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Abstracts tagged "secukinumab"

  • Abstract Number: 0908 • ACR Convergence 2021

    Evaluation of the Nonsteroidal Anti-Inflammatory Drug-Sparing Effect of Secukinumab in Patients with Ankylosing Spondylitis: Multicenter, Randomised, Double-blind, Phase IV Study

    Uta Kiltz1, Xenofon Baraliakos1, Jan Brandt-Jrgens2, Ulf Wagner3, Sebastian Lieb4, Christian Sieder5, Christian Mann5 and Jürgen Braun1, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Rheumatologische Schwerpunktpraxis, Berlin, Germany, 3Universitätsklinikum Leipzig, Leipzig, Germany, 4Novartis Pharma GmbH, Immunology, Hepatology and Dermatology, Nürnberg, Germany, 5Novartis Pharma GmbH, Nürnberg, Germany

    Background/Purpose: Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat inflammatory back pain in patients (pts) with ankylosing spondylitis (AS). However, an increased risk of side…
  • Abstract Number: 1738 • ACR Convergence 2021

    Uveitis Status in Patients with Ankylosing Spondylitis or Psoriatic Arthritis Under Secukinumab Treatment – Real World Data from a German Observational Study

    Uta Kiltz1, Jan Brandt-Jrgens2, Peter Kästner3, Elke Riechers4, Daniel Peterlik5, Annika Boas6 and Hans-Peter Tony7, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Rheumatologische Schwerpunktpraxis, Berlin, Germany, 3Ambulantes Rheumazentrum Erfurt, Erfurt, Germany, 4Department for Rheumatology and Immunology, Hannover Medical University, Hannover, 5Novartis Pharma GmbH, Nürnberg, Germany, 6Novartis Pharma GmbH, Nuernberg, Germany, 7Universitätsklinikum Würzburg, Wuerzburg, Germany

    Background/Purpose: Uveitis is a well-known non-musculoskeletal manifestation of spondyloarthropathies. Patients typically suffer from blurred vision, pain, and photophobia and have an increased risk of ocular…
  • Abstract Number: 1832 • ACR Convergence 2021

    Secukinumab Therapy in Biologic-naïve vs. Biologic-experienced Patients: Real-world Effectiveness, Persistence and Safety Results from the Rheumatic Diseases Portuguese Registry

    Soraia Azevedo1, Jose Tavares-Costa2, Pedro Laires3, Salomé Garcia4, Patricia Nero5, Jorge Pestana6, Joana Martins-Martinho7, Ana Bento Silva8, Joana Rodrigues9, Graca Sequeira10, Emanuel Costa11, Filipe Cunha Santos12, Carolina Furtado13, Bernardo Santos14, Ana Raposo15, Liliana Saraiva16, Beatriz Samões17, Filipe Barcelos18, Maria José Santos6 and Helena Santos19, 1Unidade Local de Saude do Alto Minho, Ponte de lima, Portugal, 2Rheumatology Department - Unidade Local de Saude do Alto Minho, Ponte de Lima, Portugal, 3Novartis Portugal / ENSP – NOVA University of Lisbon, Lisbon, Portugal, 4Rheumatology Department, Centro Hospitalar Universitário de São João EPE, Porto, Portugal, 5CUF, TELHEIRAS, Portugal, 6Rheumatology Department, Hospital Garcia de Orta, Almada, Portugal, 7Centro Hospitalar Universitario Lisboa Norte, Lisboa, Portugal, 8Rheumatology Department, Hospital de Egas Moniz, Centro Hospitalar Lisboa Ocidental, Lisbon, Portugal, 9Rheumatology Department, ULSAM, Ponte de Lima, Portugal, 10Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, 11Hospital de Braga, Braga, Portugal, 12Rheumatology Department, Local Health Unit of Guarda, Guarda, Portugal, 13Rheumatology Department, Hospital do Divino Espírito Santo de Ponta Delgada, Ponta Delgada, Portugal, 14Rheumatology Department, Centro Hospitalar do Baixo Vouga, Aveiro, Portugal, 15Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real, Portugal, 16Rheumatology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal, 17Rheumatology Department, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal, 18Instituto Português de Reumatologia, Lisbon, Portugal, 19Portuguese Institute of Rheumatology, Lisbon, Portugal

    Background/Purpose: Secukinumab has demonstrated to be efficacious for both psoriatic arthritis (PsA) and ankylosing spondylitis (AS): PASI, ACR and ASAS magnitudes of response have generally…
  • Abstract Number: 934 • 2019 ACR/ARP Annual Meeting

    Predictors of Survival of Secukinumab Treatment in a Multicenter Cohort of 556 Spondylarthritis

    Benoit Flachaire1, Jean-Guillaume Letarouilly 2, Céline Labadie 3, Nicolas Cohen 4, Vincent Pradel 5, Jérémie Sellam 6, Pascal Richette 7, Philippe Dieudé 8, Pascal Claudepierre 9, Bruno Fautrel 10, Eric Houvenagel 11, Chi Duc Nguyen 12, Marie-Hélène Guyot 13, Nicolas Segaud 14, Frédéric Maury 15, Laurent Marguerie 16, Xavier Deprez 17, Jean-Hugues Salmon 18, Guy Baudens 19, Elisabeth Gervais 20, Corinne Miceli-Richard 21, Isabelle Chary-Valckenaere 22, Pierre Lafforgue 23, Damien Loeuille 24, Christophe Richez 25, René-Marc Flipo 26 and Thao Pham 23, 1Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, Provence-Alpes-Cote d'Azur, France, 2University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, Nord-Pas-de-Calais, France, 3Bordeaux University, CHU Bordeaux, department of Rheumatology, 33,000 Bordeaux, France, Bordeaux, Aquitaine, France, 4APHM -Assistance publique des hôpitaux de Marseille, Marseille, France, 5APHM -Assistance publique des hôpitaux de Marseille, Marseille, Finland, 6Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, 7Department of Rheumatology, AP-HP Lariboisiere Hospital, Paris, France, 8Rheumatology, Bichat Hospital, APHP, Paris;, Paris, France, 9Rheumatology, CHU Henri Mondor Créteil, Paris, France, 10Pitié-Salpêtrière Hospital, Department of Rheumatology, AP-HP, Sorbonne University, UPMC university, Paris, Ile-de-France, France, 11Rheumatology, Saint Philibert Hospital, Lille Cathololic Institute, Lomme, Lomme, France, 12Rheumatology, Hospital of Béthune, Béthune, Béthune, France, 13Rheumatology, Hospital of Roubaix, Roubaix, Roubaix, France, 14Internal Medicine, Hospital of Armentières, Armentières, Armentières, France, 15Rheumatology, Private Practice, Beuvry, Beuvry, France, 16Rheumatology, Calot Institute, Berck, Berck-sur-Mer, 17Rheumatology, Hospital of Valenciennes, Valenciennes, Valenciennes, France, 18Rheumatology, Reims University Hospital, Reims, Reims, France, 19Rheumatology, Private Practice, Valenciennes, Valenciennes, France, 20CHU de Poitiers, Rheumatology, Poitiers, France, 21Paris Descartes University, Department of Rheumatology - Hôpital Cochin, Assistance Publique - Hôpitaux de Paris, Paris, France, 22Centre Hospitalier Universitaire de Nancy, VANDOEUVRE, France, 23Aix-Marseille University, CHU Marseille, department of Rheumatology, 13,000 Marseille, France, Marseille, France, 24Rheumatology, Nancy University Hospital and and UMR 7365 CNRS-UL IMoPA, Université de Lorraine, VANDOEUVRE, France, 25Pellegrin Hospital, University Hospital of Bordeaux, Bordeaux, France, 26University of Lille, CHU Lille, department of rheumatology, 59,000 Lille, France, Lille, France

    Background/Purpose: Secukinumab (SEC) is an interleukin-17 inhibitor used to treat patients with axial spondylarthritis (axSpA) and psoriatic arthritis (PsA). Drug survival is often used as…
  • Abstract Number: 1494 • 2019 ACR/ARP Annual Meeting

    Guselkumab Was More Effective Than Secukinumab in Patients with Plaque Psoriasis and the Subset of Patients with Self-Reported Psoriatic Arthritis in a Randomized, Double-blind, Head-to-head Comparison Study over 1 Year

    Joseph Merola1, Shu Li 2, Ming-Chun Hsu 2, Chetan Karyekar 3, Susan Flavin 2, Bruce Randazzo 4 and Laura Coates 5, 1Brigham and Women's Hospital, Harvard Med School, Boston, MA, 2Janssen Research & Development, LLC, Spring House, PA, 3Janssen Global Services, LLC, Horsham, PA, 4Janssen Research & Development, LLC/University of Pennsylvania, Spring House/Philadelphia, PA, 5University of Oxford, Oxford, United Kingdom

    Background/Purpose: Guselkumab (GUS, an antibody against IL-23) and secukinumab (SEC, an antibody against IL-17A) are both approved for the treatment of psoriasis (PsO). Up to…
  • Abstract Number: 1498 • 2019 ACR/ARP Annual Meeting

    A Randomized, Placebo-Controlled Study Evaluating the Safety and Efficacy of Secukinumab in US Biologic-Naive Patients with Active Psoriatic Arthritis and Psoriatic Skin Lesions

    Tien Nguyen1, Melvin Churchill 2, Robert Levin 3, Guillermo Valenzuela 4, Joseph Merola 5, Alexis Ogdie 6, Ana-Maria Orbai 7, Jose Scher 8, Arthur Kavanaugh 9, Shital Agawane 10, Farid Kianifard 11, Chauncy Rollins 11 and Olivier Chambenoit 11, 1Department of Dermatology, University of California, Irvine, Irvine, CA, 2Arthritis Center of Nebraska, Lincoln, NE, 3Clinical Research of West Florida, Inc and University of South Florida, Clearwater/Tampa, FL, 4Integral Rheumatology & Immunology Specialists, Plantation, FL, 5Harvard Medical School, Brigham and Women’s Hospital, Boston, MA, 6Department of Medicine and Rheumatology and Department of Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 7Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 8Division of Rheumatology, New York University School of Medicine and NYU Langone Orthopedic Hospital, New York, NY, 9University of California, San Diego School of Medicine, La Jolla, CA, 10Novartis Healthcare Pvt Ltd, Hyderabad, India, 11Novartis Pharmaceuticals Corporation, East Hanover, NJ

    Background/Purpose: Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that often develops in patients (pts) with psoriasis. Secukinumab (SEC) inhibits IL-17A, a key inflammatory cytokine…
  • Abstract Number: 1553 • 2019 ACR/ARP Annual Meeting

    Impact of Peripheral Swollen and Tender Joints at Baseline on Response to Treatment with Secukinumab in Ankylosing Spondylitis

    Philip Mease1, Atul Deodhar 2, Renato Calheiros 3, Xiangyi Meng 3, Todd Fox 4 and Xenofon Baraliakos 5, 1Swedish Medical Center/Providence St Joseph Health, and University of Washington, Seattle, WA, 2Oregon Health & Science University, Portland, OR, 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, 4Novartis Pharma AG, Basel, Switzerland, 5Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany

    Background/Purpose: AS is a chronic, inflammatory disease of the axial skeleton associated with pain, stiffness, disability, and reduced quality of life (QOL).1 AS is defined…
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