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Abstracts tagged "Sjögren’s syndrome"

  • Abstract Number: 0814 • ACR Convergence 2022

    Clinical Correlation of Dense Fine Speckled (DFS) Pattern of ANA

    Smarika Sapkota1, Jerry Molitor2, michael evans2, Benjamin Kofoed3, Adam Lord3, Londyn Robinson3 and John crosson2, 1University of Colorado, Aurora, CO, 2University of Minnesota, Minneapolis, MN, 3University of Minnesota Medical School, Minneapolis, MN

    Background/Purpose: The clinical significance of Dense Fine Speckled (DFS) pattern Anti-nuclear antibodies (ANA) by indirect immunofluorescence method (IIF) is unclear and has been inversely associated…
  • Abstract Number: 1734 • ACR Convergence 2022

    Identification of Sjögren’s Disease-Associated T Cell Receptors Through Deep Sequencing and Single-Cell Transcriptomics

    Ananth Aditya Jupudi1, Michelle Joachims1, Christina Lawrence1, Charmaine Lopez-Davis1, Bhuwan Khatri1, Astrid Rasmussen1, Lida Radfar2, Kiely Grundahl1, R. Hal Scofield2, Judith James1, Joel Guthridge1, Christopher Lessard1, Linda F. Thompson1 and A. Darise Farris1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: Sjögren's disease (SjD) is a chronic rheumatic autoimmune disorder that primarily targets the lacrimal and salivary glands (SG) resulting in dry eyes and dry…
  • Abstract Number: 2031 • ACR Convergence 2022

    Efficacy and Safety of Telitacicept in Primary Sjögren’s Syndrome: A Randomized, Double-blind, Placebo-controlled, Phase 2 Trial

    Dong Xu1, Shangzhu Zhang1, Cibo Huang2, Chenghui Huang3, Li Qin4, Xiaomei Li5, Meiqing Chen6, Xiumei Liu7, Yi Liu8, Zhijun Li9, Jiankang Hu10, Chunde Bao11, wei Wei12, Jing Tian13, Xinwang Duan14, Jianmin Fang15 and Xiaofeng Zeng16, 1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China, 2Beijing Hospital, Beijing, China, 3The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 4Huzhou Third Municipal Hospital, Huzhou, China, 5Anhui Provincial Hospital, Hefei, China, 6The First Affiliated Hospital of Xiamen University, Xiamen, China, 7The First Hospital of Shanxi Medical University, Taiyuan, China, 8West China Hospital of Sichuan University, Chengdu, China, 9The First Affiliated Hospital of Bengbu Medical College, Bengbu, China, 10Jiangxi Pingxiang People’s Hospital, Shanghai, China, 11Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, 12Tianjin Medical University General Hospital, Tianjin, China, 13Second Xiangya Hospital of Central South University, Changsha, China, 14The Second Affiliated Hospital of Nanchang University, Nanchang, China, 15Shanghai Tongji Hospital, Shanghai, China, 16Department of Rheumatology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Beijing, China

    Background/Purpose: To evaluate the efficacy and safety of telitacicept in adult patients with primary Sjögren’s syndrome (pSS) in a phase II randomized double-blind placebo-controlled trial.Methods:…
  • Abstract Number: 2047 • ACR Convergence 2022

    Discriminative Power of Salivary Gland Ultrasound in Relation to Symptom-based Endotypes in Suspected and Definite Primary Sjögren’s Syndrome

    Liselotte Deroo1, Helena Achten2, Eva Genbrugge2, Wouter Bauters2, Dimitri Roels2, Frederick Dochy2, David Creytens2, Ann-Sophie Kathleen De Craemer2, Filip Van den bosch3, Dirk Elewaut4 and isabelle peene5, 1Ghent University, Gent, Belgium, 2Ghent University Hospital, Gent, Belgium, 3Department of Internal Medicine and Paediatrics, Ghent University and VIB Centre for Inflammation Research, Ghent, Belgium, 4Department of Rheumatology, Ghent University Hospital, Belgium, VIB-UGent Center for Inflammation Research, Ghent University, Heusden, Belgium, 5Ghent University Hospital, Ghent, Belgium

    Background/Purpose: Primary Sjögren's Syndrome (pSS) is characterized by xerophthalmia, xerostomia and increased lymphoma risk. To address heterogeneity in symptoms, Tarn et al. applied cluster analysis…
  • Abstract Number: 0827 • ACR Convergence 2022

    Unpublished Clinical Trials of Major Rheumatic Diseases

    Connor Pedersen1, Mike Putman2, Erin Valley1, Kathryn Henry3, Ali Duarte-Garcia4, Shikha Singla5 and Shannon Tai1, 1Medical College of Wisconsin, Milwaukee, WI, 2The Medical College of Wisconsin, Milwaukee, WI, 3Medical College of Wisconsin, Manitowoc, WI, 4Mayo Clinic, Rochester, MN, 5MCW, Fox Point, WI

    Background/Purpose: Randomized controlled trials (RCTs) provide high-quality evidence for treatment efficacy, but many RCTs remain unpublished. The objective of this study was to describe the…
  • Abstract Number: 1947 • ACR Convergence 2022

    Medication Use in Childhood Sjogren Disease

    Erin Treemarcki1, Matthew Basiaga2, Scott Lieberman3 and Sara Stern1, 1University of Utah, Salt Lake City, UT, 2Mayo Clinic, Inver Grove Heights, MN, 3University of Iowa, Iowa City, IA

    Background/Purpose: Childhood Sjogren’s Disease (childSD) is a rare complex chronic autoimmune disease primarily affecting lacrimal and salivary glands. Currently there is a paucity of information…
  • Abstract Number: 2032 • ACR Convergence 2022

    Major Salivary Gland Ultrasound and Elastography for Assessment of Disease Activity in Patients of Primary Sjögren’s Syndrome

    Kunal Chandwar1, Juhi Dixit1, Kriti Kishor1, DOGGA PRASANNA KUMAR2, DIGVIJAY EKBOTE3, PUNEET KUMAR1 and Urmila Dhakad1, 1King George's Medical University, Lucknow, India, 2KGMU, LUCKNOW, Uttar Pradesh, India, 3KING GEORGE MEDICAL UNIVERSITY, LUCKNOW, Uttar Pradesh, India

    Background/Purpose: To assess major salivary gland involvement by ultrasonography and elastography in patients with Sjögren's syndrome , compare it with controls and correlate the severity…
  • Abstract Number: 2048 • ACR Convergence 2022

    Serology Driven Pulmonary Phenotype Characterization of Sjögren Syndrome-associated Interstitial Lung Disease: A Monocentric Cohort Study

    Gaetano La Rocca1, Francesco Ferro2, Giovanni Fulvio3, Silvia Fonzetti4, Inmaculada Concepción Navarro García5, Elena Elefante6, Chiara Romei7, Marta Mosca6 and Chiara Baldini3, 1University of Pisa, Rheumatology Unit, Palermo, Palermo, Italy, 2Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Pisa, Italy, 3University of Pisa, Pisa, Pisa, Italy, 4Azienda Ospedaliera Universitaria Pisana, Pisa, Italy, 5Clinical and Experimental Medicine Department, Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy, 6University of Pisa, Pisa, Italy, 7University of Pisa, Rheumatology Unit, Pisa, Italy

    Background/Purpose: Interstitial lung disease (ILD) is a relatively frequent manifestation of Sjögren's Syndrome (pSS), potentially presenting with a wide spectrum of clinical-radiological characteristics. Anti-Ro52 autoantibodies…
  • Abstract Number: 0005 • ACR Convergence 2021

    Maturation and Dysfunction of Autoreactive B Cell Clones in Tissues of Patients with Sjögren’s Syndrome

    Mathijs Broeren1, Giulia Balzaretti2, Jing Wang3, Patricia Groenen1, Barbera van Schaik4, Tim Chataway3, Charlotte Kaffa1, Sander Bervoets1, Konnie Hebeda1, Gergana Bounova5, Ger Pruijn1, Tom Gordon3, Niek De Vries6 and Rogier Thurlings7, 1Radboud University Medical Center, Nijmegen, Netherlands, 2Amsterdam, Netherlands, 3Flinders University, Adelaide, Australia, 4Amsterdam University Medical Centers, Amsterdam, Netherlands, 5Enpicom BV, Den Bosch, Netherlands, 6Amsterdam UMC, Amsterdam, Netherlands, 7Radboud University Medical Centre, Nijmegen, Netherlands

    Background/Purpose: Sjögren's syndrome (SjS) involves chronic inflammation of exocrine glands that can be complicated by extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). We…
  • Abstract Number: 0310 • ACR Convergence 2021

    Histopathology, Salivary Flow and Ultrasonography of the Parotid Gland: Three Complementary Measurements in Primary Sjögren’s Syndrome

    Martha S. van Ginkel1, Esther Mossel2, Erlin A. Haacke2, Suzanne Arends3, Silvia Liefers1, Konstantina Delli1, Jolien F. van Nimwegen4, Alja J. Stel5, Fred Spijkervet1, Arjan Vissink6, Bert van der vegt1, Frans Kroese3 and Hendrika Bootsma3, 1University of Groningen, University Medical Center Groningen, Groningen, Netherlands, 2University of Groningen, University Medical Center Groningen, Groningen, 3University Medical Center Groningen, Groningen, Netherlands, 4Univeristy of Groningen, University Medical Center Groningen, Groningen, Netherlands, 5University of Groningen, University Medical Centre Groningen, Groningen, Netherlands, 6University of Groningen, University Medical Center Groningen, Leek, Netherlands

    Background/Purpose: Primary Sjögren’s syndrome is a systemic autoimmune disease characterized by dryness of the mouth and eyes. The impact of the disease on salivary glands…
  • Abstract Number: 0839 • ACR Convergence 2021

    Comparative Treatment Effectiveness in Rheumatoid Arthritis with and Without Concomitant Sjögren’s Syndrome – Results from the Swiss Clinical Quality Management Cohort

    Lisa Christ1, Seraphina Kissling2, Ruediger B. Mueller3, Axel Finckh4, Benjamin Fisher5, Britta Maurer1, Burkhard Moeller6 and Florian Kollert1, 1Department of Rheumatology and Immunology, University Hospital (Inselspital) and University of Bern, Bern, Switzerland, 2Statistics and Data Management Group, Swiss Clinical Quality Management Foundation, Zurich, Switzerland, 3Clinic of Rheumatology, Medical University Hospital Aarau, Aarau, Switzerland, 4University Hospital of Geneva, Geneve - Vesenaz, Switzerland, 5Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham; National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre and Department of Rheumatology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom, 6Inselspital - University Hospital Bern, Bern, Switzerland

    Background/Purpose: The variety of treatment options in RA contrasts with a lack of personalized medicine. The presence of concomitant SjS might be associated with differerences…
  • Abstract Number: 0165 • ACR Convergence 2021

    Shear-Wave Elastography Evaluation of Major Salivary Glands and Correlation with B-mode Findings in Patients with Primary Sjögren’s Syndrome

    Ana Prata1, Joao Freitas2, Mary Lucy Marques3, Flavio Costa4, Mariana Santiago5, Sara Serra1, Margarida Coutinho1, Tânia Santiago1, João Pedro Lopes Rovisco1 and Jose Pereira da Silva6, 1Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 2Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal, 3Leiden University Medical Center, Leiden, Netherlands, 4Centro Hospitalar de Vila Nova de Gaia/Espinho, Coimbra, Portugal, 5Centro Hospitalar e Universitário de Coimbra, Unknown, Colombia, 6University of Coimbra | UC · Clínica Universitária de Reumatologia. Faculty of Medicine, Columbia, Portugal

    Background/Purpose: Salivary-gland ultrasound has recently shown to help in the diagnosis and monitoring of primary Sjögren’s syndrome (pSS)1. Shear-wave elastography (SWE) is a promising tool…
  • Abstract Number: 0311 • ACR Convergence 2021

    Ultra High‐frequency Ultrasound (UHFUS) of Labial Glands in Primary Sjögren’s Syndrome: Serological and Histological Correlations

    Giovanni Fulvio1, Francesco Ferro1, Rossana Izzetti2, Gianmaria Governato1, Silvia Fonzetti1, Gaetano La Rocca1, Valentina Donati3, Davide Caramella4, Marta Mosca5 and Chiara Baldini6, 1University of Pisa, Rheumatology Unit, Pisa, Italy, 2University of Pisa, Unit of Dentistry and Oral Surgery, Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, Pisa, Italy, 3AOUP, Unit of Pathological Anatomy, Pisa, Italy, 4University of Pisa, 3Diagnostic and Interventional Radiology, Department of Translational Research and of New Technologies in Medicine and Surgery, Pisa, Italy, 5Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, 6University of Pisa, Pisa, Italy

    Background/Purpose: Last‐generation ultra high‐frequency ultrasound (UHFUS) transducers are highly sensitive tools potentially able to open new avenues for the identification of imaging biomarkers. Recently UHFUS…
  • Abstract Number: 0984 • ACR Convergence 2021

    Human Papillomavirus Infection Increases Risk of Primary Sjogren’s Syndrome: A Population-based Cohort Study over a 15-year Follow-up

    Kevin Sheng-Kai Ma, Center for Global Health, Perelman School of Medicine, University of Pennsylvania, Philidelphia, PA

    Background/Purpose: Viral infection has been considered as an exogeneous risk factor for primary Sjogren’s syndrome (pSS). We determined whether human papillomavirus (HPV) infection was associated…
  • Abstract Number: 0296 • ACR Convergence 2021

    The Impact of Delayed Primary Sjögren’s Syndrome Diagnosis on Patient Outcomes: A Real-World Survey in the US

    Briana Ndife1, Sophie Barlow2, Megan Hughes2 and Nicola Booth2, 1Novartis, East Hanover, NJ, 2Adelphi Real World, Bollington, United Kingdom

    Background/Purpose: Diagnosis of primary Sjögren’s syndrome (pSS) is challenging due to the disease’s phenotypic heterogeneity. pSS patients frequently experience a prolonged period between symptomatic onset…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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