Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 0984 • ACR Convergence 2021
Human Papillomavirus Infection Increases Risk of Primary Sjogren’s Syndrome: A Population-based Cohort Study over a 15-year Follow-up
Kevin Sheng-Kai Ma, Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philidelphia, PA
Background/Purpose: Viral infection has been considered as an exogeneous risk factor for primary Sjogren’s syndrome (pSS). We determined whether human papillomavirus (HPV) infection was associated…
Abstract Number: 0296 • ACR Convergence 2021
The Impact of Delayed Primary Sjögren’s Syndrome Diagnosis on Patient Outcomes: A Real-World Survey in the US
Briana Ndife¹, Sophie Barlow², Megan Hughes² and Nicola Booth², ¹Novartis, East Hanover, NJ, ²Adelphi Real World, Bollington, United Kingdom
Background/Purpose: Diagnosis of primary Sjögren’s syndrome (pSS) is challenging due to the disease’s phenotypic heterogeneity. pSS patients frequently experience a prolonged period between symptomatic onset…
Abstract Number: 0312 • ACR Convergence 2021
Prognostic Value of Salivary Gland Ultrasonography in Primary Sjögren’s Syndrome
Francesco Ferro¹, Gianmaria Governato¹, Giovanni Fulvio¹, Gaetano La Rocca¹, Silvia Fonzetti¹, Giacomo Aringhieri², Valentina Donati³, Marta Mosca⁴ and Chiara Baldini⁵, ¹University of Pisa, Rheumatology Unit, Pisa, Italy, ²University of Pisa, 3Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, Pisa, Italy, ³AOUP, Unit of Pathological Anatomy, Pisa, Italy, ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, ⁵University of Pisa, Pisa, Italy
Background/Purpose: In the last decade, salivary gland ultrasonography (SGUS) has appeared as a useful tool for the diagnosis of primary Sjögren’s syndrome (pSS) and for…
Abstract Number: 0985 • ACR Convergence 2021
Sjӧgren’s Symptom Burden Drives Immunomodulatory Therapies but Correlates Poorly with Disease Severity Markers
Sara McCoy¹, Miguel Woodham¹, Ian Saldanha², Esen Akpek³, VATINEE BUNYA⁴ and Alan Baer⁵, ¹University of Wisconsin, Madison, WI, ²Brown University School of Public Health, Providence, RI, ³Wilmer Eye Institute, JHU, Baltimore, MD, ⁴University of Pennsylvania, Penn Valley, PA, ⁵Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Sjӧgren’s syndrome (SS) patients have lower quality of life driven by symptoms of pain, depression and fatigue. These symptoms often do not respond to…
Abstract Number: 0297 • ACR Convergence 2021
Describing the Disease Burden of Primary Sjögren’s Syndrome Patients: Results from a Real-World Survey in the US
Briana Ndife¹, Ben Hoskin², Megan Hughes² and Nicola Booth², ¹Novartis, East Hanover, NJ, ²Adelphi Real World, Bollington, United Kingdom
Background/Purpose: Primary Sjogren’s syndrome is a highly heterogeneous condition, with limited understanding of the burden of disease. The objective of this study was to describe…
Abstract Number: 0313 • ACR Convergence 2021
Do Primary Sjögren’s Syndrome Patients with Normal Major Salivary Gland Ultrasound Have Less Active Disease?
Katja Perdan Pirkmajer¹, Matija TOMSIC¹ and Alojzija Hocevar², ¹University Medical Centre Ljubljana, Ljubljana, Slovenia, ²UKC Ljubjana, Ljubjana, Slovenia
Background/Purpose: Ultrasonographically depicted morphological changes of major salivary glands (SG) have been recently correlated with the disease activity in primary Sjögren’s (pSS)1. The aim of…
Abstract Number: 0986 • ACR Convergence 2021
Ianalumab (VAY736) Safety and Efficacy in Patients with Sjögren’s Syndrome: 52 Week Results from a Randomized, Placebo-controlled, Phase 2b Dose-ranging Trial
Thomas Dörner¹, Simon J Bowman², Robert Fox³, Xavier Mariette⁴, Athena Papas⁵, Thomas Grader-Beck⁶, Ben A Fisher², Filipe Barcelos⁷, Salvatore De Vita⁸, Hendrik Schulze-Koops⁹, Robert Moots¹⁰, Guido Junge¹¹, Janice Woznicki¹², Monika Sopala¹¹, Wen-Lin Luo¹² and Wolfgang Hueber¹¹, ¹Charite Universitätsmedizin Berlin and Deutsches Rheumaforschungszentrum (DRFZ), Berlin, Germany, ²Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, ³Scripps Memorial Hospital and Research Institute, San Diego, CA, ⁴Université Paris- Saclay, Rheumatology, Paris, France, ⁵Division of Oral Medicine, Tufts School of Dental Medicine, Boston, MA, ⁶Johns Hopkins University, Baltimore, MD, ⁷Instituto Português de Reumatologia, Lisbon, Portugal, ⁸Division of Rheumatology, DAME, University Hospital of Udine, Udine, Italy, ⁹Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, University of Munich, Munich, Germany, ¹⁰Academic Rheumatology Department, Aintree University Hospital, Liverpool, United Kingdom, ¹¹Novartis Pharma AG, Basel, Switzerland, ¹²Novartis Pharmaceuticals Corporation, East Hanover, NJ
Background/Purpose: Sjögren’s syndrome (SS) is an autoimmune disease affecting excretory glands and characterized by B-cell hyperactivity. Ianalumab (VAY736) is a human monoclonal antibody to B-cell…
Abstract Number: 105 • 2019 ACR/ARP Annual Meeting
The DLEU2/miR-15a/16-1 Cluster Inhibit Foxp3+ Treg Cells in Salivary Glands of pSS via Targeting Foxp3
Xuan Wang¹, Zhenzhen Wu ¹, Jincheng Pu ¹, Run Feng ¹ and Jianping Tang ¹, ¹1. Department of Rheumatology and Immunology, Tongji Hospital, Tongji University School of Medicine, Shanghai, Shanghai, China (People's Republic)
Background/Purpose: Primary Sjögren’s Syndrome (pSS) is a systemic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands cells form a large part…
Abstract Number: 2878 • 2013 ACR/ARHP Annual Meeting
The Importance Of Germinal Center-Like Structures In Primary Sjögren’s Syndrome Salivary Glands Beyond Lymphoma Risk
Elke Theander¹, Thomas Mandl², Rolf Liedholm³, Roland Jonsson⁴, Malin V. Jonsson⁵ and Gunnar Warfvinge⁶, ¹Section of Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden, ²Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden, ³Department of oral and maxillofacial surgery, Skåne University Hospital Malmö, Lund University, Malmö, Sweden, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ⁶Department of oral pathology, Skåne University Hospital Malmö, Lund University, Malmö, Sweden
Background/Purpose: The association between germinal center (GC)-like structures and lymphoma in primary Sjögren's syndrome (pSS) has been demonstrated recently (1). Here we present a comprehensive…
Abstract Number: 2186 • 2012 ACR/ARHP Annual Meeting
Ultrasonography of Major Salivary Glands in Primary Sjögren’s syndrome
Malin V. Jonsson¹, Daniel Hammenfors², Johan G. Brun² and Roland Jonsson³, ¹Department of Clinical Dentistry - Section for Oral and Maxillofacial Radiology, University of Bergen, Bergen, Norway, ²Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ³Broegelmann Research Laboratory, the Gade Institute, University of Bergen, Bergen, Norway
Background/Purpose: Minor salivary gland biopsy is part of the diagnostic process for primary Sjögren’s syndrome (pSS), but is not suitable for repeated follow-up. Ultrasound (US)…

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