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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 2291 • ACR Convergence 2025

    Correlation and Concordance Between the Oxford Grading Scale, Ocular Staining Score, and van BijsterveldScore in the diagnosis of Sjögren’s Disease

    Alejandro Gómez Gómez1, Eric Kirkegaard-Biosca2, Sergio H. Martínez Mateu3, Iago Alvarez Saez4, Natalia Boix- Martí5, Antonio Julià1, Jose Luis Andreu6 and Sara Marsal1, 1Vall d'Hebron Hospital Research Institute, Rheumatology Research Group, Barcelona, Spain, 2Hospital Univetsitari Vall d'Hebron, Ophthalmology Department, Barcelona, Spain, 3IMIDomics, Barcelona, Spain, 4Hospital Univetsitari Vall d'Hebron, Maxilofacial Surgery Department, Barcelona, Spain, 5Hospital Univetsitari Vall d'Hebron, Rheumatology Department, Barcelona, Spain, 6Hospital Universitario Puerta de Hierro, Majadahonda, Spain

    Background/Purpose: Sjögren’s Disease (SjD) is a systemic autoimmune disorder marked by mucosal dryness and ocular surface damage. For diagnosis, the ACR-EULAR 2016 criteria require the…
  • Abstract Number: 1680 • ACR Convergence 2025

    Major salivary gland ultrasonographic features of lymphoma and high lymphoproliferative risk lesions in Sjögren’s Disease: a systematic review

    Alen Zabotti1, Valeria Manfrè1, Maria Teresa Rizzo1, Alessia Nano1, Garifallia Sakellariou2 and Luca Quartuccio1, 1Division of Rheumatology, Department of Medicine (DMED), Academic Hospital "Santa Maria della Misericordia", ASUFC, University of Udine, Udine, Italy, Udine, Italy, 2Department of Internal Medicine and Therapeutics, Università Di Pavia, Pavia, Italy; Istituti Clinici Scientifici Maugeri IRCCS Pavia, Pavia, Italy

    Background/Purpose: Sjögren's disease (SjD) is burdened by significant lymphoproliferative risk. Up to date there is no established consensus on the salivary gland ultrasonographic (SGUS) features…
  • Abstract Number: 1392 • ACR Convergence 2025

    Cancer Mortality in Sjogren’s Disease: Disproportionate Increase in Mortality from Cancers in Sjogren’s Disease Relative to All-Cancers

    Margaret Essien and Ram Singh, UCLA David Geffen School of Medicine, Los Angeles, CA

    Background/Purpose: Sjögren's disease (SjD), an autoimmune condition with chronic inflammation in exocrine glands, is associated with increased risks of cancers. The impact of cancer on…
  • Abstract Number: 1223 • ACR Convergence 2025

    Pain and Fibromyalgia Across Autoimmune and Inflammatory Diseases in the AMP AIM Cohort

    Alexis Ogdie1, Astrid Rasmussen2, Dana Orange3, Michelle Petri4, Caroline Shiboski5, Rebecca Haberman6, Mala Masson7, Daniel Goldman4, Peter Izmirly8, Brooke Cohen9, Jennifer Seifert10, Jennifer Anolik11, Wade DeJager12, Alan Baer13, Jill Buyon14 and Yvonne Lee15, 1Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Wilmington, DE, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3The Rockefeller University, New York, NY, 4Johns Hopkins University School of Medicine, Timonium, MD, 5University of California San Francisco, San Francisco, CA, 6NYU Langone Health, New York, NY, 7NYU Langone Medical Center- Division of Rheumatology, New York, NY, 8New York University Grossman School of Medicine, New York, NY, 9Yale Physician Associate Program, New Haven, CT, 10University of Colorado and Oklahoma Medical Research Foundation, Aurora, CO, 11University of Rochester Medical Center, Rochester, NY, 12Oklahoma Medical Research Foundation, Oklahoma City, 13Johns Hopkins University School of Medicine, Baltimore, MD, 14NYU Grossman School of Medicine, New York, NY, 15Northwestern University, Chicago, IL

    Background/Purpose: The Accelerating Medicines Partnership Autoimmune and Immune-Mediated Diseases (AMP AIM) network seeks to understand the cellular and molecular interactions that lead to inflammation and…
  • Abstract Number: 0511 • ACR Convergence 2025

    Submandibular Gland Ratio Stratifies Salivary Function and Reveals a Senescence Peak in Anti-SSA Positive Sjögren’s Syndrome

    Chiao-Feng Cheng1, Tseng-Cheng Chen2, Min-Shu Hsieh3, TING-YUAN LAN4, Jui-Hung Kao5, Yu Heng Lin6, Mei-Fang Cheng7, Yi-Chieh Chen8, Hsiao-Sang Chu9, Yi-Min Huang10, Cheng-Hsun Lu11, Ko-Jen Li11, Chieh-Yu Shen1 and Song-Chou Hsieh12, 1Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 2Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 3Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100225, Taiwan, Taipei, Taiwan (Republic of China), 4National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan, 5Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, Taipei, Taiwan (Republic of China), 6Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan, Taipei, Taiwan (Republic of China), 7Department of Nuclear Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 8Department of Nuclear Medicine, National Taiwan University Hospital, Taipei, Taiwan., Taipei, Taiwan (Republic of China), 9Department of Ophthalmology, National Taiwan University Hospital, Taipei City, Taiwan., Taipei, Taiwan (Republic of China), 10Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan, Taipei, Taiwan (Republic of China), 11National Taiwan University Hospital, Taipei, Taiwan, 12National Taiwan Unuversity Hospital, Taipei City, Taiwan (Republic of China)

    Background/Purpose: In primary Sjögren’s syndrome (pSS), the histologic focus score reflects immune infiltration but does not capture irreversible glandular damage. We evaluated a submandibular gland…
  • Abstract Number: 1048 • ACR Convergence 2024

    Self-Perception of Oral Health and Habits in Patients with Sjögren’s Syndrome, Rheumatoid Arthritis, and Systemic Lupus Erythematosus

    Karina Palomo-Arnaud1, Gabriel Figueroa-Parra2, Angel Kevin Garza-Elizondo1, Margarita Isabel Alarcon Jarquin3, Jesus Cardenas-de la Garza4, Dionicio Galarza-Delgado5 and Janett Riega Torres2, 1Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, San Nicolás de los Garza, Mexico, 2Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico, 3Division of Rheumatology, University Hospital "Dr. Jose Eleuterio Gonzalez", Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Leon, Mexico, 4Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 5UANL Hospital Universitario, Monterrey, Nuevo León, Mexico

    Background/Purpose: Oral manifestations, especially periodontitis and tooth loss, are highly prevalent in patients with rheumatic diseases. Sjogren’s syndrome (SS), rheumatoid arthritis (RA), and systemic lupus…
  • Abstract Number: 1419 • ACR Convergence 2024

    Antiphospholipid Antibodies and Hypercoagulable Events in Patients with Sjogren’s Syndrome

    Katelyn Kaufman1 and Schartess Culpepper Pace2, 1University of Miami Holy Cross Hospital, Fort Lauderdale, FL, 2University of Miami, Pembroke Pines, FL

    Background/Purpose: The association between antiphospholipid antibodies (aPL) and autoimmune processes, such as systemic lupus erythematosus (SLE) is well documented, however, there are limited data on…
  • Abstract Number: 1861 • ACR Convergence 2024

    CD8T Cells Depletion Promotes Human Tph/Tfh Cells Proliferation and Sjogren Syndrome Like Symptoms Without Graft versus Host Diseases in PBMC Transferred-humanized Mice

    Yuzo Koda1, Piruzyan Mariam1, Sota Fujimori1, Ryota Sato2 and Sayuka Kato1, 1Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 2Mitsubishi Tanabe Pharma Corporation, Brighton, MA

    Background/Purpose: Peripheral helper T (Tph) and follicular helper T (Tfh) cells are known to play a central role in the interaction between T and B…
  • Abstract Number: 2297 • ACR Convergence 2024

    Mortality and Its Predictor Variables in Patients with Sjögren Disease: Data from SjögrenSER-Pros Prospective Registry

    Olga Rusinovich1, Zulema Plaza2, Mónica Fernández Castro3, José Rosas-Gómez de Salazar4, Victor Manuel Martinez Taboada5, Alejandro Olive6, Raúl Menor Almagro7, Belen Serrano Benavente8, Judit Font Urgelles9, Angel Garcia-Aparicio10, Sara Manrique-Arija11, Jesus A García-Vadillo12, Ruth Lopez Gonzalez13, Javier Narvaez-García14, Maria Beatriz Rodriguez15, Carlos Galisteo16, Jorge Gonzalez Martin17, Paloma Vela-Casasempere18, Cristina Bohorquez19, MARIA CELIA ERAUSQUIN ARRUABARRENA20, MARIA BEATRIZ PAREDES ROMERO21, ELENA Aurrecoechea22, Sheila Melchor Diaz23, José María Pego-Reigosa24, Sergi Heredia Martin25, Clara Moriano26, Maria Angeles Blazquez Canamero27, Paula Estrada-Alarcón28, enrique Judez29, Joaquin María Belzunegui:30, Consuelo Ramos31, Marta de la Puerta32, Fernando Sánchez-Alonso33 and Jose Luis Andreu34, 1Hospital Universitario Puerta de Hierro Majadahonda., Boadilla del Monte, Spain, 2Fundacion Española de Reumatología, Madrid, Spain, 3Hospital Universitario Puerta de Hierro Majadahonda., Madrid, Madrid, Spain, 4Hospital Marina Baixa, PALMA DE MALLORCA, Comunidad Valenciana, Spain, 5Facultad de Medicina. Universidad de Cantabria, Santander, Cantabria, Spain, 6Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain, 7Department of Rheumatology, Hospital Jerez de la Frontera, Jerez de la Frontera, Spain, 8Hospital Gregorio Marañón, Madrid, Madrid, Spain, 9Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 10Hospital Universitario de Toledo, Toledo, Spain, 11Biomedical Research Institute of Malaga (IBIMA)-Bionand Platform, Department of Rheumatology, Regional University Hospital of Malaga, Malaga, Spain, 12H La Princesa, Madrid, Spain, 13Complejo Hospitalario de Zamora, Zamora, Castilla y Leon, Spain, 14Hospital Universitario de Bellvitge, Barcelona, Spain, 15H Universitario de Canarias, La Laguna- Tenerife, Canarias, Spain, 16Hospital Universitario Parc Taulí, Sabadell, Spain, 17H Madrid Norte SanChinarro, Madrid, Spain, 18Hospital General Universitario Alicante, Alicante, Spain, 19Hospital Universitario Príncipe de Asturias, Alcalá De Henares, Madrid, Spain, 20Gob Canarias, Tenerife, Canarias, Spain, 21H Infanta Sofia, Madrid, Spain, 22HOSPITAL SIERRALLANA, CANTABRIA, Spain, 2312 de Octubre University Hospital, Madrid, Spain, 24Galicia Health Service (SERGAS), Vigo, Spain, 25Hospital de L’Hospitalet, Barcelona, Spain, 26Hospital León, LEON, Spain, 27Hospital Ramon y Cajal, Madrid, Madrid, Spain, 28Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, 29H de Albacete, Albacete, Spain, 30H de Donostia, Donostia-San Sebasti, Spain, 31Hospital Universitario Virgen de Valme, Sevilla, Spain, 32Spanish Society of Rheumatology, Madrid, Spain, 33Sociedad Española de Reumatología, Madrid, Spain, 34Hospital Universitario Puerta de Hierro Majadahonda., Majadahonda, Spain

    Background/Purpose: It remains debated if patients with Sjögren´s disease (SjD) have a greater mortality risk. The objective of our study was to determine the magnitude…
  • Abstract Number: 2530 • ACR Convergence 2024

    Single-cell Multi-omics Analysis of Reactive Lymph Nodes, Affected Tissues, and Blood Reveals a Naive-like CD4+TRAIL+ T Cell Population That Differentially Directs Effector Anti-nuclear Antigen Reactive Responses in Patients with Sjogren’s Syndrome and Systemic Sclerosis

    Theodoros Ioannis Papadimitriou1, Prashant Singh2, Arjan van Caam3, Madelon Vonk4, Irene E. van der Horst-Bruinsma5, Peter van der kraan3, Erik Aarntzen6, Martijn Huijnen7, Hans Koenen8 and Rogier Thurlings1, 1Radboudumc, Department of Rheumatology, Nijmegen, Gelderland, Netherlands, 2Radboudumc, Department of Medical BioSciences, Nijmegen, Netherlands, 3Radboudumc, Department of Rheumatology, Nijmegen, Netherlands, 4Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Department of Rheumatology, Radboud University Medical Centre, Nijmegen, Netherlands, 6Radboudumc, Department of Medical Imaging, Nijmegen, Netherlands, 7Radboudumc, Department of Medical BioSciences, Nijmegen, Gelderland, Netherlands, 8Radboudumc, Department of Medical Immunology, Nijmegen, Gelderland, Netherlands

    Background/Purpose: Recognition of self-peptides by autoreactive CD4+ T-cells is central to the disruption of immune tolerance. Although systemic autoimmune diseases such as Sjogren’s syndrome (SjS)…
  • Abstract Number: 1130 • ACR Convergence 2024

    Safety of Bispecific T-cell Engager Therapy in Autoimmune Disease

    Melanie Hagen1, Laura Bucci1, Sebastian Boeltz2, Danae-Mona Noethling2, Tobias Rothe2, Maria Gabriella Raimondo1, Carlo Tur1, Andreas Wirsching1, Jochen Wacker1, Aline Bozec1, Georg Schett3 and Ricardo Grieshaber-Bouyer1, 1Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Bayern, Germany, 2Department of Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, 3Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Background/Purpose: B-cells and plasma cells are key drivers of systemic autoimmune diseases (AID). Recent data demonstrated preliminary safety and efficacy of using the CD3xCD19 bispecific…
  • Abstract Number: 1420 • ACR Convergence 2024

    Alignment Between Rheumatology and Neurology of Nomenclature for Peripheral Nervous System Neuropathies

    Ghaith Noaiseh1, George Sarka2, Anahita Deboo3, Arun Varadhachary4, Robert Fox5, Matthew Baker6, Stamatina Danielides7, Eduardo de Sousa8, Julie Frantsve Hawley9, Brent Goodman10, Katherine Hammitt9, Jennifer King11, Steven Mandel12, Pantelis Pavlakis13, Daniel Wallace14, Robert Hal Scofield15, Nancy Carteron16 and Steven Carsons17, 1University of Kansas Medical Center, Kansas City, KS, 2UCLA, Laguna Hills, CA, 3Temple University, Philadelphia, 4Washington University in St. Louis, St. Louis, MO, 5Rheumatology Clinic, San Diego, CA, 6Stanford University, Menlo Park, CA, 7Vcu, Glen Allen, VA, 8Mercy, Moore, OK, 9Sjogren's Foundation, Reston, VA, 10Mayo Clinic, Scottsdale, AZ, 11UCLA, Los Angeles, CA, 12Hofstra, Hempstead, 13Hospital for Special Surgery, New York, NY, 14Cedars Sinai Medical Center, Studio City, CA, 15Oklahoma Medical Research Foundation, Oklahoma City, OK, 16University of California, Berkeley & San Francisco, Angwin, CA, 17NYU Long Island School of Medicine, Mineola, NY

    Background/Purpose: The Sjögren’s Foundation Clinical Practice Guidelines for Peripheral Nervous System (PNS) diagnosis, management and treatment in Sjögren’s brought to the fore a major issue…
  • Abstract Number: 1866 • ACR Convergence 2024

    Identification of Sjögren’s Disease-Associated CD4+ T Cell Receptor (TCR) Motifs and Repertoire Landscape Through TCR Deep Sequencing

    Ananth Aditya Jupudi1, Michelle L. Joachims2, Christina Lawrence2, Charmaine Lopez-Davis2, Bhuwan Khatri2, Astrid Rasmussen2, Kiely Grundahl2, Robert Hal Scofield2, Judith James2, Joel Guthridge2, Christopher Lessard2, Linda F. Thompson2 and A. Darise Farris2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: Sjögren’s disease (SjD) is a chronic rheumatic autoimmune disorder characterized by focal lymphocytic infiltration of the lacrimal and salivary glands (SG). CD4+ T cells…
  • Abstract Number: 2298 • ACR Convergence 2024

    Fibroblast-driven Ttek Activation May Drive Acinar Cell Dysfunction in Sjögren’s Disease, Prior to Lymphocytic Infiltration

    Ting Yang1, Rick Wilbrink1, Janneke Terpstra1, Silvia Liefers2, Arjan Vissink1, Fred Spijkervet1, Hendrika Bootsma3, Frans Kroese4 and Sarah Pringle4, 1UMCG, Groningen, Netherlands, 2University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, 3Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, 4University Medical Center Groningen, Groningen, Netherlands

    Background/Purpose: Lymphocytic infiltration of the salivary glands (SGs) represents one hallmark of the autoimmune conditions Sjögren’s Disease (SjD). It is becoming apparent however that loss…
  • Abstract Number: 2537 • ACR Convergence 2024

    Sjögren’s Disease and Non-Sjögren’s Sicca Patient Subsets Exhibit Cell Type-specific Transcriptional Dysregulations That May Identify Early Molecular Predictors of Disease Transition

    James Li1, Chuang Li2, Bhuwan Khatri2, Anna Stolarczyk2, Kandice Tessneer2, Astrid Rasmussen2, Joel Guthridge2, Judith James2, Robert Hal Scofield2, He Li3, A. Darise Farris2, Kathy Sivils4 and Christopher Lessard2, 1University of Oklahoma Health Sciences Center, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Oklahoma City, OK, 3Janssen Research & Development, LLC, Therapeutics Discovery, Spring House, PA, 4Johnson & Johnson Innovative Medicine, Edmond, OK

    Background/Purpose: Sjögren's disease (SjD) is an autoimmune disorder characterized by inflammatory destruction of the exocrine glands. SjD heterogeneity has been described through the presence or…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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