France, ¹⁶Rhumatologie, Hopital La Source, La Source, France, ¹⁷Department of Internal Medicine, Pitié-Salpêtrière Hospital, Paris, France, ¹⁸Rheumatology, Rouen University Hospital &INSERM U905, Rouen, France, ¹⁹Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, ²⁰Epidemiologist, PARIS, France, ²¹Rheumatology, Rheumatology department, Bicetre Hospital, Paris-Sud University, Le Kremlin Bicetre, France
Background/Purpose: Little is known about the natural history of primary Sjögren’s syndrome due to the limited number of prospective cohorts followed up in a yearly…
Abstract Number: 663 • 2016 ACR/ARHP Annual Meeting
Cytokine and Chemokine Levels in Serum and Tears As Disease Activity Biomarkers in Patients with Primary Sjögren´s Syndrome
Angel Alejandro Castillo-Ortiz¹, Rosa Elda Barbosa-Cobos², Lizbeth Becerril-Mendoza³, Gustavo Lugo-Zamudio⁴, Virgilio Lima-Gómez⁴, Adan Moreno-Eutimio⁵, Nayeli Nieto-Velázquez⁵ and Angel Tzec-Pérez⁵, ¹Rheumatology, Hospital Juárez de México, Mérida, Mexico, ²Rheumatology, Hospital Juárez de México, Mexico, Mexico, ³Hospital Juárez de México, Mexico, Mexico, ⁴Hospital Juárez de México, México city, Mexico, ⁵Hospital Juárez de México, Mexico city, Mexico
Background/Purpose: Evidence suggests that levels of different cytokines in primary Sjögren´s syndrome (pSS) are associated with cell infiltration degree within lacrimal and salivary glands and…
Abstract Number: 2662 • 2016 ACR/ARHP Annual Meeting
Effect of Tobacco Smoking on the Clinical, Histopathological, and Serological Manifestations of SjöGren’s Syndrome
Astrid Rasmussen¹, Donald U. Stone², Dustin Fife³, Michael Brown⁴, Keith Earley⁵, Lida Radfar⁶, C. Erick Kaufman⁷, David M. Lewis⁸, Nelson L. Rhodus⁹, Barbara M. Segal¹⁰, Daniel J Wallace¹¹, Michael Weisman¹², Swamy Venuturupalli¹³, Michael T. Brennan¹⁴, Christopher J Lessard³, Courtney G. Montgomery¹⁵, R. Hal Scofield¹⁵ and Kathy L. Sivils¹⁵, ¹Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, USA, Oklahoma City, OK, ²King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia, ³Arthritis and Clinical Immunology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁴Pfizer Inc., Groton, CT, ⁵59th Medical Wing, US Air Force, San Antonio, TX, ⁶Oral Diagnosis and Radiology Department, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁷Medicine, University of Oklahoam Health Sciences Center, Oklahoma City, OK, ⁸Department of Oral and Maxillofacial Pathology, University of Oklahoma College of Dentistry, Oklahoma City, OK, ⁹Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, ¹⁰Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN, ¹¹Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹²Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹³Division of Rheumatology, Cedars Sinai Medical Center, Los Angeles, CA, ¹⁴Department of Oral Medicine, Carolinas Medical Center, Charlotte, NC, ¹⁵Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: To assess the prevalence of smoking in patients with Sjögren’s syndrome (SS) and non-Sjögren’s sicca (non-SS sicca), and the association of smoking habits with…
Abstract Number: 2806 • 2016 ACR/ARHP Annual Meeting
A Type-I Interferon Signature Is Associated with Autoantibody Profiles in Connective Tissue Diseases: Results from the Lupus Extended Autoimmune Phenotype (LEAP) Study
John A. Reynolds^1,2, Mumtaz Khan³, Tracy A. Briggs⁴, Gillian Rice⁵, Yanick Crow⁵, Ben Parker⁶ and Ian N. Bruce^1,7, ¹NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ²Arthritis Research UK Centre for Epidemiology, The University of Manchester, Manchester, United Kingdom, ³Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ⁴Institute of Human Development, University of Manchester, Manchester, United Kingdom, ⁵Manchester Academic Health Science Centre, Institute of Human Development, University of Manchester, Manchester, United Kingdom, ⁶Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ⁷Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Sciences Centre, Manchester, United Kingdom
Background/Purpose: Type I interferon has been implicated in the pathogenesis of systemic lupus erythematosus (SLE), but much less is known about its role in other…
Abstract Number: 665 • 2016 ACR/ARHP Annual Meeting
Salivary Gland Secretome: A Novel Tool to Identify Biomarkers of Dryness and Immunopathology in Primary Sjogren’s Syndrome and Non-Autoimmune Sicca Patients
Sofie L.M. Blokland^1,2, Maarten R. Hillen^1,2, Aike A. Kruize³, Timothy R.D.J. Radstake^1,2 and Joel A.G. van Roon^1,2, ¹Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands, ²Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, Netherlands, ³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Salivary gland biopsy is essential in primary Sjögren’s syndrome (pSS) diagnostics. However, tissue analysis using the traditional method has several limitations including inaccuracy of quantification of lymphocytic infiltration and poor correlation with dryness.…
Abstract Number: 2663 • 2016 ACR/ARHP Annual Meeting
Antimalarials Protect Against Damage Accrual in Primary SjöGren’s Syndrome
Gabriela Hernandez-Molina¹, Valeria Valim², Yemil Atisha-Fregoso³, Anastasia Secco⁴, Emmanuel Guerra⁵, Marianela Adrover⁵, Anna Julha Lage Santos⁶ and Antonio Catalan Pellet⁴, ¹Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico City, Mexico, ²Rheumatology, Department of Medicine, Universidade Federal do Espírito Santo, Vitória, Brazil, Vitória, Brazil, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴Rheumatology, Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁵Hospital Bernardino Rivadavia, Buenos Aires, Argentina, ⁶Universidade Federal do Espírito Santo, Vitória, Brazil
Background/Purpose: Antimalarials are frequently used in patients with primary Sjögren’s syndrome (SS). The aim of this study was to assess their impact on damage accrual…

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