Abstracts tagged "Salivary gland"

Abstract Number: 1451 • 2019 ACR/ARP Annual Meeting
Histological Characteristics in SICCA Syndrome – Clinical and Serological Association
Maria de Lourdes Flores ¹, Gabriela Alejandra Gutierrez-Robles ¹, Flavio Cesar Estrada-Gil ¹, Miguel Alejandro Davalos-Benitez ¹, Jorge Ernesto Garcia-Alvarado ¹, Alejandra de Lourdes Farias-Sierra¹, Ignacio Garcia-De La Torre ², Gerardo Orozco-Barocio ¹, Carlos Gerardo Riebeling-Navarro ³ and Arnulfo Hernan Nava-Zavala ⁴, ¹HGO SSJ, U de G, PNPC CONACYT, Guadalajara, Mexico, ²Centro de Estudios de Investigación Básica y Clínica, S.C., Guadalajara, Jalisco, Mexico, ³UIEC UMAE HP CMN-SXXI IMSS / UNAM, Ciudad de Mexico, Mexico, ⁴UIB02 UMAE HE CMNO IMSS / HGO SSJ / PIM UAG / PNPC U de G, Guadalajara, Mexico
Background/Purpose: The xerostomia and/or xerophtalmia (SICCA syndrome: items I and II of 2002 AECG criteria) are conspicuous characteristics of primary Sjögren´s syndrome (pSS). pSS diagnostic…
Abstract Number: 2417 • 2019 ACR/ARP Annual Meeting
A Phase 2a Study of MEDI5872 (AMG557), a Fully Human Anti-ICOS Ligand Monoclonal Antibody in Patients with Primary Sjögren’s Syndrome
Xavier Mariette¹, Michele Bombardieri ², Ilias Alevizos ³, Rachel Moate ⁴, Barbara Sullivan ⁵, Ghaith Noaiseh ⁶, Marika Kvarnström ⁷, William Rees ³, Liangwei Wang ³ and Gabor Illei ³, ¹Université Paris-Sud, Paris, France, Paris, Centre, France, ²Queen Mary University of London, London, UK, London, United Kingdom, ³Viela Bio, Gaithersburg, MD, USA, Gaithersburg, MD, ⁴AstraZeneca, Cambridge, UK, Cambridge, United Kingdom, ⁵Amgen Inc., South San Francisco, CA, USA, South San Francisco, CA, ⁶University of Pittsburgh, PA, USA, Pittsburgh, PA, ⁷Karolinska Institutet, Stockholm, Sweden, Stockholm, Sweden
Background/Purpose: The interaction of inducible T cell costimulatory ligand (ICOSL) and the ICOS receptor is key in the pathogenesis of primary Sjögren’s syndrome (pSS). MEDI5872…
Abstract Number: 2436 • 2019 ACR/ARP Annual Meeting
The Salivary Glands as the Key Site of Inflammation and Lymphoproliferation Leading to Lymphoma in Primary Sjögren’s Syndrome: Relevance for Dedicated Scoring, Biomarker Development and Lymphoma Prevention
Salvatore De Vita¹, Saviana Gandolfo ¹, Chiara Baldini ², Miriam Isola ³, Michael Voulgarelis ⁴, Andreas Goules ⁴, Ginevra De Marchi ⁵, Marco Binutti ¹, Sara Zandonella Callegher ⁵, Francesco Ferro ², Claudio Battistella ³, Loukas Chatzis ⁴ and Athanasios Tzioufas ⁴, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ²Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ³Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ⁴Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ⁵Rheumatology Clinic, Udine University Hospital, Udine, Italy, Udine, Italy
Background/Purpose: Since the risk of B-cell non-Hodgkin’s lymphoma (NHL) evolution is increased in primary Sjögren’s syndrome (pSS), its prevention represents a relevant therapeutic end-point. A…
Abstract Number: 2807 • 2019 ACR/ARP Annual Meeting
Activation of the STING Pathway Is a Shared Feature of Salivary Gland and Lung Inflammation in Sjogren’s Syndrome
Joanna Papinska ¹, Grzegorz Gmyrek ², Umesh Deshmukh¹ and Harini Bagavant ¹, ¹Oklahoma Medical Research Foundation, Oklahoma City, OK, ²Oklahoma Medical Research Foundation, Oklahoma City
Background/Purpose: Sjögren’s syndrome is a chronic autoimmune disorder characterized by an increased type 1 interferon gene signature. The engagement of stimulator of interferon genes (STING)…
Abstract Number: 1214 • 2018 ACR/ARHP Annual Meeting
Comparison of Ultrasound Features of Major Salivary Glands in Sarcoidosis, Amyloidosis, and Sjögren’s Syndrome
Shing Law¹, Praveen Govender², S. Reza Jafarzadeh³, Xianbang Sun⁴, Vaishali Sanchorawala⁵ and Eugene Y. Kissin⁶, ¹Rheumatology, Boston Medical Center, Boston, MA, ²The Pulmonary Center, Sarcoidosis Center, Boston University School of Medicine, Boston, MA, ³Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, ⁴Boston University, Boston, MA, ⁵Division of Hematology and Oncology, Boston University School of Medicine, Boston, MA, ⁶Rheumatology, Boston University, Boston, MA
Background/Purpose: Salivary gland enlargement occurs in conditions such as Sjögren’s syndrome (SS), sarcoidosis (SAR), and AL amyloidosis (AL). Salivary gland ultrasound (US) has been shown…
Abstract Number: 2884 • 2018 ACR/ARHP Annual Meeting
Correlation between Salivary Gland Ultrasonography, Minor Salivary Gland Histhopatology and Sialometry: Towards a Composite Assessment of Salivary Gland Involvement in Primary Sjögren’s Syndrome
Chiara Baldini¹, Nicoletta Luciano¹, Francesco Ferro¹, Antonella Cecchettini², Valentina Donati³, Marta Mosca¹ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Pisa, Italy, ²IFC, CNR, Pisa, Italy, ³Pathology Unit, University of Pisa, Pisa, Italy
Background/Purpose:: Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease that specifically involves salivary glands. Several complementary tools including salivary gland ultrasonography (SGUS), histology and…
Abstract Number: 1497 • 2017 ACR/ARHP Annual Meeting
Clinical and Laboratory Features of Patients with Focal Lymphocytic Sialadenitis on Minor Salivary Gland Biopsy for Sicca Symptoms: A 16 Year Experience
Bibi Ayesha¹, Ruth Fernandez-Ruiz², Devin Shrock³, Rebecca Tuetken⁴, Scott Lieberman⁵, Elizabeth Field⁶ and Namrata Singh⁷, ¹Internal Medicine and Division of Rheumatology, MD, BRONX, NY, ²Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, ³Pathology, MD, Iowa, IA, ⁴MD, PhD, Iowa, IA, ⁵Division of Rheumatology, Stead Family Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, IA, ⁶Iowa City VA, Iowa City, IA, ⁷VA Nebraska-Western Iowa Health Care System and University of Iowa, Omaha, IA
Background/Purpose: Focal lymphocytic sialadenitis (FLS) on minor salivary gland biopsy (MSGB) is one of the classification criteria for Sjögren's syndrome (SS). As no diagnostic criteria…
Abstract Number: 100 • 2017 Pediatric Rheumatology Symposium
Improvement of Salivary Gland Ultrasound Findings in Juvenile Sjögren’s Syndrome after Systemic Corticosteroid Treatment
Akaluck Thatayatikom¹, Renee F Modica², Daniel S. Hammenfors³, Natalie Jane Shiff¹ and Melissa E Elder², ¹Pediatrics, University of Florida, Gainesville, FL, ²Department of Pediatrics, University of Florida, Gainesville, FL, ³Department of Rheumatology, Haukeland University Hospital, Bergen, Norway
Background/Purpose: Juvenile Sjögren’sSyndrome (jSS) is a rare systemic autoimmune disease affecting predominantly salivary glands (SG) in children who do not meet criteria for SLE or MCTD. Currently, no specific criteria for…
Abstract Number: 2660 • 2016 ACR/ARHP Annual Meeting
Do Ultrasonographic Lesions of Salivary Glands Evolve in SjöGren Patients during Follow-up ?
Alain Saraux¹, Valerie Devauchelle², Sandrine Jousse-Joulin³, Divi Cornec⁴, Pierre Gazeau⁵ and Dewi Guellec⁵, ¹Rheumatology Department, CHU de la Cavale Blanche, Brest Cedex, France, ²Service de Rhumatologie, Department of Rheumatology, Brest University Hospital, Brest, France, Brest, France, ³Rheumatology, CHu La cavle Blanche, Brest, France, ⁴Department of rheumatology, Brest Occidentale University, Brest, France, ⁵Rheumatology, CHU Brest, Brest, France
Background/Purpose: to evaluate if the salivary glands ultrasonographic score (SGUS) is modified during follow-up in primitive Sjögren patients (pSS) and to compare pSS with idiopathic…
Abstract Number: 528 • 2014 ACR/ARHP Annual Meeting
Calcium-Calcineurin-NFAT Signaling Pathway Regulates AQP5 Expression in Primary Salivary Gland Acinar Cells
Shyh-Ing Jang¹, Hwei Ling Ong¹, Indu Ambudkar² and Illias Alevizos³, ¹Molecular Physiology and Therapeutics Branch, NIDCR, Bethesda, MD, ²NIDCR, MPTB, NIH, Bethesda, MD, ³NIDCR, Bethesda, MD
Background/Purpose Aquaporin (AQP) 5 belongs to a family of small integral membrane proteins which function as a water channels in cells. AQP5 plays a critical…

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