Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 1440 • ACR Convergence 2021
Targeting Endogenous Mesenchymal Stromal Cell Response to Interferong in Sjӧgren’s Syndrome
Sara McCoy, Ilya Gurevic, Maxwell Parker and Jacques Galipeau, University of Wisconsin, Madison, WI
Background/Purpose: Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that is associated with a lymphoma risk 14-fold that of the general population. Greater focal lymphocytic…
Abstract Number: 0300 • ACR Convergence 2021
Salivary Gland Epithelial Cells Transcriptomic Analysis Highlight Their Potential Involvement in Extracellular Matrix Modification in Sjögren’s Syndrome
Elodie Rivière¹, Juliette Pascaud¹, Franck Letourneur², Gaetane Nocturne¹ and Xavier Mariette³, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184 ; Rheumatology, APHP, Université Paris Saclay, Le Kremlin Bicêtre, France, ²Plateforme Génomique : GENOM'IC — Institut Cochin, Paris, France, ³Université Paris- Saclay, Rheumatology, Paris, France
Background/Purpose: Salivary gland epithelial cells (SGECs) participate to the hyper activation of the immune system in primary Sjögren’s syndrome (pSS). This study aimed to analyze…
Abstract Number: 0316 • ACR Convergence 2021
Exploring Alternative Responder Definitions for EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) for Use in Sjögren’s Clinical Trials
Samantha Wratten¹, Linda Abetz-Webb², Ethan Arenson², Mike Greenwood², Rebecca Hall³, Pip Griffiths⁴, Simon J Bowman⁵, Wolfgang Hueber⁶, Briana Ndife⁷, Daniel Kuessner⁶ and Pushpendra Goswami⁶, ¹Adelphi Values, Macclesfield, United Kingdom, ²Adelphi Values, Bollington, United Kingdom, ³Adelphi Values Ltd, Bollington, United Kingdom, ⁴Former Adelphi Values, Bollington, United Kingdom, ⁵Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis, East Hanover, NJ
Background/Purpose: Sjögren’s is a chronic autoimmune disease symptomatically characterized by dryness, pain and fatigue, which are typically assessed in clinical trials using EULAR Sjögren’s Syndrome…
Abstract Number: 1464 • ACR Convergence 2021
Ambulatory Fetal Heart Rate Monitoring (FHRM) to Surveil Pregnancies at Risk for Congenital Heart Block
Mala Masson¹, Colin Phoon¹, Elena Sinkovskaya², Lisa Howley³, Ruben Acherman⁴, Majd Makhoul⁵, Nelangi Pinto⁶, Miao Chang¹, Robert Clancy⁷, Bailey Drewes⁸, Bettina Cuneo⁹ and Jill Buyon⁷, ¹NYU Langone Health, New York, NY, ²East Virginia Medical School, Norfolk, ³Children's Hospitals and Clinics of Minnesota, Minneapolis, MN, ⁴Sunrise Children's Hospital, Las Vegas, NV, ⁵UK Kentucky Children's Hospital, Lexington, KY, ⁶University of Utah, Salt Lake City, UT, ⁷NYU Grossman School of Medicine, New York, NY, ⁸CU Anschutz Medical Campus, Aurora, ⁹Children's Hospital Colorado, Aurora, CO
Background/Purpose: Congenital Heart Block (CHB) complicates 2% of anti-Ro/SSA antibody positive pregnancies and carries substantial perinatal morbidity and mortality. Almost all survivors require lifelong pacing.…
Abstract Number: 0301 • ACR Convergence 2021
Activation of Akt Signaling Pathway in the Minor Salivary Glands of Patients with Primary Sjögren’s Syndrome Does Not Relate with Clinical Phenotype
Ioanna Stergiou¹, Loukas Chatzis², Asimina Papanikolaou³, Stavroula Giannouli⁴, Athanasios Tzioufas², Michael Voulgarelis² and Efstathia Kapsogeorgou², ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, ²Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ³Department of Haemopathology, "Evangelismos" Hospital, Athens, Greece, Athens, Greece, ⁴2nd Department of Internal Medicine, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece
Background/Purpose: Akt is a phosphoinositide-dependent serine/threonine kinase with diverse regulatory functions that has been implicated in numerous pathological processes, including oncogenesis and autoimmune diseases. Indirect…
Abstract Number: 0317 • ACR Convergence 2021
Patient and Physician Perspectives on EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) and EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI): A Qualitative Interview Study
Samantha Wratten¹, Carl Cooper², Jessica Flynn², Natasha Griffiths², Rebecca Hall³, Linda Abetz-Webb², Simon J Bowman⁴, Wolfgang Hueber⁵, Briana Ndife⁶ and Pushpendra Goswami⁵, ¹Adelphi Values, Macclesfield, United Kingdom, ²Adelphi Values, Bollington, United Kingdom, ³Adelphi Values Ltd, Bollington, United Kingdom, ⁴Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ⁵Novartis Pharma AG, Basel, Switzerland, ⁶Novartis, East Hanover, NJ
Background/Purpose: The aim of this research was to gain qualitative patient and physician feedback on the EULAR Sjögren’s syndrome patient reported index (ESSPRI) and the…
Abstract Number: 1636 • ACR Convergence 2021
Pediatric Rheumatologists’ Perspectives on Diagnosis, Treatment and Outcomes of Sjögren Syndrome in Children and Adolescents
Rachel Randell¹, Sara Stern², Heather Van Mater¹, Scott Lieberman³ and Matthew Basiaga⁴, ¹Duke University, Durham, NC, ²University of Utah, Salt Lake City, UT, ³University of Iowa, Iowa City, IA, ⁴Mayo Clinic, Inver Grove Heights, MN
Background/Purpose: Sjögren syndrome in children and adolescents often presents differently from adult disease, with many pediatric patients failing to meet adult criteria. Additionally, treatment and…
Abstract Number: 105 • 2019 ACR/ARP Annual Meeting
The DLEU2/miR-15a/16-1 Cluster Inhibit Foxp3+ Treg Cells in Salivary Glands of pSS via Targeting Foxp3
Xuan Wang¹, Zhenzhen Wu ¹, Jincheng Pu ¹, Run Feng ¹ and Jianping Tang ¹, ¹1. Department of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands cells form a large part…
Abstract Number: 2878 • 2013 ACR/ARHP Annual Meeting
The Importance Of Germinal Center-Like Structures In Primary Sjögren’s Syndrome Salivary Glands Beyond Lymphoma Risk
Elke Theander¹, Thomas Mandl², Rolf Liedholm³, Roland Jonsson⁴, Malin V. Jonsson⁵ and Gunnar Warfvinge⁶, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden, ³Department of oral and maxillofacial surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ⁶Department of oral pathology, Skåne University Hospital Malmö, Lund University, Malmö, Sweden
Background/Purpose: The association between germinal center (GC)-like structures and lymphoma in primary Sjögren's syndrome (pSS) has been demonstrated recently (1). Here we present a comprehensive…
Abstract Number: 2186 • 2012 ACR/ARHP Annual Meeting
Ultrasonography of Major Salivary Glands in Primary Sjögren’s syndrome
Malin V. Jonsson¹, Daniel Hammenfors², Johan G. Brun² and Roland Jonsson³, ¹Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ³Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway
Background/Purpose: Minor salivary gland biopsy is part of the diagnostic process for primary Sjögren’s syndrome (pSS), but is not suitable for repeated follow-up. Ultrasound (US)…

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