Abstracts tagged "Sjögren’s syndrome"

Abstract Number: 0320 • ACR Convergence 2021
Performance of the Clinical Trials ESSDAI (ClinTrialsESSDAI), an Adjusted ESSDAI Score, in Two Randomised Clinical Trials in Patients with Primary Sjögren’s Syndrome
Liseth de Wolff¹, Suzanne Arends², Elena Pontarini³, Michele Bombardieri³, Simon J Bowman⁴ and Hendrika Bootsma², ¹University Medical Centre Groningen, Groningen, Netherlands, ²University Medical Center Groningen, Groningen, Netherlands, ³Queen Mary University of London, William Harvey Research Institute, London, United Kingdom, ⁴Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom
Background/Purpose: Recent randomised controlled trials (RCTs) in primary Sjögren’s syndrome (pSS) failed to show clinical efficacy.1-3 Several RCTs used the EULAR Sjögren’s Syndrome Disease Activity…
Abstract Number: 1935 • ACR Convergence 2021
Skewed Escape from X-inactivation: Insights into the Female Bias of Sjögren’s Syndrome
Teressa Shaw¹, Wei Zhang², Sara McCoy³, Xueer Qiu¹, Adam Pagenkopf¹, Robert Hal Scofield⁴, Jacques Galipeau³ and Yun Liang¹, ¹University of Wisconsin-Madison, Madison, WI, ²University of California San Diego, La Jolla, CA, ³University of Wisconsin, Madison, WI, ⁴Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Many autoimmune diseases feature increased prevalence in females, with primary Sjögren's syndrome (pSS) being the most female-predominant autoimmune disease with a female-to-male ratio of…
Abstract Number: 0305 • ACR Convergence 2021
Artificial Neural Networks Approaches to Predict Myocardial Fibrosis in Primary Sjögren Syndrome Patients Without Cardiac Symptoms
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Atsuma Nishiwaki¹, Isamu Yokoe¹, Haraoka Masaki³, Eichi Takaya³, Yousuke Nagasawa¹, Noboru Kitamura¹, Masami Takei¹ and Hideki Nakamura¹, ¹Nihon University School of Medicine, Itabashi, Japan, ²St. Marianna University School of Medicine, kowasaki, Japan, ³St. Marianna University School of Medicine, Kawaski, Japan
Background/Purpose: A recent meta-analysis of cardiovascular diseases demonstrated that the odds of heart failure (HF) was more than 2.54-fold higher in primary Sjögren syndrome (pSS)…
Abstract Number: 0321 • ACR Convergence 2021
Sequential Administration of Belimumab and Rituximab in Primary Sjögren’s Syndrome Reduces Minor Salivary Gland–Resident B Cells and Delays B-Cell Repopulation in Circulation
André van Maurik¹, David Gardner², Saba Nayar², Charlotte Smith², Kenneth Clark¹, Prafull Mistry¹, Rajesh Punwaney³, David Roth³, Robert Henderson¹, Xavier Mariette⁴ and Francesca Barone², ¹GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, ²University of Birmingham, College of Medical and Dental Sciences, Birmingham, United Kingdom, ³GlaxoSmithKline, Collegeville, PA, ⁴Université Paris- Saclay, Rheumatology, Paris, France
Background/Purpose: Primary Sjögren’s syndrome (pSS) is characterized by B-cell hyperactivity and elevated serum and saliva B-lymphocyte stimulator (BLyS) levels.1 Sequential administration of belimumab (BEL; anti-BLyS)…
Abstract Number: 0306 • ACR Convergence 2021
Allergic Disorders in Primary Sjögren’s Syndrome Compared with Rheumatoid Arthritis
Misako Higashida-Konishi¹, Keisuke Izumi², Tatsuya Shimada³, Satoshi Hama⁴, Mitsuhiro Akiyama⁵, Hisaji Oshima⁴ and Yutaka Okano⁶, ¹Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Meguroku, Japan, ²Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ⁴Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, tokyo, Japan, ⁵Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Palo Alto, CA, ⁶Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Kawasaki, Japan
Background/Purpose: Allergic disorders are occasionally seen in patients with primary Sjögren's syndrome (pSS) [1]. Risk factors are unclear for allergic disorders.We aimed to compare the…
Abstract Number: 0322 • ACR Convergence 2021
Histopathological Changes in Parotid and Labial Salivary Gland Tissue in Primary Sjögren’s Syndrome Patients After Abatacept Treatment
Uzma Nakshbandi¹, Liseth de Wolff², Frans Kroese¹, Silvia Liefers³, Neelanjana Ray⁴, Gwenny Verstappen¹, Fred Spijkervet³, Marleen Nys⁵, Arjan Vissink⁶, Robert Wong⁷, Bert van der vegt³ and Hendrika Bootsma¹, ¹University Medical Center Groningen, Groningen, Netherlands, ²University Medical Centre Groningen, Groningen, Netherlands, ³University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁴Bristol-Myers Squibb Company, Lawrenceville, GA, ⁵Bristol Myers Squibb, Braine-l'Alleud, Belgium, ⁶University of Groningen, University Medical Center Groningen, Leek, Netherlands, ⁷Bristol Myers Squibb, Basking Ridge, NJ
Background/Purpose: In a previous open-label phase II study, we showed that abatacept treatment might inhibit local formation of autoreactive memory B cells in parotid glands…
Abstract Number: 0307 • ACR Convergence 2021
Cerebellar Ataxia in Primary Sjogren’s Syndrome, Is Gluten Sensitivity the Answer?
Fu Chuen Kon¹, Mohammed Akil², Rachael Kilding², Kar-Ping Kuet², Priya Shanmugarajah³, Nigel Hoggard⁴ and Marios Hadjivassiliou³, ¹Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, ²Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, ³Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Royal Hallamshire Hospital, Sheffield United Kingdom, Sheffield, United Kingdom, ⁴Academic Unit of Radiology, Royal Hallamshire Hospital, Sheffield, United Kingdom
Background/Purpose: Cerebellar ataxia is an uncommon neurological complication of Primary Sjogren’s Syndrome (PSS), with case reports being the highest level of evidence available. The underlying…
Abstract Number: 0323 • ACR Convergence 2021
Ro Positivity Is an Under‐Recognised Poor Prognostic Marker in Systemic Lupus Erythematosus Patients
Katie Liao¹, Thilinie De Silva¹, Julie Bonin², Rachel Koelmeyer² and Alberta Hoi³, ¹Department of Rheumatology, Monash Health, Melbourne, Australia, ²Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia, ³Department of Rheumatology, Monash Health & Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia
Background/Purpose: Antibodies to Ro60 (SSA) or Ro52 (SSB) have been described as one of the defining autoantibodies in Sjogren syndrome but they are also commonly…
Abstract Number: 0308 • ACR Convergence 2021
Sleep Disorders and Serum Brain-derived Neurotrophic Factor Levels in Patients with Primary Sjögren’s Syndrome
Yaxin Han¹, Li Long², Xixi Chen², Qing Peng², GUO TANG³, Jiajun Liu² and Yan Liu², ¹The People's Hospital of Wenjiang,China; Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China；Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), ²Department of Rheumatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China (People's Republic), ³Chongqing Bishan People's Hospital, Chongqing, China (People's Republic)
Background/Purpose: This study aimed to evaluate the sleep quality and its influenced factors in patients with primary Sjögren's syndrome (pSS), and another purpose is to…
Abstract Number: 0530 • ACR Convergence 2021
Dysregulation of IGFI/IGF1R Pathway and IGF1R+3179A/G Polymorphism in Pathogenesis of Sjögren’s Syndrome
Charalampos Skarlis¹, Adrianos Nezos², Nikolaos Marketos¹, Asimina Papanikolaou³, Athanasios Tzioufas⁴, Michael Koutsilieris¹, Haralampos Moutsopoulos⁵ and Clio Mavragani¹, ¹National and Kapodistrian University of Athens, Athens, Greece, ²National & Kapodistrian University of Athens, Athens, Greece, ³Department of Haemopathology, "Evangelismos" Hospital, Athens, Greece, Athens, Greece, ⁴Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ⁵Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece
Background/Purpose: Sjӧgren’s syndrome (SS) is an autoimmune exocrinopathy characterized by chronic salivary and lacrimal gland dysfunction. Alterations of Insulin-like growth factor (IGF) pathway has been…
Abstract Number: 0002 • ACR Convergence 2021
Salivary Sodium Levels in the Parotid Salivary Gland of SS Patients Suggest B-cell Mediated Epithelial Sodium Channel Disruption
Sarah Pringle¹, Bas Berkhof¹, Martha S. van Ginkel², Silvia Liefers¹, Bert van der vegt², Fred Spijkervet², Hendrika Bootsma¹, Arjan Vissink¹ and Frans Kroese¹, ¹University Medical Center Groningen, Groningen, Netherlands, ²University of Groningen, University Medical Center Groningen, Groningen, Netherlands
Background/Purpose: Patients with Sjögren’s syndrome (SS) suffer from significantly reduced saliva production. Saliva is important for oral health. A careful of sodium, chloride, potassium and…
Abstract Number: 0309 • ACR Convergence 2021
Lymphopenia and Leukopenia in Sjogren Syndrome
Loukas Chatzis¹, Ioanna Stergiou², Vasilis Pezoulas³, Paraskevi Voulgari⁴, Dimitrios Fotiadis⁵, Fotini Skopouli⁶, Haralampos Moutsopoulos⁷, Michael Voulgarelis¹, Athanasios Tzioufas¹ and Andreas Goules², ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ²Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, ³Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Ioannina, Greece, Ioannina, Greece, ⁴Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, ⁵Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece, Ioannina, Greece, ⁶Department of Nutrition and Clinical Dietetics, Harokopio University of Athens, Athens, Greece, ⁷Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece
Background/Purpose: Peripheral lymphopenia and leukopenia in Sjögren’s syndrome (SS) may suggest systemic disease activity and have been proposed as lymphoma predictors. However, the clinical phenotype…
Abstract Number: 0761 • ACR Convergence 2021
Development of a Symptom Diary for Use in Patients with Sjogren’s Syndrome
Briana Ndife¹, Sheri Fenel², Sandy Lewis² and Neetu Agashivala³, ¹Novartis, East Hanover, NJ, ²RTI Health Solutions, Research Triangle Park, NC, ³Novartis Pharmaceutical Corporation, East Hanover, NJ
Background/Purpose: Sjögren’s Syndrome (SS) is a systemic autoimmune disease associated with a wide range of symptoms and long-term complications. While clinical indices are useful in…
Abstract Number: 0005 • ACR Convergence 2021
Maturation and Dysfunction of Autoreactive B Cell Clones in Tissues of Patients with Sjögren’s Syndrome
Mathijs Broeren¹, Giulia Balzaretti², Jing Wang³, Patricia Groenen¹, Barbera van Schaik⁴, Tim Chataway³, Charlotte Kaffa¹, Sander Bervoets¹, Konnie Hebeda¹, Gergana Bounova⁵, Ger Pruijn¹, Tom Gordon³, Niek De Vries⁶ and Rogier Thurlings⁷, ¹Radboud University Medical Center, Nijmegen, Netherlands, ²Amsterdam, Netherlands, ³Flinders University, Adelaide, Australia, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Enpicom BV, Den Bosch, Netherlands, ⁶Amsterdam UMC, Amsterdam, Netherlands, ⁷Radboud University Medical Centre, Nijmegen, Netherlands
Background/Purpose: Sjögren's syndrome (SjS) involves chronic inflammation of exocrine glands that can be complicated by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). We…
Abstract Number: 0310 • ACR Convergence 2021
Histopathology, Salivary Flow and Ultrasonography of the Parotid Gland: Three Complementary Measurements in Primary Sjögren’s Syndrome
Martha S. van Ginkel¹, Esther Mossel², Erlin A. Haacke², Suzanne Arends³, Silvia Liefers¹, Konstantina Delli¹, Jolien F. van Nimwegen⁴, Alja J. Stel⁵, Fred Spijkervet¹, Arjan Vissink⁶, Bert van der vegt¹, Frans Kroese³ and Hendrika Bootsma³, ¹University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ²University of Groningen, University Medical Center Groningen, Groningen, ³University Medical Center Groningen, Groningen, Netherlands, ⁴Univeristy of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁵University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, ⁶University of Groningen, University Medical Center Groningen, Leek, Netherlands
Background/Purpose: Primary Sjögren’s syndrome is a systemic autoimmune disease characterized by dryness of the mouth and eyes. The impact of the disease on salivary glands…

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