Abstracts tagged "Scleredema"

Abstract Number: 2572 • 2013 ACR/ARHP Annual Meeting
An Atypical Cyclin-Dependent Kinase Mediates Fibrosis and Is a Novel Target In Scleroderma
Jun Wei¹, Roberta G. Marangoni², Wenxia Wang³, Jingang Huang⁴, Joerg H. W. Distler⁴ and John Varga⁵, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²Division of Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, ⁴Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Cyclin-dependent kinase 5 (CDK5), expressed primarily in the central nervous system, plays important roles in axonal guidance, dopaminergic signaling, neuronal migration, and pain sensing.…
Abstract Number: 1936 • 2013 ACR/ARHP Annual Meeting
Quality Of Care In Patients At Risk For Pulmonary Involvement: Assessment Of Pulmonary Screening In Systemic Sclerosis and Myositis Patients In a General Rheumatology Clinic
Michael G. Indelicato¹, Janet E. Lewis², Vincent J. Giuliano³ and Donald L. Kimpel⁴, ¹Rheumatology, University of Virginia, Charlottesville, VA, ²Rheumatology, University of Virginia School of Medicine, Charlottesville, VA, ³University of Virginia, Charlottesville, VA, ⁴Rheumatology and Immunology, University of Virginia School of Medicine, Charlottesville, VA
Background/Purpose: As a quality assessment tool to evaluate patient care in a general Rheumatology Clinic, we determined the frequency of screening for pulmonary hypertension and…
Abstract Number: 903 • 2013 ACR/ARHP Annual Meeting
A Qualitative Study Of The Educational Needs Of Children With Scleroderma and Their Parents
Cindy F. Mendelson¹, Ana-Alicia Huerta², Jane Kastning³, Bernadette Vargas³ and Janet L. Poole⁴, ¹College of Nursing, University of New Mexico, Albuquerque, NM, ²Univeristy of New Mexico, Albuquerque, NM, ³Occupational Therapy, University of New Mexico, Albuquerque, NM, ⁴Occupational Therapy Program, University of New Mexico, Albuquerque, NM
Background/Purpose: Scleroderma is a rare disease, especially in childhood. Skin changes can be physically disfiguring which can lead to lowered self-esteem, especially during the adolescent…
Abstract Number: 820 • 2013 ACR/ARHP Annual Meeting
CC-220: A Clinical Stage Immunomodulatory, Antifibrotic Drug For Systemic Sclerosis
Jörg HW Distler¹, Yongqing Wang², Pawel Zerr³, Katrin Palumbo⁴, Gerald Horan⁵, Peter Schafer⁵ and Bashar Kahaleh⁶, ¹Department of Internal Medicine, Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ²Medicine, University of Toledo, Toledo, OH, ³Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁴Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁵Department of Translational Development, Celgene Corporation, Summit, NJ, ⁶Medicine/Rheumatology, University of Toledo, Toledo, OH
Background/Purpose: Systemic Sclerosis (SSc) is an autoimmune fibrotic disease in which B cells may play a crucial role in pathogenesis. CC-220 is an immunomodulatory drug…
Abstract Number: 667 • 2013 ACR/ARHP Annual Meeting
IL6 and CCL2 Co-Regulate Fibroblast Dependent Trans-Endothelial Migration Of Mononuclear Cells and Fibrotic Response In Scleroderma
Rebecca Alade¹, Korsa Khan², Xu Shiwen³, Christopher P. Denton⁴ and Voon Ong⁵, ¹Centre for Rheumatology and Connective Tissue Diseases,, UCL Medical School, London, United Kingdom, ²Centre for Rheumatology and Connective Tissue Diseases, UCL medical School, London, United Kingdom, ³Rheumatology, Royal Free Hospital, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁵Department of Rheumatology, UCL Medical School, London, England
Background/Purpose: IL6 is a key mediator recently implicated in activation of extracellular matrix (ECM) proteins in scleroderma (SSc) fibroblasts. CCL2 is a proinflammatory chemokine that…
Abstract Number: 660 • 2013 ACR/ARHP Annual Meeting
Bleomycin Delivery By Mini-Osmotic Pump: A Novel Multi-Organ Murine Model For Fibrosis
Rebecca Lee¹, Elena Tourkina², Richard P. Visconti³ and Stanley Hoffman⁴, ¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ²Rheumatology, Medical University of SC, Charleston, SC, ³Cell Biology and Regenerative Medicine, Medical University of South Carolina, Charleston, SC, ⁴Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic sclerosis (SSc, Scleroderma) is a rare but severe systemic connective tissue disorder involving the skin and multiple internal organs, in particular lung, kidney,…

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].