Abstracts tagged "signal transduction"

Abstract Number: 817 • 2019 ACR/ARP Annual Meeting
Enhanced Expression of mRNA for TAK1 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis
Shunsei Hirohata¹, Tatsuo Nagai ², Tetsuya Tomita ³ and Hideki Yoshikawa ³, ¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, ²Kitasato University School of Medicine, Sagamihara, Japan, ³Osaka University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia, consisting of type A macrophage-like synoviocytes and type B fibroblast-like synoviocytes (FLS).…
Abstract Number: 126 • 2018 ACR/ARHP Annual Meeting
Direct Interaction between Autoreactive B Cells and Endothelial Colony Forming Cells Induces Cytokine Production from B Cells through B Cell Receptor and IL-6-JAK2-STAT3 Signaling Pathway, Suppressing Proliferation of Endothelial Colony Forming Cells in Systemic Sclerosis
Takemichi Fukasawa¹, Ayumi Yoshizaki¹, Satoshi Ebata¹, Kouki Nakamura¹, Yoshihide Asano¹, Yutaka Kazoe², Kazuma Mawatari², Takehiko Kitamori² and Shinichi Sato¹, ¹Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, ²Department of Applied Chemistry, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disorder that is characterized by fibrosis and vascular damage in the skin and other visceral organs, with…
Abstract Number: 2928 • 2017 ACR/ARHP Annual Meeting
STAT3 As an Important Integrator of Profibrotic Pathways in Systemic Sclerosis
Debomita Chakraborty¹, Barbora Šumová², Tatjana Mallano³, Chih-Wei Chen³, Alfiya Distler³, Christina Bergmann³, Andreas Ramming⁴, Oliver Distler⁵, Georg Schett³, Ladislav Senolt⁶ and Jörg Distler³, ¹Department of Internal Medicine 3- Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ²Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, ³Department of Internal Medicine 3 – Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁴Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Erlangen, Germany, ⁵Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁶Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Background/Purpose: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates key cellular processes such as proliferation, apoptosis, invasion, angiogenesis, metastasis…
Abstract Number: 2573 • 2013 ACR/ARHP Annual Meeting
The Role Of STAT-3 In The Development Of Pulmonary and Dermal Fibrosis
Mesias Pedroza¹, Sarah To¹, Anuh T. George¹, David J. Tweardy² and Sandeep K. Agarwal¹, ¹Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, ²Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX
Background/Purpose: Fibrosis is the accumulation of excessive extra-cellular matrix in tissues, leading to tissue damage. In systemic sclerosis, the trigger is postulated to be an…
Abstract Number: 1448 • 2012 ACR/ARHP Annual Meeting
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice
Kunihiro Ichinose¹, Atsushi Kawakami² and George C. Tsokos³, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Inhibition of Calcium/Calmodulin-Dependent Protein Kinase IV Suppresses the Autoimmunity in Lupus-Prone Mice. Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic inflammatory disease associated with abnormal…
Abstract Number: 1075 • 2012 ACR/ARHP Annual Meeting
Effects of siRNA Depletion of Interferon Regulatory Factor 5 On Pro-Inflammatory Cytokine Production and IgG Secretion by Primary Human Immune Cells in Response to TLR7/8 Stimulation
Dinesh Srinivasan¹, Sandip Panicker², Gang Lu³, Yajuan Gu³, Rothschild Soto², Seng-Lai Tan³ and Julie Demartino¹, ¹Inflammation Discovery, Hoffmann-La Roche, Nutley, NJ, ²Inflammation, Hoffmann La Roche, Nutley, NJ, ³Inflammation, Hoffmann-La Roche, Nutley, NJ
Background/Purpose: Interferon regulatory factor 5 (IRF5) has been identified as a genetic risk factor for multiple human autoimmune disorders, including systemic lupus erythematosus (SLE), rheumatoid…
Abstract Number: 17 • 2012 ACR/ARHP Annual Meeting
Synovial Overexpression of Wnt and Wnt-1-Induced Secreted Protein 1 Induces Cartilage Damage by Skewing of TGF-Beta Signaling and Reduction of the Anti-Hypertrophy Factor Sox9
Martijn H. van den Bosch¹, Arjen B. Blom¹, Peter L. van Lent², Henk M. van Beuningen¹, Fons A. van de Loo³, Esmeralda N. Blaney Davidson¹, Peter M. van der Kraan¹ and Wim B. van den Berg⁴, ¹Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research & Advanced Therpeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ³Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Although many osteoarthritis (OA) patients show significant synovial involvement, consequences are largely unknown. We found highly increased expression of canonical Wnts 2b and 16…

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