Abstract Number: 2757 • 2017 ACR/ARHP Annual Meeting
Kidney and Skin Single-Cell RNA Sequencing in Lupus Nephritis Provides Mechanistic Insights and Novel Potential Biomarkers
Background/Purpose: Classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Single-cell RNAseq (scRNAseq) analysis may accurately differentiate types of renal…Abstract Number: 181 • 2017 ACR/ARHP Annual Meeting
Identification of Disease-Susceptible Lncrna Contributed to Abnormal Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus
Background/Purpose: Dysregulation or dysfunction of some key moleculars in signaling pathway is involved in disease pathogenesis. Long non-coding RNA (lncRNA), as a regulator of gene…Abstract Number: 302 • 2017 ACR/ARHP Annual Meeting
From Monocytes to Macrophages: the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Background/Purpose: We have generated a CD11c-Flip-KO mouse line (HUPO) that spontaneously develops erosive arthritis with incidence 70-80% at age ≥ 20 weeks. This study aimed…Abstract Number: 799 • 2016 ACR/ARHP Annual Meeting
Biomarker Identification & Molecular Sub-Classification in Systemic Sclerosis for Precision Medicine Using RNA-Seq
Background/Purpose: Systemic sclerosis (SSc) is a complex and highly heterogeneous disease with multi-organ involvement. Accurate tools for disease sub-classification are lacking. In most patients, skin…Abstract Number: 1080 • 2016 ACR/ARHP Annual Meeting
B-Cell Clonal Expansions in Parotid Glands of Sjogren’s Patients Are Associated with Increased Numbers of N-Glycosylation Motifs in the Immunoglobulin Heavy Chain Genes
Background/Purpose: Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease characterized by chronic inflammation of salivary and lacrimal glands. Patients with pSS have increased clonal…Abstract Number: 1120 • 2016 ACR/ARHP Annual Meeting
Interleukin-1β Stabilize CXCL2 mRNA and Increase Its Expression
Background/Purpose: Changes in gene expression are closely related to inflammation and joint destruction in RA. Recently, it has been recognized that post-transcriptional regulation of the…Abstract Number: 1217 • 2016 ACR/ARHP Annual Meeting
Identification of Sjogren’s Syndrome-Associated Long Non-Coding RNAs That Are Co-Expressed with Key Protein-Coding Transcripts Involved in Dysregulated Interferon Responses
Background/Purpose: The “interferon signature”, marked by transcriptional upregulation of interferon (IFN)-inducible (IFI) genes, is a common finding in Sjögren’s syndrome (SS) that is associated with…Abstract Number: 1576 • 2016 ACR/ARHP Annual Meeting
Identifying Rheumatoid Arthritis Subtypes Using Synovial Tissue Gene Expression Profiling, Histologic Scoring and Clinical Correlates
Background/Purpose: The histopathologic features of synovial tissue vary widely among patients with rheumatoid arthritis (RA) undergoing arthroplasty and the clinical significance of this variability is…Abstract Number: 2070 • 2016 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Master Regulator of Extracellular Matrix Production in Systemic Sclerosis and Other Fibrotic Disease
Background/Purpose: Long noncoding RNAs (lncRNAs) are an emerging class of large noncoding transcripts involved in the regulation of gene expression in health and disease. We…Abstract Number: 2455 • 2016 ACR/ARHP Annual Meeting
Transcriptome Profile of Cells Isolated from a CHB Heart Support an Exuberant Inflammatory ⁄Pro-Fibrotic Cascade
Background/Purpose: Histologic correlates of anti-Ro associated congenital heart block (CHB) are apoptosis and calcification of cardiomyocytes with fibrosis of the AV node surrounded by infiltrating macrophages…Abstract Number: 3045 • 2016 ACR/ARHP Annual Meeting
Immunometabolism in ANCA-Associated Glomerulonephritis
Background/Purpose: Mounting an inflammatory response requires immune cells to undergo major changes in metabolism. Mediators such as cytokines can specifically alter the metabolism of different…Abstract Number: 3046 • 2016 ACR/ARHP Annual Meeting
Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome
Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…Abstract Number: 303 • 2015 ACR/ARHP Annual Meeting
Mining RNA-Seq of Peripheral Blood Mononuclear Cells from JDM Alone Compared with JDM Plus Psoriasis for Biomarkers of Disease Activity
Background/Purpose: Our CureJM JDM Registry/Repository contains sequential samples of peripheral blood mononuclear cells (PBMCs) and sera obtained every 6 months from over 467 children with…Abstract Number: 1071 • 2015 ACR/ARHP Annual Meeting
Single-Cell RNA Sequencing of Human Podocytes, Endothelial Cells, and Tubular Cells Identifies Markers and Gene Profiles Differentiating Class IV and Class V Renal Disease in Lupus Nephritis
Background/Purpose: Currently, classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Transcriptome analysis may accurately differentiate types of renal involvement,…Abstract Number: 1855 • 2015 ACR/ARHP Annual Meeting
Systemic Lupus Erythematosus Exosomes Contain Distinct RNA Transcripts That Differentiate Disease Activity and Modulate Cellular Function
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple organ systems and periods of waxing and waning disease activity. The lack of…
ACR Meeting Abstracts