Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 1375 • ACR Convergence 2023
The Relative Burden of Fatigue Is Associated with High TSH/fT4 Ratio in Korean Patients with Primary Sjogren’s Syndrome
Jee-in Lee¹, Se Rim Choi², You-Jung Ha², Eun Ha Kang³, Keun-Suh Kim⁴, Joon Young Hyon⁵ and Yun Jong Lee⁶, ¹Seoul National University of Bundang Hospital, Seongnam, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnamsi, South Korea, ³Seoul National University Bundang Hospital, Seongnam, South Korea, ⁴Department of Periodontology, Section of Dentistry, Seoul National University Bundang Hospital, Seongnamsi, South Korea, ⁵Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnamsi, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea
Background/Purpose: To investigate the prevalence of anti-thyroid autoantibodies, abnormal thyroid function, and their clinical impacts in Korean patients with primary Sjögren's syndrome (pSS). Methods: One…
Abstract Number: 2041 • ACR Convergence 2023
An Analysis of Recurrent Parotitis Patients Referred to Rheumatology Clinic
Yiressy Pina¹, Elton Lambert², Maria Pereira² and Marietta De Guzman², ¹Baylor College of Medicine, Richmond, TX, ²Baylor College of Medicine, Houston, TX
Background/Purpose: Juvenile recurrent parotitis (JRP) is characterized by non-obstructive, non-suppurative inflammation of the parotid glands of unknown etiology. The onset of symptoms occurs typically between…
Abstract Number: 2192 • ACR Convergence 2023
New Inducible Mouse Model of Sjögren’s Syndrome Represents a Valuable Tool to Assess the Impact of Gene Knockout on the Disease’s Physiopathology
Dorian Parisis¹, Nargis Bolaky², Anissa Benchehida², Christoph Küper³, jason Perret², Muhammad Soyfoo¹ and Christine Delporte², ¹Hôpital Universitaire de Bruxelles - Hôpital Erasme, Brussels, Belgium, ²Faculté de médecine - Université Libre de Bruxelles, Brussels, Belgium, ³Institute for Molecular Medicine, MSH Medical School Hamburg, Hamburg, Germany
Background/Purpose: Primary Sjögren's syndrome (pSS) is a chronic rheumatic disease characterized by lymphocytic infiltration of exocrine glands, resulting in sicca syndrome with extra-glandular autoimmune features.…
Abstract Number: 1220 • ACR Convergence 2023
Sjögren’s Patients’ Experiences and Content Validity of the Dry Eye Disease Symptom Questionnaire (DED-SQ)
Denise Kruzikas¹, Ann Eldred², Shelly Kafka³, Janet Church⁴, Katherine Hammitt⁴, Patricia Koochaki⁵ and Christina O'Donnell⁶, ¹AbbVie, Inc., North Chicago, IL, ²AbbVie, Inc., Lake Bluff, IL, ³AbbVie, Inc., Norristown, PA, ⁴Sjögren’s Foundation, Reston, VA, ⁵ICON Clinical Research LLC, Raleigh, NC, ⁶ICON plc, Raleigh, NC
Background/Purpose: Dry eye is one of the most important and prevalent symptoms experienced by patients with Sjögren's Disease (SJD). The DED-SQ is a 12-item patient…
Abstract Number: 1376 • ACR Convergence 2023
SJOGRENSER Registry: Prospective Evaluation of a Cohort of Patients with Primary Sjögren’s Syndrome After 8 Years of Follow-up
Mónica Fernández-Castro¹, Zulema Plaza², Jose Rosas³, Victor Martinez-Taboada⁴, Alejandro Olivé⁵, Raúl Menor-Almagro⁶, SARA MANRIQUE⁷, Ruth López-González⁸, Celia Erausquin⁹, Antonio Naranjo⁹, Rocío Caño-Alameda¹⁰, Silvia Gómez-Sabater¹⁰, Jesús Alberto García Vadillo¹¹, Belen Serrano Benavente¹², Sheila Melchor¹³, Paula V. Estrada-Alarcón¹⁴, Angel Garcia-Aparicio¹⁵, Cristina Bohorquez¹⁶, Enrique Júdez¹⁷, Ximena Larco¹⁸, Javier Loricera¹⁹, Nerea Alcorta Lorenzo²⁰, Beatriz Paredes Romero²¹, Jorge González Martín²², María Ángeles Blázquez Cañamero²³, Consuelo Ramos-Giráldez²⁴, Fernando Alonso²⁵, Marta Domínguez²⁶ and Jose Luis Andreu-Sánchez²⁷, ¹Rheumatology Department Hospital Puerta de Hierro Majadahonda, Majadahonda, Spain, ²Universidad Autónoma de Madrid, Madrid, Spain, ³Hospital Marina Baixa, Alicante, Spain, ⁴Rheumatology, Hospital Marqués de Valdecilla, Santander, Spain, ⁵Rheumatology Department Hospital Germans Trias i Pujol, Badalona, Spain, ⁶Rheumatology, Hospital Jerez, Puerto De Santa María, Spain, ⁷Division of Rheumatology, Hospital Regional Universitario Carlos Haya, Malaga, Spain, ⁸Rheumatology Department Hospital Virgen de la Concha, Zamora, Spain, ⁹Rheumatology Department Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain, ¹⁰Rheumatology Department, Dr. Balmis University General Hospital, Alicante. Institute for Health and Biomedical Research (ISABIAL), Alicante, Spain, ¹¹Rheumatology Department Hospital de la Princesa, Madrid, Spain, ¹²Rheumatology Department Hospital Gregorio Marañón, Madrid, Spain, ¹³Rheumatology Department Hospital Doce de Octubre, Madrid, Spain, ¹⁴Hospital de San Juan Despí Moisès Broggi, Barcelona, Spain, ¹⁵Hospital Universitario de Toledo, Toledo, Spain, ¹⁶Rheumatology Unit, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain, ¹⁷Rheumatology Department Hospital de Albacete, Albacete, Spain, ¹⁸Rheumatology Department Hospital de León, León, Spain, ¹⁹Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²⁰University Hospital Donostia, San Sebastian, Spain, ²¹Rheumatology Department Hospital Infanta Sofía, San Sebastian de los Reyes, Spain, ²²Rheumatology Department Hospital Madrid Norte Sanchinarro, Madrid, Spain, ²³Rheumatology Department Hospital Ramon y Cajal, Madrid, Spain, ²⁴Rheumatology Department Hospital Universitario Virgen de Valme, Sevilla, Spain, ²⁵Spanish Society of Rheumatology, Madrid, Spain, ²⁶Sociedad Española de Reumatología, Madrid, Spain, ²⁷Rheumatology, Hospital Universitario Puerta de Hierro, Majadahonda, Spain
Background/Purpose: Describe the evolution of patients with Sjögren's syndrome (SS) in relation to the appearance of new systemic manifestations and disease activity, as well as…
Abstract Number: 2177 • ACR Convergence 2023
Characterization of Crevicular Fluid Microbiota in Primary Sjögren’s Syndrome
Gabriela Hernandez-Molina¹, Alberto Lopez-Reyes², Carlos Hernandez-Hernandez³, Vanessa Ruiz³, Amaya Llorente-Chavez⁴, Vanessa Saavedra-González⁴, Luis llorente⁴ and Gabriela Martínez-Nava², ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Laboratorio de Gerociencias, Instituto Nacional de Rehabilitación Luis Guillermo Ibarra Ibarra, Mexico City, Mexico, ³Servicio Dental. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁴Departamento de Inmunología y Reumatología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico
Background/Purpose: To describe the taxonomic composition of the microbiota in the crevicular fluid of patients with primary Sjögren's syndrome (PSS), and to assess their association…
Abstract Number: 2193 • ACR Convergence 2023
Anti-citrullinated Protein Antibodies in Sjögren’s Syndrome Define a Subset of Patients with Lower B Cell Activation Markers and Higher Risk of Lung Involvement
Augusto Silva¹, Filipa Costa², Mariana Silva², Giovanni Fulvio³, Matilde Bandeira², Manuel Silvério-António⁴, Nikita Khmelinskii², Chiara Baldini³ and Vasco Romão², ¹Santa Maria Hospital, Maceira, Portugal, ²Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, ³University of Pisa, Pisa, Italy, ⁴Hospital Santa Maria, Lisboa, Portugal
Background/Purpose: Extraglandular manifestations may occur in up to 40-50% of patients with SS, including inflammatory arthralgia and chronic polyarthritis (1-3). ACPA are prototypical markers of…
Abstract Number: 1245 • ACR Convergence 2023
Evaluating a Diagnostic Algorithm for Childhood Sjögren’s Disease
Sara Stern¹, Matthew Basiaga², Linda Amoafo¹, Seunghee Cha³, Akaluck Thatayatikom⁴, Erin Treemarcki¹, Rachel Randell⁵, Brian Dizon⁶, Jamie Diianni⁷, Sharon Tiger⁸, Janet Orrock⁹, Simone Appenzeller¹⁰, Cuoghi Edens¹¹ and Scott Lieberman¹², ¹University of Utah School of Medicine, Salt Lake City, UT, ²Mayo Clinic, Rochester, MN, ³Department of Oral & Maxillofacial Diagnostic Sciences, University of Florida College of Dentistry and Center for Orphaned Autoimmune Disorders (COAD), Gainesville, FL, ⁴AdventHealth for Children, Orlando, FL, Orlando, FL, ⁵Duke University School of Medicine, Durham, NC, ⁶National Institute of Arthritis and Musculoskelatal and Skin Diseases, Bethesda, MD, ⁷Childhood Arthritis and Rheumatology Research Alliance (CARRA), Washington, DC, ⁸Childhood Arthritis and Rheumatology Research Alliance (CARRA), Beltsville, MD, ⁹The University of Texas at Austin Dell Medical School, Austin, TX, ¹⁰UNICAMP, Campinas, Brazil, ¹¹University of Chicago, Chicago, IL, ¹²University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: There are no widely accepted diagnostic or classification criteria for childhood Sjögren's disease (cSjD). To address the urgent need for consensus, the Childhood Arthritis…
Abstract Number: 1377 • ACR Convergence 2023
Characterization of Pulmonary Manifestations of Sjögren Syndrome: A Multicenter Retrospective Study
Loïc Meudec¹, Cindy Marques², Pierre-Antoine Juge³, Robin Dhote⁴, Anne-Laure Fauchais⁵, Emanuelle Dernis⁶, Olivier Vittecoq⁷, Alain SARAUX⁸, Jacques-Eric Gottenberg⁹, Eric Hachulla¹⁰, Véronique Le Guern¹¹, Philippe Dieudé¹², Marie-Pierre Debray¹³, Antoine Beurnier¹⁴, Raphaele Seror¹⁵, Xavier Mariette¹⁶ and Gaetane Nocturne¹⁷, ¹CHU Kremlin-Bicêtre, Rheumatology, Le Kremlin-Bicêtre, France, ²CHU Pitié Salpétrière, Internal Medicine 1, Paris, France, ³Division of Rheumatology, Inflammation, and Immunity Brigham & Women’s Hospital, Boston, MA, ⁴Department of Internal Medicine, Centre Hospitalier Avicenne, Bobigny, France, ⁵Dupuytren Hospital, Limoges, France, ⁶CH Le Mans, Le Mans, France, ⁷CHU Rouen, Rheumatology, Rouen, France, ⁸CHU Brest, Brest, France, ⁹Rheumatology Department, Strasbourg University Hospital, Strasbourg, France, ¹⁰CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-immunes Systémiques Rares du Nord et Nord-Ouest de France (CeRAINO), Lille, France, ¹¹APHP Hôpital Cochin, Paris, France, ¹²Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, INSERM UMR1152, University de Paris Cité, Department of Rheumatology, Paris, France, ¹³CHU Bichat, Radiology, Paris, France, ¹⁴CHU Kremlin-Bicêtre, Functional Explorations, Le Kremlin-Bicêtre, France, ¹⁵University Hospital Paris Saclay, Le Kremlin-Bicêtre, France, ¹⁶Université Paris-Saclay, Le Kremlin-Bicêtre, France, ¹⁷APHP, Le Kremlin-Bicêtre, France
Background/Purpose: Sjögren disease (Sjo) is a systemic immune-related disease with pulmonary manifestations occurring in up to 16% of patients [1], including interstitial lung disease (SS-ILD)…
Abstract Number: 2178 • ACR Convergence 2023
Increased Risk of Dementia in Patients with Primary Sjogren’s Syndrome: A Nationwide Population-based Cohort Study
Kyung-Ann Lee¹, Hyeji Jeon¹, Hyun-Sook Kim¹ and Gi Hyeon Seo², ¹Soonchunhyang University Seoul Hospital, Seoul, South Korea, ²Health Insurance Review and Assessment Service, Wonju, South Korea
Background/Purpose: Autoimmunity and systemic inflammation may play a role in early-stage dementia. Few studies have investigated whether primary Sjogren's syndrome (pSS) increases the risk of…
Abstract Number: 2194 • ACR Convergence 2023
Association of Self-perceived Oral Health Status with ESSPRI Reported by Sjögren’s Syndrome Patients
Oscar E. Alvarez-González¹, Hector Guerra², Elena A. Quintana-Aguilar², Sandra P. Arroyo-Sánchez², Jesus S. Cortez-Gutierrez², Jesus Alberto Cardenas-De la Garza³, Francisco J. Torres-Quintanilla⁴, Janett Riega-Torres⁵, Cassandra Michele Skinner-Taylor⁵ and Dionicio A. Galarza-Delgado⁶, ¹Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Mexico, ²Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico, ³Hospital Universitario "Dr. José Eleuterio González", San Nicolas, Mexico, ⁴Hospital Universitario "Dr. José Eleuterio González", UANL, Monterrey, Mexico, ⁵Hospital Universitario "Dr. José Eleuterio González", Monterrey, Mexico, ⁶Hospital Universitario UANL, Monterrey, Mexico
Background/Purpose: Salivary gland hypofunction, manifested as xerostomia in Sjögren's syndrome (SS), causes dental, language, and nutritional problems, leading to a detriment in oral health. The…
Abstract Number: 0008 • ACR Convergence 2023
Differential Induction of Anti-Muscarinic Type-3-Receptor Antibodies by Immunization with 4-Hydroxy-2-nonenal-Modified Ro60 in BALB/c Mice
Biji T Kurien¹, Devavrat Dave¹, Martha Tsaliki¹, Valerie Lewis¹ and R Hal Scofield², ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma City Veterans Affairs Medical Center, Oklahoma City, OK
Background/Purpose: Sjögren's Disease is an autoimmune condition in which patients exhibit decreased salivary/lacrimal gland function and express autoantibodies that target the 60k molecular weight Ro…
Abstract Number: 1251 • ACR Convergence 2023
Neurologic Manifestations of Pediatric Sjogren’s Disease Patients: Case Series from an Academic Children’s Hospital
Maya Faison¹, Catherine Lavallee², Joseph McDonald¹ and Cuoghi Edens¹, ¹University of Chicago Medicine, Chicago, IL, ²Virginia Tech Carilion School of Medicine, Roanoke, VA
Background/Purpose: The prevalence of Sjogren's disease (SD) is becoming increasingly recognized in pediatric rheumatology. Despite fewer sicca symptoms, it has been shown that pediatric SD…
Abstract Number: 1378 • ACR Convergence 2023
The UCSD Shortness of Breath Questionnaire Is a Useful Tool for the Assessment of Dyspnea in Primary Sjögren’s Syndrome Patients with Interstitial Lung Disease: A Monocentric Cross-Sectional Study
Gaetano La Rocca¹, Francesco Ferro², Elena Elefante³, Silvia Fonzetti⁴, Giovanni Fulvio⁵, Inmaculada Conception Navarro Garcia³, Chiara Romei⁶, Marta Mosca³ and Chiara Baldini⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, ³Rheumatology Unit, Department of clinical and experimental medicine, University of Pisa, Pisa, Italy, ⁴AOUP, Pisa, Italy, ⁵University of Pisa, Pisa, Italy, ⁶Department of Diagnostic Imaging, Diagnostic Radiology 2, Pisa University Hospital, Pisa, Italy
Background/Purpose: In clinical trials investigating new drugs for the management of Interstitial Lung Disease (ILD) patient reported outcomes (PRO) are increasingly employed as outcome measures…
Abstract Number: 2179 • ACR Convergence 2023
Disease Burden of Patients with Primary Sjögren’s Disease: Results from a Multinational Real-World Survey
Sara McCoy¹, Alan Baer², Ann Xi³, Corey Moorhead⁴, Giorgio Castellano⁴, Anthony Amatucci⁵, Ilias Alevizos⁶ and Haridarshan Patel⁷, ¹University of Wisconsin School of Medicine and Public Health, Middleton, WI, ²Johns Hopkins University School of Medicine, Baltimore, MD, ³Horizon Therapeutics, Indianapolis, IN, ⁴Adelphi Real World, Bollington, United Kingdom, ⁵Horizon Therapeutics, Cambridge, MA, ⁶Horizon Therapeutics, Rockville, MD, ⁷Horizon Therapeutics, Deerfield, IL
Background/Purpose: Sjögren's disease (SjD) is a debilitating disease that has been shown to impact patients' quality of life (QoL). Though oral and ocular dryness are…

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