Abstracts tagged "RNA"

Abstract Number: 1931 • 2018 ACR/ARHP Annual Meeting
Abundance of Plasma Microbial Small RNAs Are Predictive of Improvement in Disease Activity after DMARD Initiation for Rheumatoid Arthritis
Michelle J. Ormseth¹, Quanhu Sheng¹, Shilin Zhao¹, Joseph F. Solus¹, Qiong Wu¹, Ryan Allen¹, Yan Guo¹, Fei Ye¹, Marisol Ramirez¹, Kasey Vickers¹, S. Louis Bridges Jr.², Jeffrey R. Curtis³ and C Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ³University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Small RNAs (sRNAs) are important regulators of biological processes and are potential biomarkers of disease and drug response. We previously found that microbial sRNAs…
Abstract Number: 1967 • 2018 ACR/ARHP Annual Meeting
Detection of Association of Long Noncoding RNA ATP6V0E2-AS1 Single Nucleotide Polymorphism with Susceptibility to Myeloperoxidase-ANCA Associated Vasculitis Based on Transcriptome Analysis
Yuka Iwahashi^1,2, Aya Kawasaki^1,2, Takayo Tsuchiura³, Ken-ei Sada⁴, Fumio Hirano^5,6, Daisuke Tsukui⁷, Shigeto Kobayashi⁸, Hidehiro Yamada⁹, Hiroshi Furukawa^1,2,10, Kenji Nagasaka¹¹, Takahiko Sugihara¹², Nao Nishida³, Kunihiro Yamagata¹³, Takayuki Sumida¹⁴, Shigeto Tohma^10,15, Shoichi Ozaki⁹, Hiroshi Hashimoto¹⁶, Hirofumi Makino¹⁷, Yoshihiro Arimura¹⁸, Hajime Kono¹⁹, Masayoshi Harigai²⁰ and Naoyuki Tsuchiya^1,2, ¹University of Tsukuba, Graduate School of Comprehensive Human Sciences, Masters' Program in Medical Sciences, Tsukuba, Japan, ²University of Tsukuba, Faculty of Medicine, Molecular and Genetic Epidemiology Laboratory, Tsukuba, Japan, ³Genome Medical Science Project, National Center for Global Health and Medicine, Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan, ⁵Tokyo Medical and Dental University, Graduate School of Medical and Dental Sciences, Department of Rheumatology, Tokyo, Japan, ⁶Tokyo Medical and Dental UniversityGraduate School of Medical and Dental Sciences, Department of Lifetime Clinical Immunology, Tokyo, Japan, ⁷Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan, ⁸Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁹St. Marianna University, School of Medicine, Department of Internal Medicine, Kawasaki, Japan, ¹⁰National Hospital Organization Sagamihara l Hospital, Clinical Research Center for Allergy and Rheumatology, Sagamihara, Japan, ¹¹Department of Rheumatology, Ome Municipal General Hospital, Ome, Japan, ¹²Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, ¹³University of Tsukuba, Faculty of Medicine, Department of Nephrology, Tsukuba, Japan, ¹⁴Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹⁵National Hospital Organization Tokyo National Hospital, Kiyose, Japan, ¹⁶Juntendo University School of Medicine, Tokyo, Japan, ¹⁷Okayama University Hospital, Okayama, Japan, ¹⁸Kyorin University School of Medicine, First Department of Internal Medicine, Tokyo, Japan, ¹⁹Teikyo University School of Medicine, Department of Internal Medicine, Tokyo, Japan, ²⁰Tokyo Women's Medical University, Division of Epidemiology and Pharmacoepidemiology of Rheumatic Diseases, Institute of Rheumatology, Tokyo, Japan
Background/Purpose: Because of the low prevalence, only three genome-wide association studies, all from the Caucasian populations, have been reported on ANCA-associated vasculitis (AAV) thus far;…
Abstract Number: 2018 • 2018 ACR/ARHP Annual Meeting
Microenvironment Driven Re-Shaping of Pathogenic T Effector and Regulatory Subset in Active Juvenile Idiopathic Arthritic Patients
Jing Yao Leong¹, Pavanish Kumar¹, Phyllis Chen², Joo Guan Yeo^2,3, Camillus Chua², Sharifah Nur Hazirah², Suzan Saidin¹, Thaschawee Arkachaisri^2,3, Alessandro Consolaro⁴, Marco Gattorno⁵, Alberto Martini⁶ and Salvatore Albani², ¹Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore, Singapore, ²Translational Immunology Institute, Singhealth/Duke-NUS Academic Medical Centre, Singapore Health Services Pte Ltd, Singapore, Singapore, ³KK Women's and Children's Hospital, Singapore, Singapore, ⁴Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genova, Italy, ⁵Second Paediatric Division, University of Genoa and G Gaslini Institute, Genova, Italy, Genoa, Italy, ⁶Pediatric Rheumatology International Trial Organization (PRINTO) Coordinating Centre, Genoa, Italy
Background/Purpose: We have previously identified two CD4 pathogenic circulatory subsets in both T effector (CPLs) and T regulatory (iaTreg) compartments that are both HLA-DR+, antigen…
Abstract Number: 2055 • 2018 ACR/ARHP Annual Meeting
Laser Capture Microdissection to Interrogate B Cells in RA Synovial Tissue
Javier Rangel-Moreno¹, Nida Meednu², Andrew McDavid³, Linda Callahan⁴, V. Kaye Thomas⁴, Jennifer Albrecht², Edward F. DiCarlo⁵, Dana Orange⁶, Susan M. Goodman⁶, Laura T. Donlin⁷ and Jennifer Anolik², ¹Medicine- Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, ³Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, ⁴University of Rochester Medical Center, Rochester, NY, ⁵Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁶Hospital for Special Surgery, New York, NY, ⁷Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, NY
Background/Purpose: Rheumatoid arthritis is an autoimmune disease characterized by immune cell infiltration in synovial tissue and progressive bone damage. B cells are abundant in the…
Abstract Number: 2324 • 2017 ACR/ARHP Annual Meeting
Single Cell RNA-Sequencing of Bone Marrow Macrophages Identifies a Distinct Subpopulation in Systemic JIA with Features of Interferon Response, Endocytic Vesicles and Phagocytosis
Grant Schulert¹, Nathan Salomonis², Sherry Thornton³ and Alexei A. Grom⁴, ¹Pediatric Rheumatology, Division of Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ²Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁴Division of Pediatric Rheumatology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, United States Minor Outlying Islands
Background/Purpose: Macrophage activation syndrome (MAS) is a life-threatening complication of systemic juvenile idiopathic arthritis (SJIA), characterized by activation and expansion of cytolytic lymphocytes and macrophages…
Abstract Number: 2432 • 2017 ACR/ARHP Annual Meeting
Longitudinal Changes in Gene Expression Associated with Disease Activity during Pregnancy and Post-Partum Among Women with Rheumatoid Arthritis
Dana E. Goin^1,2, Mette Smed³, Nicholas Jewell², Lior Pachter^2,4, J. Lee Nelson^5,6, Hanne Kjaergaard³, Jørn Olsen⁷, Merete Lund Hetland^8,9, Bent Ottesen³, Vibeke Zoffmann³ and Damini Jawaheer^1,7,10, ¹UCSF Benioff Children's Hospital Oakland/CHORI, Oakland, CA, ²University of California, Berkeley, Berkeley, CA, ³Juliane Marie Center, Copenhagen, Denmark, ⁴California Institute of Technology, Pasadena, CA, ⁵Fred Hutchinson Cancer Research Center, Seattle, WA, ⁶University of Washington, Seattle, WA, ⁷Aarhus University, Aarhus, Denmark, ⁸The DANBIO registry and the Danish Departments of Rheumatology, Glostrup, Denmark, ⁹University of Copenhagen, Copenhagen, Denmark, ¹⁰University of California, San Francisco, San Francisco, CA
Background/Purpose: Many women with rheumatoid arthritis (RA) experience an improvement in disease activity during pregnancy, and a predictable flare in the months after they give…
Abstract Number: 2575 • 2017 ACR/ARHP Annual Meeting
The Role of Interferon in Autoimmune-Susceptible Ro60 Knockout Mice
Masaoki Kawasumi¹, Daiki Rokunohe¹, Edward Chiou², Xizhang Sun², Lena Tanaka², Sandra L. Wolin³ and Keith B. Elkon⁴, ¹Medicine/Dermatology, University of Washington, Seattle, WA, ²Medicine/Rheumatology, University of Washington, Seattle, WA, ³RNA Biology Laboratory, National Cancer Institute, Frederick, MD, ⁴Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: The Ro60 protein is a prominent autoantigen in systemic lupus erythematosus (SLE) and Sjogren’s syndrome (SS). Anti-Ro antibodies are strongly associated with UV-mediated skin…
Abstract Number: 2757 • 2017 ACR/ARHP Annual Meeting
Kidney and Skin Single-Cell RNA Sequencing in Lupus Nephritis Provides Mechanistic Insights and Novel Potential Biomarkers
Evan Der¹, Hemant Suryawanshi², Saritha Ranabothu³, Beatrice Goilav⁴, H. Michael Belmont⁵, Peter M. Izmirly⁶, Nicole Bornkamp⁵, Nicole Jordan⁷, Tao Wang¹, Ming Wu⁶, Judith A. James⁸, Joel M. Guthridge⁹, Soumya Raychaudhuri¹⁰, Thomas Tuschl¹¹, Jill P. Buyon¹² and Chaim Putterman¹³, ¹Albert Einstein College of Medicine, Bronx, NY, ²The Rockefeller University, New York, NY, ³Nephrology, Children's Hospital at Montefiore, Bronx, NY, ⁴Albert Einstein College of Medicine/Montefiore Medical Center, New York, NY, ⁵Medicine, New York University School of Medicine, New York, NY, ⁶New York University School of Medicine, New York, NY, ⁷Montefiore Medical Center, New York, NY, ⁸Arthritis & Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁹Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹⁰Divisions of Genetics and Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ¹¹Rockefeller University, New York, NY, ¹²Rheumatology, New York University School of Medicine, New York, NY, ¹³Division of Rheumatology, Albert Einstein College of Medicine, Bronx, NY, USA, Bronx, NY
Background/Purpose: Classification and treatment decisions in lupus nephritis (LN) are largely based on renal histology. Single-cell RNAseq (scRNAseq) analysis may accurately differentiate types of renal…
Abstract Number: 181 • 2017 ACR/ARHP Annual Meeting
Identification of Disease-Susceptible Lncrna Contributed to Abnormal Activation of Type I Interferon Pathway in Systemic Lupus Erythematosus
Nan Shen^1,2, Yuanjia Tang³, Zhixin Xue³ and Chaojie Cui⁴, ¹Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ²The Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America, Cincinnati, OH, ³Shanghai Institute of Rheumatology,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
Background/Purpose: Dysregulation or dysfunction of some key moleculars in signaling pathway is involved in disease pathogenesis. Long non-coding RNA (lncRNA), as a regulator of gene…
Abstract Number: 302 • 2017 ACR/ARHP Annual Meeting
From Monocytes to Macrophages: the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang¹, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter³ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: We have generated a CD11c-Flip-KO mouse line (HUPO) that spontaneously develops erosive arthritis with incidence 70-80% at age ≥ 20 weeks. This study aimed…
Abstract Number: 387 • 2017 ACR/ARHP Annual Meeting
F4/80hi Synovial Macrophages in the Pathogeneses of Spontaneous Inflammatory Arthritis in CD11c-Flip-KO (HUPO) Mice
Qi Quan Huang^1,2, Renee E. Doyle², Philip J. Homan¹, Harris Perlman³, Deborah R. WInter⁴ and Richard M. Pope², ¹Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Synovial tissue macrophages (STMs) are critical in the pathogenesis of rheumatoid arthritis (RA). During homeostasis, the majority of murine synovial tissue resident macrophages (TRMs)…
Abstract Number: 770 • 2017 ACR/ARHP Annual Meeting
Integrating Analysis of Skin RNA in Situ Hybridization Using Rnascope and Whole Skin Gene Expression in Systemic Sclerosis Skin to Localize Key Pathogenic Drivers of Skin Fibrosis
Corrado Campochiaro¹, Emma C. Derrett-Smith¹, Voon H. Ong², Gail Pearse³, Katherine Nevin³, Shaun Flint³, Mary Morse³, Nicolas Wisniacki⁴ and Christopher Denton⁵, ¹Centre for Rheumatology and Connective Tissue Diseases, UCL Division of Medicine, London, United Kingdom, ²Rheumatology, UCL Division of Medicine, London, United Kingdom, ³GlaxoSmithKline, Stevenage, United Kingdom, ⁴ImmunoImflammation, GlaxoSmithKline, Stevenage, United Kingdom, ⁵Department of Rheumatology, University College London, Royal Free Hospital, London, United Kingdom
Background/Purpose: Skin gene expression profiling can distinguish SSc from normal skin and can detect different subsets of disease. Previous studies have reported a cross-sectional relationship…
Abstract Number: 1026 • 2017 ACR/ARHP Annual Meeting
Gene Expression Analysis Reveals Common Pathways of Tissue Pathogenesis in Lupus Organ Involvement
Amrie Grammer¹, Sarah Heuer¹, Robert Robl¹, Adam Labonte¹, Prathyusha Bachali¹, Sushma Madamanchi¹ and Peter E. Lipsky², ¹AMPEL BioSolutions and RILITE Research Institute, Charlottesville, VA, ²AMPEL BioSolutions, LLC, Charlottesville, VA
Background/Purpose: Lupus is a prototypic autoimmune disease characterized by B cell hyperactivity, autoantibody formation and resultant tissue damage. The mechanisms underlying tissue pathology in lupus…
Abstract Number: 1330 • 2017 ACR/ARHP Annual Meeting
Rhesus Theta Defensin 1 (RTD-1) Suppresses Disease-Associated Genes and Induces Anti-Inflammatory Expression Signature in Synovial Tissues of Rat Model of Rheumatoid Arthritis
Prasad Tongaonkar¹, Vasu Punj², Akshay Subramanian³, Dat Tran³, Katie Trinh⁴, Justin Schaal¹, Percio S. Gulko⁵, Andre Oullette³ and Michael Selsted³, ¹Pathology and Laboratory Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ²Medicine, Keck School of Medicine University of Southern California, Los Angeles, CA, ³Keck School of Medicine University of Southern California, Los Angeles, CA, ⁴Pathology, Keck School of Medicine University of Southern California, Los Angeles, CA, ⁵Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Theta (θ) defensins are the only known macrocyclic peptides found in the Animal kingdom and are exclusively expressed in Old World monkeys. θ-defensins were…
Abstract Number: 1721 • 2017 ACR/ARHP Annual Meeting
Long Noncoding RNA H19X Is a Key Regulator of Apoptosis and Proliferation of Fibroblasts in Systemic Sclerosis and Other TGFβ-Driven Fibrotic Diseases
Elena Pachera¹, Adam Wunderlin¹, Shervin Assassi², Gloria Salazar², Mojca Frank Bertoncelj¹, Rucsandra Dobrota¹, Matthias Brock³, Carol A. Feghali-Bostwick⁴, Gerard Dijkstra⁵, Gerhard Rogler⁶, Tobias van Haaften Wouter⁶, Jörg Distler⁷, Gabriela Kania¹ and Oliver Distler¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Rheumatology, University of Texas Health Science Center at Houston, Houston, TX, ³Department of Pulmonology, University Hospital Zurich, Zurich, Switzerland, ⁴Division of Rheumatology and Immunology, Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, SC, United States, Charleston, SC, ⁵Department of Gastroenterology and Hepatology, University Medical Center Groningen, Groningen, Switzerland, ⁶Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland, ⁷Internal Medicine 3, University of Erlangen, Erlangen, Germany
Background/Purpose: Long noncoding RNAs (lncRNAs) are a class of transcripts regulating gene expression. We have recently identified a novel lncRNA, H19X, which was upregulated in…

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