Abstracts tagged "scleroderma and systemic sclerosis"

Abstract Number: 720 • 2012 ACR/ARHP Annual Meeting
Left-Heart Disease Is a Frequent Cause of Pulmonary Hypertension in Systemic Sclerosis, Is Associated with Increased Levels of MR-ProANP and MR-ProADM but Is Unrelated to Elevated NT-ProBNP Levels: A Retrospective Cohort Analysis
Lada Miller¹, Sandra Chartrand¹, Martial Koenig², Jean-Richard Goulet³, Eric Rich¹, Michal Abrahamowicz⁴, Jean-Luc Senécal¹ and Tamara Grodzicky¹, ¹Rheumatology, Hôpital Notre-Dame du CHUM, Montreal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ⁴Centre Universitaire de Santé McGill (CUSM), Montreal, QC, Canada
Background/Purpose: Pulmonary hypertension (PH) is a significant cause of morbidity and mortality in systemic sclerosis (SSc). Pulmonary arterial hypertension (PAH) is reportedly the most frequent…
Abstract Number: 721 • 2012 ACR/ARHP Annual Meeting
Measurement of Pulmonary Arteries by Cardiac Magnetic Resonance Imaging: A Simple and Useful Tool for the Detection of Pulmonary Hypertension in Systemic Sclerosis Patients without Overt Cardiac Microvascular Perfusion Defects or Fibrosis
Sandra Chartrand¹, Lada Miller¹, Martial Koenig², Jean-Richard Goulet¹, Eric Rich¹, Anne S. Chin³, Yves Provost³, Carl Chartrand-Lefebvre³, Pauline Gou¹, Jean-Luc Senécal¹ and Tamara Grodzicky¹, ¹Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Radiology, Hôtel-Dieu de Montréal du CHUM, Montréal, QC, Canada
Background/Purpose: Pulmonary hypertension (PH) is a major complication of systemic sclerosis (SSc). We observed that a significant proportion of our SSc patients with PH as…
Abstract Number: 710 • 2012 ACR/ARHP Annual Meeting
Optical Density Measure of the Papillary Dermis Discriminates As Abnormal Clinically Uninvolved Skin in Systemic Sclerosis and Correlates with Severity of Skin Thickness
Giuseppina Abignano¹, Sibel Z. Aydin², Concepcion Castillo-Gallego³, Daniel Woods⁴, Adam Meekings⁵, Dennis McGonagle⁶, Paul Emery⁷ and Francesco Del Galdo⁸, ¹Chapel Allerton Hospital Leeds Insitute of Molecular medicine, Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ²Unit of Rheumatology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey, ³Rheumatology, Hospital La Paz - IdiPaz, Madrid, Spain, ⁴Michelson Diagnostics Ltd, Kent, United Kingdom, ⁵Michelson Diagnostics Ltd, Kent, United Kingdom, Kent, United Kingdom, ⁶Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ⁷Division of Rheumatic and Musculoskeletal Disease, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom, ⁸Musculoskeletal Diseases, University of Leeds, Leeds Institute of Molecular Medicine and LMBRU, Leeds, United Kingdom
Background/Purpose: Skin involvement in systemic sclerosis (SSc) is often primary outcome in clinical trials and its severity inversely correlates with prognosis. Nevertheless, an objective quantitative…
Abstract Number: 92 • 2012 ACR/ARHP Annual Meeting
Combined Response Index in Diffuse Systemic Sclerosis (CRISS)—Which External Anchors to Use When Developing the Index? Baseline Analysis
Dinesh Khanna¹, Veronica Berrocal², James R. Seibold³, Peter A. Merkel⁴, Maureen D. Mayes⁵, Kristine Phillips⁶, Robert W. Simms⁷, Shervin Assassi⁵, Philip J. Clements⁸ and Daniel Furst⁹, ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, University of Michigan, Ann Arbor, MI, ³Scleroderma Research Consultants LLC, Avon, CT, ⁴University of Pennsylvania, Philadelphia, PA, ⁵Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ⁶Rheumatology, University of Michigan, Ann Arbor, MI, ⁷Rheumatology, Boston University School of Medicine, Boston, MA, ⁸University of California, Los Angeles, Department of Medicine, Los Angeles, CA, ⁹Div of Rheumatology, UCLA Medical School, Los Angeles, CA
Background/Purpose: As part of an NIH sponsored effort to develop a data-driven CRISS, we evaluated the face, content, and construct validity (convergent and discriminant) of…
Abstract Number: L3 • 2012 ACR/ARHP Annual Meeting
Classification Criteria for Systemic Sclerosis: Preliminary Results
Janet E. Pope¹, Dinesh Khanna², Jaap Fransen³, Sindhu R. Johnson⁴, Murray Baron⁵, Alan G. Tyndall⁶, Marco Matucci-Cerinic⁷, Raymond P. Naden⁸, Frank H.J. van den Hoogen⁹ and ACR/EULAR Classification Criteria for Systemic Sclerosis¹⁰, ¹Medicine/Rheumatology, St. Joseph Health Care London, University of Western Ontario, London, ON, Canada, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Dept of Rheumatology, Toronto Western and Mt. Sinai Hospitals, University of Toronto, Toronto, ON, Canada, ⁵Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁶Rheumatology, University of Basel, Basel, Switzerland, ⁷Department of Biomedicine & Division of Rheumatology AOUC, University of Florence, Florence, Italy, ⁸Auckland City Hospital, Auckland, New Zealand, Austria, ⁹Rheumatology, Rheumatology Centre Sint Maartenskliniek and Radboud university medical center, Ubbergen (Nijmegen), Netherlands, ¹⁰Janet Pope, London, ON, Canada
Background/Purpose: The existing 1980 classification criteria for systemic sclerosis (SSc) are suboptimal for patients with early SSc and some patients with limited cutaneous SSc (lcSSc)…
Abstract Number: 2422 • 2012 ACR/ARHP Annual Meeting
Sexual Activity and Sexual Functioning Among Women with Systemic Sclerosis Compared to Women From a Population Sample
Brooke Levis¹, Andrea Burri², Marie Hudson³, Murray Baron⁴ and Brett D. Thombs⁵, ¹Epidemiology, McGill University, Montreal, QC, Canada, ²Twin Research and Genetic Epidemiology, King's College, London, United Kingdom, ³Jewish General Hospital, McGill University, Montreal, QC, Canada, ⁴Pavillion A, Rm 216, Lady David Institute for Medical Research and Jewish General Hospital, Montreal, QC, Canada, ⁵Psychiatry, McGill University, Montreal, QC, Canada
Background/Purpose: Systemic sclerosis (SSc), or scleroderma, is a chronic, multi-system, connective tissue disorder characterized by thickening and fibrosis of the skin and internal organ involvement.…
Abstract Number: 2303 • 2012 ACR/ARHP Annual Meeting
Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study
Lara Bossini-Castillo¹, Jose Ezequiel Martin², Carmen Pilar Simeon³, Lorenzo Beretta⁴, Olga Y. Gorlova⁵, Madelon C. Vonk⁶, Patricia Carreira⁷, the Spanish Scleroderma Group⁸, Annemie Schuerwegh⁹, Alexandre Voskuyl¹⁰, Anna-Maria Hoffmann-Vold¹¹, Roger Hesselstrand¹², Annika Nordin¹³, Claudio Lunardi¹⁴, Jaap Van Laar¹⁵, Paul Shiels¹⁶, Ariane Herrick¹⁷, Jane Worthington¹⁸, Carmen Fonseca¹⁹, Christopher P. Denton¹⁹, Shervin Assassi²⁰, Bobby P.C. Koeleman²¹, Maureen D. Mayes²², T.R.D.J. Radstake²³ and Javier Martin¹, ¹Immunology, Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, ²Immunology, Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, ³Servicio de Medicina Interna, Hospital Valle de Hebron, Barcelona, Spain, ⁴Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ⁵Department of Epidemiology, UT M. D. Anderson Cancer Center, Houston, TX, ⁶Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁷Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ⁸Granada, Spain, ⁹Leids Univ Medisch Centrum, Leiden, Netherlands, ¹⁰Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ¹¹Rheumatology, Oslo University Hospital, Oslo, Norway, ¹²Rheumatology, Lund University, Lund, Sweden, ¹³Department of Rheumatology, Karolinska Institute, Stockholm, Sweden, ¹⁴Department of Medicine, Università degli Studi di Verona, Verona, Italy, ¹⁵Rheumatology, Leiden University Hospital, Leiden, Netherlands, ¹⁶University of Glasgow, Glasgow, United Kingdom, ¹⁷Musculoskeletal Research Group, University of Manchester, Salford, United Kingdom, ¹⁸Arthritis Research UK Epidemiology Unit, Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester, United Kingdom, ¹⁹Centre for Rheumatology, Royal Free and University College Medical School, London, United Kingdom, ²⁰Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²¹Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands, ²²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ²³Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands
Background/Purpose: Systemic sclerosis or scleroderma (SSc) is a complex autoimmune disorder that affects the connective tissue causing fibrosis in the skin and different internal organs.…
Abstract Number: 2295 • 2012 ACR/ARHP Annual Meeting
Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells in Vitro
Zhaodong Li¹, Peter J. Wermuth², Bryan Benn², Michael P. Lisanti³ and Sergio A. Jimenez², ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, ³Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Recent studies demonstrated that the phenotypic transition of endothelial cells (EC) into activated mesenchymal cells, a process known an endothelial-to-mesenchymal transition (EndoMT), may be…
Abstract Number: 1805 • 2012 ACR/ARHP Annual Meeting
The Pro-Fibrotic Cytokines IL-33 and IL-13 Modulates Dermal Fibrosis Via the A2A Adenosine Receptor
Ross C. Radusky¹, Jessica L. Feig², Bruce N. Cronstein³, Andrew G. Franks Jr.⁴ and Edwin SL Chan¹, ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine. Department of Translational Medicine, New York University School of Medicine, New York, NY, ³Internal Medicine, NYU School of Medicine, Division of Rheumatology, New York, NY, ⁴Dermatology & Medicine (Rheumatology), New York University, New York, NY
Background/Purpose: We have previously demonstrated that the nucleoside adenosine mediates collagen production and induce dermal fibrosis in in vitro and in vivo models. IL–13 expression…

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