Abstracts tagged "Scleroderma"

Abstract Number: 709 • 2012 ACR/ARHP Annual Meeting
Fingertip Skin Hardness in Limited Scleroderma: Durometry versus Manual Assessment
Thomas Osborn¹, Eric L. Matteson¹, Floranne Ernste², Cynthia S. Crowson³, Deana D. Hoganson⁴ and Irene Z. Whitt⁵, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Division of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ³Department of Health Sciences Research, Mayo Clinic, Rochester, MN, ⁴Rheumatology, Mercy Arthritis and Osteoporosis Center, Urbandale, IA, ⁵NIH/NIEHS/Environmental Autoimmunity Group, Bethesda, MD
Background/Purpose: Skin manifestations of scleroderma involve the digits in nearly all patients. Assessment of change at the level of digital skin involvement is difficult. The Modified…
Abstract Number: L14 • 2012 ACR/ARHP Annual Meeting
Treatment of Diffuse Systemic Sclerosis Patients with Anti-Transforming Growth Factor-Beta, Fresolimumab, Inhibits Transforming Growth Factor-Beta-Regulated Gene Expression in Skin and Is Associated with a Rapid Decline in Skin Score
Robert Lafyatis¹, Sashidhar Nakerakanti², Allison Mathes², Cristina Padilla², Sarah McLaughlin³, Michael R. York², Giuseppina Farina⁴, Romy Christmann¹, Richard P. Polisson⁵ and Robert W. Simms¹, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Division of Rheumatology, Boston University Medical Center, Boston, MA, ⁴Arthritis center, Boston University, Boston, MA, ⁵Sanofi-Aventis US, Cambridge, MA
Background/Purpose: Transforming growth factor-beta (TGFb) has long been suspected to mediate fibrotic signals in systemic sclerosis (SSc) as it potently stimulates collagen deposition in vitro,…

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