Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…Abstract Number: 2152 • 2015 ACR/ARHP Annual Meeting
Long Noncoding H19X Is a Key Mediator of Tgf-Beta Induced Pro-Fibrotic Effects in the Pathogenesis of Systemic Sclerosis and Other Fibrotic Diseases
Background/Purpose: Long noncoding RNAs (LncRNAs) are emerging as a novel class of noncoding transcripts involved in the regulation of gene expression. So far, for only…Abstract Number: 2978 • 2014 ACR/ARHP Annual Meeting
Characterization of the Sjögren’s Syndrome Intergenic Non-Coding RNA 1 (SSINCR1)
Background/Purpose Sjögren’s syndrome (SS) is a common autoimmune disorder characterized by immune-mediated exocrine gland destruction and systemic inflammatory responses that contribute to clinical heterogeneity. Widespread…Abstract Number: 2094 • 2014 ACR/ARHP Annual Meeting
Deep Sequencing Reveals Differential RNA Expression during Malignant Transformation in Major Salivary Glands in a Mouse Model of Sjogren’s Syndrome
Background/Purpose – Sjšgren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that targets salivary and lacrimal glands and may be accompanied bymultiorgan systemic manifestations. To further…Abstract Number: 1723 • 2014 ACR/ARHP Annual Meeting
Identification of the Microbiome As a Potential Trigger of Systemic Sclerosis By Metagenomic RNA-Sequencing of Skin Biopsies
Background/Purpose: Systemic sclerosis (SSc) is a rare and poorly understood systemic autoimmune disease that results in skin fibrosis and severe internal organ involvement. There…Abstract Number: 1607 • 2014 ACR/ARHP Annual Meeting
B Cell and Neutrophil-Related Transcripts Predict and Characterize a Lupus Flare
Background/Purpose Lupus flare reflects an increase of disease activity that is associated with significant morbidity and accumulation of tissue damage. Prediction and prevention of lupus…Abstract Number: 1619 • 2014 ACR/ARHP Annual Meeting
Interferon Dysregulation in an Academic SLE Cohort Is Associated with Distinct Signaling Differences in Blood Neutrophils Versus PBMCs
Background/Purpose Interferons (IFNs) have long been implicated in the pathogenesis of systemic lupus erythematosus (SLE). However, the specific consequences of the IFN activity have not…Abstract Number: 1128 • 2014 ACR/ARHP Annual Meeting
Regulation of PIWIL4 By Histone Modifications in Rheumatoid Arthritis
Background/Purpose Analog to miRNAs that bind to argonaute proteins to suppress gene expression, a new group of non-coding RNAs piwi-interacting RNAs (piRNAs, 26-31 nt) build…Abstract Number: 1002 • 2014 ACR/ARHP Annual Meeting
Global Transcriptome Analysis in Osteoarthritic Cartilage Reveals Significant Differential Gene Expression and Associations with Histologic Disease Progression
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic disability affecting 40% of individuals over the age of 70 and costing $128 billion annually in…Abstract Number: 332 • 2014 ACR/ARHP Annual Meeting
Improvement of the Stability of RNA Aptamers Against Interleukin-17A
Background/Purpose Aptamers are RNA or DNA oligonucleotides selected for their capacity to specifically bind and inhibit the function of a target protein. The effect is…Abstract Number: 2194 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing In Peripheral Blood Mononuclear Cells Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Juvenile Idiopathic Arthritis
Background/Purpose: Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. The aetiology of JIA remains largely unknown, but the interplay between genes…Abstract Number: 2025 • 2013 ACR/ARHP Annual Meeting
Distinctive Expression Profiles Of Long Intergenic Non-Coding RNA Between Polymyalgia Rheumatica and Rheumatoid Arthritis Might Contains Helpful Suggestions For Understanding and Discriminating These Diseases
Background/Purpose: There are many clinical similarities between polymyalgia rheumatica (PMR) and rheumatoid arthritis (RA). It has been reported that the specificity for discriminating PMR from…Abstract Number: 1485 • 2013 ACR/ARHP Annual Meeting
RNA Transcripts From Peripheral Blood Mononuclear Cells As Predictors Of Clinical Responsiveness In Rheumatoid Arthritis Subjects Treated With Abatacept
Background/Purpose: Biologics, including abatacept (CTLA4Ig), improve outcomes for many RA patients. However, approximately 40-50% of RA patients fail to respond to abatacept, and there are…Abstract Number: 1489 • 2013 ACR/ARHP Annual Meeting
RNA-Sequencing Identifies Novel Differentially Expressed Coding and Non-Coding Transcripts In Sjögren’s Syndrome
Background/Purpose: Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. SS…Abstract Number: 148 • 2013 ACR/ARHP Annual Meeting
Microarray Analysis Of Synovial Specimen of Early Human (CHECK) and Experimental Osteoarthritis to Identify Pathways and Processes Associated with Pathology
Background/Purpose: The majority of osteoarthritis (OA) patients show synovial inflammation, even relatively early during the disease. We used microarray analysis of synovial tissue of early…
ACR Meeting Abstracts