ACR Meeting Abstracts

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Abstracts tagged "Scleroderma"

  • Abstract Number: 2464 • ACR Convergence 2024

    Thymic Size Longitudinal Changes on Chest High-resolution Computed Tomography After Autologous Hematopoietic Stem Cell Transplantation for Diffuse Cutaneous Systemic Sclerosis

    Grégory Pugnet1, Samia Collot2, Antoine Petermann3, Pauline Lansiaux4, Gwenaelle Larion4, Mathieu Resche-rigon4, Cécile Borel5, Zora Marjanovic6 and Dominique Farge4, 1Toulouse Rangueil University Hospital, Toulouse, France, 2CHU Toulouse, Toulouse, France, 3Clinique Pasteur, Toulouse, France, 4APHP, PAris, France, 5IUCT, Toulouse, France, 6APHP, Toulouse, France

    Background/Purpose: The thymus is a central lymphatic organ responsible for T-cell differentiation and maturation throughout life. The thymus reaches its maximum absolute weight at puberty,…
  • Abstract Number: 0614 • ACR Convergence 2023

    Self-Reported Sexual Dysfunction and Perceptions of Rheumatologist Engagement on This Issue in Patients with Systemic Sclerosis

    Liza Morales1, Robert Spiera2, Jessica Gordon1, Deanna Jannat-Khah1 and Kimberly Lakin1, 1Hospital for Special Surgery, New York, NY, 2Hosptial for Special Surgery, New York, NY

    Background/Purpose: Few studies have investigated the prevalence and risk factors of sexual dysfunction among individuals with systemic sclerosis (SSc). The purpose of this study is…
  • Abstract Number: 0655 • ACR Convergence 2023

    A Novel Association Between Lipodermatosclerosis and Key Vascular Outcomes in Systemic Sclerosis

    Srijana Davuluri1, Puneet Kapoor2, Swarna Nandyala2, David Fiorentino3, Julia Simard4 and Lorinda Chung5, 1Stanford University- School of Medicine, Sunnyvale, CA, 2Stanford University- School of Medicine, Palo Alto, CA, 3Department of Dermatology, Stanford University, Redwood City, CA, 4Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, 5Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Woodside, CA

    Background/Purpose: Lipodermatosclerosis (LDS) is a progressive manifestation of chronic venous insufficiency characterized by distinctive lower extremity changes, including an "inverted champagne bottle" appearance, skin hyperpigmentation,…
  • Abstract Number: 0955 • ACR Convergence 2023

    GRB2 Serves as a Viable Target Against Skin Fibrosis in Systemic Sclerosis by Regulating Endothelial Cell Apoptosis

    Yan Huang, Han Zhao, Xiangguang Shi, Jing Liu, Jui-Ming Lin, Qianqian Ma, Shuai Jiang, Weilin Pu, Yanyun Ma, Jianlan Liu, Wenyu Wu, Jiucun Wang and Qingmei Liu, Shanghai, Shanghai, China

    Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune disease characterized by vascular and immune system dysfunction, along with tissue fibrosis. Vascular damage has been recognized as…
  • Abstract Number: 1661 • ACR Convergence 2023

    Spatial Transcriptional Alterations in the Cellular Landscape of Pediatric Scleroderma Skin

    Kathryn Torok1, Ying-Ju Lai2, Zhongli Xu3, Anwesha Sanyal3, Giffin Werner3, Theresa Hutchins3, Claire Cheng3 and Wei Chen3, 1University of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA, 2University of Pittbsurgh, Pittsburgh, PA, 3University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Recent single-cell RNA sequencing (scRNA seq) data has been generated across several tissues in autoimmune diseases, helping to understand the cellular and molecular underpinnings…
  • Abstract Number: 0616 • ACR Convergence 2023

    Does Systemic Sclerosis Affect the Interpretation of Mammograms? A Retrospective Cohort Study

    Lea Meir1, Tegveer Sandhu2, Weiwei Chi2 and Gabriela Santiago2, 1Icahn School of Medicine, New York, NY, 2Icahn School of Medicine at Mount Sinai, New York, NY

    Background/Purpose: Systemic Sclerosis is an autoimmune disorder marked by thickened and hardened skin. Cutaneous cutis, the deposition of insoluble calcium salts in the skin and…
  • Abstract Number: 0658 • ACR Convergence 2023

    Evaluating the Associations Between Autonomic Dysfunction, Clinical Phenotype and Gastrointestinal Transit in Patients with Systemic Sclerosis

    Maria Paula Alvarez Hernandez1, Brittany Adler2, Jamie Perin3, Michael Hughes4 and Zsuzsanna McMahan5, 1Hospital Clinico San Carlos, Madrid, Spain, 2Johns Hopkins University, Baltimore, MD, 3Johns Hopkins University School of Medicine, Baltimore, MD, 4Northern Care Alliance NHS Foundation Trust, Salford Care Organisation, Salford, United Kingdom, 5Johns Hopkins Rheumatology, Lutherville, MD

    Background/Purpose: The gastrointestinal (GI) tract is the second most commonly impacted organ in systemic sclerosis (SSc). However, the pathogenesis and clinical expression of GI involvement…
  • Abstract Number: 0957 • ACR Convergence 2023

    Rationale for Targeting Insulin-like Growth Factor Signalling in Systemic Sclerosis

    Voon Ong1, Shiwen Xu2, Li Xue2, Brajesh Kumar3 and Christopher Denton2, 1UCL Medical School Royal Free Campus, London, United Kingdom, 2University College London, London, United Kingdom, 3Horizon Therapeutics, South San Francisco, CA

    Background/Purpose: Previous studies have shown that insulin like growth factor (IGF) pathways may promote extracellular matrix deposition and be upregulated in systemic sclerosis (SSc). Teprotumumab,…
  • Abstract Number: 1666 • ACR Convergence 2023

    TNF-mediated Pulmonary Hypertension Is Marked by Aberrant Bone Morphogenic Protein (BMP) and Integrin/Basement Membrane Ligand-Receptor Signaling

    Javier Rangel-Moreno1, Maria de la Luz Garcia-Hernandez2, Qingfu Xu3 and Benjamin Korman1, 1University of Rochester, Rochester, NY, 2University of Rochester, West Henrietta, NY, 3University of Rochester Medical Center, Rochester, NY

    Background/Purpose: : We recently described TNF-transgenic mice as a novel model of pulmonary hypertension (PH) and have shown that they express altered endothelial and mesenchymal…
  • Abstract Number: 0621 • ACR Convergence 2023

    Scleroderma Renal Crisis: A Large Single-center Experience

    Rushab Shah1, laura ross2, Kathleen Morrisroe3, Wendy Stevens4 and Mandana Nikpour5, 1St Vincent's Hospital Melbourne/ Alfred Hospital, Melbourne, Australia, 2St. Vincent's Hospital Melbourne, Fitzroy, Australia, 3The University of Melbourne at St Vincent’s Hospital Melbourne, Fitzroy, Australia, 4Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Australia, 5The University of Melbourne at St. Vincent’s Hospital Melbourne, Departments of Medicine and Rheumatology, Melbourne, Australia

    Background/Purpose: Scleroderma renal crisis (SRC) is a life-threatening vascular manifestation of systemic sclerosis (SSc) occurring in up to 5% of SSc patients. This condition continues…
  • Abstract Number: 0661 • ACR Convergence 2023

    Assessment of Systemic Sclerosis-Associated Myocarditis: A Single Center Case Series Study

    Nafsika Gerolymatou1, NIck Koletsos1, Aliki Venetsanopoulou2, Anastasia Giantsouli3, Sophie Mavrogeni4 and PARASKEVI VOULGARI5, 1Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, 2Medical School of Ioannina, Ioannina, Greece, 3Radiology Department, University Hospital of Ioannina, Ioannina, Greece, 4Department of Cardiology, Onassis Cardiac Surgery Center, Athens, Greece, 5Rheumatology Clinic, Department of Internal Medicine, University of Ioannina, Ioannina, Greece

    Background/Purpose: Myocardial involvement is a significant contributor to mortality in patients with Systemic Sclerosis (SSc). The objective of this study was to analyze the clinical…
  • Abstract Number: 0961 • ACR Convergence 2023

    Transcriptomic Analysis of Scleroderma Monocytes Identifies Distinct Clinically Relevant Clusters and Novel Genes Associated with Disease Complications

    Mehmed Dinc1, Fatima El Adili2, Justin Lui3, Giovanni Ligresti3, Robert Lafyatis4, Maria Trojanowska3 and Andreea Bujor3, 1Boston University School of Medicine, Boston, MA, 2Boston University School of Medicine, Revere, MA, 3Boston University, Boston, MA, 4University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by skin and internal organ fibrosis, vascular abnormalities, and immunological disturbances. Monocytes play a critical role…
  • Abstract Number: 1871 • ACR Convergence 2023

    Utility of Infrared Thermography in Patients with Digital Gangrene

    Nidhish Chandra M, Puneet Kumar, Urmila Dhakad, Shweta Bhardwaj, Sanjay Pruthviraj Buddha, Parag Vijayvergia and Lily Singh, King George Medical University, Lucknow, India

    Background/Purpose: Digital gangrene has been described as a complication of several Autoimmune Inflammatory Rheumatic Diseases(AIIRD). Due to multiple underlying mechanisms causing digital gangrene in AIIRD…
  • Abstract Number: 0622 • ACR Convergence 2023

    The Effectiveness of Breath-holding Test to Predict Pulmonary Function in Systemic Sclerosis Patients Using Machine Learning Model

    Jina Yeo1, Min Hyuk Lim2, Ju Yeon Kim3, Ji In Jung4, Saram Lee2 and Eun Bong Lee3, 1Division of Rheumatology, Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, South Korea, 2Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, South Korea, 3Seoul National University Hospital, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose: Pulmonary involvement is major causes of mortality in patients with systemic sclerosis (SSc). The breath-holding test (BHT), rapid bedside test, is a useful surrogate…
  • Abstract Number: 0665 • ACR Convergence 2023

    A Descriptive Study of Disease Characterisics of SSc Patients with the U2RNP Autoantibody

    Mridula Dilip1, Maureen Laffoon2, Yongseok Park3, Robert Lafyatis4, Thomas Medsger5, Virginia Steen6, Leigh Freno2 and Robyn Domsic4, 1University of Pittsburgh School of Medicine, Pittsburgh, PA, 2University of Pittsburgh Medical Center, Pittsburgh, PA, 3University of Pittsburgh School of Public Health, Pittsburgh, PA, 4University of Pittsburgh, Pittsburgh, PA, 5University of Pittsburgh School of Medicine, Verona, PA, 6Georgetown University School of Medicine, Washington, DC

    Background/Purpose: U2RNP is a spliceosome-associated autoantibody that has in prior case reports presented with scleroderma with myositis (SSc/PM)and SLE overlap. Autoantibodies are growing in prognostic…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. Academic institutions, private organizations and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part a scientific presentation or presentation of additional new information that will be available at the time of the meeting) is under embargo until Saturday, November 11, 2023.

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying financial and other sponsors about this policy. If you have questions about the abstract embargo policy, please contact the public relations department at [email protected].

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