ACR Meeting Abstracts

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Abstracts tagged "scleroderma and systemic sclerosis"

  • Abstract Number: 1878 • 2018 ACR/ARHP Annual Meeting

    Immunosuppression in Diffuse Systemic Sclerosis Improves Outcomes Using a Novel Composite Response Index

    Boyang Zheng1, Mianbo Wang2 and Murray Baron3, 1Rheumatology, McGill University Health Center (MUHC), Montreal, QC, Canada, 2Lady Davis Institute for Medical Research, Montreal, QC, Canada, 3Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada

    Background/Purpose: Diffuse systemic sclerosis (dcSSc) is a devastating multi-organ disease where the mainstay of treatment is immunosuppression. Data on these therapies are mostly based on…
  • Abstract Number: 1879 • 2018 ACR/ARHP Annual Meeting

    The Effects of Riociguat on Raynaud’s Phenomenon and Digital Ulcers in Patients with Diffuse Systemic Sclerosis: Results from the Phase IIb RISE-SSc Study

    Dinesh Khanna1, Yannick Allanore2, Christopher P. Denton3, Masataka Kuwana4, Marco Matucci-Cerinic5, Janet E. Pope6, Janethe Pena7, Kaisa Laapas8, Zhen Yao9 and Oliver Distler10, 1Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI, 2Rheumatology A Department, Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris, France, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 5Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 6Department of Medicine, University of Western Ontario, London, ON, Canada, 7Clinical Development, Bayer US LLC, Whippany, NJ, 8StatFinn Oy, Espoo, Finland, 9Bayer AG, Berlin, Germany, 10Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland

    Background/Purpose: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of pulmonary arterial hypertension associated with connective tissue disease. It was anticipated that…
  • Abstract Number: 814 • 2018 ACR/ARHP Annual Meeting

    NON Diffuse SSc, Peripheral Neuropathy, Concomitant Sjogren Syndrome and ANTI-RNA Polymerase III Represent Risk Factors for the Higher Frequency of Cancer in a Large Single Cohort of Patients with Systemic Sclerosis

    Ana Paula Luppino-Assad1, Adriana Bortoluzzo2, Henrique Carriço da Silva3, Danieli Andrade4 and Percival Sampaio-Barros4, 1Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., sao paulo, Brazil, 2c Instituto Insper de Educação e Pesquisa, São Paulo, SP, Brasil, sao paulo, Brazil, 3Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., SAO PAULO, Brazil, 4Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, Brazil

    Background/Purpose: A higher prevalence of cancer has been described in patients with systemic sclerosis (SSc), but the magnitude of this risk and the type of…
  • Abstract Number: 903 • 2018 ACR/ARHP Annual Meeting

    Riociguat in Patients with Early Diffuse Cutaneous Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Phase IIb Study (RISE-SSc)

    Oliver Distler1, Yannick Allanore2, Christopher P. Denton3, Masataka Kuwana4, Marco Matucci-Cerinic5, Janet E. Pope6, Janethe Pena7, Kaisa Laapas8, Zhen Yao9 and Dinesh Khanna10, 1Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Rheumatology A Department, Cochin Hospital, Paris Descartes University, Sorbonne Paris Cité, Paris, France, 3UCL Division of Medicine, Royal Free Campus, London, United Kingdom, 4Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo, Japan, 5Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy, 6Department of Medicine, University of Western Ontario, London, ON, Canada, 7Clinical Development, Bayer US LLC, Whippany, NJ, 8StatFinn Oy, Espoo, Finland, 9Bayer Healthcare Co. Ltd.,, Beijing, China, 10Division of Rheumatology, Department of Internal Medicine, University of Michigan Scleroderma Program, University of Michigan, Ann Arbor, MI

    Background/Purpose: There are few disease-modifying therapies for the treatment of systemic sclerosis (SSc), particularly the more severe diffuse cutaneous form (dcSSc). The soluble guanylate cyclase…
  • Abstract Number: 1108 • 2018 ACR/ARHP Annual Meeting

    Antibody Repertoire Dynamics in Systemic Sclerosis after Myeloablative Autologous Hematopoietic Stem-Cell Transplantation or Cyclophosphamide Treatment

    Julia Z. Adamska1,2, Leslie Crofford3, Daniel E. Furst4,5, Ellen Goldmuntz6, Lynette Keyes-Elstein7, Maureen D. Mayes8, Peter McSweeney9, Richard Nash9, Ashley Pinckney10, Beverly Welch11, Keith Sullivan12 and William H. Robinson1,2, 1Stanford University, Stanford, CA, 2VA Palo Alto Health Care System, Palo Alto, CA, 3Division of Rheumatology and Immunology, Vanderbilt University Medical Center, Nashville, TN, 4University of California Los Angeles, Los Angeles, CA, 5University of Washington, Seattle, WA, 6NIAID, NIH, Bethesda, MD, 7Clinical Statistics, Rho Federal Systems, Inc., Chapel Hill, NC, 8Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9Colorado Blood Cancer Institute, Denver, CO, 10Rho Federal Systems, Inc., Chapel Hill, NC, 11National Institutes of Health, Bethesda, MD, 12Duke University Medical Center, Durham, NC

    Background/Purpose: Myeloablative autologous hematopoietic stem-cell transplantation (HSCT) was recently demonstrated to provide benefit over monthly cyclophosphamide (CYC) in the treatment of diffuse cutaneous systemic sclerosis…
  • Abstract Number: 1725 • 2018 ACR/ARHP Annual Meeting

    Fecal Microbiota Transplantation in Patients with Systemic Sclerosis- a Pilot Study

    Håvard Fretheim1, Oyvind Midtvedt1, Anders Heiervang Tennøe1, Henriette Didriksen1, Torhild Garen1, Espen Bækkevold1, Johannes R. Hov1, Knut EA Lundin2, Marius Trøseid1, Øyvind Molberg1 and Anna-Maria Hoffmann-Vold1, 1Oslo University Hospital, Oslo, Norway, 2Dept of gastroenterology, Oslo University Hospital, Oslo, Norway

    Background/Purpose: Up to 90% of patients with systemic sclerosis (SSc) have symptoms from the gastrointestinal (GI) tract. Earlier studies have shown a distinct alteration of…
  • Abstract Number: 1742 • 2018 ACR/ARHP Annual Meeting

    Disease-Specific Autoantibodies Associate with Remarkably Different Risk of Development of Significant Lung Fibrosis in Systemic Sclerosis

    Svetlana I. Nihtyanova1, Alper Sari2, Anna Leslie3, Voon H. Ong4 and Christopher P. Denton5, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 2Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey, 3Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 4Division of Medicine, University College London, London, United Kingdom, 5University College London, London, United Kingdom

    Background/Purpose: Pulmonary fibrosis (PF) is a leading cause of disease-related death in SSc patients. Some studies suggest that the timing of PF development differs between…
  • Abstract Number: 1695 • 2017 ACR/ARHP Annual Meeting

    Baseline Characteristics and Outcomes in a Retrospective Cohort of Patients with Systemic Sclerosis Related Interstitial Lung Disease

    Robert L. Mango1, Eric L. Matteson2, Cynthia S. Crowson3, Jay H. Ryu4 and Ashima Makol2, 1Internal Medicine, Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, MN, 2Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 3Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, MN, 4Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, Rochester, MN

    Background/Purpose: Interstitial lung disease (ILD) is a major contributor to morbidity and mortality in systemic sclerosis (SSc). We sought to identify the distribution of clinical…
  • Abstract Number: 1713 • 2017 ACR/ARHP Annual Meeting

    Defining Genetic Risk for Scleroderma Renal Crisis in RNA-Polymerase III Antibody Positive Patients

    Edward Stern1, Sandra Guerra1, Harry Chinque1, David Gonzalez Serna2, Markella Ponticos1, Javier Martin2, Maureen D. Mayes3, Shervin Assassi4, Carmen Fonseca1 and Christopher Denton5, 1UCL Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom, 2Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain, 3Internal Medicine/Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, 4University of Texas McGovern Medical School, Houston, TX, 5Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom

    Background/Purpose: Scleroderma renal crisis (SRC), characterised by accelerated hypertension and acute kidney injury, is a life-threatening complication of systemic sclerosis (SSc). Most SSc cases have…
  • Abstract Number: 1922 • 2017 ACR/ARHP Annual Meeting

    Cell Type Specific Gene Expression Analysis of Early Systemic Sclerosis Skin Shows a Prominent Activation Pattern of Innate and Adaptive Immune System in the Prospective Registry for Early Systemic Sclerosis (PRESS) Cohort

    Shervin Assassi1, Dinesh Khanna2, Monique Hinchcliff3, Virginia D. Steen4, Faye Hant5, Jessica K. Gordon6, Ami A. Shah7, Jun Ying8, William Swindell9, Wenjin Zheng10, Lisha Zhu10, Victoria K. Shanmugam11, Robyn T. Domsic12, Flavia V. Castelino13, Elana J. Bernstein14 and Tracy M. Frech15, 1University of Texas McGovern Medical School, Houston, TX, 2University of Michigan, Ann Arbor, MI, 3Rheumatology, Northwestern Medicine, Chicago, IL, 4Rheumatology, MedStar Georgetown University Hospital, Washington, DC, 5Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, 8Department of Internal Medicine - Rheumatology, University of Texas McGovern Medical School, Houston, TX, 9Dermatology, University of Michigan - Ann Arbor, Ann Arbor, MI, 10University of Texas - School of Biomedical Informatics, Houston, TX, 11Rheumatology, The George Washington University, Washington, DC, 12Rheumatology, University of Pittsburgh, Pittsburgh, PA, 13Rheumatology, Harvard Medical School, Boston, MA, 14Rheumatology, Columbia University, New York, NY, 15Division of Rheumatology, University of Utah, Salt Lake City, UT

    Background/Purpose: To examine the global gene expression profile in patients with very early diffuse systemic sclerosis (SSc). Methods: Skin biopsies were obtained from patients enrolled…
  • Abstract Number: 1923 • 2017 ACR/ARHP Annual Meeting

    Single Cell RNA Sequencing Reveals a Signature of Endothelial Injury in Scleroderma Skin

    Sokratis Apostolidis1, Giuseppina Stifano2, Tracy Tabib3, Lisa Rice2, Christina Morse3, Bashar Kahaleh4 and Robert A. Lafyatis3, 1Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, 2Boston University School of Medicine, Boston, MA, 3Medicine, Rheumatology, University of Pittsburgh Medical Center, Pittsburgh, PA, 4Medicine/Rheumatology, University of Toledo, Toledo, OH

    Background/Purpose: Vascular injury is a hallmark event in the pathogenesis of Systemic Sclerosis (SSc). Endothelial dysfunction happens early in the course of the disease and…
  • Abstract Number: 2665 • 2017 ACR/ARHP Annual Meeting

    Mortality in an Early Diffuse Cutaneous Systemic Sclerosis Cohort—Data from the Prospective Registry for Early Systemic Sclerosis

    Tracy M. Frech1, Shervin Assassi2, Elana J. Bernstein3, Flavia V. Castelino4, Robyn T. Domsic5, Jessica K. Gordon6, Faye Hant7, Monique Hinchcliff8, Bernie LaSalle9, Victoria K. Shanmugam10, Virginia D. Steen11 and Dinesh Khanna12, 1Division of Rheumatology, University of Utah, Salt Lake City, UT, 2University of Texas McGovern Medical School, Houston, TX, 3Department of Medicine, Division of Rheumatology, Columbia University, New York, NY, 4Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 5Medicine - Rheumatology, University of Pittsburgh, Pittsburgh, PA, 6Rheumatology, Hospital for Special Surgery, New York, NY, 7Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, 8Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 9University of Utah, Salt Lake City, UT, 10Rheumatology, The George Washington University, Washington, DC, 11Division of Rheumatology, Department of Medicine, MedStar Georgetown University Hospital, Washington, DC, 12University of Michigan, Ann Arbor, MI

    Background/Purpose: The Prospective Registry of Early Systemic Sclerosis (PRESS) cohort is an early diffuse cutaneous systemic sclerosis (dcSSc) that provides an opportunity to assess the…
  • Abstract Number: 2674 • 2017 ACR/ARHP Annual Meeting

    The Association between the Extent of Skin Thickness and Organ Involvement, Function and Quality of Life in Early Diffuse Cutaneous Systemic Sclerosis

    Janet E. Pope1, Murray Baron2, Tatiana Nevskaya3, Carl Baxter4 and Dena Ramey5, 1Medicine, Divsion of Rheumatology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada, 2Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, 3Rheumatology Division, St. Joseph’s Health Care London, London, ON, Canada, 4Global Outcomes Research, MSD Ltd, Hoddesdon, United Kingdom, 5Epidemiology, Merck & Co., Upper Gwynedd, PA

    Background/Purpose: To estimate whether severity of skin thickness is associated with disease severity, function, quality of life (QoL) and progression of internal organ involvement over…
  • Abstract Number: 257 • 2017 ACR/ARHP Annual Meeting

    The Use of Positron Emission Tomography (PET)-Scan for the Quantitative Assessment of Interstitial Lung Disease in Systemic Sclerosis

    Daphne Peelen1, Ben Zwezerijnen2, Esther Nossent1, Lilian Meijboom1, Otto Hoekstra3, Conny van der Laken4 and Alexandre Voskuyl4, 1VUmc, Amsterdam, Netherlands, 2Nuclear Medicine, VUmc, Amsterdam, Netherlands, 3Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands, 4Department of Rheumatology, Amsterdam Rheumatology and immunology Center - location VU University Medical Center, Amsterdam, The Netherlands, Amsterdam, Netherlands

    Background/Purpose: Interstitial lung disease (ILD) in systemic sclerosis is treated by immunosuppressive drugs (e.g. cyclophosphamide), aimed at reduction of inflammatory response . Differentiation between inflamed…
  • Abstract Number: 2690 • 2017 ACR/ARHP Annual Meeting

    Plasma D-Dimer Levels Are More Frequently Elevated in Limited Than Diffuse Cutaneous Systemic Sclerosis but Do Not Reflect Disease Duration or Vasculopathy

    Anna Gill1, Svetlana I. Nihtyanova2, Pratima Chowdary3 and Christopher Denton1, 1Division of Medicine, Centre for Rheumatology and Connective Tissue Disease, University College London, London, United Kingdom, 2Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, University College London, London, United Kingdom, 3Department of Haematology, Royal Free Hospital, London, United Kingdom

    Background/Purpose: D-dimers are degradation products of cross linked fibrin and are biomarkers of activation of the coagulation system. Plasma D-dimer levels can be raised in…
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