ACR Meeting Abstracts

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Abstracts tagged "sex hormones"

  • Abstract Number: 0050 • ACR Convergence 2024

    Elucidating Androgen Effects on Osteoclast Precursor Populations and Osteoclastogenesis

    Kiana Chen1, Lauren Benoodt2, Michael Christof3 and Homaira Rahimi4, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY, 3University of Rochester, Irvington, NY, 4University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a female predominant disease characterized by chronic inflammatory erosive joint disease. Androgen, the dominant sex hormone in males, is anti-inflammatory…
  • Abstract Number: 0981 • ACR Convergence 2024

    The Causal Effect of Sex Hormone-related Drugs on the Risk of Osteoarthritis – A Mendelian Randomization Study

    Xing Xing1, Ziyuan Shen2, Jianan Zhu3, Yining Wang2, Xingzhong Jin4 and Guoqi Cai2, 1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Baltimore, MD, 2Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China (People's Republic), 3Department of Biostatistics, School of Public Health, New York University, New York, NY, 4Centre for Big Data Research in Health, University of New South Wales, Sydney, Australia

    Background/Purpose: Osteoarthritis (OA) is a prevalent joint disorder characterized by joint pain, disability, and the loss of articular cartilage, imposing a significant burden on patients…
  • Abstract Number: 2544 • ACR Convergence 2024

    Spatial Transcriptomics Suggests Synovial Macrophage Niches Are Sexually Dimorphic in a Mouse Inflammatory Arthritis Model

    Richard Bell1, Ruoxi Yuan2, Mary Huang2, Ewurama Cann2, Chao Yang2, Franck Barrat1 and Lionel Ivashkiv1, 1Hospital for Special Surgery, New York, NY, 2HSS, New York, NY

    Background/Purpose: Monocytes and Macrophages (MФ) play a key pathogenic role in Rheumatoid Arthritis (RA), a disease that exhibits female sex bias. Recent work using scRNAseq…
  • Abstract Number: 0724 • ACR Convergence 2023

    Synovial Macrophage Subsets Defined by ScRNAseq Demonstrate Sexually Dimorphic Gene Expression in RA and a Mouse Inflammatory Arthritis Model

    Richard Bell, Ewurama Cann, Chao Yang, Accelerating Medicine Partnership Rheumatoid Arthritis, Amit Lakhanpal, Laura Donlin and Lionel Ivashkiv, Hospital for Special Surgery, New York, NY

    Background/Purpose: Macrophages (MФ) play a key pathogenic role in Rheumatoid Arthritis (RA), a disease that exhibits female sex bias. Recent work using scRNAseq has defined…
  • Abstract Number: 0910 • ACR Convergence 2023

    17β-estradiol and B-cell Intrinsic Type I Interferon Amplify Toll-like Receptor 7 Signaling Loop in B Cells of Female Lupus Prone BXD2 Mice

    Kathryn Sullivan, Yong Wang, Winn Chatham, John Mountz and Hui-chen Hsu, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: While systemic lupus erythematosus (SLE) disproportionally affects women versus men, elevation in estradiol (E2) alone is not sufficient to promote the development of autoantibody…
  • Abstract Number: 1357 • ACR Convergence 2023

    Systemic Lupus Erythematosus and Assisted Reproductive Technology: A Case Series and Systematic Literature Review

    Erinn Coe1, Emily Petrinec1 and Omer Pamuk2, 1Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH, 2Division of Rheumatology, Case Western Reserve University/University Hospitals, Cleveland, OH

    Background/Purpose: Systemic lupus erythematosus (SLE) is one of the most common autoimmune diseases in women of childbearing age and female sex hormones are known to…
  • Abstract Number: 1715 • ACR Convergence 2023

    Androgen Treatment Exhibits a Protective Role Against Focal Erosions in TNF-Induced Inflammatory Arthritis in Mice

    Kiana Chen1, Adelaide Weidner2, Olga Astapova2, Edward Schwarz2 and Homaira Rahimi2, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint inflammation and bone erosion and is female predominant. The TNF-transgenic (TNF-Tg) murine model of RA develops…
  • Abstract Number: 0048 • ACR Convergence 2022

    Combination of Repetitive Inhalant Endotoxin Exposure and Collagen-induced Arthritis Interact in a Testosterone-dependent Manner to Drive Inflammatory Lung Disease Processes and Arthritis Severity in Mice

    Elizabeth Ramler1, Ted Mikuls2, Geoffrey Thiele3, Amy Nelson3, Michael Duryee3, Rohit Gaurav3, Todd Wyatt1, Aaron Schwabb3, carlos hunter3, Bryant England3 and Jill Poole3, 1University of Nebraska Medical Center, Omaha, 2Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Respiratory-related diseases are among the most common causes of death in rheumatoid arthritis (RA). Although autoimmune diseases are reported in higher frequency in females,…
  • Abstract Number: 0052 • ACR Convergence 2022

    Elucidating Androgen Effects on Focal Erosions in TNF-Induced Inflammatory Arthritis

    Kiana Chen1, H. Mark Kenney2, Edward Schwarz1 and Homaira Rahimi3, 1University of Rochester Medical Center, Rochester, NY, 2University of Rochester Medical Center, Henrietta, NY, 3University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is characterized by chronic joint disease and is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA develops inflammatory-erosive arthritis and…
  • Abstract Number: 1904 • ACR Convergence 2022

    Is Treating Painful Hand Osteoarthritis with Hormone Replacement Therapy Feasible? Primary Results from a Randomised Controlled Trial in Post-menopausal Women

    Jennifer Williams1, Mae Chester-Jones1, Megan Goff2, Anne Francis1, Gretchen Brewer1, Ioana Marian1, Malvika Gulati1, Charles Mackworth-Young3, Victoria Glover4, Sarah Lamb1, Tonia Vincent5, Katy Vincent1, Susan Dutton1 and Fiona Watt6, 1University of Oxford, Oxford, United Kingdom, 2University of Oxford, London, United Kingdom, 3Imperial College Healthcare NHS Trust, London, United Kingdom, 4White Horse Medical Practice, Faringdon, United Kingdom, 5Kennedy Institute of Rheumatology, University of Oxford, Oxford, United Kingdom, 6Imperial College London, London, United Kingdom

    Background/Purpose: Hand osteoarthritis (OA) is more common in females and relative risk increases further around the age of menopause, potentially implicating sex hormone deficiency. There…
  • Abstract Number: 0580 • ACR Convergence 2021

    Association Between Female Reproductive Factors and Gout: A Nationwide Population-based Cohort Study of 1 Million Postmenopausal Women

    Yeonghee Eun1, In Young Kim2, Kyungdo Han3, Kyu Na Lee3, Dong-Yun Lee1, Dong Wook Shin1, Seonyoung Kang1, Seulkee Lee1, Hoon-Suk Cha1, Eun-Mi Koh1, Jaejoon Lee1 and Hyungjin Kim1, 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2National Police Hospital, Seoul, Republic of Korea, 3Soongsil University, Seoul, Republic of Korea

    Background/Purpose: Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the…
  • Abstract Number: 1052 • ACR Convergence 2021

    Female Reproductive Factors and Risk of Joint Replacement Arthroplasty of the Knee and Hip Due to Osteoarthritis in Postmenopausal Women: A Nationwide Cohort Study of 1.36 Million Women

    Yeonghee Eun1, Jung Eun Yoo2, Kyungdo Han3, Dahye Kim3, Jaejoon Lee1, Dong-Yun Lee1, Dae-Hee Lee1, Dong Wook Shin1 and Hyungjin Kim1, 1Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, 2Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea, 3Soongsil University, Seoul, Republic of Korea

    Background/Purpose: Previous studies of the relationships between female reproductive factors and osteoarthritis (OA) have shown conflicting results. In this study, we aimed to explore the…
  • Abstract Number: 1891 • ACR Convergence 2021

    Variable Effects of Testosterone on Male versus Female Derived Macrophages in Inflammatory Arthritis

    Kiana Chen1, Xi Lin1, Lianping Xing2, H. Mark Kenney3, Richard Bell4, Edward Schwarz5 and Homaira Rahimi5, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Webster, NY, 3University of Rochester Medical Center, Rochester, NY, 4Hospital for Special Surgery, New York, NY, 5University of Rochester, Rochester, NY

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that is female predominant. The TNF-transgenic (TNF-Tg) mouse model of RA also develops a sexually…
  • Abstract Number: 0299 • ACR Convergence 2021

    Sex Hormones and Risk of Sjögren’s Syndrome: Hypothesis Generating Findings Implicating Androgen and Estrogen Ratios

    Sara McCoy1, Christie Bartels2, Scott Hetzel1 and Jeffrey VanWormer3, 1University of Wisconsin, Madison, WI, 2University of Wisconsin School of Medicine and Public Health, Madison, WI, 3Marshfield Research Institute, Marshfield, WI

    Background/Purpose: Sjӧgren’s syndrome (SS) is the most female predominant systemic autoimmune disease, with peak onset around perimenopause. Estrogen appears to protect against SS, but prior…
  • Abstract Number: 0081 • ACR Convergence 2020

    Prevalence of Systemic Autoimmune Diseases in Polycystic Ovary Syndrome

    Saika Sharmeen1, Hafsa Nomani2, Erin Taub3 and Qingping Yao3, 1Stony Brook University Renaissance School of Medicine, Dix Hills, NY, 2Stony Brook University Renaissance School of Medicine, West Babylon, NY, 3Stony Brook University Renaissance School of Medicine, Stony Brook, NY

    Background/Purpose: Polycystic ovary syndrome (PCOS) is characterized by hormonal abnormality, chronic anovulation, hyperandrogenism, and obesity. Due to the hormonal imbalance, we hypothesize that patients with…
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