Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 2298 • ACR Convergence 2025
When Imaging and Biopsy Disagree: Diagnostic Value of Doppler Ultrasound and Histologic Features beyond the Focus Score
kyung-Ann Lee¹, Yeonhee Kim¹, Se Hee Kim² and Hyun-Sook Kim³, ¹Soonchunhyang University Hospital Seoul: Soonchunhyang University Hospital, Seoul, Republic of Korea, ²Kyung Hee University College of Medicine, Seoul, Republic of Korea, ³Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea
Background/Purpose: Salivary gland ultrasound (SGUS) and minor salivary gland biopsy (MSGB) are widely used in the diagnosis of primary Sjögren’s syndrome (pSS). However, discordance between…
Abstract Number: 1881 • ACR Convergence 2025
Silent Impact: Two Decades of Sjögren’s Syndrome Mortality in the United States
Aziz-ur-Rahman Khalid¹, Ghassan Makhoul², Hasan Munshi², Islam Rajab², MD Walid Akram Hussain², Reshma John², Elvira Assaf², Amer Al Badawy², Barbare Khatiashvili², Rouba Isshak², John Salama², Ibrahim Sabah² and Robert Lahita³, ¹St. Joseph's University Medical Center, wayne, ²St. Josephs University Medical Center, Paterson, ³St. Josephs University Medical Center, Wayne, NJ
Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands with potential systemic involvement. Despite its known complications, population-level mortality…
Abstract Number: 1398 • ACR Convergence 2025
Reproductive Challenges and Cardiovascular Risks in Sjögren’s Syndrome and Systemic Sclerosis: A Meta-Analysis of Fertility, Pregnancy Outcomes, and Maternal Cardiac Health
R. Mohamad Javier¹, Bernadus Bramantyo², Arkan Berlian³, Mahardika Nugraha⁴, Azzura Simanulang¹, Eko Setyo Herwanto⁵, Athaya Febriantyo Purnomo⁶, Jonathan Jonathan⁷, Ananingati Ananingati⁵, Budi Prakoso⁸ and Aisyah Rizki Nirmala Hanum⁵, ¹University of Indonesia Hospital, Jakarta Selatan, Jakarta Raya, Indonesia, ²Sardjito General Hospital, Daerah Istimewa Yogyakarta, Yogyakarta, Indonesia, ³Dr. Cipto Mangunkusumo Hospital, Jakarta Barat, Jakarta Raya, Indonesia, ⁴Universitas Islam Sultan Agung, KOTA SEMARANG, Jawa Tengah, Indonesia, ⁵Universitas Muhammadiyah Malang, Malang, Jawa Timur, Indonesia, ⁶Saiful Anwar General Hospita, Malang, Jawa Timur, Indonesia, ⁷RSUD Kalideres, Jakarta, Jakarta Raya, Indonesia, ⁸Department of Internal Medicine, RST dr Soepraoen, Malang, Jawa Timur, Indonesia
Background/Purpose: Autoimmune rheumatic diseases such as Sjögren’s Syndrome (SS) and Systemic Sclerosis (SSc) can significantly impact reproductive health and increase maternal cardiovascular risk. These conditions…
Abstract Number: 1381 • ACR Convergence 2025
Self-Reported and Actigraphic Sleep and Circadian Rhythm Disruptions in Patients with Sjögren’s Disease: Associations with Disease Activity and Patient-Reported Outcomes
Caterina Di Pede¹, Alessandro Colitta², Marco Di Galante³, Simone Bruno⁴, Stefano Donati¹, Beatrice Dei¹, Giovanni Fulvio¹, Gaetano La Rocca⁵, Rosaria Talarico⁶, Marta Mosca¹, Chiara Baldini⁷ and Ugo Faraguna⁴, ¹Rheumatology Unit, University of Pisa, Pisa, Toscana, Italy, ²Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa, Pisa, Toscana, Italy, ³Sleepacta srl, Montacchiello, Pisa, Italy, Pisa, Toscana, Italy, ⁴Department of Translational Research and of New Surgical and Medical Technologies, University of Pisa., Pisa, Toscana, Italy, ⁵University of Pisa, Rheumatology Unit, Pisa, Pisa, Italy, ⁶Azienda Ospedaliero Universitaria Pisana, Pisa, Pisa, Italy, ⁷University of Pisa, Pisa, Pisa, Italy
Background/Purpose: Patients with Sjögren’s Disease (SjD) frequently report debilitating symptoms such as pain, fatigue, and dryness, significantly impacting health-related quality of life. Although sleep disturbances…
Abstract Number: 0517 • ACR Convergence 2025
Gut Microbiota Dysbiosis and Clinical Predictors of Fatigue in Primary Sjögren’s Syndrome: A Multi-Omics Study
Qiguo Cui¹, Pan Wang², Bin Zhou¹ and QIn Huang³, ¹Southern Medical Univercity Nanfang Hospital, guang zhou, China (People's Republic), ²southern medical university Nanfang Hospital, Guangzhou, China (People's Republic), ³Nanfang Hospital, Guangzhou, China (People's Republic)
Background/Purpose: Fatigue affects 70% of primary Sjögren's syndrome (pSS) patients, but its mechanisms remain unclear. We investigated clinical predictors and gut microbiota associations in pSS-related…
Abstract Number: 0443 • ACR Convergence 2024
Significance of anti-Ro52 Antibody in Pregnancy Complicated with Anti-SS-A Antibody Positive Rheumatic Disease Patients
Hiromi Shimada¹, Rina Mino², taichi miyagi³, Yusuke Ushio⁴, Koichi Sugihara⁵, Mao Mizusaki², Hayamasa yamaguchi², Naoto Manabe², Shusaku Nakashima¹ and Hiroaki Dobashi¹, ¹Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan, ²Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Japan, ³Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, kidagun, Japan, ⁴Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki, Kita District, Kagawa, Japan, ⁵Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University, Miki-cho, Kita-gun, Kagawa Prefecture, Japan
Background/Purpose: Anti-SS-A antibodies are associated with neonatal lupus erythematosus and congenital heart block (CHB). Ro/SS-A autoantigen is comprised of 52kDa Ro (Ro52) and 60kDa Ro…
Abstract Number: 1413 • ACR Convergence 2024
Pilot Trial of Ustekinumab for Primary Sjogren’s Syndrome
Ummara Shah¹ and Andrea Coca², ¹University of Rochester, Webster, NY, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Sjogren’s Syndrome (SS) is a chronic autoimmune disease characterized by keratoconjunctivitis sicca and xerostomia. Currently there is no approved systemic treatment for primary SS. …
Abstract Number: 1429 • ACR Convergence 2024
Association of Bone Erosion and Microarchitecture with Disease Activity and Damage in Sjögren’s Disease
Andre Franco¹, Igor Murai², Thomas Yang², Valeria Caparbo³, Virginia Bonoldi², Diogo Domiciano¹, Lissiane Guedes², Sandra Pasoto¹, Camille Figueiredo³ and Rosa M R Pereira³, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina da USP, São Paulo, SP, Brazil, ³Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil
Background/Purpose: Sjögren's disease (SjD) is a chronic multisystem autoimmune condition characterized by sicca syndrome and inflammatory arthralgia, more common in women. Bone involvement can result…
Abstract Number: 2291 • ACR Convergence 2024
The Relationship of the ESSDAI to Health-Related Quality of Life in People Living with Sjogren’s Disease
Dana DiRenzo¹, Chadwick Johr¹, Nora Sandorfi¹, Sara McCoy² and Thomas Grader-Beck³, ¹University of Pennsylvania, Philadelphia, PA, ²University of Wisconsin, Middleton, WI, ³Johns Hopkins, Baltimore, MD
Background/Purpose: Historically, Heath Related Quality of Life (HRQL) in Sjogren’s Disease (SjD) has been measured by the EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI), which…
Abstract Number: 2307 • ACR Convergence 2024
Deep Spatial Profiling Unveils Dominant Double Negative B Cells in Severe Forms of Sjögren’s Syndrome
Loukas chatzis¹, Patrice Hemon², Yvonne Scuiller³, Andreas Goules⁴, Divi Cornec⁵, Athanasios Tzioufas⁶ and Jacques-Olivier Pers³, ¹Pathophysiology Department, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Cholargos Athens, Greece, ²LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, ³LBAI, UMR1227, Univ Brest, INSERM, Brest, France, Paris, France, ⁴GENERAL HOSPITAL LAIKO ATHENS, Athens, Greece, ⁵Service de Rhumatologie, CHU de Brest, Brest, France, ⁶LAIKO HOSPITAL, Athens, Greece
Background/Purpose: Imaging mass cytometry (IMC) is a powerful high throughput technique that enables in-situ multiparametric analysis of a single fixed tissue section while preserving spatial…
Abstract Number: 0451 • ACR Convergence 2024
Macrophages and Interferon Upregulation in Placentas from Patients with Systemic Lupus Erythematosus, Primary Sjögren’s Disease and Antiphospholipid Syndrome
Juan J. Fierro¹, Mirthe Schoots¹, Silvia Liefers¹, Berber Doornbos-van der Meer², Gilles Diercks¹, Hendrika Bootsma³, Jelmer R. Prins¹, Johanna Westra¹ and Karina de Leeuw⁴, ¹University Medical Center Groningen, University of Groningen, Groningen, Groningen, Netherlands, ²University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ³Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Groningen, Netherlands, ⁴University Medical Center Groningen, Groningen, Groningen, Netherlands
Background/Purpose: SLE, primary Sjögren’s disease (pSjD) and APS are systemic rheumatic diseases (SRD) that mainly affect women of childbearing age and have been associated with…
Abstract Number: 1414 • ACR Convergence 2024
Evidence-Based Guidelines for Sjögren’s Disease Peripheral Nervous System Manifestations
Robert Fox¹, Anahita Deboo², Matthew Baker³, Stamatina Danielides⁴, Eduardo de Sousa⁵, Julie Frantsve Hawley⁶, Brent Goodman⁷, Katherine Hammitt⁶, Jennifer King⁸, Matt Makara⁶, Steven Mandel⁹, Ghaith Noaiseh¹⁰, Pantelis Pavlakis¹¹, George Sarka¹², Arun Varadhachary¹³, Daniel Wallace¹⁴, Robert Hal Scofield¹⁵, Nancy Carteron¹⁶ and Steven Carsons¹⁷, ¹Rheumatology Clinic, San Diego, CA, ²Temple University, Philadelphia, ³Stanford University, Menlo Park, CA, ⁴Vcu, Glen Allen, VA, ⁵Mercy, Moore, OK, ⁶Sjogren's Foundation, Reston, VA, ⁷Mayo Clinic, Scottsdale, AZ, ⁸UCLA, Los Angeles, CA, ⁹Hofstra, Hempstead, ¹⁰University of Kansas Medical Center, Kansas City, KS, ¹¹Hospital for Special Surgery, New York, NY, ¹²UCLA, Laguna Hills, CA, ¹³Washington University in St. Louis, St. Louis, MO, ¹⁴Cedars Sinai Medical Center, Studio City, CA, ¹⁵Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁶University of California, Berkeley & San Francisco, Angwin, CA, ¹⁷NYU Long Island School of Medicine, Mineola, NY
Background/Purpose: Peripheral Nervous System (PNS) manifestations occur frequently in Sjögren’s disease and can encompass mononeuropathy, polyneuropathy, and autonomic neuropathy. Guidance is needed for rheumatologists, neurologists,…
Abstract Number: 1430 • ACR Convergence 2024
C57BL/6.NOD-Aec1Aec2 Mice Recapitulate Sjögren’s Serology Better Than NOD.B10Sn-H2b Models and JAK Inhibitor Treatment Improves Immunoglobulins and Salivary Gland Inflammation but Not Salivary Flow in Sjögren’s Mice
Sara McCoy¹ and Ilya Gurevic², ¹University of Wisconsin, Middleton, WI, ²University of Wisconsin, Madison
Background/Purpose: Sjögren’s disease (SjD) is a systemic autoimmune disease in which interferons (IFNs) are believed to play a major role/ JAK inhibitors (JAKinibs) block IFN…
Abstract Number: 2292 • ACR Convergence 2024
Fibroblasts with High Expression of CD74 Promote Lymphocytes Infiltration in Salivary Gland in Sjӧgren’s Disease
Xinwei zhang¹, Yixuan Li¹, Hongyan Qian¹, Chaoqiong Deng¹, Shiju Chen¹, Guixiu Shi² and Yuan Liu¹, ¹xiamen university, xiamen, China (People's Republic), ²xiamen university, xiamen
Background/Purpose: Sjӧgren's disease (SjD) is characterized by persistent focal infiltration of B- and T lymphocytes in the exocrine gland, mainly salivary gland. Though it is…
Abstract Number: 2308 • ACR Convergence 2024
Characterization of Damage in a Primary Sjogren’s Syndrome Cohort
Ana Mafalda Abrantes¹, Pedro Gaspar² and David Isenberg³, ¹Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Lisbon, Portugal, ²Internal Medicine Department, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisbon, Portugal, Povoa de Santa Iria, Portugal, ³University College London, London, United Kingdom
Background/Purpose: Damage is irreversible and represents a permanent loss in organ function. Outcome measures are critical for minimizing and prevent damage acquisition. There are two…

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